720370Tangent Reprofiling. Development of prototype: TAN2004, a safe, known drug formulated for treatment of prostate and lung cancer.ClosedGRD Development of PrototypeInnovate UKSome cancerous tumors require, or grow faster in the presence of, steroid hormones such as estrogen or testosterone. These cancers can be treated by chemotherapy drugs to prevent the tumor using hormones found naturally in the body. Many of these drugs work by blocking the receptors for the hormone on the outside edges of the tumor, starving the tumor by preventing it from recognizing the hormone. However, many hormone-dependant tumors develop resistance to these drugs by learning to make the hormones internally. We used our proprietary technology to study drugs that are currently used in non-cancer diseases. One drug was identified as being capable of preventing internal hormone production by tumors. This drug is already in clinical use for an alternative disease which requires long term use, so the safety and side effects are already well characterized across a broad population of patients. We propose combining this drug with a common, safe nutritional supplement to attack the tumor from within while maintaining the starvation procedure described above. We already have data to demonstrate a reduction in growth of prostate cancer cells with the drug in vitro, and preliminary efficacy data for prostate tumors in mice, however, we now need to expand this to optimise the prototype drug combination formulation and dosing schedule. We also look to expand the use into lung cancer, for which we have already seen promising in vitro data. This project includes a first in vivo lung cancer model as well as advanced stage prostate cancer mouse models. This project period will develop our prototype cancer treatment from proof of concept to clinic-ready, ensuring partnering for clinical development is likely on conclusion. We believe this offers an exciting opportunity to prolong successful treatment of a range of common cancers including prostate and lung cancer.