10144691A next-generation hybrid flow diverter for the transformation of brain aneurysm treatmentActiveCollaborative R&DInnovate UKAnnually 6,600 UK citizens suffer a subarachnoid haemorrhage (SAH) resulting from a ruptured intracranial aneurysm (IA), with 40% mortality and 40% morbidity (severe neurological disabilities). However, SAHs are entirely avoidable through early intervention. Over the last decades, IA standard-of-care has moved from invasive, risky, and expensive open surgeries (clipping) to less-risky and more efficient minimally invasive endovascular coiling. Here metal coils are inserted into the aneurysm to prevent growth and rupture. However, for wide-necked, large, and complex aneurysms, coils can dislodge and migrate into the parent artery, leading to thrombosis and stroke. To address this challenge, stents are placed over the aneurysm neck. However, this is expensive and introduces new risks, such as stent-associated thrombosis. Flow-diverters (FDs) are 'stent-like' devices that are placed over the aneurysm to divert blood flow, thereby preventing growth/rupture and enabling natural healing. By their nature, FDs have the potential to effectively treat wide-necked, large, and complex aneurysms. However, FDs have failed to live up to expectations, reporting higher complication rates than coiling. Limitations are inherent to the FD braided-mesh design, driving weak and non-uniform radial forces, resulting in incomplete device opening, poor vessel apposition and conformity, and variable porosity; leading to poor deployment/placement accuracy (surgical complications), suboptimal aneurysm occlusion and endothelialisation (healing), and device migration and FD-associated thrombosis/stroke. These performance and safety limitations/risks restrict use for many aneurysm types. OxiFlow is a next-generation 'hybrid' flow-diverter design, enabling efficient treatment of all aneurysm-types, regardless of size and shape, with reduced surgical complications, improved patient outcomes, and healthcare efficiencies.