10075828Automated Technoeconomic Analysis for Biomanufacturing OptimisationClosedGrant for R&DInnovate UKNew Wave Biotech (NWB) is developing software that uses computational modelling to optimise downstream processes (DSP) for biomanufacturing, accelerating R&D and reducing final production costs of alternative proteins and other synthetic biology products. This solution transforms how DSP optimisation is done -- moving it from a slow, expensive and inefficient approach reliant on expert experience, to one that is rapid, driven by efficient computational modelling, with targeted experiments on high potential processes. We combine machine learning models with mechanistic approaches to unite an understanding of the underlying system dynamics with the nuances of real-world operation. This is then combined with a smart optimisation system to search the billions of possible process and parameter combinations to identify the optimal downstream process through in-silico testing. New Wave Biotech is now developing functionality to automate techno-economic analysis, allowing our customers to have a clear view of the costs and payback time of different bioprocessing options.