700565Rafi-tone: Market testing resubmissionClosedGRD Proof of MarketInnovate UKViral induced wheeze or chronic wheeze associated with asthma affects 5.5 million children under 5 in Europe and the US. Our company, Clin-e-cal Ltd, has developed Rafi-tone, an innovative device which has been created to aid compliance of young children to inhaler medication delivered via a spacer device. Rafi-tone addresses two problems: in the short term, the anxiety associated with the delivery of this medication; and in the longer term maintenance of correct inhaler technique. Initially developed with a partnership between the University of Manchester and the Central Manchester Foundation Trust (CMFT), we now wish to evaluate the commercial viability of our novel product. When a child develops a wheeze, delivery of inhaled medication can be a significant challenge and can lead to substantial distress to the child and their parents. Screaming and struggling can exacerbate the wheeze and reduce the amount of drug delivered to the child. Clin-e-cal Ltd has developed an innovative solution which operates a simple and fun to use educational device when the spacer is used correctly. The device is engaging, simple and intuitive to operate for children as young as 18 months which will drive adoption. As the child continues to use the spacer, the concern shifts from the acute problem to an ongoing concern that the inhaler medication is actually being delivered in an effective dose and the correct inhaler technique is maintained. Solutions which have previously been developed to address this need have focused on novel spacer designs, rather than creating an accessory to the patient’s existing spacer. Our technology can be used with all of the most commonly used spacer devices and therefore will be accessible to over 97% of current users of spacers. Our research to date leads us to believe that Rafi-tone will be welcomed by parents and healthcare professionals, reducing a significant source of stress during what is already a highly demanding situation.