710485The development of a hand held, point of care, device by Kanichi Research Services Ltd to measure ammonia in breath as a new approach for the immediate diagnosis,treatment and monitoring of Helicobacter Pylori infection facilitating mass population screenClosedGRD Proof of ConceptInnovate UKThere has been a considerable research into chemicals in breath linking their presence, or excess, with disease or disorders. There are over 30 diseases where research has made this link. Current diagnosis is often dependent on the analysis of blood, saliva,urine and stools. It can be invasive or unpleasant for the individual, and there can be significant Laboratory delays in obtaining results. A point of care hand held device capturing breath for speedy diagnosis and management of disease has high potential for use by medical professionals and for home monitoring. Kanichi plans to develop a platform technology measuring chemicals in breath using electrochemical sensors housed within a portable breath collection device. Our first target is ammonia. This is because our initial market research showed that elevated levels of ammonia have been associated with nine different medical conditions and as such a device could have multiple applications. The two most attractive indications were determined to be the point of care measurement of the effectiveness of dialysis in end stage renal disease, and in the diagnosis of Helicobacter Pylori infection. These two indications were extensively researched in 2013 through a TSM POM project. The outcome was that a need was not established for the dialysis application but that strong support was received from Medical consultants and researchers for a better method for Helicobacter Pylori diagnosis and immediate treatment. Kanichi has developed patented electrochemical sensors which measure at the required 100's ppb level. We have also designed a concept for collection of the ammonia in breath for presentation to the sensor. The purpose of this project is to prove this concept and develop a basic working prototype in collaboration with an industrial partners specialising in gas sensing and medical device development and marketing. We will also refine our knowledge of the market space and determine our entry strategy