700276Personalised tissue repair scaffolds: assessment of market and clinical attractivenessClosedGRD Proof of MarketInnovate UKThe project proposed in this application has the aim of exploring the attractiveness of a number of demanding technical options for increasing the proportion of the market addressable by Neotherix’ electrospun scaffold technology. We will consider the benefits of seeding the scaffold with autologous cells before administration to the patient and of a system for the intra-operative manufacture of scaffolds tailored to the needs of individual (or groups of) patients. We will also examine the relative advantages and disadvantages of synthetic acellular scaffolds and of biologic acellular scaffolds with a view to establishing the prime clinical indications for which synthetic electrospun scaffolds are favoured. In each case, we will gather the views of clinical specialists on clinical needs that could be addressed by the innovative product and process design technology supporting these options. We will also work with clinicians and review the literature to determine the anticipated benefits to patients and the NHS (and other health systems). The project will examine the route to market of the two broad product concepts outlined above so that the regulatory classification and market access challenges are understood and documented. The size and dynamics of the potential market and the trends in disease and surgical incidence will be analysed using literature reviews and market reports and used as items in a selection matrix to which all product concepts - generated in-house or through consultation with clinicians – are submitted. The main output of the project will be a report on the lead options and applications for product development. A full assessment of the possible product or process concepts will be made and the most attractive of these will be recommended to be taken forward to a Smart Proof of Concept application. The feasibility of producing scaffolds at a price appropriate to the chosen markets will also be considered .