1025213D culture model for Non-Alcoholic SteatoHepatitis (NASH) drug discoveryClosedCollaborative R&DInnovate UKNASH presents a significant unmet medical need in more economically developed nations, affecting up to 5% of the US population alone. There is currently no medical treatment for NASH, where the condition is a precursor to cirrhosis and hepatocellular carcinoma, conditions with very poor prognoses. One key limiting factor in the development of a treatment for NASH is a lack of suitable in vitro models. The project will produce a highly representative, medium throughput, 3D perfused model of NASH using both primary human and induced pluripotent stem cell derived hepatocytes, kupffer and stellate co-cultures. These models can be used in collaboration with industry to enable highly effective drug discovery studies and macrosteatotically relevant ADME/Toxicology studies.