<?xml version="1.0" encoding="UTF-8"?><ns2:project xmlns:ns1="http://gtr.rcuk.ac.uk/gtr/api" xmlns:ns2="http://gtr.rcuk.ac.uk/gtr/api/project" xmlns:ns3="http://gtr.rcuk.ac.uk/gtr/api/fund" xmlns:ns4="http://gtr.rcuk.ac.uk/gtr/api/person" xmlns:ns5="http://gtr.rcuk.ac.uk/gtr/api/project/outcome" xmlns:ns6="http://gtr.rcuk.ac.uk/gtr/api/organisation" ns1:created="2026-06-22T07:57:45Z" ns1:href="http://gtr.ukri.org/gtr/api/projects/E75F398D-02ED-4452-A5F7-E7493DCCE6AA" ns1:id="E75F398D-02ED-4452-A5F7-E7493DCCE6AA"><ns1:links><ns1:link ns1:href="http://gtr.ukri.org/gtr/api/persons/9190F372-8AF5-43F6-A382-D49BCB0A53A9" ns1:rel="PM_PER"/><ns1:link ns1:href="http://gtr.ukri.org/gtr/api/organisations/5B97C0A2-8978-4DE5-AA56-D0F8DF2797FA" ns1:rel="LEAD_ORG"/><ns1:link ns1:href="http://gtr.ukri.org/gtr/api/organisations/38CF3AB0-B06C-4A19-ACD0-386A7C74160F" ns1:rel="PARTICIPANT_ORG"/><ns1:link ns1:href="http://gtr.ukri.org/gtr/api/organisations/5B97C0A2-8978-4DE5-AA56-D0F8DF2797FA" ns1:rel="PARTICIPANT_ORG"/><ns1:link ns1:end="2026-03-30T23:00:00Z" ns1:href="http://gtr.ukri.org/gtr/api/funds/8EF8CF34-2079-4303-8061-18501CB64AE1" ns1:rel="FUND" ns1:start="2024-07-31T23:00:00Z"/></ns1:links><ns2:identifiers><ns2:identifier ns2:type="RCUK">10113998</ns2:identifier></ns2:identifiers><ns2:title>Developing Targeted Solid Lipid Nanoparticle Therapeutics for Paediatric Brain Tumours</ns2:title><ns2:status>Closed</ns2:status><ns2:grantCategory>Collaborative R&amp;D</ns2:grantCategory><ns2:leadFunder>Innovate UK</ns2:leadFunder><ns2:abstractText>Sferola Ltd is developing a next-generation Solid Lipid Nanoparticle Therapeutics for Paediatric Brain Tumours, capable of delivering targeted therapeutic nanoparticles to tumour tissues while being able to cross the blood-brain-barrier, and partnering up with University of Leeds / St James' Hospital to test its potential to improve the outcome of children suffering from DIPG (Diffuse Intrinsic Pontine Glioma).

DIPG brain tumour represents a significant public health burden, affecting children, yet our ability to treat this type of cancer is lacking, with approximately 1% survival after 5 years.</ns2:abstractText></ns2:project>