730011Methodology for Producing New Heterocyclic Building Blocks for Drug SynthesisClosedLegacy RDA Grant for R&DInnovate UKCombinatorial chemistry is a technique by which large numbers of structurally distinct molecules may be synthesised in a time and resource-effective manner, and then submitted for pharmacological assay in a variety of forms. The key feature of combinatorial chemistry is that compound synthesis is designed such that a range of analogues can be produced using similar reaction conditions, either in the same reaction vessel, or individually in parallel using semi-automated synthesis. In this way, the bench-chemist can single-handedly prepare many hundreds or thousands of compounds in the time usually taken to prepare only a few by orthodox methodology. Combinatorial chemistry is thus a major tool in the drug discovery process. Effective application of this technology requires the availability of a wide range of chemical building blocks with diverse structures.