Stereoretentive enantioconvergent synthesis
Lead Research Organisation:
UNIVERSITY OF EDINBURGH
Department Name: School of Chemistry
Abstract
This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive enantioconvergent catalysis. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no deracemisation required. Several approaches will be pursued to demonstrate proof-of principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.
Organisations
People |
ORCID iD |
| Description | I have focused a Diels-Alder dimersation as part of my project. Specifically I have been working towards the synthesis of the monomer, and trying to make to monomer in a large quantity so I can later scope different chiral reagents and catalysts to render the original Diels-Alder dimerisation enantioconvergent. |
| Exploitation Route | The synthesis of the monomer |
| Sectors | Chemicals Pharmaceuticals and Medical Biotechnology |