EPSRC-Royal Society fellowship engagement (2012) The Union of Asymmetric Organocatalysis with Transition Metal Chemistry
Lead Research Organisation:
Imperial College London
Department Name: Chemistry
Abstract
Please refer to attached Royal Society application
Planned Impact
Please refer to attached Royal Society application
People |
ORCID iD |
| Christopher James (Principal Investigator / Fellow) |
Publications
Cheng L
(2015)
Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex
in Angewandte Chemie
Cheng LJ
(2017)
Enantioselective propargylic [1,3]-rearrangements: copper-catalyzed O-to-N migrations toward C-N bond formation.
in Chemical science
Cheng LJ
(2015)
Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex.
in Angewandte Chemie (International ed. in English)
Cordier C
(2018)
From Propargylic Fluorinations to [1,3]-Rearrangements: Anion and Ligand Effects in Cu-Acetylide Chemistry
in Synlett
Cordier C
(2017)
Recent Advances in Catalytic Transformations Involving Copper Acetylides
in Synthesis
| Description | Key discoveries include, the first method for site-selective carbon-fluorine bond formation for a unique class of chemical motifs. This discovery will be of interest to the pharmaceutical and agrochemical industries. Additional findings that identified the activation of other small molecules that can be used to construct challenging now bonds to the same unique class of chemical structures. |
| Exploitation Route | The activation of ready available chemical feedstocks for the construction of new bonds to carbon, such as bonds to fluorine atoms, is of particular interest to pharmaceutical companies that rely on site selective fluorination methods. The extremely mild conditions associated with our new methodology opens the door to the construction of other challenging structural motifs, as a result of the fundamental chemical understanding that we have gathered. Additional grant applications to expand our analytical equipment will enable us to broaden the impact of our discoveries. |
| Sectors | Agriculture, Food and Drink,Chemicals,Healthcare,Pharmaceuticals and Medical Biotechnology |