Enantioconvergent Multi-Component Reactions.
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
Asymmetric synthesis is the branch of synthetic chemistry associated with making molecules in single-handed form (i.e., left-handed or right-handed form). The aim of this project is to experimentally establish a new concept in asymmetric synthesis called enantioconvergent multi-component reactions. This will represent a completely new method for accessing single-handed materials starting from mixtures of left- and right-handed molecules. Thanks to a statistical phenomenon known as the Horeau Principle, this new method will result in single-handed materials in exceptionally high purity. The ability to synthesise these left/right-handed molecules in pure form is vitally important, particularly for the pharmaceutical industry. This is because biological molecules exhibit handedness and the left-handed and right-handed form of a chemical (i.e., a drug/medicine) often interact very differently with living organisms.
Organisations
People |
ORCID iD |
Andrew Lawrence (Principal Investigator) |
Description | The aim of this project was to experimentally establish a new concept in asymmetric synthesis called enantioconvergent multi-component reactions. This has been achieved and represents a completely new method for accessing single-handed materials starting from mixtures of left- and right-handed molecules. Thanks to a statistical phenomenon known as the Horeau Principle, this new method gave single-handed materials in exceptionally high purity. These findings will be published very soon. |
Exploitation Route | The ability to synthesise these left/right-handed molecules in pure form is vitally important, particularly for the pharmaceutical industry. This is because biological molecules exhibit handedness and the left-handed and right-handed form of a chemical (i.e., a drug/medicine) often interact very differently with living organisms. |
Sectors | Agriculture, Food and Drink,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |