EPSRC-Royal Society fellowship engagement (2013):Visualising thoughts: ESR measurement of nanodiamonds targetted to neural structures

Lead Research Organisation: University of Oxford
Department Name: Physiology Anatomy and Genetics

Abstract

Please refer to attached Royal Society application

Planned Impact

Please refer to attached Royal Society application
 
Description We have developed microscope technologies that integrate multiple recently developed experimental approaches. We have found that small particles of diamond are excellent markers for microscopy. They do not degrade over time, so some of the measurement approaches, which require tens or even hundreds of conventional images to generate computationally enhanced data are more effective when we use nanodiamond. We are also developing general approaches to designing microscope hardware with mutliple modes of operation and we are consistently improving how we communicate these methods to the research community.
Exploitation Route We are just now developing the experimental approaches that will be disseminated - we are currently developing potential collaborations with biological researchers in the fields of anti-microbial resistance and with cancer research with the aim of disseminating our techniques both to the wider research community and also, ideally, to industry.
Sectors Agriculture, Food and Drink,Education,Electronics,Environment,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
 
Description Direct Wavefront Sensing for Efficient Measurement of Electronic Spin in Nanodiamond
Amount £14,676 (GBP)
Funding ID RG170189 
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 03/2019
 
Description EPSRC Quantum Technologies Grant
Amount £18,068 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 11/2014 
End 03/2015
 
Description Follow-up Program of the JSPS Frontiers of Science (FoS) Symposium.
Amount ￥252,000 (JPY)
Funding ID JSPS/ IRI-2/19001 
Organisation Japan Society for the Promotion of Science (JSPS) 
Sector Public
Country Japan
Start 09/2019 
End 10/2020
 
Description University of Strathclyde Chancellors Fellowship
Amount £250,000 (GBP)
Organisation University of Strathclyde 
Sector Academic/University
Country United Kingdom
Start 08/2016 
End 08/2021
 
Description Collaboration with NPL on quantum sensing with nanodiamond 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution We are providing expertise on microscopy design and quantum sensing measurements with nanodiamond.
Collaborator Contribution They are providing chemistry and biochemistry expertise relating to optical generation of radicals.
Impact Early stage collaboration, no outputs yet. Multidisciplinary: Physics, biology, chemistry
Start Year 2021
 
Description IBIN Collaboration with Dr Izzy Jayasinghe 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution We supplied macrophages for use with Dr. Jayasinghe's localisation microscopy technique
Collaborator Contribution They provided a protocol for labelling nanodiamond and imaging parameters to ensure blinking.
Impact We obtained ~£5k funding from the IBIN consortium based in Kings College London for a travel grant to test the imaging technique.
Start Year 2019
 
Description Nanodiamond imaging and characterisa\tion 
Organisation University of Bristol
Department MRC Integrative Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution We provided material and co-wrote the paper (10.1021/acsphotonics.5b00732) that arose from this partnership
Collaborator Contribution Provided the imaging technology, performed the experiments, co-wrote the paper
Impact Paper: DOI 10.1021/acsphotonics.5b00732
Start Year 2015