Role of Hippocampal Neurogenesis in Learning, Memory and Affective Behaviours

Lead Research Organisation: University College London
Department Name: The Wolfson Inst for Biomedical Research

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Angelo M (2006) Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. in Journal of neurochemistry

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Antunes-Martins A (2007) Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation. in Learning & memory (Cold Spring Harbor, N.Y.)

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Engmann O (2009) Crosstalk between Cdk5 and GSK3beta: Implications for Alzheimer's Disease. in Frontiers in molecular neuroscience

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Giese KP (2007) Novel insights into the beneficial and detrimental actions of cdk5. in Molecular interventions

 
Title Camkk mutant mice 
Description These mutants are useful tools to investigate sex differences in memory formation 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Our research findings are fundamental for understanding sex differences in learning & memory in health and disease. 
 
Description Role of calcium/calmodulin kinase kinases in glucose metabolism 
Organisation Medical Research Council (MRC)
Department MRC Clinical Sciences Centre (CSC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution provided CaMKK mutant mice
Collaborator Contribution Our collaboration Prof. Dominc Withers established that there is no glucose metabolism phenotype in conditional CaMKK mutant mice
Impact A publication resuylted from this work: Claret et al., 2011, Diabetes (PMID: 21266325).