Epidemiological and statistical research on health problems of developing countries: MRC Tropical Epidemiology Group

Lead Research Organisation: London Sch of Hygiene and Trop Medicine
Department Name: Epidemiology and Population Health

Abstract

While there have been major improvements over the past century in the health of populations all over the world, there are still deep inequalities between the rich and poor nations. Gains in health in many of the poor countries have been reversed recently due to the global epidemic of HIV/AIDS and steep increases in TB and malaria. Life expectancy in some parts of Africa has fallen by more than 20 years. There is an urgent need to find effective means of controlling these major killer diseases in order to bring down the high burden of mortality and ill health.

The MRC Tropical Epidemiology Group is a group based at the London School of Hygiene and Tropical Medicine whose main aim is to conduct research on these infectious diseases in Africa and other parts of the developing world. We collaborate with scientific groups overseas, assisting especially with the planning and analysis of research studies. These studies are designed to improve our understanding of risk factors for these diseases, and to evaluate the impact of different control measures.

During the next five years, our main focus will be on HIV, TB and malaria which between them cause around eight million deaths each year. We will study various ways of preventing HIV infection, as well as approaches to providing treatment for HIV-positive people in Africa where health-care resources are limited. Because the risk of TB is increased by HIV infection, TB is now out of control in some countries with major HIV epidemics, and we will therefore study new ways of preventing and treating TB. In malaria, our research will focus on intermittent preventive treatment, a new approach whereby all children and pregnant women are given periodic doses of antimalarial treatment, and on improved methods of controlling the mosquitoes that transmit malaria. We will also carry out work to develop new methods that can be used to study these health problems in developing countries.

As well as reporting our work in scientific journals, we frequently write articles aimed at a non-specialist audience, as well as contributing to television and radio programmes.

Technical Summary

The MRC Tropical Epidemiology Group initiates and collaborates in research on the epidemiology and control of public health problems of developing countries. We provide statistical and epidemiological support for the MRC Units in Uganda and The Gambia while also collaborating with other groups carrying out high-quality research overseas. We carry out observational and experimental studies, but the main emphasis is on intervention studies, including cluster-randomised trials (CRTs) in which we have special expertise. We have major programmes of work on HIV and other sexually transmitted infections (STIs), tuberculosis (TB) and malaria, but also carry out research on other diseases of public health importance.

In HIV/STI research, we will complete trials of adolescent sexual health interventions and of the Pro-2000 vaginal microbicide, continue our work on herpes control for HIV prevention, and develop research on the implementation of male circumcision services. A trial of home-based antiretroviral treatment (ART) will be completed and new research conducted on adherence, drug resistance, and different models of ART provision. Work on human papilloma virus (HPV) will include a bridging study of HPV vaccine and seroepidemiological studies to guide vaccination policy. In TB research, we will continue to collaborate with the CREATE consortium and three CRTs of TB control interventions in HIV-endemic populations will be completed, as will a trial of a four-month TB treatment regimen. Malaria research will focus on trials of different strategies of intermittent preventive therapy (IPT) in children and pregnant women, with special emphasis on IPT regimens in areas of seasonal transmission. We will collaborate in trials of two malaria vaccine candidates and research on the effectiveness of improved methods of vector control. Research on acute respiratory infections will focus on population-level effects of vaccination programmes. We will expand our work on mental health, with trials of interventions against common mental disorders and alcohol misuse.

Mathematical modelling work will include studies of HIV transmission in adolescents, and the evolving HIV epidemic in Uganda; studies aimed at interpreting the CRTs of TB control interventions; and research to explore the effects of household clustering on trachoma control. Methodological work will be carried out on the analysis of CRTs, analytical methods for zero-inflated data and highly skewed endpoints such as viral loads and parasite counts, and implementation of GCP procedures in resource-poor settings. We will support the development of the new MRC-supported Intervention Trials Unit in Mwanza and strengthen our programme of TEG training fellowships.

Organisations

Publications

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Al-Taiar A (2009) Socioeconomic and environmental factors important for acquiring non-severe malaria in children in Yemen: a case-control study. in Transactions of the Royal Society of Tropical Medicine and Hygiene

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Al-Taiar A (2006) Severe malaria in children in Yemen: two site observational study. in BMJ (Clinical research ed.)

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Alexander N (2010) Assessing agreement between malaria slide density readings. in Malaria journal

 
Description Citation in policy documents: Involvement in international consultations
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Participation in WHO/UNAIDS consultations on HIV prevention
 
Description Citation in policy documents: Sudanese national treatment guidelines for Visceral Leishmaniasis
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
 
Description Citation in policy documents: WHO Technical Report for Control of Leishmaniases
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
 
Description Citation in policy documents: WHO policy recommendation on IPTi
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
Impact IPTi for malaria prevention in children does not impair serological repsonses to EPI vaccines
 
Guideline Title DENGUE GUIDELINES FOR DIAGNOSIS, TREATMENT, PREVENTION AND CONTROL
Description DENCO
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
URL http://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf
 
Description HPV Vaccination in Tanzania
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
Impact This study of HPV vaccination delivery strategies in Tanzania assisted the Tanzanian national HPV vaccination programme to plan it's roll-out.
 
Description HSV-2 trial results
Geographic Reach Africa 
Policy Influence Type Participation in a national consultation
Impact This was the first trial in the world to demonstrate that acyclovir had no effect on HIV incidence and the results have recently been published in the New England Journal of Medicine. The impact on policy being that this intervention would not now be seen as useful.
 
Description Health systems project on Chronic diseases in Africa
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
 
Description MEMA Kwa Vijana Further Survey workshops attended by policymakers.
Geographic Reach Africa 
Policy Influence Type Participation in a national consultation
Impact Impact on policymakers in Tanzania through their attendance at workshops.
 
Description Member of 2 external scientific advisory committees of the Innovative Vector Control Consortium (IVCC), based at Liverpool School of Tropical Medicine.
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Member of USAID's President's Malaria Initiative's Impact Evaluation Technical Advisory Group
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Member of the WHO-EMRO/UNEP sponsored Regional Scientific and Technical Advisory Committee (STAC) of the project on "Demonstration of sustainable alternatives to DDT and strengthening of vector control"
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Membership of guideline committee: WHO/UNAIDS Technical Consultation on Male Circumcision and HIV Prevention: Research Implications for Policy and Programming
Geographic Reach Africa 
Policy Influence Type Membership of a guidance committee
Impact Scale of circumcision services for HIV prevention
 
Description Participation in advisory committee: Developing research agenda on HIV treatment for prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
Impact Funding of large-scale trials of HIV treatment for prevention
 
Description Participation in advisory committee: Pneumococcal Vaccination
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
Impact Vaccination was introduced following completion of the trial
 
Description Participation in advisory committee: WHO Technical Advisory Group on Male Circumcision
Geographic Reach Africa 
Policy Influence Type Participation in advisory committee
Impact The purpose of the group is to review information on technical innovations related to the male circumcision procedure and advise WHO on the type and quality of evidence required, further research and clinical assessments needed with a view to recommending for use in the scale-up of male circumcision for HIV prevention
 
Description SMC
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
Impact The evidence suggests that SMC using AQ+SP monthly for up to 4 months during the transmission season in children less than 5 years of age:   - Prevents approximately 75% of all malaria episodes   - Prevents approximately 75% of severe malaria episodes   - May result in a  decrease in child mortality of around 1 in 1000   - Probably reduces the incidence of moderately severe anaemia   - Does not result in an increase in clinical malaria in the following malaria transmission season after one year of administration but the consequences of giving SMC for several years have not yet been evaluated.   - Serious adverse events have not been reported and are probably rare
URL http://www.who.int/malaria/mpac/feb2012/smc_policy_recommendation.pdf
 
Description Training of practitioners/researchers: Hib vaccine in developing countries
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact This study is widely quoted to support introduction of Hib vaccine in developing countries
 
Description Treatment of Visceral leishmaniasis - new standard regimen
Geographic Reach Africa 
Policy Influence Type Citation in other policy documents
Impact New standard treatment regimen for affected patients in the national treatment guidelines in following countries - Sudan, Kenya, Uganda and Ethiopia.
 
Description WHO nominated member of the DDT expert group established under the Stockholm Convention on Persistent Organic Pollutants
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Zamstar: Citation in WHO guidelines on active case-finding for TB
Geographic Reach Africa 
Policy Influence Type Membership of a guidance committee
 
Description Zamstar: Influence on policy and practice in South Africa for provision of TB and HIV diagnosis and linkage to care in the households of TB cases
Geographic Reach Africa 
Policy Influence Type Participation in a national consultation
 
Description EDCTP: Call for the support of clinical trials, capacity building and networking on treatment of HIV/AIDS
Amount £267,222 (GBP)
Organisation Sixth Framework Programme (FP6) 
Department European and Developing Countries Clinical Trials Partnership
Sector Public
Country European Union (EU)
Start 12/2010 
End 01/2015
 
Description EDCTP: Call for the support of clinical trials, capacity building and networking on treatment of HIV/AIDS
Amount £474,902 (GBP)
Organisation Sixth Framework Programme (FP6) 
Department European and Developing Countries Clinical Trials Partnership
Sector Public
Country European Union (EU)
Start 03/2011 
End 03/2015
 
Description EDCTP: Site preparation & capacity strengthening trials of vaginal mirobicides
Amount £1,784,522 (GBP)
Organisation Sixth Framework Programme (FP6) 
Department European and Developing Countries Clinical Trials Partnership
Sector Public
Country European Union (EU)
Start 06/2007 
End 12/2011
 
Description EU FP7 Theme: Low-cost interventions for disease control in resource poor settings
Amount £316,216 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2013 
End 12/2015
 
Description Joint Global Health Trials Development Grant
Amount £200,000 (GBP)
Funding ID MR/P020283/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2017 
End 10/2018
 
Description NIH-HPTN: Call for Proposals for HIV Combination Prevention
Amount £24,000,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States of America
Start 01/2011 
End 12/2016
 
Description Wellcome Trust: Epidemiology of HIV infection among adolscents in Africa
Amount £311,400 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start  
 
Title Methodological Research Papers 
Description Research papers developing methodological approaches and techniques in the field of tropical epidemiology 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Adoption of new / revised methodological approaches within the discipline 
 
Title Vaginal Practice Pictoral Diary 
Description Pictorial data collection tool in which participants record their vaginal practice and sexual history daily. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Submitted paper to Sexually Transmitted Diseases "Vaginal practices diary: development of a pictorial data collection tool for sensitive behavioural data" 
 
Description A randomised trial of home-based versus facility-based HIV care in Jinja, Uganda 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Writing the proposal and securing funding
Collaborator Contribution Implementation, coordination and management of trial
Impact This trial is the largest study of task shifting and of community delivery of HIV care conducted in Africa. The findings were used by the World Health Organisation to inform part of the new guidelines on the treatment of HIV-infection.
Start Year 2008
 
Description A randomised trial of home-based versus facility-based HIV care in Jinja, Uganda 
Organisation The AIDS Support Organization (TASO)
Country Uganda, Republic of 
Sector Charity/Non Profit 
PI Contribution Writing the proposal and securing funding
Collaborator Contribution Implementation, coordination and management of trial
Impact This trial is the largest study of task shifting and of community delivery of HIV care conducted in Africa. The findings were used by the World Health Organisation to inform part of the new guidelines on the treatment of HIV-infection.
Start Year 2008
 
Description Analysis and reporting of Tanzania national HIV care and treatment data 
Organisation Kilimanjaro Christian Medical Centre (KCMS)
Country Tanzania, United Republic of 
Sector Hospitals 
PI Contribution Conduct of statistical analyses, report production and development of publications
Collaborator Contribution Conduct of workshops, collation of data and writing up of results
Impact Kilama B, Todd J, Ewings F, Nondi J, Sambu V, Kisendi R, Josiah R, Ramadhani A, Mmbando D. Tanzanian experience: Treatment outcomes after 7 years of a national public-driven HIV care and treatment program. Int AIDS Soc. Malaysia (TULBPE39); 2013.
Start Year 2012
 
Description Analysis and reporting of Tanzania national HIV care and treatment data 
Organisation Ministry of Health and Social Welfare
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Conduct of statistical analyses, report production and development of publications
Collaborator Contribution Conduct of workshops, collation of data and writing up of results
Impact Kilama B, Todd J, Ewings F, Nondi J, Sambu V, Kisendi R, Josiah R, Ramadhani A, Mmbando D. Tanzanian experience: Treatment outcomes after 7 years of a national public-driven HIV care and treatment program. Int AIDS Soc. Malaysia (TULBPE39); 2013.
Start Year 2012
 
Description Capacity Development 
Organisation Xinjiang Medical University
Department Department of Epidemiology and Biostatistics
Country China, People's Republic of 
Sector Academic/University 
PI Contribution Training in Epidemiology
Collaborator Contribution Providing research data
Impact Training programme established between Xinjiang and LSHTM
Start Year 2013
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation Imperial College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation National Institutes of Health (NIH)
Department HIV Prevention Trials Network HPTN
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation University of Stellenbosch
Department Desmond Tutu TB Centre
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: HIV combination prevention (PopArt) 
Organisation Zambia AIDS Related Tuberculosis (ZAMBART)
Country Zambia, Republic of 
Sector Academic/University 
PI Contribution Chief Investigator; Trial design; Protocol development; Trial Statistician; Supervision; Administration
Collaborator Contribution Trial is carried out in partnership with NIH HIV Prevention Trials Network; Trial management, laboratory activities and data management and analysis supported by HPTN Core, Network Laboratory and Data and Statistics Center; Field work coordinated at Zambart and DTTC; Modelling and economics components coordinated by Imperial College.
Impact Funding for trial secured, research group established, protocol version 1.0 approved, IRB submissions
Start Year 2011
 
Description Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States of America 
Sector Public 
PI Contribution Contributing to trial design, leading statistical analysis
Collaborator Contribution Trial leadership, implementation of circumcision
Impact Ethical approval confirmed and project implementation initiated
Start Year 2011
 
Description Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania 
Organisation Jhpiego
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership, implementation of circumcision
Impact Protocol drafted
Start Year 2011
 
Description Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Research Centre (MRC)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership, implementation of circumcision
Impact Protocol drafted
Start Year 2011
 
Description Clinical Trial: Increasing uptake of voluntary medical male circumcision in Tanzania 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Research Centre (MRC)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Contributing to trial design, leading statistical analysis
Collaborator Contribution Trial leadership, implementation of circumcision
Impact Ethical approval confirmed and project implementation initiated
Start Year 2011
 
Description Clinical Trial: NETSS project 
Organisation National Centre for Research and Training on Malaria (CNRFP)
Country Burkina Faso 
Sector Public 
PI Contribution Trial design, protocol development, statistical support
Collaborator Contribution Financial support
Impact Trial completed, showed substantial additional benefit of IPT in preventing malaria in children using insecicide treated bednets
Start Year 2007
 
Description Clinical Trial: NETSS project 
Organisation University of Bamako
Department Malaria Research and Training Centre (MRTC) Bamako
Country Mali, Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical support
Collaborator Contribution Financial support
Impact Trial completed, showed substantial additional benefit of IPT in preventing malaria in children using insecicide treated bednets
Start Year 2007
 
Description Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol drafted
Start Year 2012
 
Description Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe 
Organisation Ministry of Health and Child Welfare of the Republic of Zimbabwe
Country Zimbabwe, Republic of 
Sector Public 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol drafted
Start Year 2012
 
Description Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe 
Organisation University College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol drafted
Start Year 2012
 
Description Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe 
Organisation University of Zimbabwe
Country Zimbabwe, Republic of 
Sector Academic/University 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol drafted
Start Year 2012
 
Description Clinical Trial: RCT to compare safety, acceptability and cost of conducting early infant male circumcision using two devices in Zimbabwe 
Organisation Zimbabwe Population Services International (PSI)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol drafted
Start Year 2012
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Foundation for Professional Development
Country South Africa, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical Trial: TB Fast Track: a cluster randomised trial to evaluate the effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. Recruitment to end in Dec 2014. Symposium at the Union TB conference in Barcelona 2014 on empiric TB treatment organised by TB Fast Track investigators
Start Year 2012
 
Description Clinical Trial: Treatment for visceral leischmaniasis in East Africa 
Organisation Addis Ababa University
Country Ethiopia, Federal Democratic Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical analysis, capacity building
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens.
Start Year 2012
 
Description Clinical Trial: Treatment for visceral leischmaniasis in East Africa 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution Trial design, protocol development, statistical analysis, capacity building
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens.
Start Year 2012
 
Description Clinical Trial: Treatment for visceral leischmaniasis in East Africa 
Organisation Institute for Endemic Diseases IEND
Country Sudan, Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical analysis, capacity building
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens.
Start Year 2012
 
Description Clinical Trial: Treatment for visceral leischmaniasis in East Africa 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya, Republic of 
Sector Public 
PI Contribution Trial design, protocol development, statistical analysis, capacity building
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens.
Start Year 2012
 
Description Clinical Trial: Treatment for visceral leischmaniasis in East Africa 
Organisation Makerere University
Country Uganda, Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical analysis, capacity building
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Funding secured and protocols finalised for one phase III trial and one phase II trial of short course treatment regimens.
Start Year 2012
 
Description Clinical Trial: cluster randomised trial of HPV vaccination delivery in schoolgirls in Mwanza 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Contributed to trial design, led statistical analysis
Collaborator Contribution Collaborative involvement in field research; mutually reinforcing collaboration involving exchange of ideas
Impact Impact on national Tanzanian policy on HPV vaccination
Start Year 2009
 
Description Clinical Trial: cluster randomised trial of an intensified TB/HIV prevention intervention, linking home-based HIV-testing with the option of self-testing with HIV case 
Organisation University of Malawi
Department College of Medicine
Country Malawi, Republic of 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, baseline data collected, intervention and follow-up underway
Start Year 2010
 
Description Clinical Trial: cluster randomised trial of an intensified TB/HIV prevention intervention, linking home-based HIV-testing with the option of self-testing with HIV case 
Organisation Wellcome Trust
Department Malawi-Liverpool Wellcome Trust Clinical Research Programme
Country Malawi, Republic of 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, baseline data collected, intervention and follow-up underway
Start Year 2010
 
Description Clinical Trial: cluster randomised trial of intensive versus standard anthelminthic treatment, examining effects on allergy-related and general health outcomes 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Contributing to trial design, will lead statistical analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, public randomisation ceremony collected, baseline data currently being collected
Start Year 2011
 
Description Clinical Trial: cluster randomised trial of using mobile text messaging and medication monitor in TB case management 
Organisation Bill and Melinda Gates Foundation
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Financial contribution; access to study cohort; exchange of ideas
Impact Protocol drafted & CRFs, trial completed, statistical analysis currently underway
Start Year 2010
 
Description Clinical Trial: cluster randomised trial of using mobile text messaging and medication monitor in TB case management 
Organisation Government of China
Department Ministry of Health of the People's Republic of China
Country China, People's Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Financial contribution; access to study cohort; exchange of ideas
Impact Protocol drafted & CRFs, trial completed, statistical analysis currently underway
Start Year 2010
 
Description Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia 
Organisation Amhara National Regional State
Country Ethiopia, Federal Democratic Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal
Start Year 2007
 
Description Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia 
Organisation Carter Centre
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal
Start Year 2007
 
Description Clinical Trial: surgical treatment of trachomatous trichiasis in Ethiopia 
Organisation Moorfields Eye Hospital NHS Foundation Trust
Department Retinal Imaging
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact There was no evidence that absorbable polyglactin-910 sutures were associated with lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal
Start Year 2007
 
Description Clinical Trial: treatment of minor trichiasis in Ethiopia 
Organisation Amhara National Regional State
Country Ethiopia, Federal Democratic Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011
Start Year 2007
 
Description Clinical Trial: treatment of minor trichiasis in Ethiopia 
Organisation Carter Centre
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011
Start Year 2007
 
Description Clinical Trial: treatment of minor trichiasis in Ethiopia 
Organisation Moorfields Eye Hospital NHS Foundation Trust
Department NIHR Moorfields Biomedical Research Centre
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Epilation had a comparable effect to surgery on visual acuity and corneal outcomes. We suggest that surgery be performed whenever possible but epilation be used for treatment of minor trichiasis patients without access to or declining surgery. Trial published in PLoS Med 2011
Start Year 2007
 
Description Clinical trial: Azithromycin mass treatment delivery strategies for trachoma in The Gambia 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution Statistical analysis
Collaborator Contribution Significant intellectual input and exchange of ideas. Project leadership.
Impact Forty-eight communities in The Gambia were followed bi-annually for 3 years. Preparation of manuscripts is underway to report the impact of mass treatment delivery strategies on the primary trachoma outcomes, as well as secondary outcomes such as child mortality, child nutrition parameters and possible malaria co-morbidity.
Start Year 2008
 
Description Clinical trial: Azithromycin mass treatment delivery strategies for trachoma in The Gambia 
Organisation University of California
Country United States of America 
Sector Academic/University 
PI Contribution Statistical analysis
Collaborator Contribution Significant intellectual input and exchange of ideas. Project leadership.
Impact Forty-eight communities in The Gambia were followed bi-annually for 3 years. Preparation of manuscripts is underway to report the impact of mass treatment delivery strategies on the primary trachoma outcomes, as well as secondary outcomes such as child mortality, child nutrition parameters and possible malaria co-morbidity.
Start Year 2008
 
Description Clinical trial: Community-based perinatal care in Pakistan 
Organisation Aga Khan University
Country Pakistan, Islamic Republic of 
Sector Academic/University 
PI Contribution Mutually reinforcing collaboration involving exchange of ideas
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact The objective of this pilot study was to investigate the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan. The study found that observed stillbirth and neonatal mortality rates improved. As such, female community health workers (i.e. LHWs and Dais) can be effective in implementing a community and outreach package that leads to improved home care practices by families, increased care-seeking behaviour and greater utilization of skilled care providers.
 
Description Clinical trial: Community-based perinatal care in Pakistan 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Mutually reinforcing collaboration involving exchange of ideas
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact The objective of this pilot study was to investigate the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan. The study found that observed stillbirth and neonatal mortality rates improved. As such, female community health workers (i.e. LHWs and Dais) can be effective in implementing a community and outreach package that leads to improved home care practices by families, increased care-seeking behaviour and greater utilization of skilled care providers.
 
Description Clinical trial: Comparison of home and facility-based HIV care 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States of America 
Sector Public 
PI Contribution Trial design; statistical input and data analysis
Collaborator Contribution Access to data and study cohortAccess to health care facilities
Impact The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9
 
Description Clinical trial: Comparison of home and facility-based HIV care 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Trial design; statistical input and data analysis
Collaborator Contribution Access to data and study cohortAccess to health care facilities
Impact The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9
 
Description Clinical trial: Comparison of home and facility-based HIV care 
Organisation Ministry of Health, Uganda
Country Uganda, Republic of 
Sector Public 
PI Contribution Trial design; statistical input and data analysis
Collaborator Contribution Access to data and study cohortAccess to health care facilities
Impact The trial found that a home-based HIV-care strategy could improve quality of and access to HIV treatment, particularly in areas with poor infrastructure and access to clinic care. The cost of providing home-based care were marginally less than facility-based care. Findings published in Jaffar et al. Lancet, 2009;374:2080-9
 
Description Clinical trial: Delivery strategies of IPT in an area of seasonal malaria transmission in the Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Trial design and statistical support for a CRT comparing delivery of intermittent preventative therapy (IPT) for malaria to older children using village health workers vs reproductive and child health trekking teams
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Trial found that delivery through village health workers achieved substantially higher coverage than reproductive and child health trekking teams. Coverage was unrelated to wealth and the cost of delivery by village health workers was half that of reproductive and child health trekking teams. Paper submitted for publication
Start Year 2008
 
Description Clinical trial: Effectiveness of lay health worker led intervention for depression and anxiety in primary care 
Organisation Sangath
Country India, Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical analysis and advice on trial design
Collaborator Contribution Significant intellectual input and exchange of ideas; access to study cohort and provision of training
Impact Study found that lay health counsellor led intervention comprising case management, psycho-social support and medication administered by primary care physicians resulted in a modest improvement in recovery from common mental disorders. Evidence can be used to improve mental health services in settings where mental health professionals are scarce. Results published in Patel et al; Lancet, 2010 and Patel et al; Br J Psychiatry, 2011
Start Year 2008
 
Description Clinical trial: Effectiveness of lay health worker led intervention for depression and anxiety in primary care 
Organisation Voluntary Health Association of Goa (VHAG)
Country India, Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical analysis and advice on trial design
Collaborator Contribution Significant intellectual input and exchange of ideas; access to study cohort and provision of training
Impact Study found that lay health counsellor led intervention comprising case management, psycho-social support and medication administered by primary care physicians resulted in a modest improvement in recovery from common mental disorders. Evidence can be used to improve mental health services in settings where mental health professionals are scarce. Results published in Patel et al; Lancet, 2010 and Patel et al; Br J Psychiatry, 2011
Start Year 2008
 
Description Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load 
Organisation National Institute for Medical Research, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Trial design and statistical analysis
Collaborator Contribution Significant intellectual input; access to study cohort and data; Mutual exchange of ideas
Impact The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9)
Start Year 2007
 
Description Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load 
Organisation University of Paris - Descartes
Country France, French Republic 
Sector Academic/University 
PI Contribution Trial design and statistical analysis
Collaborator Contribution Significant intellectual input; access to study cohort and data; Mutual exchange of ideas
Impact The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9)
Start Year 2007
 
Description Clinical trial: Efficacy of HSV suppressive therapy on genital and plasma HIV viral load 
Organisation Wellcome Trust
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Trial design and statistical analysis
Collaborator Contribution Significant intellectual input; access to study cohort and data; Mutual exchange of ideas
Impact The study found there was no effect of HSV suppressive therapy on either genital or plasma HIV during 30 months of follow-up which suggests that it is unlikely to be a useful long-term strategy to reduce HIV transmission. Results published in Tanton et al. Journal of Infectious Diseases, 2010; 201(9)
Start Year 2007
 
Description Clinical trial: Enhanced TB case finding in Harare, Zimbabwe 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals.
Collaborator Contribution Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis
Impact Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376
 
Description Clinical trial: Enhanced TB case finding in Harare, Zimbabwe 
Organisation Biomedical Research and Training Institute (BRTI)
Country Zimbabwe, Republic of 
Sector Charity/Non Profit 
PI Contribution Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals.
Collaborator Contribution Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis
Impact Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376
 
Description Clinical trial: Enhanced TB case finding in Harare, Zimbabwe 
Organisation Harare City Health Department
Country Zimbabwe, Republic of 
Sector Public 
PI Contribution Designed and supported a trial comparing the effectiveness of two strategies (door-to-door and mobile van) for detecting TB in symptomatic individuals.
Collaborator Contribution Significant intellectual support and exchange of ideas; Access to health facilities and study cohort; Data analysis
Impact Trial found that mobile vans significantly out-performed door-to-door visits for detecting TB. As such, the mobile van approach could have significant and rapid effects on TB transmission and prevalence. Results published in Corbett et al. Lancet, 2010;376
 
Description Clinical trial: Entomological approaches to malaria control 
Organisation Durham University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical support
Collaborator Contribution Financial contribution
Impact Trials completed showing value of house screening for malaria prevention and feasibility of larval control, published in Lancet (2009) and AJTMH (2009)
 
Description Clinical trial: Entomological approaches to malaria control 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Trial design, protocol development, statistical support
Collaborator Contribution Financial contribution
Impact Trials completed showing value of house screening for malaria prevention and feasibility of larval control, published in Lancet (2009) and AJTMH (2009)
 
Description Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe)
Impact Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16)
 
Description Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe 
Organisation Medical Research Council (MRC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe)
Impact Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16)
 
Description Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe)
Impact Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16)
 
Description Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe 
Organisation University College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe)
Impact Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16)
 
Description Clinical trial: HIV prevention among adolescents in Tanzania and Zimbabwe 
Organisation University of Zimbabwe
Country Zimbabwe, Republic of 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas; Access to study cohort and data; Trial leadership (Zimbabwe)
Impact Neither trial found evidence that sexual health education coupled with improved access to reproductive health services reduced HIV incidence in adolscents. However, both trials showed increased knowledge and corresponding reductions in some risky behaviours. Findings published in Doyle et al. PLoS Med. 2010; 7(6) and Cowan et al. AIDS. 2010; 24(16)
 
Description Clinical trial: House screening interventions to prevent exposure to malaria in the Gambia 
Organisation Durham University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Designed and supported a trial to assess 2 types of house screening and their impact on entry of malaria vectors and frequency of anaemia in children.
Collaborator Contribution Significant intellectual input and exchange of ideas; Trial leadership
Impact Trial found that the number of mosquitos caught in houses without screening was almost twice the number found in houses with screening. There was a corresponding reduction in anaemia. Results published in Kirby et al. Lancet 2009;374
 
Description Clinical trial: House screening interventions to prevent exposure to malaria in the Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Designed and supported a trial to assess 2 types of house screening and their impact on entry of malaria vectors and frequency of anaemia in children.
Collaborator Contribution Significant intellectual input and exchange of ideas; Trial leadership
Impact Trial found that the number of mosquitos caught in houses without screening was almost twice the number found in houses with screening. There was a corresponding reduction in anaemia. Results published in Kirby et al. Lancet 2009;374
 
Description Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood 
Organisation Entebbe District Hospital
Country Uganda, Republic of 
Sector Hospitals 
PI Contribution Designed and supported randomised trial evaluating 3 interventions at 2 stages.
Collaborator Contribution Trial leadership; Access to study cohort
Impact Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old.
Start Year 2006
 
Description Clinical trial: Impact of helminths on the response to immunisation and on incidence of infection and disease in childhood 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Designed and supported randomised trial evaluating 3 interventions at 2 stages.
Collaborator Contribution Trial leadership; Access to study cohort
Impact Trial found that anthelminthic treatment during pregnancy increased incidence of eczema in childhood, and that quarterly anthelminthic treatment during early childhood decreased the incidence of malaria. Apart from this, there were no other effects of anthelminthic treatment during pregnancy and childhood on responses to immunisations, incidence of infectious diseases, growth or anaemia. Main trial results have been published in the Lancet and in PLoS ONE. Children are now being follow-up to 10 years old.
Start Year 2006
 
Description Clinical trial: Implementation and evaluation of an optimized model for scaling up TB/HIV integration at primary care clinics in Ekurhuleni north sub-district, South Africa 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Protocol and CRFs drafted; trial completed and data currently being analysed. Paper published on trial design (Contemporary Clinical Trials 2014)
Start Year 2011
 
Description Clinical trial: Microbicides Development Programme 
Organisation Medical Research Council (MRC)
Department Microbicides Development Programme
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution PI for Mwanza field site; statistical input to trial
Collaborator Contribution Collaborative involvement in Phase III trial of Pro2000 vaginal microbicide
Impact Successful completion and publication of MDP301 Phase III trial; further publications in progress; capacity building in partner sites in Africa; development of proposal for MDP302 trial
 
Description Clinical trial: Micronutrient-fortified complementary foods in Lusaka 
Organisation University Teaching Hospital (UTH)
Country Zambia, Republic of 
Sector Academic/University 
PI Contribution Advice on design of trial to evaluate micro-nutrient fortified porridge vs non-fortified porridge among HIV-exposed and unexposed infants aged 6 months and over.
Collaborator Contribution Access to study cohort and data
Impact Trial found that fortification improved iron status at 18 months. No significant difference was found between trial arms in terms of stunting and hospital referral but children of HIV infected mothers that breast-fed for less than 6 months displayed reduced stunting with fortified porridge. Provision of such fortified foods may benefit the health of these high risk infants. Results published in PLoS One, 2010
 
Description Clinical trial: Treatment and prevention strategies for HIV-associated cryptococcal meningitis 
Organisation St George's University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design and data analysis
Collaborator Contribution Significant intellectual input and mutual exchange of ideas
Impact Findings published in several high impact journals. A second trial is now underway to determine the most effective and sustainable regimens for patients presenting with cryptococcal meningitis in resource-poor settings
Start Year 2006
 
Description Clinical trial: WELL London 
Organisation University of East London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Advice on design and analysis of cluster randomised trial
Collaborator Contribution Collaborative involvement in trial of wellbeing intervention in deprived areas of London
Impact Publication of trial design; trial completed and analysis in progress
Start Year 2008
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation Aurum Institute
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation National Health Laboratory Services, South Africa
Country South Africa, Republic of 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Clinical trial: Xpert MTB/RIF for diagnosis of tuberculosis: evaluating impact and cost-effectiveness in the routine roll-out in South Africa "Xpert for TB: Evaluating a New Diagnostic" (XTEND) trial and XPHACTOR study 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Contributed to trial design, statistical support, data analysis
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Funding for trial secured; research group established; protocol and CRFs drafted; trial started. XTEND trial completed and results presented at CROI (2014) and South Africa TB conference (2014). Main paper under review and other papers in progress. XPHACTOR recruitment and follow-up completed, data currently being analysed. Interim data presented at South Africa TB (2014) and Union TB Conference (2014); Papers in progress.
Start Year 2011
 
Description Health Platform 
Organisation El Bosque University
Department Instituto de Salud y Ambiente
Country Colombia, Republic of 
Sector Academic/University 
PI Contribution Design and analysis of the trial, including publications.
Collaborator Contribution Obtaining funding; directing and implementing the trial.
Impact Overgaard et al. Trials 2012, 13:182 http://www.trialsjournal.com/content/13/1/182
Start Year 2010
 
Description Health Platform 
Organisation Norwegian University of Life Sciences (NMBU)
Country Norway, Kingdom of 
Sector Academic/University 
PI Contribution Design and analysis of the trial, including publications.
Collaborator Contribution Obtaining funding; directing and implementing the trial.
Impact Overgaard et al. Trials 2012, 13:182 http://www.trialsjournal.com/content/13/1/182
Start Year 2010
 
Description Health systems project on chronic diseases in Africa 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Overall PI and main applicant is TEG staff member currently based at MITU. ; study co-run by LSHTM, MITU and MoH Tanzania. TEG provides Statistical support - analysis, reporting of results. Ugandan PI based at MRC/UVRI Uganda Unit; study co-run by LSHTM, MRC Uganda and MoH Uganda. TEG provides statistical support - analysis, reporting of results.
Collaborator Contribution MITU: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. MRC Uganda: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision.
Impact Recognition by MoH Tanzania of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. Recognition by MoH Uganda of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2.
Start Year 2011
 
Description Health systems project on chronic diseases in Africa 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Overall PI and main applicant is TEG staff member currently based at MITU. ; study co-run by LSHTM, MITU and MoH Tanzania. TEG provides Statistical support - analysis, reporting of results. Ugandan PI based at MRC/UVRI Uganda Unit; study co-run by LSHTM, MRC Uganda and MoH Uganda. TEG provides statistical support - analysis, reporting of results.
Collaborator Contribution MITU: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision. MRC Uganda: local research management. Conduct of cross-sectional surveys. MoH: collaboration on surveys; input in intervention design and supervision.
Impact Recognition by MoH Tanzania of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2. Recognition by MoH Uganda of high burden of some NCDs and related risk factors. Several manuscripts in draft from phase 1 (surveys); planning for phase 2/3 (RCT) underway. MRC UK approved activities for phase 2.
Start Year 2011
 
Description Literature review: Combining indoor residual spraying and insecticide treated net interventions 
Organisation Government of Equatorial Guinea
Department Ministry of Health Equatorial Guinea
Country Equatorial Guinea, Republic of 
Sector Public 
PI Contribution We conducted a literature review and analysed data from Bioko and Zambezia.
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81
Start Year 2007
 
Description Literature review: Combining indoor residual spraying and insecticide treated net interventions 
Organisation Government of Mozambique
Department Ministry of Health Mozambique
Country Mozambique, Republic of 
Sector Public 
PI Contribution We conducted a literature review and analysed data from Bioko and Zambezia.
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81
Start Year 2007
 
Description Literature review: Combining indoor residual spraying and insecticide treated net interventions 
Organisation World Health Organization (WHO)
Department Global Malaria Programme
Country Switzerland, Swiss Confederation 
Sector Charity/Non Profit 
PI Contribution We conducted a literature review and analysed data from Bioko and Zambezia.
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact 5 of the 8 studies reviewed reported a reduced risk of infection in those communities protected by both interventions compared with one intervention alone. Surveys in Bioko and Zambezia found that spraying combined with nets resulted in a 1/3 increase in protective effect compared with IRS alone. These results justify the additional resources required for combining spraying and nets. Findings published in Kleinschmidt et al. American Journal of Tropical Medicine and Hygiene, 2009;81
Start Year 2007
 
Description Malaria elimination trial 
Organisation Aix-Marseille University
Country France, French Republic 
Sector Academic/University 
PI Contribution LSHTM are responsible for the co-ordination of the trials.
Collaborator Contribution The University of Marseilles is contributing in terms of statistical spatial analysis, and genotyping to identify parasite strains.
Impact No outputs as yet to report.
Start Year 2013
 
Description Mathematical modelling: Global estimates of newborn deaths by cause 
Organisation Save the Children
Department Saving Newborn Lives SNL
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Development of a statistical model to estimate the cause distribution of neonatal deaths
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact National estimates used by WHO
Start Year 2007
 
Description Modelling serotype replacement in The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Developing a model for super-infection and simulating the impact of vaccination on pneumococcal carriage
Collaborator Contribution Conducting sensitivity analyses to assess whether our findings are robust to moderate levels of co-infection
Impact Paper published late 2013
Start Year 2009
 
Description Nonspecific effects of childhood vaccination on bacterial carriage 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Providing statistical support
Collaborator Contribution Assessing non-specific effects of childhood vaccines on bacterial carriage.
Impact Paper currently in preparation
Start Year 2012
 
Description Observational Study: Rotavirus infection among Indian children living in slum areas 
Organisation Christian Medical College, Vellore
Country India, Republic of 
Sector Academic/University 
PI Contribution Statistical support, data analysis and advice on trial design.
Collaborator Contribution Trial leadership
Impact Study concluded that an urban slum population had lower natural protection from rotavirus infection because of high viral diversity, early infection and frequent reinfection giving some explanation why rotavirus vaccine may be less efficacious in Asian settings. Results published in Gladstone BP et al., 2011, Protective effect of natural rotavirus infection in an Indian birth cohort, New England Journal of Medicine, Jul 28;365(4):337-46.
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Medical Care Development International (MCDI)
Country United States of America 
Sector Private 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation University of Texas
Country United States of America 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Observational study: Bioko Island Malaria Control Projects, Phase I 
Organisation Yale University
Country United States of America 
Sector Academic/University 
PI Contribution Design of monitoring and surveillance systems, annual survey design and analsysis, impact evaluation of multiple interventions
Collaborator Contribution Multicountry analysis of combined interventions; evaluation of surveillance methods and impact assessment; significant intellectual input and mutual exchange of ideas
Impact Phase I found a major reduction in child mortality following an intensification of malaria control initiatives over a 4 year period on Bioko Island, Equatorial Guinea. Results published in Kleinschmidt et al. American Journal of Tropical Medicine & Hygiene, 2009; 80:882-888
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Bill and Melinda Gates Foundation
Country United States of America 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Centers for Disease Control and Prevention (CDC)
Country United States of America 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Georgia Institute of Technology
Country United States of America 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ghana Health Service
Country Ghana, Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Health Protection and Research Organisation (HPRO)
Country Afghanistan, Islamic Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation HealthNet
Country Afghanistan, Islamic Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ifakara Health Institute
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Karolinska Institute
Department Department of Public Health Sciences
Country Sweden, Kingdom of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Kilimanjaro Christian Medical Centre (KCMS)
Country Tanzania, United Republic of 
Sector Hospitals 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Kintampo Health Research Centre
Country Ghana, Republic of 
Sector Hospitals 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Makerere University
Country Uganda, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Merlin, Afghanistan
Country Afghanistan, Islamic Republic of 
Sector Private 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Ministry of Health, Uganda
Country Uganda, Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Institute for Medical Research, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Malaria Control Programme, Cambodia
Country Cambodia, Kingdom of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation National Malaria Control Programme, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of California, San Francisco
Country United States of America 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Cape Town
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Copenhagen
Country Denmark, Kingdom of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Malawi
Country Malawi, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Nigeria
Country Nigeria, Federal Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation University of Yaoundé
Country Cameroon, Republic of 
Sector Academic/University 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: Consortium for research on delivery of artemisinin combination therapy (ACT) 
Organisation Zanzibar Malaria Control Program (ZMCP)
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical advice, study design
Collaborator Contribution Intellectual input and mutual exchange of ideas; financial contribution; access to data and facilities
Impact Progress in research on delivery of artemisinin combination therapy; uptake of rapid diagnostic tests (RDTs) and health facility training with associated effects on diagnostic practices and patient outcomes; secondary analysis of trial data and preparation of cross-cutting papers; modelling of long-acting ACT for malaria case-management
Start Year 2008
 
Description Partnership: HPV in Africa Research Consortium 
Organisation University of Montpellier
Country France, French Republic 
Sector Academic/University 
PI Contribution Contributed to trial design, leading data management and analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, baseline data collected, follow-up underway
Start Year 2010
 
Description Partnership: HPV in Africa Research Consortium 
Organisation University of Ouagadougou
Department Centre of International Research for Health
Country Burkina Faso 
Sector Academic/University 
PI Contribution Contributed to trial design, leading data management and analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, baseline data collected, follow-up underway
Start Year 2010
 
Description Partnership: HPV in Africa Research Consortium 
Organisation University of the Witwatersrand
Department Reproductive Health and HIV Research Unit (RHRU) Witwatersrand
Country South Africa, Republic of 
Sector Academic/University 
PI Contribution Contributed to trial design, leading data management and analysis
Collaborator Contribution Trial leadership and all other aspects
Impact Protocol finalised, baseline data collected, follow-up underway
Start Year 2010
 
Description Partnership: IPTi consortium 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Statistical analysis of the effect of IPTi on serological responses to EPI vaccines
Collaborator Contribution Financial contribution
Impact Contributed to WHO policy recommendation for IPTi
 
Description Partnership: Integrated Vector Control Consortium (IVCC) 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Study design, data analaysis, writing and publishing paper
Collaborator Contribution Enabled multi country analysis of the effect of combining two malaria vector control methods
Impact One publication is being cited in support of Global Fund applications proposing use of combination of vector control methods A second paper on the impact of pyrethroid resistance on operational malaria control in Malawi has just been published. Wondji CS, et al.; 2012, Proceedings of the National Academy of Sciences, Nov 20;109(47):19063-70
Start Year 2007
 
Description Partnership: Malaria IPT research group Senegal 
Organisation Institute of Development Research (IRD)
Department IRD, Senegal
Country Senegal, Republic of 
Sector Public 
PI Contribution Writing grant proposals and protocols, securing funding, coordinating research projects
Collaborator Contribution It has led to new research projects on malaria elimination in W Africa It has led to new research projects on malaria elimination in W Africa
Impact Ongoing trial to show safety and effectiveness of malaria IPT delivered through health service. A series of publications are planned.
Start Year 2006
 
Description Partnership: Malaria IPT research group Senegal 
Organisation University of Dakar
Country Senegal, Republic of 
Sector Academic/University 
PI Contribution Writing grant proposals and protocols, securing funding, coordinating research projects
Collaborator Contribution It has led to new research projects on malaria elimination in W Africa It has led to new research projects on malaria elimination in W Africa
Impact Ongoing trial to show safety and effectiveness of malaria IPT delivered through health service. A series of publications are planned.
Start Year 2006
 
Description Partnership: Malaria Vaccine Advisory Committee 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Advice on design and analysis of malaria vaccine trials
Collaborator Contribution Financial contribution
Impact Better trials and more reliable data
Start Year 2007
 
Description Partnership: Malaria in pregnancy consortium 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Trial design, protocol development, and statistical support
Collaborator Contribution Financial contribution
Impact Trial of simplified regimens for malaria prevention in pregnancy to start 2010
Start Year 2008
 
Description Partnership: TB preventive therapy and case finding with the consortium to respond effectively to the AIDS and TB epidemics (CREATE) 
Organisation Johns Hopkins University
Country United States of America 
Sector Academic/University 
PI Contribution TEG has contributed to the design of two clinical trials: Zamstar and Thibela TB. We have also developed the trial protocols and provided statistical support and led on data analysis.
Collaborator Contribution Collaborative involvement in statistical analysis of cluster randomised trials and data management of large field-based studies
Impact Both trials have been completed successfully. Zamstar results presented at Union World Conference on Lung Health (2011) and CROI (2012). Thibela results presented at CROI (2012) and the South African TB Conference (2012). Trial results have been published - Zamstar in Lancet (2013) and Thibela in NEJM (2014). Several publications are in progress and we intend to apply the learning from both trials to future trial design.
Start Year 2006
 
Description Review: Design issues in TB drug trials 
Organisation World Health Organization (WHO)
Department Tropical Disease Research (TDR)
Country Switzerland, Swiss Confederation 
Sector Public 
PI Contribution We assessed TB trial design using 6 criteria on method, outcome and duration
Collaborator Contribution Intellectual input and exchange of ideas
Impact Findings presented at the 40th Union World Conference on Lung Health in Cancun, 2009.
Start Year 2008
 
Description Seasonal Malaria Chemoprevention working group 
Organisation Roll Back Malaria
Country Switzerland, Swiss Confederation 
Sector Charity/Non Profit 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Seasonal Malaria Chemoprevention working group 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Seasonal Malaria Chemoprevention working group 
Organisation Worldwide Antimalarial Resistance Networkn WWARN
Country Global 
Sector Charity/Non Profit 
PI Contribution Chairing monitoring and evaluation subcommittee.
Collaborator Contribution Members of the monitoring and evaluation subcommittee.
Impact Regional meetings of malaria control programme managers in west Africa
Start Year 2013
 
Description Statistical support for design and analysis of clinical research projects and support for data management and reporting 
Organisation Addis Ababa University
Country Ethiopia, Federal Democratic Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011
 
Description Statistical support for design and analysis of clinical research projects and support for data management and reporting 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011
 
Description Statistical support for design and analysis of clinical research projects and support for data management and reporting 
Organisation Institute for Endemic Diseases IEND
Country Sudan, Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011
 
Description Statistical support for design and analysis of clinical research projects and support for data management and reporting 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya, Republic of 
Sector Public 
PI Contribution Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011
 
Description Statistical support for design and analysis of clinical research projects and support for data management and reporting 
Organisation Makerere University College of Health Sciences
Country Uganda, Republic of 
Sector Academic/University 
PI Contribution Trial design, protocol development, statistical input and data analysis, capacity building, steering and DSMB committee membership
Collaborator Contribution Collaborative involvement in a number of Phase II and Phase III trials
Impact Development of a specialist Clinical Trials Data Management Centre based in Nairobi. Four trials have been completed. Combined data from two trials showed comparable efficacy and safety of a two-week combination treatment regimen of Paramomycin plus Sodium Stubogluconate (SSG) to the standard one-month SSG monotherapy regimen. The new shorter course combination regimen have been incorporated into national treatment guidelines in Sudan, Kenya, Ethiopia and Uganda and also WHO guidelines. The results of two trials evaluating alternative short-course treatment regimens are being prepared for publication. Funding secured and protocol finalised for a Phase II trial to evaluate a new chemical entity. Results published in Musa et al; PLoS Neglected Diseases, 2012, Hailu et al; PLoS Neglected Diseases, 2010. Protocols published in Edwards et al; Trials, 2011, Omollo et al; Trials, 2011
 
Description Statistical support: Comparison of active and passive surveillance for malaria case detection in Burkina Faso 
Organisation National Centre for Research and Training on Malaria (CNRFP)
Country Burkina Faso 
Sector Public 
PI Contribution Statistical support- analysis, reporting results.
Collaborator Contribution Study conducted in Burkina Faso
Impact 1 manuscript currently under review.
Start Year 2013
 
Description Statistical support: Evaluating methods for vaccine efficacy 
Organisation National University of Singapore
Country Singapore, Republic of 
Sector Academic/University 
PI Contribution Methodological research
Collaborator Contribution Financial contribution
Impact Papers on methods for estimating vaccine efficacy with multiple events
Start Year 2007
 
Description Statistical support: Evaluating methods for vaccine efficacy 
Organisation University of Hong Kong
Country Hong Kong, Special Administrative Region of China 
Sector Academic/University 
PI Contribution Methodological research
Collaborator Contribution Financial contribution
Impact Papers on methods for estimating vaccine efficacy with multiple events
Start Year 2007
 
Description Statistical support: IPT for the prevention of malaria and related complications in patients with sickle-cell disease in Nigeria 
Organisation University of Ilorin Teaching Hospital, Nigeria
Country Nigeria, Federal Republic of 
Sector Academic/University 
PI Contribution Statistical support- analysis and reporting of results
Collaborator Contribution Study conducted in Nigeria
Impact Manuscript currently being prepared.
Start Year 2013
 
Description Statistical support: MRC The Gambia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Research support
Collaborator Contribution Increased research output
Impact Large number of collaborative research papers and impact on policy. Secured collaborative research funding.
 
Description Statistical support: MRC Uganda 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Study design, data analysis, writing and publishing papers, PhD supervision, writing grant proposals, support for quinquennial review proposal
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Collaborative studies and research papers; ; successful outcome of MRC quinquennial review
 
Description Statistical support: Missed opportunities for HIV treatment of women linked to HIV testing in pregnancy 
Organisation University of Nairobi
Country Kenya, Republic of 
Sector Academic/University 
PI Contribution PhD supervision
Collaborator Contribution Local host for PhD Student
Impact Successful completion of fieldwork for study
Start Year 2008
 
Description Statistical support: Mwanza MITU/NIMR 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Epidemiological and statistical input to field studies; design of new studies and preparation of funding applications; capacity building
Collaborator Contribution Collaborative involvement in and field sites for studies of the epidemiology and control of HIV and related infections
Impact HIV microbicide and vaccine feasibility studies, and studies of HPV vaccination and epidemiology successfully completed. Studies of chronic diseases and structural interventions to reduce gender violence ongoing
Start Year 2006
 
Description Statistical support: Nutritional support for African adults starting antiretroviral therapy (NUSTART) 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Research Centre (MRC)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Statistical support- analysis, reporting results. PI based at LSHTM.
Collaborator Contribution Study sites at UTH and NIMR carry out study. LSHTM PI obtained funding and directing the trial
Impact 1 manuscript currently under review.
Start Year 2010
 
Description Statistical support: Nutritional support for African adults starting antiretroviral therapy (NUSTART) 
Organisation University Teaching Hospital (UTH)
Country Zambia, Republic of 
Sector Academic/University 
PI Contribution Statistical support- analysis, reporting results. PI based at LSHTM.
Collaborator Contribution Study sites at UTH and NIMR carry out study. LSHTM PI obtained funding and directing the trial
Impact 1 manuscript currently under review.
Start Year 2010
 
Description Statistical support: The relationship between anaemia and pubertal growth spurt in Tanzanian sickle cell patients 
Organisation Muhimbili Wellcome Programme
Country Tanzania, United Republic of 
Sector Charity/Non Profit 
PI Contribution Statistical support- analysis and data management
Collaborator Contribution Study conducted in Tanzania
Impact Research instigated.
Start Year 2013
 
Description Statistical support: Wellcome Trust Bloomsbury Centre Fellows 
Organisation Wellcome Trust
Department Wellcome Trust Bloomsbury Centre
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Epidemiological and statistical support for Wellcome Trust fellows
Collaborator Contribution Collaborative involvement in field research carried out by Wellcome Trust fellows
Impact Successful completion of wide range of field studies including publications in peer-review journals
 
Description Statistical support: the impact of maternal infection with M. Tuberculosis on the infant response to BCG immunisation 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Statistical design and analysis of the study
Collaborator Contribution Design of the study, obtaining funding, co-ordinating the study
Impact No outputs as yet.
Start Year 2013
 
Description Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection 
Organisation National Malaria Control Programme, Namibia
Country Namibia, Republic of 
Sector Public 
PI Contribution Design, study co-ordination, analysis and interpretation of results
Collaborator Contribution Design, study co-ordination, analysis and interpretation of results
Impact Protocols finalised.
Start Year 2012
 
Description Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection 
Organisation University of California
Country United States of America 
Sector Academic/University 
PI Contribution Design, study co-ordination, analysis and interpretation of results
Collaborator Contribution Design, study co-ordination, analysis and interpretation of results
Impact Protocols finalised.
Start Year 2012
 
Description Study: Epidemiology of border malaria in Northern Namibia: Case control study to determine risk factors for malaria infection 
Organisation University of Namibia
Country Namibia, Republic of 
Sector Academic/University 
PI Contribution Design, study co-ordination, analysis and interpretation of results
Collaborator Contribution Design, study co-ordination, analysis and interpretation of results
Impact Protocols finalised.
Start Year 2012
 
Description Study: Health systems response to chronic diseases in Africa 
Organisation MRC/UVRI Uganda Research Unit on AIDS
Country Uganda, Republic of 
Sector Public 
PI Contribution Contributed to study design, leading statistical analysis
Collaborator Contribution Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas
Impact Protocol finalised, data collection underway
Start Year 2012
 
Description Study: Health systems response to chronic diseases in Africa 
Organisation Medical Research Council (MRC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Contributed to study design, leading statistical analysis
Collaborator Contribution Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas
Impact Protocol finalised, data collection underway
Start Year 2012
 
Description Study: Health systems response to chronic diseases in Africa 
Organisation National Institute for Medical Research, Tanzania
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Contributed to study design, leading statistical analysis
Collaborator Contribution Collaborative involvement in field research; trial leadership at Uganda site; significant intellectual input and exchange of ideas
Impact Protocol finalised, data collection underway
Start Year 2012
 
Description Study: Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium, Kingdom of 
Sector Academic/University 
PI Contribution Contributed to study design, will lead statistical analysis
Collaborator Contribution Collaborative involvement in field research
Impact Baisley, K., et al; 2012, Uptake of Voluntary Counselling and Testing among Young People Participating in an HIV Prevention Trial: Comparison of Opt-Out and Opt-In Strategies, PLOS One, 7(7):e42108
Start Year 2011
 
Description Study: Preparing for clinical trials of interventions to improve the reproductive health of adolescent girls in sub-Saharan Africa 
Organisation National Institute for Medical Research, Tanzania
Department Mwanza Intervention Trials Unit (MITU)
Country Tanzania, United Republic of 
Sector Public 
PI Contribution Contributed to study design, will lead statistical analysis
Collaborator Contribution Collaborative involvement in field research
Impact Baisley, K., et al; 2012, Uptake of Voluntary Counselling and Testing among Young People Participating in an HIV Prevention Trial: Comparison of Opt-Out and Opt-In Strategies, PLOS One, 7(7):e42108
Start Year 2011
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation Cameroon National Malaria Control Programme
Country Cameroon, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation Kenya National Malaria Control Programme
Country Kenya, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation National Malaria Control Programme (NMCP)
Country Ghana, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation Sudan's National Malaria Prevention and Control Program (NMCP)
Country Sudan, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation The National Malaria Control Programme of Benin
Country Benin, Republic of 
Sector Public 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: The impact of insecticide resistance on the effectiveness of malaria vector control 
Organisation World Health Organization (WHO)
Department Global Malaria Programme
Country Switzerland, Swiss Confederation 
Sector Charity/Non Profit 
PI Contribution Design and co-ordination of epidemiological component of study
Collaborator Contribution Funding and overall oversight; Entomological expertise and co-ordination of entomological component of the study; In country co-ordination and execution of the studies.
Impact Protocols finalised. Initial data collection completed.
Start Year 2010
 
Description Study: modelling and analysis for childhood and pediatric care 
Organisation Kenyan Institute for Medical Research (KEMRI)
Country Kenya, Republic of 
Sector Public 
PI Contribution Statistical analysis and capacity building
Collaborator Contribution Significant intellectual input and exchange of ideas. Project leadership.
Impact Statistical supportand training was provided to national and international scientists at the KEMRI-Wellcome Trust Research Programme in Nairobi, Kenya. Results published in Ayieko et al; PLoS One, 2012, Gitonga et al; Tropical Medicine and International Health, 2012. Development of materials and teaching on short courses and workshops in Kenya: Clinical Trials, 2011, Multilevel Models, 2010, Specialist Data Management, 2010
Start Year 2010
 
Description Study: modelling and analysis for childhood and pediatric care 
Organisation University of Oxford
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Statistical analysis and capacity building
Collaborator Contribution Significant intellectual input and exchange of ideas. Project leadership.
Impact Statistical supportand training was provided to national and international scientists at the KEMRI-Wellcome Trust Research Programme in Nairobi, Kenya. Results published in Ayieko et al; PLoS One, 2012, Gitonga et al; Tropical Medicine and International Health, 2012. Development of materials and teaching on short courses and workshops in Kenya: Clinical Trials, 2011, Multilevel Models, 2010, Specialist Data Management, 2010
Start Year 2010
 
Description Support and supervision: Uncertainty in estimates of disease burden 
Organisation UN Population Division
Country United States of America 
Sector Public 
PI Contribution Directed the work of research fellow
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group
Start Year 2007
 
Description Support and supervision: Uncertainty in estimates of disease burden 
Organisation UNICEF
Country Global 
Sector Public 
PI Contribution Directed the work of research fellow
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group
Start Year 2007
 
Description Support and supervision: Uncertainty in estimates of disease burden 
Organisation World Bank Group
Country United States of America 
Sector Private 
PI Contribution Directed the work of research fellow
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group
Start Year 2007
 
Description Support and supervision: Uncertainty in estimates of disease burden 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Directed the work of research fellow
Collaborator Contribution Mutually reinforcing collaboration involving exchange of ideas
Impact Findings presented to interagency group for mortality estimation, with proposals for improving methods incorporated into methods used by the inter-agency group
Start Year 2007
 
Description Support for design and analysis of clinical research projects & support for data management and reporting of clinical projects 
Organisation Drugs for Neglected Diseases initiative (DNDi)
Country Switzerland, Swiss Confederation 
Sector Private 
PI Contribution We provide ongoing statistical and epidemiological support for trials of the treatment of visceral leishmaniasis in multi-centre studies in East Africa, coordinated from a data centre in KEMRI, Nairobi. The grant also supports participation in a Data Safety and Monitoring Committee for similar trials, also conducted under the sponsorship of DNDi in India and Bangladesh.
Collaborator Contribution Implementation of trial, coordination and management.
Impact Paper led to informing national treatment policy in Sudan, Kenya, Uganda and Ethiopia. (Sodium stibogluconate plus paramomycin incorporated as the new standard treatment regimin for patients with VL)
 
Description Systematic Review: Male circumcision and the risk of HIV infection in women 
Organisation Joint United Nations Programme on HIV/AIDS (UNAIDS)
Country Global 
Sector Public 
PI Contribution Conducted the systematic review and led the publications
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Review found little evidence that male circumcision directly reduces risk of HIV in women but also no evidence of harm, informing scale-up of circumcision in Africa. Findings published in Weiss et al. Lancet Infectious Diseases, 2009; 9;669-77
Start Year 2007
 
Description Systematic Review: Male circumcision and the risk of HIV infection in women 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Conducted the systematic review and led the publications
Collaborator Contribution Significant intellectual input and exchange of ideas
Impact Review found little evidence that male circumcision directly reduces risk of HIV in women but also no evidence of harm, informing scale-up of circumcision in Africa. Findings published in Weiss et al. Lancet Infectious Diseases, 2009; 9;669-77
Start Year 2007
 
Description Systematic Review: Mycoplasma genitalium and HIV infection 
Organisation Government of South Africa
Department Department of Health
Country South Africa, Republic of 
Sector Public 
PI Contribution Identified and reviewed epidemiological studies of the association of mycoplasma genitalium and HIV infection in adults.
Collaborator Contribution Sample testing; significant intellectual input and exchange of ideas
Impact Review found a strong association between mycoplasma genitalium and HIV infection. Findings published in Napierala Mavedzenge and Weiss, AIDS, 2009;23:611-20
Start Year 2008
 
Description Systematic Review: Mycoplasma genitalium and HIV infection 
Organisation Medical Research Council (MRC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Identified and reviewed epidemiological studies of the association of mycoplasma genitalium and HIV infection in adults.
Collaborator Contribution Sample testing; significant intellectual input and exchange of ideas
Impact Review found a strong association between mycoplasma genitalium and HIV infection. Findings published in Napierala Mavedzenge and Weiss, AIDS, 2009;23:611-20
Start Year 2008
 
Description Systematic review: Male circumcision and the risk of HPV infection, genital warts and penile cancer in men 
Organisation World Health Organization (WHO)
Country Global 
Sector Public 
PI Contribution Identified and reviewed 27 studies on the association between circumcision and HPV DNA. A further 8 papers were identified that evaluated the relationship between circumcision and penile cancer.
Collaborator Contribution Significant intellectual input; Mutual exchange of ideas
Impact Results suggest that expansion of circumcision services provides partial protection against HPV infection in men, with resulting benefit for women. There was no evidence of an association of circumcision with prevelence of genital warts.
Start Year 2009
 
Description Zinc supplementation in Gambian children with severe pnemonia 
Organisation Medical Research Council (MRC)
Department MRC Unit, The Gambia
Country Gambia, Republic of the 
Sector Public 
PI Contribution Providing statistical support
Collaborator Contribution Conducting a randomised trial on the effectiveness of zinc supplementation (as an adjunct therapy) in childern under 5.
Impact Results pending.
Start Year 2012
 
Description AMFm stakeholders consultation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Has the AMFm mechanism helped to reduce the cost of quality-assured ACTs to patients at public, private for-profit and not-for-profit outlets?

Stakeholders were informed of the outcomes of the AMFm project reducing quality-assured ACTs to patients.
Year(s) Of Engagement Activity 2013
 
Description Expert Panel: MEMA kwa Vijana trial, Mwanza 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Production of technical/policy briefing papers

Findings have contributed to development of global policy on adolescent sexual health and HIV
Year(s) Of Engagement Activity 2008
 
Description HPTN 071 (PopART) communications 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Health professionals
Results and Impact Press releases and interviews on launch of trial and randomisation ceremony

Increased awareness of trial
Year(s) Of Engagement Activity 2012,2013
 
Description HSV-2 trial dissemination activities 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Dissemination of the results from the trial: "Clinical epidemiology of HSV-2 and the impact of HSV suppressive therapy to reduce HIV incidence in high risk women, Tanzania" through workshops, international conferences and meetings and publications in scientific journals.

Dissemination of the results from the trial: "Clinical epidemiology of HSV-2 and the impact of HSV suppressive therapy to reduce HIV incidence in high risk women, Tanzania" through workshops. Increased awareness about the association between HIV and HSV-2 in trial participants, scientists and health care workers in Tanzania.
Year(s) Of Engagement Activity 2009
 
Description MEMA Kwa Vijana Further Survey dissemination activities 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Dissemination of the results from the "MEMA Kwa Vijana Further Survey" (Adolescent Sexual and Reproductive Health intervention) through international and regional workshops.
Year(s) Of Engagement Activity 2009
 
Description Media: Jinja trial 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact press releases, interviewed by journalists

too early to say
Year(s) Of Engagement Activity 2009
 
Description Media: PopArt Funding Decision 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Press release and publicity of funding of PopART HIV prevention trial by NIH and Gates Foundation

Increased awareness of trial
Year(s) Of Engagement Activity 2011
 
Description Open Day: Entebbe Mother and Baby Study Trial 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Large meeting for all participants and their families, and community field workers involved in trial. Poster presentations, question & answer session

Audience informed of trial results
Year(s) Of Engagement Activity 2009
 
Description Presentation: British HIV Association 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited talk to the British HIV Association annual meeting

Increasing awareness of the association of HIV & male circumcision
Year(s) Of Engagement Activity 2006
 
Description Presentation: Entebbe Mother and Baby Study Trial 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Dissemination meeting of results to colleagues and stakeholders at the Uganda Ministry of Health

Increased awareness of implications of deworming programme for allergy
Year(s) Of Engagement Activity 2009
 
Description Presentation: International AIDS Alliance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Invited talk to the International AIDS Alliance

Increasing awareness of the association of HIV & male circumcision
Year(s) Of Engagement Activity 2008
 
Description Presentation: Leishmaniasis East Africa Platform 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dissemination of clinical trial results.


Audience was informed of the results of the trial "An open-label, sequential step, safety and efficacy study to determine the optimal single dose of Ambisome for patients with Visceral Leishmaniasis"
Year(s) Of Engagement Activity 2009
 
Description Presentation: Medsin UK Global Health Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited talk to the Medsin UK Global Health Conference

Increasing awareness of the association of HIV & male circumcision
Year(s) Of Engagement Activity 2008
 
Description Presentation: Pan African Malaria Vector Control Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Invited talk to present evidence on benefit of combined use of insecticide treated nets and indoor residual spraying against malaria

Increased use of combined vector control methods in several countries
Year(s) Of Engagement Activity 2009
 
Description Presentation: WHO/UNAIDS Expert Consultation on Male Circumcision & HIV prevention 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Policymakers/parliamentarians
Results and Impact Invited talk to present evidence on male circumcision trials for HIV prevention

WHO/UNAIDS recommendation: New Data on Male Circumcision and HIV Prevention: Policy and Programme Implications
Year(s) Of Engagement Activity 2007
 
Description Produced MITU biennial report 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Produced the first MITU biennial report.

Distributed to researchers, research collaborations, funding organisations and the media.
Year(s) Of Engagement Activity 2009
 
Description Publication: Tropical Epidemiology Group Biennial Report 2009-10 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact The report summarises our research, outputs and impact over a 2 year period and was sent to over 500 partners, funders and policy makers in March 2011

The report has been well received by colleagues and collaborators. It has also increased the profile and visability of the group both internally and externally
Year(s) Of Engagement Activity 2011
 
Description Roll Back Malaria Vector Control Working Group, Genva, annually 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Participants in your research and patient groups
Results and Impact Benefits of complementary use of vector control tools; risk of malarial infection due to holed mosquito nets


None to date
Year(s) Of Engagement Activity 2010,2011,2012
 
Description Scientific symposium: HIV Prevention - Where Now? 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact The symposium included keynote presentations reviewing the research evidence on major approaches to HIV prevention in adults and focused on the prevention of heterosexual transmission of HIV in Africa. There was discussion of research gaps, future directions and methodological approaches. The media were present.

An article on the symposium featured in "Tanzania AIDS Week in Review".
Year(s) Of Engagement Activity 2009
 
Description TEG Biennial Report 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Report publication - Dissemination of recent findings of portfolio of the groups work over the past 2 years

Positive response from recipients
Year(s) Of Engagement Activity 2013
 
Description Working Group: CIGNIS Trial 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Series of talks followed by poster session and discussions

Increased knowledge of micronutrient fortification in HIV-exposed uninfected children
Year(s) Of Engagement Activity 2010
 
Description Working Group: WHO/UNAIDS wesbite 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Contributed material to the new WHO/UNAIDS wesbite: www.malecircumcision.org

Increased knowledge and awareness of male circumcision and its incorporation in HIV/Aids prevention programming
Year(s) Of Engagement Activity 2008
 
Description Workshop: CIGNIS Trial 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Large meeting for all participants & families; presentations, question and answers session.

Audience was informed of trial results
Year(s) Of Engagement Activity 2010
 
Description Workshop: Clinical Trials 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Short-course organisation, development of materials, teaching


Increased awareness of methodology and conduct of clincial trials
Year(s) Of Engagement Activity 2011
 
Description Workshop: Determining the role of IPT in malaria control 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Review of evidence on potential role of IPTc for malaria control, for national programmes and WHO representatives

A working group was established to prepare a report on IPTc for submission to WHO
Year(s) Of Engagement Activity 2008
 
Description Workshop: Herpes suppressive therapy trial, Mwanza 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Dissemination workshops for policymakers and other stakeholders in Tanzania

Attendees better informed about Herpes suppressive therapy trials in Mwanza, Tanzania
Year(s) Of Engagement Activity 2007
 
Description Workshop: Jinja trial 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Large meeting for all patients, community members, health care staff. Gave presentations, and held a question and answer session.

Audience was informed
Year(s) Of Engagement Activity 2009
 
Description Workshop: MDP301 trial of Pro2000 microbicide gel 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Participants in your research and patient groups
Results and Impact Subsantial proportion of women participating in trial attended dissemination workshops

NA
Year(s) Of Engagement Activity 2010
 
Description Workshop: MEMA kwa Vijana trial, Mwanza 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact Dissemination workshops for policymakers and other stakeholders in Tanzania

Findings have contributed to development of global policy on adolescent sexual health and HIV
Year(s) Of Engagement Activity 2008
 
Description Workshop: Microbicide feasibility study in Mwanza 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Policymakers/parliamentarians
Results and Impact National workshop in Tanzania to present results of study to government and non-governmental organisations

Increased awareness of research to develop effective HIV prevention tools
Year(s) Of Engagement Activity 2011
 
Description Workshop: Multilevel Models 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Short-course organisation, development of materials, teaching


Increased awareness of methods and applications for multilevel continuous and binary data
Year(s) Of Engagement Activity 2010
 
Description Workshop: Specialist Data Management 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Workshop organisation, series of talks followed by discussions



Increased awareness of specialist data management activities for clinical trials and networking in the East Africa region
Year(s) Of Engagement Activity 2010