Hypoxia/ischaemia and patterns of neuropathology associated with memory impairment: From infancy through adolescence

Lead Research Organisation: University College London
Department Name: Institute of Child Health

Abstract

Memory is a critical ability in the everyday lives of children, allowing them to establish a base of knowledge about the world and remember the events of everyday life and so learn from personal experiences. Certain medical conditions that affect the heart and/or the lungs can interfere with the supply of blood and oxygen to the brain, and result in injury to the hippocampus, a memory-related structure. Our past research showed that up to 30% of children who survived such conditions and were otherwise developing normally still had significant memory impairments. In our current research programme, we aim to study infants with these medical conditions, with the goal of providing information that will allow the early identification of those at risk for hippocampal injury and memory impairment so that treatments can be implemented as early as possible. We will enroll newly born babies into our study and follow their development at specific time points over a two year period, examining their behaviour and getting images of their brains to evaluate possible injury to the hippocampus. We will also determine whether other areas of the brain are damaged, and, in those cases where the injury is limited to the hippocampus, we will find out how this affects the pattern of communication between brain areas. We will also use specific memory tasks that are sensitive to the functions of the hippocampus so that we can determine when memory impairments, if they occur at all, first become evident, and assess the degree of the deficit. We will use medical information to see whether this provides any early clues to which children will be affected and to what degree. A second part of our research plan is to study older children who have had particular heart or breathing problems as babies. This part of our work builds on our previous studies which showed that children with medical conditions affecting the supply of blood and oxygen to their brains as infants had a high rate of memory difficulties. This work also indicated that whereas certain aspects of memory were affected, others remained relatively normal. We will investigate in more detail the pattern of affected and unaffected memory abilities and their brain basis. We hope that this work will give a better overall understanding of the brain basis of memory development and will also help health care professionals develop prevention and treatment strategies for memory impairment.

Technical Summary

Memory is a fundamental aspect of cognitive development, allowing children to gain a knowledge base about the world and form a store of personal memories that are essential for establishing a sense of identity. Our prior research showed that selected aspects of memory development are at risk in children with medical conditions exposing them to hypoxic-ischaemic injury to the hippocampus. The research programme we now propose aims to investigate how such memory impairments evolve by studying young infants prospectively as well as investigate in more detail both the spared and impaired memory skills and their neural correlates in older children who had sustained hippocampal injury earlier in life, often neonatally. In the first part of our programme, infants with cardiorespiratory disease requiring extracorporeal membrane oxygenation, those with transposition of the great arteries requiring open heart surgery, and those with hypoplastic left heart, will be studied from the first weeks of life until two years of age using neuroimaging, neurophysiological methods, and cognitive behavioural testing to identify the presence of hippocampal atrophy, its effects on the development of brain connectivity patterns, and its impact on memory function. In the second part of our programme, we will build on our prior work using a retrospective design to study children who experienced cardiac arrest as infants. We will examine the incidence of memory impairment in this group, the degree and selectivity of any hippocampal injury, and the long-term impacts on brain connectivity. We will also assess the sensitivity of several tests of hippocampal-dependent memory, the relation of memory performance to degree of hippocampal injury, and the neural mechanisms that enable affected children to acquire a semantic knowledge base in spite of their severe learning deficits. This research programme will provide information relevant to theories of the neurocognitive organisation of memory as well as how the brain reorganises following early injury to this critical memory structure. An important goal is the earliest possible identification of hippocampal injury in infants who have suffered hypoxia/ischaemia, as these are the cases who will be at risk for memory impairment; this will allow the earliest possible remediation efforts, including how preserved memory skills can be exploited to improve overall level of function, as well as provide key information about the trajectory of memory impairments once they appear.

Publications

10 25 50
 
Title A video clip to familiarise teachers and SENCOs with the learning difficulties of young patients with the amnesic syndrome 
Description This short video clip is developed to familiarise teachers and special education support workers with the learning problems that developmental amnesic patients face in everyday life, and in particular in the classroom situation. Amnesic patients describe their problems and seek help from their carers in ways that can improve their quality of life and their learning to gain more independence. 
Type Of Art Film/Video/Animation 
Year Produced 2015 
Impact Once completed, this video clip can be distributed to schools and special education specialists. It can also be made available via web-based channels along with reports on paediatric memory problems for families and carers. 
 
Description Contribution to Early Childhood in Focus Series 7 for policy makers
Geographic Reach National 
Policy Influence Type Citation in systematic reviews
 
Description Contribution to the Public Service Review of Science and Technology
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
 
Description Development of a doctorate programme in clinical paediatric neuropsychology
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Habit Learning in an educational setting for children with severe epilepsy
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Institute of Medicine Epilepsies Workshop; Health Care Quality and Access and Education of Health Care Providers, Patients and the Public, June 2011
Geographic Reach North America 
Policy Influence Type Participation in advisory committee
 
Description Paediatric Clinical Neuropsychology Post Graduate Diploma (PgDip)
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact This additional training route for those interested in clinical neuropsychology provides training in theoretical and practical experience for post graduate psychology students who will progress to work within the health service in preparation for clinical training.
 
Description CEL-LCRN Division 5 Funding
Amount £8,379 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2013 
End 03/2014
 
Description CLRN Contingency Support
Amount £1 (GBP)
Funding ID CEL1747 
Organisation NIHR Clinical Research Network North Thames 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2013 
End 03/2014
 
Description CRN
Amount £12,309 (GBP)
Organisation National Institute for Health Research 
Department NIHR Clinical Research Network (CRN)
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 07/2016 
End 01/2017
 
Description Great Ormond Street Hospital Comprehensive Local Research Network (CLRN) Funding
Amount £33,397 (GBP)
Funding ID 5177 
Organisation Great Ormond Street Hospital (GOSH) 
Sector Hospitals
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2012 
End 03/2013
 
Description Great Ormond Street Hospital Comprehensive Local Research Network (CLRN) Funding Scheme
Amount £20,723 (GBP)
Funding ID 5177 
Organisation Great Ormond Street Hospital (GOSH) 
Sector Hospitals
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2012 
End 03/2013
 
Description Guarantors of Brain
Amount £397 (GBP)
Organisation Association of British Neurologists (ABN) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 05/2016 
End 07/2016
 
Description Research Capability Funding
Amount £12,057 (GBP)
Funding ID 12CN02 
Organisation University College London 
Department Institute of Child Health
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2013 
End 03/2014
 
Title DTI analysis of children who received ECMO neonatally 
Description Analysis of MRI datasets of 42 healthy controls and 32 patients treated with ECMO neonatally using tract-based spatial statistics (TBSS; Smith et al, 2006), a method for quantitative analysis of diffusion tensor properties, including fractional anisotropy (FA) and mean diffusivity (MD). 
Type Of Material Biological samples 
Provided To Others? No  
Impact Presentation of a poster at Society for Neuroscience 2013: E. Patai, J. Cooper, M. Mishkin, F. Vargha-Khadem. Exploration of white matter damage in patients who underwent extracorporeal membrane oxygenation treatment in childhood. http://www.abstractsonline.com/Plan/SSResults.aspx 
 
Title Development of an tablet-based application to measure verbal and nonverbal learning and memory 
Description This research tool was developed to measure lateralisation of verbal and nonverbal memory and learning in patients undergoing temporal lobe surgery. The app was developed and evaluated in a large group of healthy children who served as controls. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact THis is pending validation of the experimental measures in different patient populations. 
 
Title Extra-hippocampal damage in macaque monkeys with hippocampal lesions 
Description In association with National Institute of Health, we developed a manual segmentation technique to assess thalamic volumes in macaque monkeys with hippocampal lesions, using in-vivo MRI images. This allowed to investigate the secondary degeneration of extra-hippocampal structures, following damage to the hippocampus. The manual measurement protocol used was directly comparable with measurement technique used in humans, allowing for direct comparison between monkeys with hippocampal lesions and patients with Developmental Amnesia. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2015 
Provided To Others? Yes  
Impact Using MRi images, we are assessing thalamic abnormalities in macaque monkeys with hippocampal lesions, to determine whether secondary degeneration impacts global thalamic volumes. 
 
Title Hippocampal volume measurements from MRI scans 
Description Hippocampal volume measurements have been obtained on 337 patients (children, adolescents and adults) exposed to neonatal hypoxia-ischaemia in early life and 126 healthy control children, adolescents and adults have been obtained (Total sample of patients & controls,N= 463). These measurements have been related to measures of memory function. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Hand measured hippocampal volume measurements are considered the gold standard in providing an indication of hippocampal integrity. Subgroups from this sample have been used to relate hippocampal volume measurements to aspects of recall of spatial memory. 
 
Title Models for measurements of subcortical structures on MRI scans of neonates 
Description Have developed guidelines for measurement of hippocampal and head of caudate boundaries on T1-weighted MRI scans of neonates exposed to hypoxia-ischaemia and normal controls 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Impact is pending publication of the findings 
 
Title Neuropsychological and structural and functional MRI in a cohort with early onset of cardiac arrest 
Description A cohort of 28 patients with a history of early cardiac arrest associated with cardiorespiratory disease, and a group of age and gender-matched healthy controls have undergone complete neuropsychological investigations of memory and language function in relation to structural and functional MRI indices of white and grey matter integrity. 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Data analysis in progress. 
 
Title development of a fMRI paradigm for evaluating language and memory in one session 
Description We have developed a paradigm that evaluates lateralisation of memory and language in one fMRI session, thus saving patient time and providing a rich source of information to clinicians prior to neurosurgical procedures in the temporal lobes 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Once the results of this new paradigm have been validated, the procedure will replace the current fMRI paradigm used for clinical diagnosis of language lateralisation. 
 
Title tracking the hippocampal circuitry in developmental amnesia 
Description For this project, we a mixture of manual and automatic techniques to investigate extra-hippocampal damage in patients with Developmental Amnesia. Voxel-based morphometry was used to provide whole-brain, automatic measure of grey matter density. In addition, volumes of thalamus and mammillary bodies were measured manually according to a protocol developed in association with collaborators at NIH and Emory University. Volumes of subcortical structures were also obtained automatically using FSL FIRST. Finally, white matter diffusion abnormalities were assessed automatically using Tract-Based Spatial Statistics (TBSS, Smith et al., 2006). 
Type Of Material Model of mechanisms or symptoms - human 
Provided To Others? No  
Impact Using these approaches, we identified that in addition to the hippocampal atrophy, patients with Developmental Amnesia have abnormalities in the thalamus and the mammillary bodies, as well as the white matter. These abnormalities were found to relate to cognitive deficits in patients. 
 
Title Data base of MRI, DTI, fMRI on neonates and young infants. 
Description Data base of MRI, DTI, fMRI on neonates and young infants. A series of 25 patients with treated Transposition of the Great Arteries and those with Hypoplastic Left Heart Syndrome) and 12 healthy controls with structural and functional MRI data sets (at 8-12 weeks of age), Bailey Scales Neurodevelopmental Assessment, EEG, and Visual Paired Comparison tasks (both at 6-8 months, and at 12-14 months) have been acquired.. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact These data are longitudinal and involve 4 time points up to age 24-30 months. We have not yet reported any of the findings, but the first set of data will be presented at the forthcoming meetings of the Society for Neuroscience in San Diego USA in November 2016. 
 
Title Data base of T1 and T2 MRI scans from infants with hypoplastic left heart syndrome 
Description A group of neonates/infants with hypoplastic left heart have undergone MRI scanning. The volume data will be used to measure the volumes of both cortical and subcortical structures and determine the extent of damage that may have resulted from the cardiac surgery procedures. We also relate these measures of brain integrity to cognitive and behavioural function at later stages of infancy. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact This research will inform the cardiac team and the families about earliest signs of damage to brain systems that may impact on developmental outcome. 
 
Title Database of kinematics 
Description Data base of kinematics (movement analysis) on infants at 6 months and 12 months of age 25 data sets at each age level. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Data analysis is in progress to chart the development of joint movements of the limbs in infants using motion capture. The findings will be presented at the meetings of the Society for Neuroscience in San Diego, USA in November 2016. 
 
Title Database on children exposed to neonatal hypoxia-ischaemia associated with prematurity 
Description A large cohort (n=41) of children (8-17 years) exposed to neonatal hypoxia-ischaemia associated with extreme prematurity has been studied. The database consists of detailed neuropsychological and neuroimaging findings relating memory and other cognitive functions to extent of hippocampal pathology and measures of white matter integrity using DTI. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact White matter abnormality is well documented in cohorts of children born extremely premature. While language and intellectual functions have been related to extent of white matter integrity, similar work has not been carried out in similar samples looking at the integrity of different aspects of white matter integrity in the memory circuit. This is the focus of our investigation in this cohort. 
 
Title Database on patients with developmental amnesia 
Description This is the largest database in the world (n=23) of patients with developmental amnesia associated with selective hippocampal pathology resulting from early exposure to hypoxia-ischaemia. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact The discovery of the syndrome of developmental amnesia has challenged existing models of long term memory in relation to its neural substrate. 
 
Title MEG Database 
Description A group of patients with severe and moderate memory impairment, together with a group of healthy controls, have undergone a MEG study to examine associative memory using pattern classifier techniques. The paradigm has been adapted to be suitable for children. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Acquisition and analysis of electrophysiological data on the encoding of associative memories and their subsequent replay. 
 
Title data base of T1 and T2 MRI scans from infants with transposition of the great arteries 
Description A MRI data base on a group of infants with transposition of the great arteries has been obtained during neonatal/early infancy. These data are analysed using quantitative techniques to determine the integrity of cortical and subcortical structures and their susceptibility to hypoxic-ischaemic events associated with their cardiac surgery 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact Data collection is still in progress. Once completed, the data will be shared with the medical colleagues within the institution in the first instance. This will inform the extent of injury that can be associated with deep circulatory arrest during open heart surgery. 
 
Title data base on patients with focal epilepsy and identifiable lesions on MRI 
Description We have collected a data base of approximately 1000 paediatric patients undergoing investigations for focal resections to relieve epilepsy. The data base is divided into focal seizures affecting different lobes and hemispheric side of involvement (Frontal, Temporal, Occipito-parietal, Multi lobar). The neuropsychological data base has access to complete set of neurological, electrophysiological and radiological information, the latter consisting of measures of memory, IQ, and academic attainments. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact The data base is being accessed by the Epilepsy Surgery Team at Great Ormond Street Hospital as part of the commissioned Children's Epilepsy Surgery Services(CESS). The neuropsychology data are part of the required investigations being carried out as part of CESS according to NICE guidelines. 
 
Description An MEG study of associative memory using multivariate pattern classifier techniques 
Organisation University College London
Department Institute of Neurology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Development of the paradigm and modifications to administer the test to children.
Collaborator Contribution Providing access to MEG system and design of paradigm to enable conducting a pilot study to examine associative memory in healthy children, patients with memory impairments and patients with developmental amnesia.
Impact The following publication has resulted from this collaboration: Pub Med ID 23177479 Presentation of poster at Society for Neuroscience 2011 A. J. HORNER, D. GADIAN, S. JENTSCHKE, L. FUENTEMILLA, T. BALDEWEG, M. MISHKIN, E. DUZEL, F. VARGHA-KHADEM. Hippocampal volume predicts source memory performance in individuals with a history of early hypoxia-ischaemia.
Start Year 2010
 
Description Cardiac Arrest Collaboration 
Organisation Great Ormond Street Hospital (GOSH)
Department Cardiac Surgery
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution We are in the process of assessing long term memory outcome in relation to indices of hippocampal pathology, and also imaging indices of in brain white matter integrity in a cohort of children who have had cardiac arrest. So far we have collected data on 12 patients and 10 controls.
Collaborator Contribution Selection of the group of patients and medical input into the identification of inclusion criteria.
Impact Data collection still in progress.
Start Year 2013
 
Description Development of an application for the assessment of verbal and nonverbal learning and memory in candidates for temporal lobe epilepsy surgery 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution My Ph.D student developed the application which is being trialled now for the preoperative assessment of candidates for temporal lobe surgery.
Collaborator Contribution Multidisciplinary investigation of each patient to provide information about aetiology, seizure focus, natural history, MRI findings, etc.
Impact Multidiscplinary project involving neuropsychiatry, neuroradiology, neurology, electrophysiology, neuropsychology, neurosurgery and neuropathology.
Start Year 2015
 
Description Dissociation between hippocampal versus neostriatal function in spatial memory 
Organisation National Institutes of Health (NIH)
Department Laboratory of Neuropsychology
Country United States of America 
Sector Public 
PI Contribution Provision of neuropsychology and neuroimaging datasets of patients with developmental amnesia and memory impairment, as well as controls.
Collaborator Contribution Data analysis and relating findings to neuroanatomy of the neostriatal and the hippocampal circuitry.
Impact Publication in preparation.
Start Year 2013
 
Description Episodic memory and motor skill learning associated with selective brain damage in children with low blood sugar (hypoglycaemia) 
Organisation Great Ormond Street Hospital (GOSH)
Department Department of Endocrinology
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution Devising of neuropsychological protocols to identify the phenotype of children with ketotic and non-ketotic hypoglycaemia.
Collaborator Contribution Provision of cohort and identification of patients into ketotic and non-ketotic sub-groups.
Impact Data collection in progress.
Start Year 2012
 
Description Follow up study of children with Hypoplastic Left Heart Syndrome at pre-school age: Speech and language outcome 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution Recruitment and testing of patients from the longitudinal infancy study, design of EEG, Neuropsychology, and where appropriate MRI protocols.
Collaborator Contribution Identification of suitable patients, help with consenting families, obtaining information about medical variables to be taken into account for interpreting data.
Impact No outcome as yet. Multidisciplinary Research; Cardiology, Cardiac Surgery, Cardiac MRI, Clinical Psychology
Start Year 2016
 
Description Foxp2 expression using antibody tracing in macaques and marmosets 
Organisation National Institutes of Health (NIH)
Department National Institute of Mental Health (NIMH)
Country United States of America 
Sector Public 
PI Contribution Extending the behavioural phenotype of the FOXP2 mutation from humans to old and new world monkeys.
Collaborator Contribution Identifying the neuroanatomical structures involved in expression of the Foxp2 gene using antibody tracings.
Impact The collaboration is multidisciplinary involving expertise in neuroanatomy, auditory memory in monkeys, antibody tracing, clinical neuropsychology,
Start Year 2016
 
Description Foxp2 expression using antibody tracing in macaques and marmosets 
Organisation RIKEN
Department RIKEN Brain Science Institute
Country Japan 
Sector Public 
PI Contribution Extending the behavioural phenotype of the FOXP2 mutation from humans to old and new world monkeys.
Collaborator Contribution Identifying the neuroanatomical structures involved in expression of the Foxp2 gene using antibody tracings.
Impact The collaboration is multidisciplinary involving expertise in neuroanatomy, auditory memory in monkeys, antibody tracing, clinical neuropsychology,
Start Year 2016
 
Description Genetics of hypoxia 
Organisation University College London
Department Neural Development, Plasticity and Repair
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Collection of a dataset of MRI findings from a cohort of infants children exposed to neonatal hypoxia-ischaemia. These data will be correlated with genetic findings from blood samples obtained from the same cohort of children. The MRI data will be used to provide biomarkers of genetic protection against hypoxia.
Collaborator Contribution The investigation of targeted genes in blood samples obtained from a cohort of infants children exposed to neonatal hypoxia-ischaemia.
Impact Data collection still in process.
Start Year 2013
 
Description MRI investigations of amygdala structure, connectivity and function in developmental amnesia 
Organisation University of Fribourg
Country Switzerland, Swiss Confederation 
Sector Academic/University 
PI Contribution Made available structural MRI and DTI datasets to enable analyses of amygdala structure and connectivity; helped design the fMRI experiment. Recruitment and testing of patients and controls.
Collaborator Contribution Performing the structural and connectivity measurements.
Impact Multidisciplinary: Neuroanatomy, Neuroimaging, Neuropsychology
Start Year 2017
 
Description Movement analysis using kinematics to monitor motor coordination 
Organisation Imperial College London
Department Department of Electrical and Electronic Engineering
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Access to patients and the kinematics laboratory. Research design and generation of questions to be studied.
Collaborator Contribution Technical input into data capture and experimental design.
Impact Design of protocol completed. Data collection has begun, and data collected on a cohort of healthy infants. Data collection will be extended to a cohort of infants with hypoplastic left heart syndrome as well as an additional cohort undergoing deep circulatory arrest; patients treated surgically for transposition of the great arteries as neonates; and patients cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates.
Start Year 2012
 
Description Movement analysis using kinematics to monitor motor coordination 
Organisation University of Sussex
Department Centre for Computational Neuroscience and Robotics (CCNR)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Access to patients and the kinematics laboratory. Research design and generation of questions to be studied.
Collaborator Contribution Technical input into data capture and experimental design.
Impact Design of protocol completed. Data collection has begun, and data collected on a cohort of healthy infants. Data collection will be extended to a cohort of infants with hypoplastic left heart syndrome as well as an additional cohort undergoing deep circulatory arrest; patients treated surgically for transposition of the great arteries as neonates; and patients cardiorespiratory disease who received treatment with extracorporeal membrane oxygenation as neonates.
Start Year 2012
 
Description Network Dysfunction following paediatric traumatic brain injury 
Organisation Imperial College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Detailed neuropsychological and clinical assessment will be performed by Prof. Vargha Khadem's team (UCL/GOSH), with clinical input from the neurodisability team
Collaborator Contribution The Imperial TBI research group will use advanced magnetic resonance imaging (MRI) methods to study brain networks
Impact No outcomes yet, research grant request
Start Year 2014
 
Description Outcome after Vein of Galen Malformation 
Organisation University College London
Department Department of Clinical Neuroscience
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Designed the experimental paradigm and trained the post doctoral fellow employed on the NIHR grant to conduct the neuropsychological evaluation of patients from across the UK.
Collaborator Contribution Recruitment of patients into the study, collation of the MRI data, development of protocols to rate the MRI scans.
Impact Multidisciplinary project with collaboration between paediatric neurology, neuroradiology and neuropsychology.
Start Year 2016
 
Description Reinstatement in developmental amnesia 
Organisation University of Texas
Department Center for Vital Longevity
Country United States of America 
Sector Academic/University 
PI Contribution Design of fMRI experiment, acquisition of data in patients and controls, analysis of results
Collaborator Contribution Consultation on experimental design, comparison of data with those obtained from patients with Alzheimer's disease.
Impact Multidisciplinary investigation involving Imaging Neuroscience, Clinical and Experimental Neuropsychology
Start Year 2016
 
Description Remote ischaemic tissue preconditioning in neonates undergoing deep circulatory arrest for treatment of major cardiac abnormality 
Organisation Great Ormond Street Hospital (GOSH)
Department Cardiac Surgery
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Hospitals 
PI Contribution Payment of MRI scanning costs for the patient cohort, purchase of DTI sequence for the MRI scanner, assessment of cognitive outcome in those patients recruited to the study
Collaborator Contribution Selection of the group of patients with Hypoplastic left heart syndrome and additional cohort undergoing deep circulatory arrest.
Impact Ethics application submitted. Grant application to the British Heart Foundation in progress.
Start Year 2012
 
Title A novel technique for learning new information in the classroom 
Description We have developed a technique for teaching new information to children who suffer from memory and learning problems. This method is particularly helpful for children who have damage to the memory structures as a result of lack of oxygen to the brain associated with epilepsy, cardiac surgery, respiratory problems, etc. The development of this technique has been facilitated by our current programme grant funding from the MRC. We have been in touch with the UCL Translational Office and the UCL Digital Health Office to seek partnership with industry, and to find another partner through the UCL Institute of Education to further this development. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2015
Development Status Actively seeking support
Impact This development could lead to new ways of teaching and examining students with memory problems in primary and secondary level education 
 
Title Memory Disorders Clinic at Great Ormond Street Hospital for Children 
Description Development of a monthly clinic for diagnosis of memory disorders and appropriate educational interventions for children with damage to the memory circuits of the brain. This clinic is funded by the NHS. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2011
Development Status Under active development/distribution
Impact This clinic provides a specialist service and contributes to evaluation of learning outcomes for children who have undergone epilepsy surgery. 
 
Title Tablet-based assessment of verbal and nonverbal learning and memory 
Description This tablet-based set of learning games has been developed to provide diagnostic information about the status of learning and memory in patients considered for epilepsy surgery, and to provide prognostic indicators of language and memory outcome after surgery for clinicians and families. This information will guide the educational programmes of the children returning to the classroom after their surgical treatment. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2015
Development Status Under active development/distribution
Impact This development may lead to shortening the neuropsychological assessments that currently take several hours. It may also lead to test development that can be made commercially available. 
 
Title new semantic learning through recognition 
Description A number of patients with developmental amnesia who show good recognition ability are systematically taught new informaiton through an array of recognition paradigms. Information appears to be consolidated and accessible to later retrieval via recognition to an impressive extent. This method of teaching children with memory impairment may become commercialised to be used in schools. 
Type Therapeutic Intervention - Psychological/Behavioural
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact Infomation about this development has not been put into the public domain pending publication of results. 
 
Description 'How does your Memory work?' - BBC Horizon 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An interview describing how the brain memory network works and how it is divided into different components, each subserving a different aspect of mnemonic function.

There is now a recognition that memory problems are a feature of many neurodevelopmental disorders requiring educational assistance. At Great Ormond Street Hospital, we will be starting a memory disorders clinic for children with brain disease/insult.
Year(s) Of Engagement Activity 2008
 
Description 'Me & My Memory' - Radio 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A radio interview about normal and abnormal memory function.

Contributed to further recognition by parents, health professionals, and educators of the importance of memory dysfunction.
Year(s) Of Engagement Activity 2006
 
Description 'Preverbal Memories'- BBC News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Discussed the concept of preverbal memories and the possibility that infantile amnesia was due to the inability of the young child to verbalize their memories of events and episodes experienced.

Many parents wrote asking to have their child assessed because of memory problems.
Year(s) Of Engagement Activity 2007
 
Description 'Working Memory' - Radio 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact A radio interview about normal and abnormal memory function.

Contributed to the further recognition by parents, health professionals, and educators of the importance of memory dysfunction and the way this problem interferes with schooling and behaviour.
Year(s) Of Engagement Activity 2008
 
Description 103. Report on Bird et al., (2015), Today.com 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 103. Report on Bird et al., (2015), Today.com, 02 Nov 2015: http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
Year(s) Of Engagement Activity 2015
URL http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
 
Description 103. Report on Bird et al., (2015), Today.com - Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 103. Report on Bird et al., (2015), Today.com, 02 Nov 2015: http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
Year(s) Of Engagement Activity 2015
URL http://www.today.com/health/want-preserve-memory-more-vividly-follow-these-steps-t52596
 
Description A plenary lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The plenary lecture covered the history of memory research and described the discoveries that have been made as a result of our research programme on developmental memory disorders
Year(s) Of Engagement Activity 2017
 
Description Al-Jazeera English interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Al-Jazeera interview with Faraneh Vargha-Khadem
Year(s) Of Engagement Activity 2015
 
Description An interview on BBC radio 4 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed as part of Life Scientific Programme on BBC Radio 4
Year(s) Of Engagement Activity 2016
 
Description Associated Press interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Associated Press interview, Faraneh Vargha-Khadem and Michelle De Haan
Year(s) Of Engagement Activity 2014
 
Description BBC 5Live Science Night with The Naked Scientists 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact One hour live radio talking about memory and taking calls from the general public

TBC
Year(s) Of Engagement Activity 2012
 
Description Centre for Brain and Cognitive Development Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a seminar entitled, 'Neonatal hypoxia, hippocampal damage and selective memory impairment'

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2013
 
Description Chaucer Club 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver talk at the Chaucer Club, MRC Brain & Cognition Unit, Cambridge
Title: Neonatal hypoxia, hippocampal damage and episodic memory impairment: A causal sequence?

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2013
 
Description Collaboration with the artist, Gayle Chong Kwan 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Collaborated with Gayle Chong Kwan who created an installation for the Wellcome Trust, Euston Road, London, UK

TBC
Year(s) Of Engagement Activity 2012
 
Description Comment in New Scientist on research on implanting memories during sleep - Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Comment in New Scientist on research on implanting memories during sleep - Neil Burgess
Year(s) Of Engagement Activity 2015
URL http://www.newscientist.com/article/dn27115-new-memories-implanted-in-mice-while-they-sleep.html#.VP...
 
Description Comment on how the brain recollects episodic memory. Neil Burgess 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 100. Comment on how the brain recollects episodic memory. 02 July 2015.
Year(s) Of Engagement Activity 2015
URL http://www.ucl.ac.uk/news/news-articles/0715/020615-how-brain-reconstructs-past.
 
Description Commentary for "Nature" 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Faraneh Vargha-Khadem - commentary in "Nature"
Year(s) Of Engagement Activity 2014
 
Description Dhaka Shishu Hospital 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact Principal investigator delivered a week of lectures and workshops to local health professionals. This included training in neuropsychological testing procedures.

Local health professionals have started administering neuropsychological assessments as part of their developmental assessments.
Year(s) Of Engagement Activity 2012
 
Description Institute of Psychiatry Clinical Neuroanatomy Seminar Series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a talk at the IoP Clinical Neuroanatomy Seminar Series
Title: Growing up without Episodic Memory

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2012
 
Description Interview with Associated Press about infant development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact An interview was conducted by Associated Press to bring awareness to our infant and toddler programme of research evaluating early development of cardiac surgery and premature-born infants. The interview was recorded and is available on the internet.
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=yrhhuopgRiU
 
Description Interviews for work on memory was reported in a range of publications (e.g. The New York Times Magazine). 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A number of interviews were given by Prof Maguire on the topic of memory. These were published in a range of reports such as The New York Times Magazine, Daily Mail, the Irish Times, ZEIT Wessen, Outside Magazine, The Psychologist.
Year(s) Of Engagement Activity 2016
 
Description Korean TV interview 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Korean TV, KBS interview, Faraneh Vargha-Khadem
Year(s) Of Engagement Activity 2015
 
Description Lecture (Royal Institution) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Delivered the prestigious Friday Evening Discourse at the Royal Institution to members of the RI and members of the public. The lecture was recorded and is now free to view online via the Ri Channel and on YouTube.

The lecture was recorded and is now free to view online via the Ri Channel and on YouTube.
Year(s) Of Engagement Activity 2014
 
Description Lecture - Jerusalem 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver a seminar entitled, Hypoxia-Ischaemia, hippocampal damage and memory impairment: A causal hypothesis?

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description Lecture Vienna 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to give a lecture, entitled Abnormalities of the articulation brain network at European Academy of Childhood Disability, Vienna, Austria.

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description Lecture at NIMH Bethesda, Maryland 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact PI invited to deliver lecture at entitled Growing up without an autobiography

Dissemination of new knowledge to an expert audience
Year(s) Of Engagement Activity 2014
 
Description London Brain Project - The Beyond Series 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact The Beyond Series have been launched by a group of Ph.D students in the PI's and Co-PI's academic groups to bring public awareness to the medical conditions that young patients suffer from (e.g. Epilepsy, Tourette's Syndrome). Patients are encouraged to use the arts to express their journey through their illness.
Year(s) Of Engagement Activity 2015
URL http://www.londonbrainproject.com
 
Description New York Times magazine - 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A story on navigation and memory for the March 20th 2016 issue of the New York Times Magazine featuring the work of Eleanor Maguire
Year(s) Of Engagement Activity 2016
 
Description Public Science festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Dissemination of information to public
Year(s) Of Engagement Activity 2014
 
Description STEM ambassador 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Luc Berthouze -I have been a STEM ambassador (http://www.stemnet.org.uk/ambassadors/) since 2014.
As part of this I have been engaged in the following activities:

STEM Career fair, Ardingly College, 06/2014 (about 300 pupils) Science Open Day, Burgess Hill School for Girls, 10/2014 (about 100 pupils) How the brain works, Estcots Primary School, East Grinstead, 05/06/2015 (about 50 pupils) Development of a end-to-end STEM development plan, Burgess Hill School for Girls, 03/2016-ongoing

Also I have been involved in Widening Participation whereby schools come to the University.

The Brain as a Complex System, 11-13/05/2015 (about 150 pupils)
Year(s) Of Engagement Activity 2014,2015,2016
URL http://www.stemnet.org.uk/ambassadors
 
Description Science Museum London 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Inclusion of research on the hippocampus and autobiographical memory in the 'Who Am I' gallery at the Science Museum, London.

This display informs the general public about autobiographical and spatial memory and the brain.
Year(s) Of Engagement Activity 2010
 
Description Science Network Interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Invited to participate in a discussion with Madeleine Keehner and Mary Hegarty on spatial cognition

TBC
Year(s) Of Engagement Activity 2011
 
Description Society for Neuroscience 2012 Nanosymposium 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact A. M. DZIECIOL, D. G. GADIAN, T. BALDEWEG, M. MISHKIN, F. VARGHA-KHADEM; White matter abnormalities associated with severe hippocampal atrophy in patients with developmental amnesia. Program No. 18.09. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online. www.sfn.org

TBC
Year(s) Of Engagement Activity 2012
 
Description Society for Neuroscience 2012 poster presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact S. GEVA, J. COOPER, D. GADIAN, M. MISHKIN, F. VARGHA-KHADEM; Performance on an immediate memory task with increasing memory load is impaired in patients with selective hippocampal pathology of early onset. Program No. 197.01/ZZ11 . 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
www.sfn.org

TBC
Year(s) Of Engagement Activity Pre-2006,2012
 
Description Society for Neuroscience 2012 poster presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact E. PATAI, J. COOPER, A. M. DZIECIOL, D. G. GADIAN, F. VARGHA-KHADEM; . Visual recall and recognition are correlated with extent of selective hippocampal injury of early onset. Program No.194.24/XX10 . 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
www.sfn.org.

TBC
Year(s) Of Engagement Activity 2012
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Dzieciol AM, Saleem KS, Saunders RC, Bachevalier J, Mishkin M, Vargha-Khadem F. Thalamic and mammillary body damage in developmental amnesia. Program 761.18/GGG26. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Geva S, Jentschke S, Vargha-Khadem F. Motor function in children exposed to hypoxia-ischemia. Program 77.03/SS9. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description Society for Neuroscience 2013 Poster Presentation 
Form Of Engagement Activity Scientific meeting (conference/symposium etc.)
Part Of Official Scheme? No
Type Of Presentation Poster Presentation
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Patai E, Cooper J, Mishkin M, Vargha-Khadem F. Exploration of white matter damage in patients who underwent extracorporeal membrane oxygenation treatment in childhood. Program 145.10/M12. 2013 Neuroscience Meeting Planner, San Diego, CA. Society for Neuroscience. Online. www.sfn.org.

Dissemination of results to academic audience; opportunity for postdoc presenting to receive critical feedback from peers.
Year(s) Of Engagement Activity 2013
URL http://www.abstractsonline.com/plan/AdvancedSearch.aspx
 
Description TED Salon Interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Online talk entitled, "Where did I park my car?" which was previously delivered at the Unicorn Theatre, London, in November 2011

TBC
Year(s) Of Engagement Activity 2011
 
Description The Great Brain Experiment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Participation in a Wellcome Trust funded project that included the development of an app that was launched during Brain Awareness Week in March 2013. The app engaged the public using games based on cognitive research.

TBC
Year(s) Of Engagement Activity 2013
URL http://www.thegreatbrainexperiment.com/
 
Description The Ideas That Make Us 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview for a BBC Radio 4 series of programmes on the history of ideas. In this particular programme, the PI discussed the impact of memory on the representation of ideas.

TBC
Year(s) Of Engagement Activity 2013
URL http://www.bbc.co.uk/programmes/b03b2g2j
 
Description United Nations Session 55: Commission on the Status of Women - Non-Governmental Organizations side event, New York, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/parliamentarians
Results and Impact Presented two talks as part of a panel of speakers addressing the potential for educating girls beyond the basic curricula.
Title of Talk 1: Rethinking education for girls and women: Beyond basic curricula
Title of Talk 2: Neuroplasticity and transformation: From the individual to society


Plans to collaborate with Stonybrook University, New York, to develop a curriculum for primary school children to improve attention and social skills to enhance learning and academic development.
Year(s) Of Engagement Activity 2011
 
Description Wondermind 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The design and development of a series of interactive games, videos and an online blog to help children learn about the science of the developing human brain. Children can access these games and other media at the Alice in Wonderland exhibition at Tate Liverpool and also via the Tate website.

Wondermind mixes science and artwork related to Alice in Wonderland in a series of pioneering interactive games, videos and an online blog to help children learn about the science of the developing human brain. It was developed through collaboration between UCL, the Tate Modern and Preloaded and funded by a Wellcome Trust Society Award. Wondermind was accessed 257, 352 times between its launch in the fall of 2011 and August 2012, with an additional 38, 010 people accessing it at terminals in the Tate Liverpool during the Alice in Wonderland exhibit. The online user survey showed that 93% of respondents said they had enjoyed using Wondermind and would use it again, and 64% agreeing that they knew 'more about the parts and development of the brain' after playing the games. The Wondermind website blog, which provided a forum for public debate and discussion, includes 469 approved user comments. The project also produced a learning resource, with accompanying teacher notes and a pupil pack for KS2-aged children. Teacher observations undertaken by EdComs indicated that teachers favourably compared Wondermind to other digital learning resources, noting the design quality and reactions from students. Wondermind has been nominated for several awards including two British Interactive Media Awards (BIMAs) - in the Leisure&Culture and Education&Outreach
Year(s) Of Engagement Activity 2011
 
Description journal articles 2015 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Eleanor Maguire - My work was also reported in a range of popular magazines (e.g. National Geographic, New Scientist, NZZ-Folio Zurich), and I gave interviews for pieces on the BBC Website, National Geographic TV, National Radio of Slovenia. I was also interviewed by a number of authors who are writing popular science books on memory or navigation (Helen Thomson; Ylva and Hilde Østby; Merim Bilalic).
Year(s) Of Engagement Activity 2015
 
Description work reported in journals 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Towards the end of 2014, my work was covered in many media publications, for example in the New York Times, Scientific American, National Geographic. It was widely reported on the web - e.g. on the BBC website. This was linked to my UCL colleague, John O'Keefe, winning the Nobel Prize.
Year(s) Of Engagement Activity 2014