Gene targeting in human embryonic stem cells: A novel in vitro approach to modelling Duchenne Muscular Dystrophy (DMD)

Lead Research Organisation: Nottingham Uni Hospitals NHS Trust
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description EU Stem Cell Patents
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description GTAC
Geographic Reach National 
Policy Influence Type Membership of a guidance committee
 
Description Masters course
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact masters levels training in stem cell technologies
 
Description NC3Rs policy document on regenerative medicine (Kevin Shakesheff 2015)
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Asha E-term fellowship
Amount £250,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 12/2013 
End 11/2015
 
Description BBSRC IPA
Amount £1,300,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2009 
End 03/2013
 
Description BHF Centre for Regen Med
Amount £2,500,000 (GBP)
Funding ID P47352/ 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2013 
End 09/2017
 
Description BHF LQTS grant (Elena)
Amount £189,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2010 
End 02/2013
 
Description BHF MyoD grant
Amount £300,000 (GBP)
Funding ID PG/14/59/31000 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 05/2015 
End 05/2018
 
Description BHF Programme Grant (2 pilot with Sian Harding)
Amount £475,000 (GBP)
Funding ID RG/11/19/29264 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2012 
End 04/2014
 
Description BHF programme 2014-17
Amount £1,125,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2014 
End 04/2017
 
Description EMDA
Amount £36,000 (GBP)
Organisation East Midlands Development Agency (EMDA) 
Sector Public
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 04/2011 
End 09/2011
 
Description EP/H028277/1 EPSRC Centre for Innovative Manufacturing in Regenerative Medicine
Amount £5,259,190 (GBP)
Funding ID EP/H028277/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2010 
End 09/2015
 
Description EPSRC 'Future-Proof' Synthetic Surfaces
Amount £2,300,000 (GBP)
Funding ID EP/H045384/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2010 
End 04/2014
 
Description EPSRC equip - seahorse
Amount £115,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 09/2014 
End 03/2015
 
Description EU - dave
Amount £300,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 09/2012 
End 08/2015
 
Description Heart Res UK (Divya)
Amount £147,000 (GBP)
Funding ID TRP01/12 
Organisation Heart Research UK 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2013 
End 01/2015
 
Description Int studentship - spandan
Amount £90,000 (GBP)
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2011 
End 12/2014
 
Description MRC DMD grant 2009
Amount £550,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2009 
End 10/2012
 
Description MRC capital equipment
Amount £714,000 (GBP)
Funding ID MR/L012618/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2013 
End 03/2014
 
Description NC3Rs main panel (Viola)
Amount £515,000 (GBP)
Funding ID NC/K000225/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 02/2013 
End 02/2016
 
Description NC3Rs-CRACK-IT phase 1
Amount £100,000 (GBP)
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 12/2013 
End 06/2014
 
Description NC3Rs-CRACK-IT phase 2
Amount £1,000,000 (GBP)
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Private
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2015 
End 01/2018
 
Description SC4SM cardiomyocyte call
Amount £80,000 (GBP)
Organisation Stem Cells for Safer Medicines (SC4SM) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2009 
End 09/2010
 
Description University of Nottingham Strategic Development Fund "Nottingham Regenerative Medicine Centre" 1.1.15-31.12.18. £602,140 (PI)
Amount £602,000 (GBP)
Funding ID n/a 
Organisation University of Nottingham 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2014 
End 10/2020
 
Description epsrc DTG (Asha)
Amount £150,000 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2011 
End 09/2014
 
Description • BHF Programme Grant RG/15/6/31436: Predicting anti-arrhythmic drug efficacy from the divergent molecular basis of RyR2 dysfunction in genetic arrhythmia syndromes
Amount £1,100,000 (GBP)
Funding ID RG/15/6/31436 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2015 
End 09/2020
 
Description • BHF Special Project no. SP/15/9/31605. "Coupling gene targeted reporters with fully automated compound library screening to mature hPSC-cardiomyocytes".
Amount £1,100,000 (GBP)
Funding ID SP/15/9/31605 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 01/2016 
End 12/2019
 
Description • BIRAX grant 04BX14CDLG. Gene targeted optogenetics in hPSC-cardiovascular cells for transplantation into animal models of heart dysfunction. 1.9.15-31.8.18. £400K
Amount £400,000 (GBP)
Funding ID 04BX14CDLG 
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2015 
End 10/2018
 
Description • EPSRC Impact Accelerator Award. A Strategic Partnership with the Australian Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM) to Commercialise Stem Cell Culture Polymers
Amount £67,000 (GBP)
Funding ID n/a 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 11/2015 
End 02/2017
 
Description • EPSRC Programme Grant EP/N006615/1: 'Next Generation Biomaterials Discovery'. PI: Morgan Alexander. Multiple Co-Is. 1.10.15-30.9.20. £6.6m
Amount £6,600,000 (GBP)
Funding ID EP/N006615/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 10/2015 
End 09/2020
 
Description • MRC grant MR/M017354/1: MICA: Development of Metrics and Quality Standards for Scale up of Human Pluripotent Stem Cells. 1.5.15-30.4.17 £1.
Amount £1,200,000 (GBP)
Funding ID MR/M017354/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom of Great Britain & Northern Ireland (UK)
Start 05/2015 
End 04/2017
 
Title Human ES cell lines 
Description We derived 2 new human ES cell lines (NOTT1 and NOTT2) that were deposited to the UK Stem Cell Bank and are available for distribution 
Type Of Material Cell line 
Year Produced 2006 
Provided To Others? Yes  
Impact Availability of new human ES cell lines for academic use 
 
Title genome editing 
Description genome editing techniques and cell lines 
Type Of Material Cell line 
Year Produced 2013 
Provided To Others? Yes  
Impact developing UK and EU portfolio of research tools and assisting collaborations / grants 
 
Title hiPSC lines 
Description hiPSC lines carrying mutations in long QT syndrome genes 
Type Of Material Cell line 
Year Produced 2011 
Provided To Others? Yes  
Impact 1. Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Research. 10(1):48-56. PMID: 23089628 
URL http://europepmc.org/abstract/MED/23089628
 
Description Automation (Development of robot) 
Organisation Tecan UK Ltd
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Bespoke robotic platform for automated culture and differentiation of human stem cells
Collaborator Contribution Role in automation
Impact Publications, grants
Start Year 2010
 
Description BIRAX interactions (Mummery, Gepstein) 
Organisation Technion - Israel Institute of Technology
Country Israel, State of 
Sector Academic/University 
PI Contribution New partnership between three labs
Collaborator Contribution Skills in progenitor cell biology and cell transplantation in vivo
Impact Early stage at present
Start Year 2015
 
Description BRIC - Loughborough 
Organisation Loughborough University
Department Department of Engineering
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Research collaboration to secure funds
Impact publications
Start Year 2009
 
Description CRACK-IT consortium 
Organisation GlaxoSmithKline (GSK)
Department Safety Assessment GSK
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution consortium working on safety assessment
Collaborator Contribution all active contributors to researcher and academic input
Impact publications and grants
Start Year 2014
 
Description CRACK-IT consortium 
Organisation Leiden University
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution consortium working on safety assessment
Collaborator Contribution all active contributors to researcher and academic input
Impact publications and grants
Start Year 2014
 
Description CRACK-IT consortium 
Organisation Pluriomics BV
Country Netherlands, Kingdom of the 
Sector Private 
PI Contribution consortium working on safety assessment
Collaborator Contribution all active contributors to researcher and academic input
Impact publications and grants
Start Year 2014
 
Description CRACK-IT consortium 
Organisation University of Glasgow
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution consortium working on safety assessment
Collaborator Contribution all active contributors to researcher and academic input
Impact publications and grants
Start Year 2014
 
Description CRACK-IT consortium 
Organisation University of Hamburg
Country Germany, Federal Republic of 
Sector Academic/University 
PI Contribution consortium working on safety assessment
Collaborator Contribution all active contributors to researcher and academic input
Impact publications and grants
Start Year 2014
 
Description DM1 grant & activity (Lochmuller) 
Organisation Newcastle University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution Joint BHF grant
Collaborator Contribution Academic collaboration; joint posts; sharing of reagents and data
Impact Joint grant, hence economic
Start Year 2015
 
Description DMD (Lochmuller) 
Organisation Centre for Life
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution led research
Collaborator Contribution publications & grant
Impact grants & publications
Start Year 2009
 
Description Electrophysiology mechanisms (Harmer / Tinker) 
Organisation Queen Mary University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution mechanism of electrophysiology in hPSC-cardiomyocytes
Collaborator Contribution Skills in detailed electrophyioslogy
Impact grants awarded. Papers in progress
Start Year 2014
 
Description Genome editing (Skarnes) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution Skills exchange and training for staff in Nottingham
Collaborator Contribution Carrying out the research and intellectual input
Impact Attracted several new grants of value £2m, introduced new skills to the team, leading to new national / international collaborations
Start Year 2012
 
Description Imperial (Sian Harding) 
Organisation Imperial College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution multiple activities on grants, papers, sharing skills, reagents etc
Collaborator Contribution multiple activities on grants, papers, sharing skills, reagents etc
Impact multiple activities on grants, papers, sharing skills, reagents etc
Start Year 2010
 
Description Industrial collaboration (GSK via CRACK-IT) 
Organisation GlaxoSmithKline (GSK)
Department Safety Assessment GSK
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Private 
PI Contribution Facilitated award of NC3Rs CRACK-IT grant
Collaborator Contribution Implicit in the sponsorship and construction of the challenge
Impact Financial, international collaboration, skills sharing, joint PhD students, researcher exchange
Start Year 2013
 
Description LQT (Staniforth) 
Organisation University of Nottingham
Department School of Clinical Sciences Nottingham
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution led collab
Collaborator Contribution publications
Impact publications and grants
Start Year 2010
 
Description MIT (Asha Patel, E-term) 
Organisation Massachusetts Institute of Technology (MIT)
Country United States of America 
Sector Academic/University 
PI Contribution E-Term Fellowship and sabbatical
Collaborator Contribution E-Term Fellowship and sabbatical
Impact E-Term Fellowship and sabbatical
Start Year 2013
 
Description MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) 
Organisation National Institute for Biological Standards and Control (NIBSC)
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Public 
PI Contribution joint grant with industrial partner
Collaborator Contribution joint grant with industrial partner
Impact joint grant with industrial partner
Start Year 2015
 
Description MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Charity/Non Profit 
PI Contribution joint grant with industrial partner
Collaborator Contribution joint grant with industrial partner
Impact joint grant with industrial partner
Start Year 2015
 
Description MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) 
Organisation Tokyo Electron
Country Japan 
Sector Private 
PI Contribution joint grant with industrial partner
Collaborator Contribution joint grant with industrial partner
Impact joint grant with industrial partner
Start Year 2015
 
Description MRC-TEL consortium (Manchester, UKSCB, Sanger, TEL) 
Organisation University of Manchester
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution joint grant with industrial partner
Collaborator Contribution joint grant with industrial partner
Impact joint grant with industrial partner
Start Year 2015
 
Description Maturation grant (Tinker, Smith, Fischer) 
Organisation Queen Mary University of London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution joint grant and development of equipment, new molecules, cell resources
Collaborator Contribution joint grant and development of equipment, new molecules, cell resources
Impact joint grant and development of equipment, new molecules, cell resources
Start Year 2015
 
Description Maturation grant (Tinker, Smith, Fischer) 
Organisation University of Glasgow
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution joint grant and development of equipment, new molecules, cell resources
Collaborator Contribution joint grant and development of equipment, new molecules, cell resources
Impact joint grant and development of equipment, new molecules, cell resources
Start Year 2015
 
Description Sharing hiPSC lines (Pluriomics) 
Organisation Pluriomics BV
Country Netherlands, Kingdom of the 
Sector Private 
PI Contribution Provision of hiPSC lines, intellectual input to project
Collaborator Contribution Used our resources and input to carry out project
Impact Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL. (2012) Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes. Stem Cell Research. 10(1):48-56. PMID: 23089628
Start Year 2011
 
Description Spannish patients (Roberto Barriales-Villa) 
Organisation University of A Coruña
Country Spain, Kingdom of 
Sector Academic/University 
PI Contribution provision of patient samples to underpin research
Collaborator Contribution provision of patient samples to underpin research
Impact provision of patient samples to underpin research
Start Year 2015
 
Description electrophysiology (CPVT, George / Williams) 
Organisation Cardiff University
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution electrophysiology of cardiomyocytes
Collaborator Contribution Developed to £1.1m BHF grant
Impact Grant secured. Working towards papers
Start Year 2010
 
Description exon skipping (Leiden, Aartsma-Rus) 
Organisation Leiden University
Country Netherlands, Kingdom of the 
Sector Academic/University 
PI Contribution brought skills to the team not available in Nottingham
Collaborator Contribution reagents and expertise in exon skipping
Impact Publication of paper
Start Year 2011
 
Description surface work (Morgan Alexander, Nottingham) 
Organisation University of Nottingham
Department School of Pharmacy
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution lead the stem cell work of this collaboration
Collaborator Contribution Multiple grant awards and papers
Impact grants and papers
Start Year 2010
 
Description syngenta 
Organisation Syngenta
Country Global 
Sector Public 
PI Contribution stem cell automation
Collaborator Contribution intellectual and financial input
Impact advances in stem cell automation
Start Year 2009
 
Description virus (Dave Darling) 
Organisation King's College London
Country United Kingdom of Great Britain & Northern Ireland (UK) 
Sector Academic/University 
PI Contribution led collab
Collaborator Contribution publications
Impact publications
Start Year 2010
 
Title GET system with James & Kevin 
Description This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided. 
IP Reference WO2015092417 
Protection Patent application published
Year Protection Granted 2015
Licensed No
Impact Scientific development with view to licensing.
 
Title New synthetic culture surfaces for human embryonic stem cells 
Description Patent filed to cover new synthetic substrate to culture human embryonic stem cells 
IP Reference  
Protection Protection not required
Year Protection Granted 2009
Licensed No
Impact Negotiations with major plasticware companies in progress through Nottingham's tech trasnfer office
 
Title Raman 
Description optical spectra for cardiomyocytes using Raman microspectroscopy defined 
IP Reference GB1018628.6 
Protection Patent application published
Year Protection Granted 2010
Licensed Commercial In Confidence
Impact linking into partners within the Bioprocess Research Industry Club
 
Description BBC East Midlands Today - BHF education on heart disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview with BBC East Midlands Today to educate on importance for research for heart disease
Year(s) Of Engagement Activity 2016
 
Description BBC News 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact more interest in lab / education

interest in lab / education
Year(s) Of Engagement Activity 2015
 
Description BBC radio Nottingham (Heart-light) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Public engaged on new research grant
Year(s) Of Engagement Activity 2015
 
Description BHF - Welcome booklet imaging (Sorrel Bunting Oct 2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Information booklet commissioned by BHF and Wellcome Trust to support research against cardiovascular disease
Year(s) Of Engagement Activity 2016
 
Description BHF Visit Outreach for Sorrel Bunting (Nov 2016) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Group of 20 workers from BHF, including shop-runners, fund raisers, office workers
Year(s) Of Engagement Activity 2016
 
Description BHF news advert / article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Advertising in national newspaper

to early to tell but part of BHF effort to continually raise funds
Year(s) Of Engagement Activity 2012
 
Description BHF public information booklet on research 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact British people with interest in heart disease engaged

to early to be determined but acts as part of continual BHF effort to raise funds
Year(s) Of Engagement Activity 2012
 
Description BIRAX press release in May 2016 to promote heart therapies 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Promoting research into treatments for heart disease
Year(s) Of Engagement Activity 2016
 
Description Blog in Huffington post 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Blog in Huffington Post which promoted new grant - global reach
Year(s) Of Engagement Activity 2015
URL http://www.huffingtonpost.co.uk/simon-gillespie/valentines-day_b_6669914.html?utm_hp_ref=science
 
Description Channel 4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Featured on channel 4 documentary

disseminated to wider public
Year(s) Of Engagement Activity 2010
 
Description Heart Res UK case study for AMRC (Nov 2016) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Case study / newsletter from Heart Research UK grant to educate on need for new medicines for heart disease
Year(s) Of Engagement Activity 2016
 
Description Invited conference presentation during 2016-2017 reporting period 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented at >20 international conferences in Europe, Middle East, Asia and USA, each having 50 to 500 delegates from professional academic, public, media, patient and industry
Year(s) Of Engagement Activity 2016,2017
 
Description Media (as a channel to the public) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact - Provision of short articles to magazines such as BioWorld International, BBSRC business, Hospital Solutions - Interview with newspapers, such as Daily Mail, Telegraph etc organised through the Science Media Centre in London - Interviewed and filmed by BBC Scotland 6 O'clock news and BBC / ITV local news stations

Increased public perception and acceptance of the importance of stem cells. Increased application rates from PhD students to our unit
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Nottingham press release (EPSRC £6.5m project) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release leading to new interactions
Year(s) Of Engagement Activity 2015
URL http://www.nottingham.ac.uk/news/pressreleases/2015/august/3d-vision-for-the-next-generation-of-biom...
 
Description Nottingham press release (heart light) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release on new grant
Year(s) Of Engagement Activity 2015
URL http://www.nottingham.ac.uk/news/pressreleases/2015/february/light-sensitive-proteins-could-help-men...
 
Description Nottingham press release (new biomaterials) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact nottingham press release on new publication. Led to additional funding and interaction
Year(s) Of Engagement Activity 2015
URL http://www.nottingham.ac.uk/news/pressreleases/2015/july/new-material-forges-the-way-for-stem-cell-f...
 
Description Observer & Guardian on Sunday 2014 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Description of research to National newspapers

follow up enquiries and public engagement
Year(s) Of Engagement Activity 2014
 
Description Public engagement day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 250 members of the public attended the British Society for Gene Therapy public day in Brighton

active engagement and enthusiasm from members of the public
Year(s) Of Engagement Activity 2011
 
Description Sara Pijuangalito (Times article on stem cell expansion, July 2016) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact New methods for stem cell manufacture picked up by The Times Newspaper
Year(s) Of Engagement Activity 2016
URL http://www.thetimes.co.uk/article/scientists-discover-way-to-mass-produce-stem-cells-cxr2mcqgc
 
Description SkyNews 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Watched by 13 million people

interest in research group
Year(s) Of Engagement Activity 2015
 
Description observer 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Observer on hiPSC-based cardiovascular work

national press and engagement with public
Year(s) Of Engagement Activity 2011
 
Description public engagement day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The engagement day was attended by approx 250 members of the public

good attendance and feedback will mean the event will be run again in 2013.
Year(s) Of Engagement Activity 2011