Biomedical Catalyst – Smart Combination Respiratory Medicines for Optimal & Cost Effective Patient Benefit
Lead Research Organisation:
Imperial College London
Department Name: UNLISTED
Abstract
The Business-led APPS2B Project aims to identify, demonstrate, and quantify for the first time the mechanism for, and potential significant clinical benefits of highly innovative orally inhaled combination respiratory therapies, that have been optimally designed, engineered and manufactured for intent using Prosonix Multi-Component Particle (MCP) Technology.
Technical Summary
The Business-led APPS2B Project aims to identify, demonstrate, and quantify for the first time the mechanism for, and potential significant clinical benefits of highly innovative orally inhaled combination respiratory therapies, that have been optimally designed, engineered and manufactured for intent using Prosonix Multi-Component Particle (MCP) Technology.
People |
ORCID iD |
Publications
Usmani OS
(2014)
Small airways dysfunction in asthma: evaluation and management to improve asthma control.
in Allergy, asthma & immunology research
Bikov A
(2013)
Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry.
in BMC pulmonary medicine
Paredi P
(2014)
A novel approach to partition central and peripheral airway nitric oxide.
in Chest
Corradi M
(2014)
NEXThaler, an innovative dry powder inhaler delivering an extrafine fixed combination of beclometasone and formoterol to treat large and small airways in asthma.
in Expert opinion on drug delivery
Hakim A
(2013)
Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
McNulty William
(2013)
Management of COPD
in GM
Kaplan A
(2013)
Treatment of small airways involvement in asthma
in Hot Topics in Respiratory Medicine
Lavorini F
(2013)
Correct inhalation technique is critical in achieving good asthma control
in Primary Care Respiratory Journal
Lavorini F
(2014)
New Inhaler Devices - The Good, the Bad and the Ugly
in Respiration
Usmani OS
(2014)
New developments in inhaled drugs: within and beyond the lungs.
in Respiration; international review of thoracic diseases
| Description | Advisory Board to Pharmaceutical Companies |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | ISAM (International Society on Aerosols Medicine) Standardization of Imaging |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | I was leading a section on the ISAM (International Society on Aerosols Medicine) Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products. This document has now internationally standardized how imaging is/should be undertaken of patients with inhaled drug (a lot of pharmaceutical companies are doing such studies wih new inhaler drugs) The sub-committee produced a supplement in JAMPDD (Volume 25, Supplement 1, 2012) to provide practical guidance and recommendations to standardize the field of deposition assessment using radionuclide imaging. |
| URL | http://www.isam.org/index.php?option=com_content&view=article&id=43:education&catid=27:home&Itemid=1... |
| Description | Nurse Asthma Training Event, SW Essex |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | I was uinvited to train senior Nurse Practitioners on how to use inhalers devices effectively and efficiently. I also gave a talk on respiratory drugs and their prescribing. |
| Description | Asthma UK Foundation Grant |
| Amount | £41,258 (GBP) |
| Organisation | Asthma + Lung UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2011 |
| End | 09/2012 |
| Description | H2020-PHC-2014-single-stage _CNECT |
| Amount | € 4,581,378 (EUR) |
| Funding ID | 643607 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2015 |
| End | 12/2017 |
| Description | TSB Biomedical Catalyst Fund Early Stage |
| Amount | £1,300,000 (GBP) |
| Funding ID | 23028-155243 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2011 |
| End | 12/2013 |
| Title | Small Airway Physiological Tests |
| Description | As part of my award, I have learnt about techniques to assess small airways physiology with novel non-invasive tests from a world leading expert -Dr Sylvia Verbanck, Dept of Physiology & Physics, University of Brussels, Belgium. I have subsequently developed and established these comprehensive techniques for small airways assessments in our institution and in the UK. |
| Type Of Material | Physiological assessment or outcome measure |
| Provided To Others? | No |
| Impact | My research output from this collaboration was 1) an oral podium presentation at the European Respiratory Society (ERS) Barcelona 2010 (A5159). 2) manuscript assessing the ageing lung - Verbanck, S., Thompson, B.R., Schuermans, D., Kalsi, H., Biddiscombe, M., Stuart-Andrews, C., Hanon, S., Van Muylem, A., Paiva, M., Vincken, W., Usmani, O., "Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung" Thorax. 67, (2012), 789-95. 3) I have taught the skills I have learnt to others in my research group (physicist, nurses, and clinical fellows) and this training opportunity has added value and built research capacity and research capability. 4) I have been invited onto the steering committee of the World Allergy Organisation (WAO) small airways working group - a dedicated scientific group for clinicians, researchers and educators around the world to be guided on the most relevant scientific, clinical and educational resources on small airway disease. |
| Title | Throat Model |
| Description | I have also collaborated with Dr Verbanck in Brussels to assess aerosol deposition in an in vitro upper airways realistic silicone throat models. This throat model we believe will help researchers understand about inhaled drug delivery in the throat - where the throat is a major obstacle to inahled aerosol deposition in the lungs. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Provided To Others? | No |
| Impact | We have published a manuscript on our model We are now (oct 2014) enaging in computational fluid dynamic work to refine our model |
| Description | Prosonix |
| Organisation | Prosonix Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | I was approached by Prosonix, a company involved in improving chemical formulations of inhaled drug, to utilise cell based models in my research group to test their inhaled compounds. |
| Collaborator Contribution | Prosonx supplied drugs and we received a grant for a Post Doc for 1 year. |
| Impact | Technology Strategy Board Grant (Total £1.3M, of which £158,284 to my group) "Smart Combination Respiratory Medicines for Optimal & Cost Effective Patient Benefit" |
| Start Year | 2012 |
| Description | Biomedical careers session to Yr12 Biology students from Paddington Academy London (March 2013) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | I gave a talk on "Biomedical careers" to Yr12 Biology students from Paddington Academy London (March 2013) at the Hammersmith Campus. This was a great honour for me, as this was my old secondary school that I attended and to my surprise, I met up with my former biology teacher. |
| Year(s) Of Engagement Activity | 2013 |
| Description | ICL World Summer School STEM (Science Technology Engineering and Medicine) on Medical Sciences (July 2013) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | I designed and organised a teaching half-day interactive session on 'Hospital Respiratory Tests' to A-level student communities (locally) under-represented in Higher Education and international school students attending ICL Summer School programme. The aim of the session was to explain the investigations and the different hospital personnel that could be encountered for patients with a respiratory disorder/lung condition. I used this opportunity to discuss the interaction between research and bedside medicine and offered career advice, in particular emphasising the important role of non-clinical staff. I explained my role as a Clinical Academic, and involved my non-clinical research staff (PhD students, Medical Physicist, Respiratory Physiologist) and clinical staff (Clinical Research Nurse) to teach and be involved in the session. After the session, I was e-mailed by a student who had been inspired by my session and the coverage of my scientific research by the BBC, and requested my help to undertake his extended science project on 'Asthma'. |
| Year(s) Of Engagement Activity | 2006,2013 |
| Description | RCUK School University Partnership-Working Group Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | I attended the launch of the ICL Reaching Further Programme (Feb 2013) recently successfully funded by the RCUK School University Partnership Initiative, in which I gave my expression of interest in the initiative when the ICL call for the bid was made (Aug 2012) led by Sir Robert Winston. Following the launch meeting, I was contacted by Lucia Perez (Science Programme Officer) to attend the RCUK-Working Group to suggest my ideas for outreach. This meeting involved headteachers, governors, teachers and members of schools' science and mathematics teams working alongside College and Exscitec personnel to translate the RCUK Reaching Further proposal into tangible activities to benefit both the schools' and university communities. Working Group were interested in my proposal and I was asked to undertake at workshop at the World Summer School STEM (Science Technology Engineering and Medicine) Programme in July 2013 |
| Year(s) Of Engagement Activity | 2013 |
| Description | school visit to institution - workshop on interactive clinical activities and advice about careers in the NHS and in research |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | NIHR Fellow Welcomes Former School to Biomedical Research Unit Dr Omar Usmani, NIHR Career Development Fellow, invited his former sixth form college, Paddington Academy, formerly North Westminster Community School, for an afternoon of interactive clinical activities and advice about careers in the NHS and in research. Held at the NIHR Respiratory Biomedical Research Unit, 16 and 17 yr old students were given the opportunity to try their hands on clinical equipment used for diagnosing patients with lung disease at the Royal Brompton Hospital including spirometry and pulse oximetry. The importance and impact of medical research in the NHS was also discussed and Dr Usmani talked about his NIHR funded research through Imperial College London on improving inhaled drug delivery to patents with lung disease. As well as hands on demonstrations, pupils were also given a flavour of the type of careers that exist within hospitals. Staff who took part included a PhD fellow (Dr Will McNulty), a senior research nurse (Ms Sally Meah), a medical physicist (Dr Martyn Biddiscombe) and a PhD scientist (Ms Natasha Madge). All answered questions in a Q&A session about their job roles, education, career pathways and their individual contributions to medical research. Dr Usmani, who was a pupil at the school himself, remarked on why it's so important to connect with schools "Working with schools helps generate interest and excitement among young people in research. We hope that by showing them the potential that research has to change lives, they as individuals will take part by seizing on the vast array of career opportunities available" After my talk I had e-mail from 2 pupils wanting to follow up on a career in nursing and dentistry I was invited to Paddington Academy's open day (Sep 2014) - where ~15 students presented their summer's interships Following this, I have been invited onto Paddington Academy's Local Advisory Board |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.rbht.nhs.uk/research/our-research/research-news/public/nihr-fellow-welcomes-old-school-to... |