Resilience in the face of crises: Evaluating the implementation of a digital healthcare tool for newborns in Zimbabwe.
Lead Research Organisation:
University College London
Department Name: Institute of Child Health
Abstract
Recent crises, including the COVID-19 pandemic, have put a huge toll on health services globally, particularly in low-middle income countries (LMIC). The importance of resilience in these health care systems in times of stress to be able to quickly and effectively respond is vital to their ability to save lives. In LMICs, such as Zimbabwe, improvements in child survival have been slender due to fundamental weaknesses in healthcare systems, including lack of skills and poor resource supplies. Challenges such as pandemics, industrial action and economic collapse further threaten health systems and thus newborn survival.
Cheap and straightforward methods of helping newborns (such as ensuring babies stay warm) are proven to improve survival, but for various reasons, including lack of training, may not be used effectively in hospitals and clinics. Smartphone and tablet technologies may be useful tools to help. The NeoTree is a tablet-based application (app) to prompt clinical care, provide education, collect information about babies, and feed data back to healthcare workers (HCWs) to encourage them to change practices where necessary. Since November 2018 the NeoTree has been used in Harare Central Hospital (HCH) neonatal unit, Zimbabwe's largest newborn tertiary care facility, delivering 12,000 newborns annually. The NeoTree is designed to improve the quality of care and thus survival for sick and vulnerable babies admitted to low-resource hospital settings.
During the period of the NeoTree implementation Zimbabwe has suffered several crises with substantial impact on the health service including economic upheaval, significant HCW industrial action and the COVID-19 pandemic. I will analyse hospital-based data collected through our existing digital system, the NeoTree; to see how these crises affect newborn survival. I will track and compare NeoTree data from HCH over a 24-month period reporting on certain factors such as; number of babies admitted and discharged home, number who die and survive and their diagnosis. I will use social science methodology including applying behavioural science theory and frameworks to answer what help and hinders HCWs to follow guidelines both in 'peace-time' and during crises. In-depth interviews with HCWs will explore how they have found using the tool and providing neonatal care during crises. I will also seek to understand how crises effect their beliefs and experiences of the healthcare system. Observation of HCWs using the tool during set timepoints will also be undertaken and will be recorded by an observer. This will help to answer "if" they are not using the guidelines or using the tool, "why not". This holistic picture will be used to guide appropriate national and local health systems interventions to deliver safe care for newborns during times of crisis. It will be used to feedback to the NeoTree team about potential improvements in real time. It will aid in the identification of strategies to overcome barriers to implementation in other sites across Zimbabwe and other LMICs.
The NeoTree project appears to be robust during economic and social upheavals, disease outbreaks and HCW industrial action, potentially due to the user-friendliness of the platform and committed local leadership from our African partners, at hospital and Ministry levels. Since the onset of the COVID-19 pandemic, the NeoTree system has continued to function, ensuring the capture of key information about babies and their outcomes, while providing HCWs with emergency care support. However, detailed assessment of crises on both how the tool is used and the quality of the data captured has not been carried out. This evaluation - how external factors effect newborn care and the use of the NeoTree , is required to provide an understanding of the delivery and use of the NeoTree (and similar interventions) in our target countries, where challenges are frequent and varied and how to make it successful.
Cheap and straightforward methods of helping newborns (such as ensuring babies stay warm) are proven to improve survival, but for various reasons, including lack of training, may not be used effectively in hospitals and clinics. Smartphone and tablet technologies may be useful tools to help. The NeoTree is a tablet-based application (app) to prompt clinical care, provide education, collect information about babies, and feed data back to healthcare workers (HCWs) to encourage them to change practices where necessary. Since November 2018 the NeoTree has been used in Harare Central Hospital (HCH) neonatal unit, Zimbabwe's largest newborn tertiary care facility, delivering 12,000 newborns annually. The NeoTree is designed to improve the quality of care and thus survival for sick and vulnerable babies admitted to low-resource hospital settings.
During the period of the NeoTree implementation Zimbabwe has suffered several crises with substantial impact on the health service including economic upheaval, significant HCW industrial action and the COVID-19 pandemic. I will analyse hospital-based data collected through our existing digital system, the NeoTree; to see how these crises affect newborn survival. I will track and compare NeoTree data from HCH over a 24-month period reporting on certain factors such as; number of babies admitted and discharged home, number who die and survive and their diagnosis. I will use social science methodology including applying behavioural science theory and frameworks to answer what help and hinders HCWs to follow guidelines both in 'peace-time' and during crises. In-depth interviews with HCWs will explore how they have found using the tool and providing neonatal care during crises. I will also seek to understand how crises effect their beliefs and experiences of the healthcare system. Observation of HCWs using the tool during set timepoints will also be undertaken and will be recorded by an observer. This will help to answer "if" they are not using the guidelines or using the tool, "why not". This holistic picture will be used to guide appropriate national and local health systems interventions to deliver safe care for newborns during times of crisis. It will be used to feedback to the NeoTree team about potential improvements in real time. It will aid in the identification of strategies to overcome barriers to implementation in other sites across Zimbabwe and other LMICs.
The NeoTree project appears to be robust during economic and social upheavals, disease outbreaks and HCW industrial action, potentially due to the user-friendliness of the platform and committed local leadership from our African partners, at hospital and Ministry levels. Since the onset of the COVID-19 pandemic, the NeoTree system has continued to function, ensuring the capture of key information about babies and their outcomes, while providing HCWs with emergency care support. However, detailed assessment of crises on both how the tool is used and the quality of the data captured has not been carried out. This evaluation - how external factors effect newborn care and the use of the NeoTree , is required to provide an understanding of the delivery and use of the NeoTree (and similar interventions) in our target countries, where challenges are frequent and varied and how to make it successful.
Technical Summary
Crises, such as the COVID-19 pandemic, will lead to excess mortality and morbidity in newborns in low-income settings, damaging recent improvements in care and survival. Few robust data exist to explore these impacts in Zimbabwe. Interventions to improve newborn care in these settings, where challenges are frequent and varied, must be resilient to be useful and require contextual process evaluation specifically during times of crises.
I propose to undertake a mixed methods evaluation of an existing digital newborn quality of care intervention (the NeoTree) to support healthcare workers (HCWs) in clinical management of newborns during times of extrinsic challenge. The NeoTree has been embedded in daily clinical practice in Zimbabwe's largest neonatal unit. It provides data capture, education, clinical support and linkage to local data dashboards. Implementation is ongoing in a second Zimbabwean hospital. During the period of the NeoTree implementation Zimbabwe has suffered from several crises with substantial impact on health service delivery including economic upheaval, significant HCW industrial action and the COVID-19 pandemic. I will use quantitative neonatal data (from the NeoTree) to track and compare trends in case fatality rates, admission and discharge diagnosis during times of extrinsic challenges. An assessment of how the quality of data changes over time both with missingness and accuracy will also be reviewed. These data will be combined with both structured observation and qualitative interviews with HCWs to explore experience of health service delivery and use of the tool, specifically during times of crises. The triangulation of quantitative, data quality, qualitative and ethnographic data will provide actionable insights into implementation for local health systems and national health policy leads; "crisis implementation science".
I propose to undertake a mixed methods evaluation of an existing digital newborn quality of care intervention (the NeoTree) to support healthcare workers (HCWs) in clinical management of newborns during times of extrinsic challenge. The NeoTree has been embedded in daily clinical practice in Zimbabwe's largest neonatal unit. It provides data capture, education, clinical support and linkage to local data dashboards. Implementation is ongoing in a second Zimbabwean hospital. During the period of the NeoTree implementation Zimbabwe has suffered from several crises with substantial impact on health service delivery including economic upheaval, significant HCW industrial action and the COVID-19 pandemic. I will use quantitative neonatal data (from the NeoTree) to track and compare trends in case fatality rates, admission and discharge diagnosis during times of extrinsic challenges. An assessment of how the quality of data changes over time both with missingness and accuracy will also be reviewed. These data will be combined with both structured observation and qualitative interviews with HCWs to explore experience of health service delivery and use of the tool, specifically during times of crises. The triangulation of quantitative, data quality, qualitative and ethnographic data will provide actionable insights into implementation for local health systems and national health policy leads; "crisis implementation science".
Organisations
People |
ORCID iD |
Hannah Gannon (Principal Investigator / Fellow) |
Publications
Chappell E
(2023)
Impact of the COVID-19 pandemic on the provision and uptake of services for the prevention of mother-to-child transmission of HIV in Zimbabwe.
in PLOS global public health
Gannon H
(2024)
Effects of the COVID-19 pandemic on the outcomes of HIV-exposed neonates: a Zimbabwean tertiary hospital experience.
in BMC pediatrics
Gannon H
(2022)
Risk factors of mortality in neonates with neonatal encephalopathy in a tertiary newborn care unit in Zimbabwe over a 12-month period
in PLOS Global Public Health
Gannon H
(2024)
Development and Implementation of Digital Diagnostic Algorithms for Neonatal Units in Zimbabwe and Malawi: Development and Usability Study
in JMIR Formative Research
Haghparast-Bidgoli H
(2023)
Development and Pilot Implementation of Neotree, a Digital Quality Improvement Tool Designed to Improve Newborn Care and Survival in 3 Hospitals in Malawi and Zimbabwe: Cost Analysis Study
in JMIR mHealth and uHealth
Heys M
(2023)
Development and implementation experience of a learning healthcare system for facility based newborn care in low resource settings: The Neotree.
in Learning health systems
Description | Clinical Decision Support influencing practice in Malawi and Zimbabwe |
Geographic Reach | Africa |
Policy Influence Type | Contribution to new or improved professional practice |
Impact | 15,677 sick and vulnerable babies have been admitted and cared for using the Neotree quality improvement platform in Malawi and Zimbabwe across the life of the grant, ensuring the standardisation of neonatal care and data capture across 3 hospital facilities. |
Description | Prevention of Mother to Child Transmission Partners meeting; Primary Health care, Ministry of Health and childcare, Zimbabwe |
Geographic Reach | National |
Policy Influence Type | Participation in a guidance/advisory committee |
Description | Evaluation of the Impact of the COVID-19 Pandemic on Provision and Uptake of Services for the Prevention of Mother-to-child Transmission of HIV and Syphilis in Zimbabwe |
Amount | £217,530 (GBP) |
Funding ID | ClinicalTrials.gov Identifier: NCT04782739 |
Organisation | Viiv Healthcare |
Sector | Private |
Country | United Kingdom |
Start | 03/2021 |
End | 12/2022 |
Description | Biomedical Research Training Institute |
Organisation | Biomedical Research and Training Institute (BRTI) |
Country | Zimbabwe |
Sector | Charity/Non Profit |
PI Contribution | We provide intellectual input alongside clinical and programme management expertise. We have mentored and trained staff, and worked collaboratively to extend Neotree implementation to new sites, and to conduct research activities. We also lead on new grant applications with BRTI as collaborator. |
Collaborator Contribution | BRTI has provided access to facilities and equipment, alongside managerial and financial support. They have also provided guidance on engagement with government (e.g., Ministry of Health), funders and other research stakeholders in Zimbabwe. |
Impact | This is a multi-disciplinary collaboration involving clinicians, data scientists, implementation scientists, epidemiologists and programme managers. Keys outputs from this collaboration include: - Extension of implementation of Neotree to Chinhoyi Provincial Hospital - Co-development and deployment of remaining functionalities of the Neotree platform, including enhanced clinical decision support, deployment of data pipeline and data dashboards at Chinhoyi Provincial Hospital and Sally Mugabe Central Hospital - Public engagement workstream including 3 participatory arts workshops with mother and nurses and one public exhibition facilitating dialogue between Mother/caregivers and policy makers, healthcare professionals and the public. - An end-of-grant dissemination event in Harare in July 2022 - Capacity building in programme management, qualitative research, statistics and metabase - Collaboration on Dr Heys NIHR Global Health Professorship grant (awarded) - 10 Research papers: 10.1002/lrh2.10310 10.12688/wellcomeopenres.18423.1 10.1136/bmjopen-2020-042124 10.1136/bmjopen-2021-056605 10.1136/bmjopen-2020-039712 10.1136/bmjoq-2020-001043 10.1371/journal.pgph.0000911 10.1136/bmjopen-2021-048955 10.1097/inf.0000000000003155 10.1016/j.siny.2021.101204 |
Start Year | 2019 |
Description | Collaboration with Ministry of Health, Zimbabwe |
Organisation | Ministry of Health and Child Welfare of the Republic of Zimbabwe |
Country | Zimbabwe |
Sector | Public |
PI Contribution | The research team has provided hardware such as tablets, printers, screens, and software (Neotree app) alongside expertise and training in neonatal units in two hospitals in Zimbabwe. |
Collaborator Contribution | Our partners have provided access to facilities, staff and data, as well as clinical and technological expertise. Facilities include Chinhoyi Provincial Hospital, Sally Mugabe Central Hospital, Parirenyatwa Central Hospital and Bindura Provincial Hospitals. |
Impact | The key outputs arising from this collaboration are as follows: 9,585 newborns in Zimbabwe have been admitted and cared for using the Neotree app over the course of the grant across two facilities; and we generated a locally available and locally owned database of 13,752 babies from four facilities for research and policy; Approximately 550 healthcare professionals in Zimbabwe have used the Neotree app to count and care for every newborn admitted to their unit; We have developed the push functionality from Neotree to the Impilo Electronic Healthcare Records System in Zimbabwe and we are in discussions with MoH partners for Neotree to be used as the neonatal module in this national system. |
Start Year | 2018 |
Description | Collaboration with Snowplow analytics |
Organisation | Snowplow Analytics |
Country | United Kingdom |
Sector | Private |
PI Contribution | Out team has provided access to technological and clinical expertise, funding for software development, and access to key partners within the Ministries of Health in Zimbabwe and Malawi. |
Collaborator Contribution | Our partner has provided intellectual oversight and project management to develop the data pipeline for Neotree and key aspects of the software development including the clinical algorithms, integration of Neotree with national aggregate electronic healthcare record systems and periodic updates to the app to enhance user functionalities. |
Impact | 183 Versions of the app developed over course of grant (5 versions a month) Includes 15 clinical algorithms to manage and diagnose sick newborns Development of data pipeline and automated linkage to data dashboards on clinical wards Completed push functionality from Neotree to national Electronic Healthcare records and demonstrated proof of concept for integration of Neotree with DHISS version 2 |
Start Year | 2019 |
Description | Medical Research Council Clinical Trials Unit (MRC CTU) at UCL |
Organisation | University College London |
Department | Medical Research Council Clinical Trials Unit (MRC CTU) at UCL |
Country | United Kingdom |
Sector | Public |
PI Contribution | Collaboration with Professor Di Gibb and her team within the MRC Clinical trials unit UCL, for the Viiv funded project "Unintended consequences of the COVID-19 pandemic on prevention of mother-to-child transmission of HIV and syphilis in Zimbabwe". We provided intellectual input and access to data. The Neotree data was used to achieve one the 5 outcomes from this project. |
Collaborator Contribution | Team members from the MRC Clinical trials unit, UCL offered their expertise and intellectual input in data analysis for interrupted time series models of the data for HIV exposed newborns. |
Impact | This was a multi-disciplinary collaboration comprised of clinicians, epidemiologists and biostatisticians. The key output to date was: International presentation at the International Workshop on HIV Pediatrics 2022, Montreal, Canada, July 2022, 2 national presentations: Prevention of Mother to Child Transmission Partners meeting; Primary Health care, Ministry of Health and childcare, Zimbabwe; 31st May 2022 National AIDS Council 3rd HIV and AIDs research symposium, Zimbabwe; November 22nd - 23rd. Currently 2 papers are in pre-print titled: "Effects of the COVID-19 pandemic on the care of HIV exposed neonates: a Zimbabwean tertiary hospital experience" submitted to BMC Paediatrics "Impact of the COVID-19 pandemic on the provision and uptake of services for the prevention of mother-to-child transmission of HIV in Zimbabwe" submitted to PLOS Global Health |
Start Year | 2020 |
Title | Neotree source code |
Description | This repository contains source codes for the following Neotree system components: The Neotree Mobile App. This application is run on Android tablets and mobile phones in the Neonatal wards and is used by Health Care Workers to guide workflow and data capture when patients are admitted and discharged. In addition, the app is also used to record lab results. Each workflow (e.g. for "admission" or "discharge" is determined via a "script", which can be customized via the web editor. (See below.) This means that the app can quickly be adapted in different environments. The app is designed to work with low or no connectivity: connectivity is only required to sync scripts (if e.g. an admission or discharge form has been updated) and post data to the backend. The Neotree Web Editor. This is an application that clinicians can use to customize each script i.e. what questions, prompts and data is collected when a patient is admitted, discharged etc. The scripts with the configuration information are stored in the Neotree backend (see below). The Neotree backend. The backend stores consists of a database and an API for managing the flow of data from the front end to the database. The database stores two types of data: The script configuration information. This data is customized in the webeditor, and determines what information, question and data is collected through the different workflows. (Admission, discharge etc.) The actual data posted from the app when e.g. a baby is admitted or discharged. The Neotree Data Pipeline. This takes the data in the database collected from the app and reshapes it into a format that makes it easier to visualize and dashboard, to serve back to staff in hospital and integrate with aggregate data systems |
Type Of Technology | Software |
Year Produced | 2022 |
Open Source License? | Yes |
Impact | The Neotree system has been implemented in three hospitals in Zimbabwe and Malawi and is continued to be used for data collection, education and clinical decision support. |
URL | https://zenodo.org/record/7380936 |
Description | End-of-grant dissemination events |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | We held two dissemination events in June and July of 2022 in Harare, Zimbabwe and Lilongwe, Zimbabwe. The purpose was to showcase and disseminate the co-development, implementation, research and public engagement work and achievements stemming from this grant (2019-2022). Presentations were made by local Principal Investigators Dr Msandeni Chiume (Malawi), Dr Simbarashe Chimhuya (Zimbabwe), nurses (Nurse Priscilla Phiri, Matron Fannie Steven), Neotree Ambassadors (Precious Dinga), Neotree programme managers (Tarisai Chiyaka, Deliwe Nkhoma), Mothers (Regina Lusubiro, Sibongile Chigodho, Millicent Mutopa), Neotree software developer (Morris Baradza), partners Lekodi Magombo (ArtGLo), Jasen Mphepo (Patsime), Neotree PI (Dr Michelle Heys) and Senior Research Fellow (Dr Emma Wilson). Attendees included senior Ministry of Health representatives, donors (e.g. UNICEF, GIZ), NGOs (Save the Children), and senior healthcare practitioners. A key output from these events was a request to scale up Neotree implementation (for example request from senior neonatalogists to implement in Blantyre). We have since submitted a grant application to the NIHR Applied Health Research Board to roll out and evaluate Neotree to 4 new facilities (two in each country). |
Year(s) Of Engagement Activity | 2022 |
Description | Neonatal Algorithm workshop |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 11 diagnosis-specific online workshops with Zimbabwean and Malawian neonatal experts were conducted (August 2021 to April 2022) encompassing: 1. Review of available evidence 2. Country specific guideline review (Essential Medicines List and Standard Treatment Guidelines for Zimbabwe (EDLIZ); Care of the infant and newborn (COIN), Malawi) 3. Identification of uncertainties within the literature for future research |
Year(s) Of Engagement Activity | 2021,2022 |