Mechanistic Understanding leading to Informed Mitigation of Troublesome Dehalogenation in Catalysed Couplings

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Chemistry

Abstract

The aims and objectives of the project are to: i) identify the mechanistic origins of troublesome side reactions that are frequently found to accompany cross-coupling and other metal-catalysed reactions; ii) in particular to identify the source of "H" - the formal reductant in aryldehalogenation, and the source of the formal oxidised species in reductive homocoupling coupling; iii) to distinguish protodeboronation from protodehalogenation in some systems, and to study protodeboronation of boronate esters; iv) on the basis of this mechanistic insight, to design means by which to mitigate or bypass such processes.

Publications

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Studentship Projects

Project Reference Relationship Related To Start End Student Name
EP/N509644/1 01/10/2016 30/09/2021
1941152 Studentship EP/N509644/1 01/10/2017 31/03/2021 Hannah Hayes