Excitation-contraction coupling in cardiac myocytes from the rainbow trout
Lead Research Organisation:
University of Manchester
Department Name: Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| Holly Shiels (Principal Investigator) |
Publications
Birkedal R
(2009)
Temperature acclimation has no effect on ryanodine receptor expression or subcellular localization in rainbow trout heart.
in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Birkedal R
(2007)
High [Na+]i in cardiomyocytes from rainbow trout.
in American journal of physiology. Regulatory, integrative and comparative physiology
Brette F
(2008)
Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio).
in Biochemical and biophysical research communications
Patrick SM
(2010)
Enhanced length-dependent Ca2+ activation in fish cardiomyocytes permits a large operating range of sarcomere lengths.
in Journal of molecular and cellular cardiology
| Description | The aim of the grant was to understand the effect of temperature on fish heart function by examining ion flux in isolated myocytes. We were able to show that chronic temperature change did not affect expression or subcellular localization of key proteins involved intracellular Ca cycling. We were also able to show that intracellular Na was not affected by thermal acclimation. |
| Exploitation Route | Others have utilised the [Na] we established. Indeed, it has been used by a number of labs as theamount of Na that should be incorporated into intracellular solutions for electrophysiology. |
| Sectors | Agriculture, Food and Drink,Environment |
| URL | http://shiels.lab.ls.manchester.ac.uk/ |
| Description | BBSRC-DTP |
| Amount | £79,446 (GBP) |
| Funding ID | from BB/J014478/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2012 |
| End | 03/2015 |
| Description | BBSRC-DTP |
| Amount | £81,369 (GBP) |
| Funding ID | from BB/J014478/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 03/2017 |