Optimising Nanodisorder for Bone Tissue Engineering
Lead Research Organisation:
University of Glasgow
Department Name: Institute of Biomedical & Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Matthew Dalby (Principal Investigator) |
Publications
Aguayo S
(2016)
Influence of biomaterial nanotopography on the adhesive and elastic properties of Staphylococcus aureus cells
in RSC Advances
Alakpa EV
(2017)
Nacre Topography Produces Higher Crystallinity in Bone than Chemically Induced Osteogenesis.
in ACS nano
Chrzanowski W
(2010)
Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler
in Advanced Engineering Materials
CURTIS A
(2009)
Cellular Response to Biomaterials
Curtis AS
(2006)
Cell signaling arising from nanotopography: implications for nanomedical devices.
in Nanomedicine (London, England)
Dalby M
(2011)
Stem Cell Engineering - Principles and Applications
Gadegaard N
(2008)
Optimizing substrate disorder for bone tissue engineering of mesenchymal stem cells
in Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena
Hay JJ
(2018)
Bacteria-Based Materials for Stem Cell Engineering.
in Advanced materials (Deerfield Beach, Fla.)
Huethorst E
(2020)
Customizable, engineered substrates for rapid screening of cellular cues.
in Biofabrication
| Description | We had developed a new topography imprinted into polymers that could direct stem cells from the bone marrow to turn into bone. In this project we optimised our patterns to get the best levels of bone production we could. |
| Exploitation Route | We are taking our work forwards through a subsequent MRC grant and through building links to orthopaedic companies. |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology |
| Description | We used the data from this project to get a consultancy that indicated that we needed in vivo data. We applied and secured MRC funding to do in vivo research and new data shows that our technology translates well from in vitro to in vivo. We have also worked with In Vibio - an orthopaedic plastics manufacturer who co-funded a PHD in the area. |
| Description | Souhtampton Collaboration |
| Organisation | University of Southampton |
| Department | Bone and Joint Research Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Collaborator Contribution | This is a long term collaboration where cells, materials and expertise are shared to drive research |
| Impact | A large number of papers, grants and IP. |
| Description | GLORI conference organisation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Planning and Organisation of Dr Monica P Tsimbouri the scientific mentor of the Glasgow Orthopaedic Research Initiative (GLORI). GLORI has been established to encourage collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, biologists, engineers and chemists not only from Glasgow and Strathclyde Universities but the rest of Scotland too and also with the view to expand to the rest of the UK. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Nanotoxicology Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk for the Naotoxicology Society |
| Year(s) Of Engagement Activity | 2016 |
| Description | Poster presentation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Layla Damiati presented a poster at GLORI2018 |
| Year(s) Of Engagement Activity | 2018 |
| Description | Royal Society of Chemistry Biomaterials Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Conference presentation |
| Year(s) Of Engagement Activity | 2017 |
| Description | Scottish Metabolomics Network |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2016 |