UK-China partnership to control Peste-des-petits-ruminants (PPR)
Lead Research Organisation:
The Pirbright Institute
Department Name: Livestock Infectious Diseases
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Bao J
(2012)
Complete genome sequence of a Peste des petits ruminants virus recovered from wild bharal in Tibet, China.
in Journal of virology
Muniraju M
(2013)
Complete Genome Sequence of a Peste des Petits Ruminants Virus Recovered from an Alpine Goat during an Outbreak in Morocco in 2008.
in Genome announcements
Parida S
(2015)
Peste des petits ruminants
in Veterinary Microbiology
Parida S
(2015)
Peste des Petits Ruminants Virus
| Description | Established collaboration with CAHEC and Lanzough Institute in China. Exchange of sequence materials and published jointly. The training of Dr F Liu on reverse genetics by PI, Satya Parida, made him to rescue PPR virus from a c-DNA clone at his own Institute, CAHEC. This showed the technology transfer from the Pirbright Institute to the Chinese laboratory. Three visitors from different Chinese laboratory were visited to discuss on future collaborative work. |
| Exploitation Route | One joint application ( EU China) funding had been requested, but was not successful.Future funding application between the collaborators are planned. Three visitors from IVDC and Nanjing agriculture Universities had visited recently to Satya for discussing on collaborative work. |
| Sectors | Agriculture, Food and Drink,Education |
| Description | Lanzhou Institute has shown interest to commercialise some of our tests developed at the Pirbright Institute for commecialization.One joint application ( EU China) funding had been requested, but was not successful.Future funding application between the collaborators are planned. Our phylogenetic analysis showed the virus spread from Central Asia caused the devastating PPR outbreak throughout China. The postdoc Dr F Liu from China Animal health and Epidemiology Centre was trained on PPR reverse genetics at the Pirbright Institute and after returning back now he has rescued the PPR virus from a c-DNA clone and further used this close to prepare multivalent vaccines for other diseases. The training at the Pirbright Institute has been acknowledged in his publication. These activities influenced three more visitors from China to visit the vaccine Differentiation Group at the Pirbright for future collaborative work. |
| First Year Of Impact | 2016 |
| Sector | Agriculture, Food and Drink,Education,Manufacturing, including Industrial Biotechology |
| Impact Types | Policy & public services |
| Description | LVRI, China |
| Organisation | Lanzhou Veterinary Research Institute |
| Country | China |
| Sector | Learned Society |
| PI Contribution | 1.Established contact. 2. Exchange of visits between scientists. |
| Collaborator Contribution | 1.Established contact. 2. Exchange of visits between scientists. |
| Impact | Exchange of visits. Delivered talk on FMD and PPR vaccines. Agreed to apply for future grant call. |
| Start Year | 2015 |
| Description | Uk-China partnering |
| Organisation | China Animal Health and Epidemiology Center (CAHEC) |
| Country | China |
| Sector | Academic/University |
| PI Contribution | 1. Established collaborations. 2. exchange visits between partners.3. Delivered invited talks at CAHEC.4 Trained a postdoc for 10 months from CHEC on PPR virus reverse genetics technique 5. Have joint publications |
| Collaborator Contribution | 1. Supplied genetic material for PPR virus for Phylogenetic analysis and publication. 2. Invited speakers from the Pirbright Institute. |
| Impact | Collaborative publications. We have demonstrated that the PPR virus caused devastating outbreaks in China is spread from Central Asia. Agreed for joint application for grants. Waiting for the opportunity. |
| Start Year | 2011 |
| Description | International workshop on PPR vaccine at wellcome centrre, London |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | An international workshop had been organised at welcome Trust centre, London on PPR research including vaccine. All the active PPR research partners were invited to the meeting including some industry and policy holders. Presentation were made on PPR research throughout the day. GPRA ( Global PPR research Alliance) was formed in this meeting. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Invited talk on epidemiology of PPR at CAHEC, QUINGDAO, China at regional OIE meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion on PPR spread worldwide and its divergence was discussed in the OIE regional meeting. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Invited talk on reverse genetics of PPR at Lanjhu veterinary Institute, China |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Study participants or study members |
| Results and Impact | Reverse genetics approach to rescue PPR virus for the development of DIVA vaccine was clearly discussed. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Project close meeting at TANUVAS, Chennai July 2018- Delivering talk on outcome of the project |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | The project team held their final workshop at TANUVAS, which concluded a four year Farmed Animal Disease and Health (FADH) grant joint funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Indian Government's Department of Biotechnology (DBT). "This grant has enabled us to collaborate with four organisations across India, and ensured that our research can be applied in the field to aid the campaign for PPR global eradication", said Professor Parida.The project covered many areas of research which are essential for understanding PPR and creating tools to help control and prevent the disease. The team have now filed a patent application for their newly developed PPR vaccine, which is the first to differentiate between vaccinated and infected animals (DIVA) - a quality that enables livestock owners to protect their animals whilst continuing to trade. The team have also investigated how the PPR virus (PPRV) infects sheep and goats and how their immune systems respond. By inserting green fluorescent protein into virulent PPRV and administering the modified virus to goats, they demonstrated that PPRV primarily infects the tonsils, challenging the earlier belief that the virus first replicates in the respiratory tract epithelial cells. The collaborative project has also generated better diagnostic tests for use in the field and laboratory, and preliminary research has identified why some Indian breeds of goats and sheep are resistant to the disease, which could help scientists to create PPRV resistant breeds in the future. Project partners, scientists from the University and 40 field veterinarians have joined the meeting. An awareness training has been conducted on PPR disease and eradication for these field veterinarians. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes... |
| Description | Workshop at Hainan province |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | An workshop was organised by CAHEC at Hainan province and researchers from Pirbright Institute working on various diseases and researchers throughout China working on PPR and related diseases had joined.Talks were delivered by these researchers throughout the day. |
| Year(s) Of Engagement Activity | 2011 |
| Description | Yearly visit (n=4) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Study participants or study members |
| Results and Impact | PI Satya Parida has visited CAHEC in each year during the project tenure and discussed work with colleagues of CAHEC working on PPR. Couple of times senior postdoc from Pirbright laboratory visited CAHEC with PI for exchange of whole genome sequencing technique discussion. Similar visits have been made by CAHEC and LVRI scientists to the Pirbrght Institute. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015 |