Mathematical Theory and Biological Applications of Diversity

Lead Research Organisation: University of Edinburgh
Department Name: Sch of Mathematics

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Planned Impact

Assessing diversity is fundamental to research across the life sciences. The project will strengthen interdisciplinary links across the mathematics-life sciences interface, enhance existing BBSRC-funded research using diversity and, if we succeed in demonstrating the power and generality of the approach, it will offer long-term impact for researchers across the life sciences and to many beneficiaries beyond the academic arena.

1. The researchers involved in this proposal will directly benefit from their enhanced understanding of the mathematical theory and biological applications of diversity, will develop their leadership skills through their joint pursuit of a currently unrecognised unifying theme across well established BBSRC research areas, and will develop their interdisciplinary skills by working across traditional academic boundaries. These promise to be long-term benefits and connections thanks to the universities' joint commitment to give permanent affiliate / visiting researcher status to each of the interchangers.

2. The Boyd Orr Centre for Population and Ecosystem Health will benefit directly from expanding its interdisciplinary remit beyond its current focus on external impact. The centre won the Queen's Anniversary Prize in 2013 for its excellence in applied interdisciplinary research, achieving a diverse range of development and policy impacts across the world. This project allows us to integrate pure mathematicians into the centre and provide them with a route for academic impact, as well as strengthening our increasingly interdisciplinary and inter-institutional foundation. It creates a new way of working that cuts across the life sciences and offers a direct link into the physical sciences, expanding the reach of the centre into more areas of basic science.

3. The development of such a new cross-cutting theme across the life sciences would also allow research areas to cross-fertilise each other more easily, with advances in analytical techniques in one area, such as quantitative genetics and animal breeding, being able to be translated to and applied in other areas, such as assessment of biodiversity impacts or landscape epidemiology.

4. Correctly identifying the links between these fields will also allow us to generate theoretically sound and widely applicable tools for analysis and provide a consistent approach to new research areas as we integrate them into this framework, leading to higher quality proposals for future research. The symposia we will run at the end of the project will specifically address this goal: discussing the conclusions of our work with our collaborators in the life sciences will enable us to utilise these developments in future applications.

5. Our use of branches of pure mathematics not previously associated with applications has already begun to draw pure mathematicians (e.g. analysts and topologists) into the study of diversity, establishing new connections between scientific disciplines and creating a rich new pathway for knowledge transfer from mathematics into the life sciences.

6. Our longer term aim is to forge close links with biodiversity research, where key beneficiaries include biodiversity and conservation organisations. By providing a coherent and powerful framework that allows the quantification of diversity and its partitioning across space and time, we will provide better and more powerful tools for assessing biodiversity loss and the impact of human activity, environment, and climate change on diversity. Policy makers responsible for decisions on biodiversity management will benefit from a more powerful and systematic scientific basis for assessing biodiversity loss. We anticipate longer-term success in global biodiversity management through impact on the newly emerging Essential Biodiversity Variables.

Publications

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Leinster T (2019) A short characterization of relative entropy in Journal of Mathematical Physics

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Leinster T (2021) Entropy modulo a prime in Communications in Number Theory and Physics

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Leinster Tom (2017) A short characterization of relative entropy in arXiv e-prints

 
Description The purpose of this FLIP grant (FLexible Interchange Programme) was for a small group of mathematicians and biologists to learn some relevant parts of each others' subjects. All the researchers concerned are involved in developing the mathematics of biological diversity, so the activities chosen were all oriented towards that goal. The researchers involved in the grant were split across the Universities of Glasgow and Edinburgh. As the sole investigator from Edinburgh, I will describe here the activities that I was involved in personally.

As one aspect of the grant, I took several courses in biological subjects relevant to our research on the measurement of diversity:

* "Evolution Today", online course run by National Museum of Natural History, Leiden, Netherlands (Sep-Nov 2016). This was a general introductory course covering the basics of evolutionary biology, including the role of amino acids and DNA, an introduction to evolutionary development biology, the basics of genetics, individuals vs. groups in evolution, and game-theoretic aspects of evolution.

* "Molecular Analyses for Biodiversity and Conservation", MSc course, Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow (Feb-Mar 2017). This provided me with training on topics including genetic diversity and the role of gene flow, the representation of phylogenetic data and DNA barcoding, and methods such as principal component analysis for inferring population structure.

* "Evolutionary Quantitative Genetics", short course, Roslin Institute, Edinburgh. After an introduction to quantitative genetics, this covered topics such as the statistical modelling of populations, the dynamics of random mating, and the notion of effective population size (which is closely related to questions about how best to measure biological diversity).

In the opposite direction, I gave an extended seminar course (11 hours of lectures) on the mathematics behind diversity measurement. This was specifically designed to be accessible to non-mathematicians, and indeed, was attended by several biologists, as well as mathematical biologists and a very mixed group of mathematicians and physicists. It was held at the University of Edinburgh in January-March 2017.

The lively participation between biologists and mathematicians at this course provoked some new mathematical results of direct biological relevance. For example, we now have precise mathematical results classifying all the measures of biodiversity that behave in a reasonable manner. Starting from my notes from this course and adding further material that arose directly from it, I have now written a book: "Entropy and Diversity: The Axiomatic Approach", to be published in April 2021 by Cambridge University Press.
Exploitation Route Being a FLIP award rather than a standard research grant, the main purpose of the award was to educate the researchers involved in each others' subjects (rather than to create new research findings). The success of interdisciplinary work depends on everyone involved knowing at least a little about the other disciplines involved: the more, the better. This award has allowed the mathematicians involved to deepen their biological knowledge, and vice versa.

More specifically, our collaborative work is about identifying and developing appropriate measures of biological diversity, that are mathematically coherent but also faithfully represent biological reality. Our deepened knowledge of each others' subjects, and the research findings that this has led to, has moved us forward in this. As a result, we have developed diversity measures for structured communities, with accompanying software packages that can be used by life scientists without having to learn the mathematics behind them.
Sectors Agriculture, Food and Drink,Environment,Healthcare,Other

URL https://golem.ph.utexas.edu/category/2017/04/functional_equations_entropy_a.html
 
Description Magnitude and diversity
Amount £53,553 (GBP)
Funding ID RF-2019-519\9 
Organisation The Leverhulme Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2019 
End 12/2020