A scoping exercise and methods exchange in relation to differential muscle loss with disuse
Lead Research Organisation:
University of Nottingham
Department Name: School of Medicine
Abstract
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People |
ORCID iD |
| Bethan Phillips (Principal Investigator) |
Publications
Bass JJ
(2021)
Atrophy Resistant vs. Atrophy Susceptible Skeletal Muscles: "aRaS" as a Novel Experimental Paradigm to Study the Mechanisms of Human Disuse Atrophy.
in Frontiers in physiology
Bass JJ
(2021)
The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.
in The Journal of physiology
Deane CS
(2021)
Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers.
in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Deane CS
(2021)
Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans.
in Journal of cachexia, sarcopenia and muscle
Deane CS
(2021)
Dietary protein, exercise, ageing and physical inactivity: interactive influences on skeletal muscle proteostasis.
in The Proceedings of the Nutrition Society
Hardy EJ
(2023)
Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake.
in European journal of clinical nutrition
Inns TB
(2022)
Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.
in The Journal of physiology
| Description | Initial data from the work funding through this award suggests that the phenomenon of atrophy resistance vs atrophy susceptibility is apparent in rat model, providing confidence in this model moving forward. Further, a fruitful and continuing collaboration has been established, including 2 early-career tenured researchers and a PhD student, all of whom have been part of this international collaboration. |
| Exploitation Route | We are currently continuing this collaboration with work looking at senolytics as a potential mitigation strategy during immobilisation, and also the impact of immobilisation on digestibility, each using rat models not available to use outside this collaboration. |
| Sectors | Agriculture, Food and Drink,Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | Utilising proteomics to better understand, and develop strategies against, inactivity-induced muscle wasting |
| Amount | £18,000 (GBP) |
| Organisation | Science and Technologies Facilities Council (STFC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 03/2023 |
| Description | Nottingham Univeristy - Ritsumeikan University Partnership |
| Organisation | Ritsumeikan University |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | As this partnership is the basis of this award, the contribution by both partners has to date been equal. Due to COVID-19, this project was delayed and only started in November 2020. Although there has been no international travel to date, due to COVID restrictions, the scoping exercise has started led by postdoctoral fellows from both the UK and Japan. Further, plans for the first international visit have begun (hopefully Autumn 2021), and this partnership has also formed the basis for the development of 'the foundation of joint research for sport and health sciences' between Nottingham, Ritsumeikan and Loughborough Universities which has it's first meeting scheduled for March 26th 2021 on an online platform. |
| Collaborator Contribution | As above. |
| Impact | None to date |
| Start Year | 2020 |
| Description | Public Research Event in Japan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A hybrid online presentation providing an overview of the UK-Japan research collaboration and a presentation by myself (with translation from Prof Fujita) to a mainly public audience on "The Benefit and Mechanisms of High Intensity Interval Training for Older Adults:. |
| Year(s) Of Engagement Activity | 2022 |