EPSRC-Royal Society fellowship engagement (2012): Development of Chemical Tools for Probing Histone Demethylases
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Please refer to attached Royal Society application
Planned Impact
Please refer to attached Royal Society application
People |
ORCID iD |
| Akane Kawamura (Principal Investigator / Fellow) |
Publications
Baker YR
(2021)
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification.
in Nucleic acids research
Bavetsias V
(2016)
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
in Journal of medicinal chemistry
Belle R
(2022)
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.
in Communications chemistry
Belle R
(2017)
Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.
in Chemical communications (Cambridge, England)
Bhushan B
(2018)
Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.
in Bioorganic & medicinal chemistry
Bonnici J
(2018)
Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases.
in Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Coleman O
(2023)
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
in Chemical Science
Dobrynin G
(2017)
KDM4A regulates HIF-1 levels through H3K9me3.
in Scientific reports
England KS
(2014)
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
in MedChemComm
Gerken PA
(2017)
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.
in Angewandte Chemie (International ed. in English)
| Description | In this project, we have developed highly selective cyclic peptide inhibitors against histone demethylases, a biomedically important enzyme family involved regulation of transcription. We have established a state-of-the-art peptide synthesis facility within the Department of Chemistry - this includes the introduction of EPSRC funded microwave assisted peptide synthesiser. This microwave peptide synthesizer has dramatically increased our throughput and the quality of the synthesis of complex peptides (including cyclic peptides). The cyclic peptides are then tested in vitro and in cells against the enzyme targets. We have established cellular assays to assess stability, permeability and target engagement of cyclic peptides. This data was crucial in taking our work on KDM4 cyclic peptides to publication (Nature Communication 2017). In addition, this facility has enabled the synthesis of a wide variety of other peptides, including that of histone substrates for the enzymes. We currently have a number of follow-up project on KDM4 cyclic peptides, first of which has been published in BioorgMedChem 2017. We have also been contacted by a number of international research groups to use our tool compounds in their biological assays / studies. Our work in this area has led to a number of collaborative projects with Pharmaceutical companies. We have also established in vitro platform for cyclic peptide selection against novel targets. This will allow for identification of binding sequences against new targets. In parallel to our inhibitor development work, we have been working on functional studies on histone demethylases. We have conducted histone substrate profiling work on this family of enzymes and have found novel substrates for certain KDMs. This work was published in Epigenetics (2015) and Nature Communications (2016). We believe that our work on biochemical functional studies of KDMs will be of interest to a wide range of scientists, including both academic and pharmaceutical scientists pursuing demethylases as therapeutic targets (particularly in oncology). |
| Exploitation Route | Our findings can have wide-ranging use - firstly and most importantly in healthcare as the research outcome will most likely be useful for development of new drugs against histone demethylases (currently being actively pursued by multiple pharmaceutical / biotechnology companies, as well as academics). |
| Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Description | The findings of this project have led to several collaborative projects with pharmaceutical companies (>5 companies) - e.g. studentships, pump-priming projects, postdoctoral projects. Our work has generated a number of important output, including several publications on the development of chemical tools and mechanistic understanding of histone demethylases/related enzymes, which has opened up further new research in this area. |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | ARC Fellowship to Alexandre Erdmann |
| Amount | € 30,000 (EUR) |
| Organisation | The ARC Foundation for Cancer Research |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 10/2015 |
| End | 09/2016 |
| Description | BHF CRE Pump Priming Fund |
| Amount | £50,000 (GBP) |
| Funding ID | RE/08/004 |
| Organisation | University of Oxford |
| Department | BHF Centre of Research Excellence |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 03/2014 |
| Description | Biomedical Vacation Studentship |
| Amount | £1,440 (GBP) |
| Funding ID | N/A |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 09/2014 |
| Description | British Heart Foundation CRE Oxford - Pump Priming Award |
| Amount | £28,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 03/2019 |
| Description | CRUK Programme Grant |
| Amount | £763,416 (GBP) |
| Funding ID | C8717/A18245 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2019 |
| Description | ERC Consolidator Grant |
| Amount | € 2,241,271 (EUR) |
| Funding ID | 101003111 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 10/2021 |
| End | 09/2026 |
| Description | ERC Starter Grant |
| Amount | € 1,758,846 (EUR) |
| Funding ID | 679479 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 04/2016 |
| End | 03/2021 |
| Description | John Fell Fund |
| Amount | £100,000 (GBP) |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2015 |
| End | 07/2016 |
| Description | NovoNordisk PhD studentship (MoSMed CDT, University of Newcastle) |
| Amount | £75,000 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 09/2021 |
| End | 09/2025 |
| Description | NovoNordisk STAR Postdoctoral Fellowship |
| Amount | £100,000 (GBP) |
| Organisation | Novo Nordisk |
| Sector | Private |
| Country | Denmark |
| Start | 10/2018 |
| End | 09/2020 |
| Description | Oxford Cancer Centre Development Fund |
| Amount | £12,000 (GBP) |
| Funding ID | CRUKDF 0318-AK |
| Organisation | University of Oxford |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2019 |
| Description | Royal Society Newton Advance Fellowship with Dr Nathan Lack, Koc University |
| Amount | £111,000 (GBP) |
| Funding ID | NA150165 |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 03/2019 |
| Title | Cellular assays for histone demethylase |
| Description | Target engagement assays in cells |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Publication just accepted, impact to be confirmed. |
| Title | Chemical tools for histone demethylase |
| Description | Potent and selective cyclic peptide inhibitors for the KDM4A-C family |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | To be determined (publication just accepted and in press) |
| Description | COST EpiChemBio CM1406 |
| Organisation | European Commission H2020 |
| Country | Belgium |
| Sector | Public |
| PI Contribution | I am a Management Committee Member representing UK for this EU COST action; I have helped organised events, contributed towards training programmes and collaborative grant writing |
| Collaborator Contribution | European wide network of epigenetic researchers |
| Impact | >200 PIs across has joined this action 5 publications arising from this action (contributions from my group) 1 Marie Curie ITN grant application (H2020-MSCA-ITN-2017) - although not funded, it provided a foundation for new collaborations / grant applications Multiple training schools, workshops and conferences across Europe |
| Start Year | 2016 |
| Description | Emily Flashman |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise, intellectual input, training of students; use of facilities and equipment |
| Collaborator Contribution | Expertise, intellectual input, training of students; use of facilities and equipment |
| Impact | Currently preparing a review for submission to Epigenomics. |
| Start Year | 2013 |
| Description | Hiro Suga |
| Organisation | University of Tokyo |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | In collaboration with Hiro Suga's group in University of Tokyo, we are generating a series of cyclic peptide inhibitors against various epigenetic targets. My lab has been characterising the peptides, in vitro and in cells, using biophysical and kinetic assays, crystallography and in cell activity assays. |
| Collaborator Contribution | My collaborators have been screening the cyclic peptide library against our targets and they have supplied the synthesised peptide hits. |
| Impact | Currently preparing a manuscript to submit to Nature Chemical Biology |
| Start Year | 2010 |
| Description | Professor Christopher Schofield |
| Organisation | University College Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise, intellectual input and training of staff. We also provide the use of the EPSRC funded peptide synthesiser to the Schofield lab also. |
| Collaborator Contribution | Expertise, intellectual input and training of staff, as well as access to facility/ equipment use. |
| Impact | Currently working closely together on a number of different projects - we have numerous published together (23 publications to date). We have a number of joint grants together, including two with BBSRC (BB/L009846/1; BB/L000121/1) and one with CRUK (C8717/A18245). |
| Start Year | 2009 |
| Description | Target Discovery Institute |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise and intellectual input |
| Collaborator Contribution | Equipment and use of facility; generation of data |
| Impact | Multiple publications; development and distribution of chemical probes to academic and industrial researchers |
| Start Year | 2009 |
| Description | UAE Ganesan |
| Organisation | University of East Anglia |
| Department | School of Pharmacy |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Biochemical analysis of the inhibitors provided by the collaborators |
| Collaborator Contribution | Synthesis of inhibitors |
| Impact | Manuscripts currently in preparation |
| Start Year | 2013 |
| Description | "Protein-Protein Interactions: the next frontier" POPPI Event, Leeds University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker to talk about my research on cyclic peptides targeting protein protein interactions. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://poppi.website/protein-protein-interactions-the-next-frontier-webinar/ |
| Description | BHF Blenheim 10K |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | BHF charity run with my research group. As researchers, we also discussed our research to the general public on the work we do. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.bhf.org.uk/get-involved/events/runs/blenheim-palace-half-marathon-10k-and-family-fun-run |
| Description | Biosense |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This was a exhibition held at the University Museum of Natural History, Oxford, targeting the general audience. The general theme of the exhibition was how living organisms sense changes in their environment. The section I was involved in was on Oxygen sensing. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.museums.ox.ac.uk/content/biosense |
| Description | Bradford University, Institute of Cancer Therapeutics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Weekly seminar organised at the Institute of Cancer Therapeutics; Research talk about my group's research, followed by 30min Q&A with PG students discussing about science / career |
| Year(s) Of Engagement Activity | 2020 |
| Description | CRUK Open Doors |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Joanna Bonnici, a Research Assistant in the lab, was involved in showing people around the Chemistry Department and discussing our group's research on cancer during this CRUK run event |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.oxfordopendoors.org.uk/events/chemistry-research-laboratory-5/ |
| Description | CRUK Race for Life |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | CRUK Race for Life charity run with my research group. As researchers, we also discussed our research to the general public on the work we do. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://raceforlife.cancerresearchuk.org/index.html |
| Description | Cancer Research UK World Cancer Day event Oxford |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 40 general public attended this event in the Chemistry Research Laboratory, University of Oxford. This involved presentations by the CRUK organiser and Prof. Chris Schofield FRS, followed by lab tours and poster session. |
| Year(s) Of Engagement Activity | 2017 |
| Description | ChemBiOX 2019 Chemical Biology Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | ChemBiOX 2019 Chemical Biology Conference - a 2-day postgraduate conference led and organised by the Chemical Biology CDT students. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://chembiox.web.ox.ac.uk |
| Description | ChemBioChem/ChemMedChem Joint Virtual Symposium: Chemical Epigenetics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Invited to talk to speak about my research on cyclic peptides targeting epigenetic proteins |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.workcast.com/register?cpak=2043663598051070&referrer=ChemViews |
| Description | Discovery on Target 2014 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I was an invited speaker at an international conference on Epigenetics Drug Discovery. The talk led to good discussions and potential collaborative opportunities. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.discoveryontarget.com/Discoveryontarget_content.aspx?id=143166 |
| Description | Epigenetics Discovery Congress 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited speaker at the Epigenetics Discovery Congress. New collaborations (academic / industry) were made as a result of my presentation. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.globaleventslist.elsevier.com/events/2015/09/the-epigenetics-discovery-congress/ |
| Description | Epigenetics in Drug Discovery, SelectBio, Cambridge, UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Conference focused on drug discovery in Epigenetics; audience included academic and industrial researchers; dissemination of data, networking and strengthened existing collaborations (and potential ones); Invited to become an editor for a volume on the chemical biology book series from the Royal Society of Chemistry |
| Year(s) Of Engagement Activity | 2010,2017 |
| URL | https://selectbiosciences.com/conferences/agenda.aspx?pid=4770&conf=EDD2017 |
| Description | GlaxoSmithKline Emerging Academics Symposium Stevenage, Oct 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited speaker at GlaxoSmithKline Emerging Academics Symposium Stevenage, Oct 2019 |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gordon Research Conference in High Throughput Chemistry & Chemical Biology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | 2019 Gordon Research Conference in High Throughput Chemistry & Chemical Biology - invited speaker |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.grc.org/high-throughput-chemistry-and-chemical-biology-conference/2019/ |
| Description | Institute of Chemical Biology MRes Conference, Sept 2019, Imperial College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Keynote speaker at Institute of Chemical Biology MRes Conference, Sept 2019, Imperial College |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Innovation |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | My research has attracted public interest and an article featuring my research was published in International Innovation (special Women in Science, 3rd Edition). This has prompted a number of contacts from the media requesting my input into the research field. |
| Year(s) Of Engagement Activity | 2014,2015 |
| URL | http://www.internationalinnovation.com/build/wp-content/uploads/2015/02/p58-59_Akane_Kawamura_Intl_I... |
| Description | International Women's Day 2020 - Newcastle University |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | International Women's day talk, about my career to date |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited lecture - 11th ABPP Meeting, Target Discovery Using Chemical Probes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Dissemination of research via giving a lecture; collaboration arising from this conference talk |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ox.ac.uk/event/11th-annual-abpp-meeting-target-discovery-using-chemical-probes |
| Description | Invited lecture - 4th International Conference on Circular Proteins and Peptides, Kawasaki, Japan |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Dissemination of research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.iccpp2018.com |
| Description | Invited lecture - AstraZeneca / Oxford Cancer Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Dissemination of research, identifying collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited lecture - Hong Kong University Chemical Biology Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research; collaborations and networking |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited lecture - Institute Pasteur, Paris |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Dissemination of research to academics; networking and collaborations |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited lecture - RSC Chemistry and Biology of Peptides, Southampton |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Dissemination of research |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.sigmaaldrich.com/chemistry/chemical-synthesis/chemical-biology/novabiochem-chemistry-and... |
| Description | Invited lecture - University of Leeds, School of Molecular and Cellular Biology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dissemination of research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited lecture - Vancouver Prostate Centre, Canada |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Dissemination of research |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk at Imperial College |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at Imperial College, Molecular Medicine Lunchtime seminar. Following on the talk, there were good discussions and potential collaborative opportunities were identified. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Invited talk at UEA |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker at School of Pharmacy at University of East Anglia, to discuss my research on Epigenetics. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Oxford Science Festival (IF), "Epigenetics: How do Identical twins differ?" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Kawamura group (7 group members) set up a stand on Epigenetics ("Epigenetics: How do Identical twins differ?") at the Oxford Science Festival (IF) in Oxford City Town Hall for a full day. It was very well attended, and we had several activities at the stand targeting all ages / backgrounds. We had several interactive activities for primary aged children which included a histone post-translational modification game, a yo-yo (for explaining how DNA is wrapped and condensed), a tablet with interactive 'cell', as well as posters and further reading for adults. It was very well received and we had many positive feedback. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://if-oxford.com/event/explorazone/ |
| Description | Periodic |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | My research was highlighted in the Oxford Chemistry Alumni magazine, Periodic. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.chem.ox.ac.uk/Periodic2015/files/basic-html/index.html |
| Description | Phenotype |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Postdoc in my team wrote an article about the group's research, which has led to a number of researchers contacting the group for further discussions on our work |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://oxphenotype.wix.com/oxphenotype15 |
| Description | RSC CSJ Symposium on Chemistry for Complex Biological Systems |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | RSC CSJ Symposium on Chemistry for Complex Biological Systems, Tohoku University, Japan Sept 2019 (UK representative); Collaborative symposium between Japanese and UK chemical biologists. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.bunshi-kyouzatsu.jp/en/event/10th-rsc-csj-joint-symposium-chemistry-for-complex-biologica... |
| Description | The Many Faces of Epigenetics: "Multidisciplinary Perspectives "over" genetics" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Multi-disciplinary workshop / discussions / lectures on epigenetics from social and scientific perspectives. CJS - invited speaker, AK - session chair |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.mfo.cnrs.fr/calendar/2017-12-06/ |
| Description | UNIQ School |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | A lecture give on the theme of epigenetics to A-level students, as part of a summer school program in Oxford. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.uniq.ox.ac.uk/chemistry |