Volatile organic compound sensing in healthcare using optical interrogation of metal-organic frameworks
Lead Research Organisation:
Brunel University London
Department Name: Life Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| Claire Turner (Principal Investigator) |
Publications
Boulind CE
(2022)
Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer.
in Cancers
Hines AR
(2023)
Multi-Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation.
in Journal of the American Society for Mass Spectrometry
| Description | We have developed a method for the quantification of the anaesthetic propofol in air, breath and headspace above blood so it can be monitored in real time. We have also used that to measure propofol in breath of a small number of patients during anaesthesia. We collected blood samples and will analyse the blood samples when we have collected them from the final patient. These will then be used to develop a model for how propofol is dispersed throughout the body by using infusion rates and amounts with blood and breath concentrations and by trying to identify breakdown products. The hope is to be able to use breath or blood monitoring in real time with these sensors also being developed in the project to be able to carefully control the amount of propofol in the body at any one time. |
| Exploitation Route | This will be published and then can be used by others monitoring volatile compounds |
| Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | We have developed a method to monitor the concentration of propofol in real time. Developments of the sensor will enable anaesthetists to monitor propofol concentrations during surgery; at the present this is done by estimating the concentration based on body mass and amount added, resulting in not being quite sure whether a patient is over or under anaesthetised. We have now taken samples from real patients during surgery who are anaesthetised with propofol meaning we should be able to relate the infusion rate and amount of propofol with the concentration measured in breath and blood |
| First Year Of Impact | 2023 |
| Sector | Healthcare |
| Impact Types | Societal |
| Title | A method for testing the accuracy of fibre-opic sensors, and for their calibration |
| Description | A method has been developed to test how effective, accurate and rapid the fibre sensors are, and to calibrate their output. This method involves making up low cost standardised volatile compound headspaces and artificial breath using physical chemistry principles and a range of published Henry's law co-efficients and temperature (enthalpy) corrections. these can then be produced rapidly and effectively, and tested alongside selected ion flow tube mass spectrometry. these standardised headspaces can then be used in the appropriate materials to test the reaction speed, sensitivity and selectivity of the fibres, and whether they can be re-sued, or how long the baseline takes to return. This work is being written up for publication. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | This work will be submitted for publication, however the method is being used in our other work to provide other standardised headspaces to test other analytical equipment. |
| Title | Materials use |
| Description | This study has provided crucial data which will inform the development of new tools and processes. These data show which materials will interfere with the analysis of volatile organic compounds (VOCs) through either absorbing them, or emitting competing and confounding VOCs. We have systematically studied a variety of materials that can be used in sample handling and fibre optic holders to see which can or can't be used, and the significance of their effects on individual VOCs. A manuscript has been prepared which will be submitted for publication shortly outlining these findings. |
| Type Of Material | Biological samples |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | A publication will result from this, which will disseminate these findings. Meantime, these findings are being used in the development of sampling and sample handling protocols for clinical samples. |