Volatile organic compound sensing in healthcare using optical interrogation of metal-organic frameworks

Lead Research Organisation: Brunel University London
Department Name: Life Sciences

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Boulind CE (2022) Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer. in Cancers

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Hines AR (2023) Multi-Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation. in Journal of the American Society for Mass Spectrometry

 
Title A method for testing the accuracy of fibre-opic sensors, and for their calibration 
Description A method has been developed to test how effective, accurate and rapid the fibre sensors are, and to calibrate their output. This method involves making up low cost standardised volatile compound headspaces and artificial breath using physical chemistry principles and a range of published Henry's law co-efficients and temperature (enthalpy) corrections. these can then be produced rapidly and effectively, and tested alongside selected ion flow tube mass spectrometry. these standardised headspaces can then be used in the appropriate materials to test the reaction speed, sensitivity and selectivity of the fibres, and whether they can be re-sued, or how long the baseline takes to return. This work is being written up for publication. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact This work will be submitted for publication, however the method is being used in our other work to provide other standardised headspaces to test other analytical equipment. 
 
Title Materials use 
Description This study has provided crucial data which will inform the development of new tools and processes. These data show which materials will interfere with the analysis of volatile organic compounds (VOCs) through either absorbing them, or emitting competing and confounding VOCs. We have systematically studied a variety of materials that can be used in sample handling and fibre optic holders to see which can or can't be used, and the significance of their effects on individual VOCs. A manuscript has been prepared which will be submitted for publication shortly outlining these findings. 
Type Of Material Biological samples 
Year Produced 2017 
Provided To Others? No  
Impact A publication will result from this, which will disseminate these findings. Meantime, these findings are being used in the development of sampling and sample handling protocols for clinical samples.