Robust manufacturable antimicrobial surfaces enabled by superhard plasmon-enhanced photocatalytic materials
Lead Research Organisation:
Sheffield Hallam University
Department Name: College of Business, Technology & Eng
Abstract
Untreatable infections are one of the biggest modern-day dangers to society, which the current SARS-CoV-2 pandemic has highlighted.
The development of antibiotics has been one of the major medical successes of the last 100 years. However, the capacity of pathogens to evolve and acquire resistance to new antibiotics makes their effectiveness necessarily precarious. Meanwhile, studies on the spread of drug-resistant pathogens such as MRSA, respiratory syncytial virus, norovirus and CoVID-19 suggest that surfaces are a major point of transmission with CoVID-19 remaining infectious on plastic and stainless steel surfaces for up to 6 days.
Surfaces with an antimicrobial function that avoid or minimise the use of antibiotics whilst maintaining good efficacy after prolonged use are critically needed in hospitals, living spaces, and on biomedical implants, to reduce healthcare-acquired and public space-acquired infections, reduce healthcare costs, and promote healthier lives.
However standard antimicrobial surfaces are not sufficiently robust to withstand the wear and tear encountered in a biomedical implant environment and in public spaces. Sheffield Hallam University and Imperial College London aim to develop superhard nanostructured surfaces with plasmonically-enhanced photocatalysis which will enable microbial inactivation in both illuminated and dark environments whilst retaining their robustness and effectiveness in the long term and which, as a result, will lead to orthopaedic implants and anti-microbial surfaces that are more functional than those produced with the current technologies.
The innovative antimicrobial surfaces will be robust due to the use of superhard nanoscale multilayer coatings with wear rates up to 1000 times better than conventional metal alloys.
At the same time the robust antimicrobial surfaces will have a dual functionality -
(1) active, they will be able to kill microorganisms by photocatalysing the production of highly reactive singlet oxygen - one of the most effective killers of pathogens. The photocatalysis will be activated by visible light from the environment. The light will interact with a carefully prepared coating material to induce plasmonic resonance on its surface and generate high energy electrons which are needed to boost the photocatalytic reaction.
(2) passive, mimicking naturally occurring surfaces such as the cicada wing, the surfaces will contain a number of appropriately dimensioned nanopillars which will stretch and mechanically rupture the walls of microorganisms. This functionality is potent in wet, dry, illuminated or dark environments.
We have developed a new plasmonic nanoscale multilayer material which activates photocatalysis under standard (visible) light and have developed technology based on high power impulse magnetron sputtering which can produce these materials at room temperature on polymers.
We will study the plasma processes needed to produce the materials and nanopillars, their response to light activation and the effect they have on microbials. This will help us to develop a cost-effective manufacturing technology to enable large scale production by upgrading systems which are already available in industry for coating deposition and nanopatterning with a digitalised system control which is driven by artificial intelligence algorithms. Together with the local NHS hospital trust we will trial the material on metal plates for door furniture and polymer sheets to cover surfaces in hospitals (beds, seating areas).
When successful we will have some of the most exciting new developments in robust antimicrobial materials and their manufacturing and take a step closer to a world with fully effective infection control.
The development of antibiotics has been one of the major medical successes of the last 100 years. However, the capacity of pathogens to evolve and acquire resistance to new antibiotics makes their effectiveness necessarily precarious. Meanwhile, studies on the spread of drug-resistant pathogens such as MRSA, respiratory syncytial virus, norovirus and CoVID-19 suggest that surfaces are a major point of transmission with CoVID-19 remaining infectious on plastic and stainless steel surfaces for up to 6 days.
Surfaces with an antimicrobial function that avoid or minimise the use of antibiotics whilst maintaining good efficacy after prolonged use are critically needed in hospitals, living spaces, and on biomedical implants, to reduce healthcare-acquired and public space-acquired infections, reduce healthcare costs, and promote healthier lives.
However standard antimicrobial surfaces are not sufficiently robust to withstand the wear and tear encountered in a biomedical implant environment and in public spaces. Sheffield Hallam University and Imperial College London aim to develop superhard nanostructured surfaces with plasmonically-enhanced photocatalysis which will enable microbial inactivation in both illuminated and dark environments whilst retaining their robustness and effectiveness in the long term and which, as a result, will lead to orthopaedic implants and anti-microbial surfaces that are more functional than those produced with the current technologies.
The innovative antimicrobial surfaces will be robust due to the use of superhard nanoscale multilayer coatings with wear rates up to 1000 times better than conventional metal alloys.
At the same time the robust antimicrobial surfaces will have a dual functionality -
(1) active, they will be able to kill microorganisms by photocatalysing the production of highly reactive singlet oxygen - one of the most effective killers of pathogens. The photocatalysis will be activated by visible light from the environment. The light will interact with a carefully prepared coating material to induce plasmonic resonance on its surface and generate high energy electrons which are needed to boost the photocatalytic reaction.
(2) passive, mimicking naturally occurring surfaces such as the cicada wing, the surfaces will contain a number of appropriately dimensioned nanopillars which will stretch and mechanically rupture the walls of microorganisms. This functionality is potent in wet, dry, illuminated or dark environments.
We have developed a new plasmonic nanoscale multilayer material which activates photocatalysis under standard (visible) light and have developed technology based on high power impulse magnetron sputtering which can produce these materials at room temperature on polymers.
We will study the plasma processes needed to produce the materials and nanopillars, their response to light activation and the effect they have on microbials. This will help us to develop a cost-effective manufacturing technology to enable large scale production by upgrading systems which are already available in industry for coating deposition and nanopatterning with a digitalised system control which is driven by artificial intelligence algorithms. Together with the local NHS hospital trust we will trial the material on metal plates for door furniture and polymer sheets to cover surfaces in hospitals (beds, seating areas).
When successful we will have some of the most exciting new developments in robust antimicrobial materials and their manufacturing and take a step closer to a world with fully effective infection control.
Organisations
- Sheffield Hallam University (Lead Research Organisation)
- IHI Corporation (United Kingdom) (Project Partner)
- Emerson & Renwick Ltd (Project Partner)
- Zimmer Biomet (United Kingdom) (Project Partner)
- Henry Royce Institute (Project Partner)
- Hauzer (Netherlands) (Project Partner)
- scia Systems GmbH (Project Partner)
Publications
Bower R
(2022)
Temperature stability of individual plasmonic Au and TiN nanodiscs
in Optical Materials Express
Doiron B
(2023)
Optimizing Hot Electron Harvesting at Planar Metal-Semiconductor Interfaces with Titanium Oxynitride Thin Films.
in ACS applied materials & interfaces
Ehiasarian A
(2022)
Real-time monitoring of plasma synthesis of functional materials by high power impulse magnetron sputtering and other PVD processes: towards a physics-constrained digital twin
in Journal of Physics D: Applied Physics
Ehiasarian A
(2024)
Novel high-efficiency plasma nitriding process utilizing a high power impulse magnetron sputtering discharge
in Journal of Vacuum Science & Technology A
Kaur A
(2023)
Development of Nanopackaging for Storage and Transport of Loaded Lipid Nanoparticles.
in Nano letters
Purandare Y
(2023)
Improving tribocorrosion resistance of a medical grade CoCrMo alloy by the novel HIPIMS nitriding technique
in Journal of Science: Advanced Materials and Devices
Wang Y
(2023)
Toward Fabrication of Devices Based on Graphene/Oxide Multilayers.
in ACS applied electronic materials
Wang Y
(2023)
Deposition of Nanocrystalline Multilayer Graphene Using Pulsed Laser Deposition
in Crystals
Yao Q
(2023)
Crystalline AuNP-Decorated Strontium Niobate Thin Films: Strain-Controlled AuNP Morphologies and Optical Properties for Plasmonic Applications.
in ACS applied nano materials
Description | 12th International Conference on HIPIMS - Oral presentation: "Room temperature deposition of plasmonic TiN" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation delivered at 12th International Conference on HIPIMS - Sheffield, UK. |
Year(s) Of Engagement Activity | 2022 |
URL | https://www.hipimsconference.com/ |
Description | Kingsbury High School Careers Week Presentations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Imperial staff (Dr Bruno Rente, Dr Ryan Bower) each gave a 30 minute career presentation discussing their current work and answering questions from students at Kingsbury High School, London. Approximately 15 Year 7/8 students attended each career session. Dr Freya Johnson also provided a brief description of her career that was included in the KHS Career Week bulletin, estimated to be read by ~700 students and staff. |
Year(s) Of Engagement Activity | 2023 |
Description | Organised 12th International Conference on High Power Impulse Magnetron Sputtering |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | The project team at Sheffield Hallam University organised and hosted the International Conference on High Power Impulse Magnetron Sputtering in Sheffield in June 2022. The event was attended by more than 120 industrialists and academics from 20 countries. Approximately half of the attendees were from industry. The event this year had a workshop dedicated to nanopatterned antimicrobial surfaces, which generated interest and awareness of the subject. |
Year(s) Of Engagement Activity | 2022 |
URL | http://www.hipimsconference.com |