(Lost-Tfh) Lost in space: How spatial dysregulation of T follicular helper cells impairs vaccine responses in ageing

A successful response to vaccination requires the cells of the immune system to get together at the right place, and at the right time. We have identified that in older bodies a particular type of white blood cell, helper T cells, does not get to the right place after immunisation. This proposal aims to determine why, and to identify what the consequences are of these lost-helpers for the immune response to vaccination and for the other cell types that they would normally interact with.