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RepState: DNA Repair State Machines

Lead Research Organisation: University of Leeds
Department Name: Sch of Molecular & Cellular Biology

Abstract

The Doctoral Network RepState aims to train a new generation of innovative scientists in biochemistry and biophysics to address central questions in biology concerning the mode of action of critical DNA Repair proteins that act as state machines. RepState consists of a highly collaborative consortium consisting of 14 participants coming from academia, industry and the creative sector, representing the natural sciences as well as the social sciences. Participating laboratories in RepState are part of established research schools within renowned research organizations and universities. This environment of excellence offers a multidisciplinary PhD program to 13 young researchers, through training in the fundamental chemical and physical principles that underlie biology and human health. In addition, training will focus on method development using technology and experience provided by the academic participants as well as by the two small technology-driven companies. Training incorporates a local program, rotations within partner laboratories, exposure to the non-academic sector and annual meetings. Fellows will follow scientific workshops, courses in transferable skills and career development, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. The RepState fellows will form a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, career perspectives in multiple sectors and an understanding of the importance of the role of fundamental science for society and human health.

Publications

10 25 50
 
Description Training of fellows in the cohort, public engagement as detailed in the proposal
First Year Of Impact 2023
Sector Pharmaceuticals and Medical Biotechnology
 
Title HDX-MS 
Description Optimized workflow for high sequence coverage and redundancy HDX-MS analysis of protein/oligonucleotide complexes involved in DNA repair 
Type Of Material Biological samples 
Year Produced 2025 
Provided To Others? Yes  
Impact Understand structural dynamics of DNA repair complexes 
 
Description Collaboration 
Organisation University of Bristol
Department School of Biochemistry Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaboration on investigating DNA repair complexes, as part of the MSCA DN (guarantee funding)
Collaborator Contribution Collaboration on investigating DNA repair complexes
Impact Research and Training as detailed in the grant programme
Start Year 2023