RepState: DNA Repair State Machines
Lead Research Organisation:
University of Leeds
Department Name: Sch of Molecular & Cellular Biology
Abstract
The Doctoral Network RepState aims to train a new generation of innovative scientists in biochemistry and biophysics to address central questions in biology concerning the mode of action of critical DNA Repair proteins that act as state machines. RepState consists of a highly collaborative consortium consisting of 14 participants coming from academia, industry and the creative sector, representing the natural sciences as well as the social sciences. Participating laboratories in RepState are part of established research schools within renowned research organizations and universities. This environment of excellence offers a multidisciplinary PhD program to 13 young researchers, through training in the fundamental chemical and physical principles that underlie biology and human health. In addition, training will focus on method development using technology and experience provided by the academic participants as well as by the two small technology-driven companies. Training incorporates a local program, rotations within partner laboratories, exposure to the non-academic sector and annual meetings. Fellows will follow scientific workshops, courses in transferable skills and career development, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. The RepState fellows will form a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, career perspectives in multiple sectors and an understanding of the importance of the role of fundamental science for society and human health.
| Description | Training of fellows in the cohort, public engagement as detailed in the proposal |
| First Year Of Impact | 2023 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Title | HDX-MS |
| Description | Optimized workflow for high sequence coverage and redundancy HDX-MS analysis of protein/oligonucleotide complexes involved in DNA repair |
| Type Of Material | Biological samples |
| Year Produced | 2025 |
| Provided To Others? | Yes |
| Impact | Understand structural dynamics of DNA repair complexes |
| Description | Collaboration |
| Organisation | University of Bristol |
| Department | School of Biochemistry Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration on investigating DNA repair complexes, as part of the MSCA DN (guarantee funding) |
| Collaborator Contribution | Collaboration on investigating DNA repair complexes |
| Impact | Research and Training as detailed in the grant programme |
| Start Year | 2023 |
