Towards understanding the biological drivers of cellular ageing
Lead Research Organisation:
University of Oxford
Department Name: Biochemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Oxford (Lead Research Organisation)
- Medical Research Council (Co-funder)
- Engineering and Physical Sciences Research Council (Co-funder)
- Biotechnology and Biological Sciences Research Council (Co-funder)
- Ministry of education and science of the Republic of Kazakhstan (Collaboration)
- AstraZeneca (United Kingdom) (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Cardiff University (Collaboration)
- UNIVERSITY OF BRIGHTON (Collaboration)
People |
ORCID iD |
| Lynne Cox (Principal Investigator) |
Publications
Alimbetov D
(2016)
Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.
in Biogerontology
Bird JL
(2012)
Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease.
in Biogerontology
Cox L
(2014)
The new science of ageing
Cox L
(2019)
Ageing here and now: current research and transformative therapies.
in Biogerontology
Cox L
(2022)
Therapeutic approaches to treat and prevent age-related diseases through understanding the underlying biological drivers of ageing
in The Journal of the Economics of Ageing
Cox L S
(2012)
Encyclopedia of DNA research
Cox LS
(2012)
Thrive in Biochemistry and Molecular Biology
Cox LS
(2017)
The role of cellular senescence in ageing of the placenta.
in Placenta
Cox LS
(2020)
Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults.
in The lancet. Healthy longevity
| Description | We have generated a novel molecular tool to remove WRN from human cells in culture in a tightly regulated manner simply by addition of a chemical switch. Our longitudinal proteomics analysis of cells as they progress along the senescence trajectory has allowed us to determine that senescent cells express a higher level of factors required to deal with damage to genetic material and general cellular stress including increased oxidative damage, suggesting that they accumulate lesions in critical cellular components during the ageing process. Moreover, we found significant changes in proteins that remodel the extracellular matrix (tissue support structures). We therefore conclude that increased stress and decreased ability to remove damaged components may drive cell senescence. Continuous treatment of human cells over a period of time with potential anti-ageing drug rapamycin significantly modulated senescence. It will now be important to test in whole organism models whether rapamycin (or newer rapalogues) can affect the accumulation of senescent cells and hence ameliorate the detrimental effects caused by the presence of senescent cells in older individuals. |
| Exploitation Route | We are pursuing our drug findings through a privately-funded research project and I am now a member of a new national a consortium to develop drugs based on these (and other) studies through to human clinical trials. Separately, we have also started on a collaborative project with a colleague in Biochemistry, Oxford, and the drug company Astra Zeneca (in their Open Discovery programme) to take the drug discovery to the next level in non-vertebrate animal trials. We have worked with the company Calico (Google ageing) and are now at the stage of data sharing preparatory to writing up a detailed paper on the -omics of senescence. Each experiment takes up to 2-3 years to complete as we are looking at ageing, hence outcomes from the award are still coming through. |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Our findings have been disseminated through publication of a project-specific booklet through the New Dynamics of Ageing programme (NDA Findings 32), through talks about biology of ageing to social scientists (eg invited speaker BSG annual conference 2013), and through collaborative book chapters aimed at changing the understanding of many social scientists about the contribution basic biological studies can make to improvements in health and social care for the elderly. Presentation at the NDA final conference to politicians, health care practitioners and the public was designed specifically to alter thinking and to promote greater collaboration and funding for the biological sciences in the field of gerontology. I have subsequently used my experiences on the NDA programme to establish an ageing network based in Oxford to bring together clinicians, carers, funders, third sector and basic scientists who share an interest in ageing; The inaugural network meeting (which was international in audience) was held in the summer of 2015. I have now applied for and received from the University of Oxford to enlarge the network, and hold 3 meetings a year for the next 2 years - as OxAgeN founder, I am also now actively engaged in setting up the Oxford ageing hub that will bring together members of the university spanning all disciplines, including social sciences, humanities, engineering, physics, mathematics and computational sciences, and university museums as well as the life and medical sciences. We have now written a book chapter reporting our findings that has been published (NDA volume 2 Policy Press 2018). Following on from recognition of expertise in the filed, I have now bene invited to participate in various investors conferences, Longevity fora, Investment leaders meetings and have also been asked to act on the advisory board of two new policy groups in the ageing space. I have now served on advisory boards of the All Party Parliamentary Group for longevity, wrote a key paper int eh APPG's National Strategy on ageing (Health of the Nation: a strategy for healthier longer lives) |
| First Year Of Impact | 2013 |
| Sector | Education,Healthcare,Other |
| Impact Types | Cultural,Societal,Economic |
| Description | All Party Parliamentary Group for Longevity - strategic advisory board member, also science, genomic and technology board member |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://appg-longevity.org/advisory-board |
| Description | Authored key paper in All Party Parliamentary Group report: The Health of the Nation: a strategy for longer healthier lives |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://appg-longevity.org/events-publications |
| Description | House of Lords science and technology select committee: oral evidence |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://parliamentlive.tv/Event/Index/1c0e8f76-2e8a-4e27-a297-4b4f2e9cb5f3 |
| Description | House of Lords select committee science and technology - ageing, science and healthy living: written evidence |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | http://data.parliament.uk/writtenevidence/committeeevidence.svc/evidencedocument/science-and-technol... |
| Description | Invited presentation on ageing mechanisms to clinical geratologists in the Oxfordshire area for their CPD and for some, in preparation for their MRC examinations. Feedback suggested that I had shown them new ideas and ways of looking at clinical ageing with the potential for new therapies on the horizon. |
| Geographic Reach | Local/Municipal/Regional |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Longevity Forum |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.thelongevityforum.com |
| Description | Longevity Leaders: advising/influencing investment by large companies including pension funds in ageing research - round table discussant |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| URL | https://www.lsxleaders.com/longevity-leaders-congress |
| Description | Master Investor: Investing in the age of longevity. Gave speech to financial leaders on emerging opportunities in ageing research |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | POSTnote on The Ageing Process and Health for Parliamentary Office of Science and Technology, circulated to all MPs and members the House of Lords |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| URL | https://researchbriefings.parliament.uk/ResearchBriefing/Summary/POST-PN-0571 |
| Description | iTAC (innovative therapeutics for ageing consortium) speaker at inaugural meeting; asked to collaborate with the work of the consortium in developing a rapid drug discovery/delivery platform in the UK. I have had subsequent meetings with two key people in the consortium to take plans forward. |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Academic collaboration with commercial company |
| Amount | $400,000 (USD) |
| Organisation | Amway |
| Sector | Private |
| Country | United States |
| Start | 05/2017 |
| End | 04/2018 |
| Description | Age-related bone fragility in type 1 diabetes - the role of bone cell senescence |
| Amount | £398,000 (GBP) |
| Funding ID | 19BX18LCRD |
| Organisation | British Council |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 01/2023 |
| Description | BBSRC Responsive mode |
| Amount | £473,213 (GBP) |
| Funding ID | BB/M006727/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 02/2018 |
| Description | Engineering polypharmacology in drug discovery for treating the underlying causes of age-related diseases |
| Amount | £453,892 (GBP) |
| Funding ID | R49716_CN003 |
| Organisation | Elysium Health Inc |
| Sector | Private |
| Country | United States |
| Start | 10/2018 |
| End | 10/2022 |
| Description | Government of Kazakhstan collaborative project - 'Small molecules' |
| Amount | £650,000 (GBP) |
| Organisation | Government of Kazakhstan |
| Sector | Public |
| Country | Kazakhstan |
| Start | 01/2011 |
| End | 12/2014 |
| Description | Identifying factors that restore DNA repair in ageing cells through WRN reactivation |
| Amount | £74,140 (GBP) |
| Organisation | United Kingdom Research and Innovation |
| Department | UK SPINE Knowledge Exchange |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 02/2021 |
| Title | Senescent cell samples |
| Description | I have spent 3 years accumulating human primary fibroblasts at all stages across their proliferation lifespan until senescence, for analysis of molecular aspects and drivers of ageing. |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | This resource has allowed me identify potentially interesting drives of cell ageing that we are now testing using pharmacological and genetic reagents. I have received several requests for collaboration based on the resource and have just started on one to study RNA processing on senescence. I am also negotiating with a major international partner to exploit this resource to study senescence at several -omics levels. |
| Title | Stable cell lines expressing WRN knockdown constructs |
| Description | 1Br3.neo cells stably transformed with constructs to express either short hairpin or ribozyme constructs targetting WRN mRNA for destruction. |
| Type Of Material | Cell line |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | We have collaborated with two labs (Prof Faragher, Brighton and Prof Campisi, Buck Institute) to investigate possible response to chemotherapeutic agent camptothecin (CPT) on WRN knockdown using these tools. Our published findings suggest that these tools (or similar) may be useful adjuncts in cancer chemotherapy as they sensitise cells to killing by CPT. |
| Description | Collaboration on drug testing in a non-vertebrate animal model of premature ageing |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Our finding have been used as preliminary data in a grant applications with a colleague in Biochemistry, Oxford, one of which has already led to a commercial collaboration with Astra Zeneca, (Open Discovery programme), and one grant proposal is under review (ERC). We have since submitted a full grant proposal to MRC which was very well reviewed but rejected at committee stage. We are now exploring alternative sources of funding through Industrial partnering awards and SRAs. |
| Collaborator Contribution | The colleague has provided the non-vertebrate model and his lab has conducted the majority of the experiments. Astra Zeneca have provided a large amount of the drug free of charge to enhance the rate of progress on the research. |
| Impact | Too soon to report outputs. |
| Start Year | 2017 |
| Description | Collaboration on drug testing in a non-vertebrate animal model of premature ageing |
| Organisation | University of Oxford |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our finding have been used as preliminary data in a grant applications with a colleague in Biochemistry, Oxford, one of which has already led to a commercial collaboration with Astra Zeneca, (Open Discovery programme), and one grant proposal is under review (ERC). We have since submitted a full grant proposal to MRC which was very well reviewed but rejected at committee stage. We are now exploring alternative sources of funding through Industrial partnering awards and SRAs. |
| Collaborator Contribution | The colleague has provided the non-vertebrate model and his lab has conducted the majority of the experiments. Astra Zeneca have provided a large amount of the drug free of charge to enhance the rate of progress on the research. |
| Impact | Too soon to report outputs. |
| Start Year | 2017 |
| Description | Kazakhstan project 'Small molecules' |
| Organisation | Cardiff University |
| Department | School of Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | One of a consortium of 4 institutions (Nazarbayev University, Kazakhstan; Cardiff University; University of Brighton and University of Oxford) |
| Collaborator Contribution | We jointly contributed scientific research to a collaborative project. Nazarbayev provided funds and two short term researchers to expedite the research. |
| Impact | Publication Kenessary et al 2012 N Biotech. originated from this, though included some input from my ongoing ESRC work. Additional publications: 1: Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7. PubMed PMID: 29041897; PubMed Central PMCID: PMC5645932. 2: Alimbetov D, Davis T, Brook AJ, Cox LS, Faragher RG, Nurgozhin T, Zhumadilov Z, Kipling D. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology. 2016 Apr;17(2):305-15. doi: 10.1007/s10522-015-9610-z. Epub 2015 Sep 23. PubMed PMID: 26400758; PubMed Central PMCID: PMC4819486. Partners on the project have now established a spin-out building on some of the findings of the project. |
| Start Year | 2011 |
| Description | Kazakhstan project 'Small molecules' |
| Organisation | Ministry of education and science of the Republic of Kazakhstan |
| Country | Kazakhstan |
| Sector | Public |
| PI Contribution | One of a consortium of 4 institutions (Nazarbayev University, Kazakhstan; Cardiff University; University of Brighton and University of Oxford) |
| Collaborator Contribution | We jointly contributed scientific research to a collaborative project. Nazarbayev provided funds and two short term researchers to expedite the research. |
| Impact | Publication Kenessary et al 2012 N Biotech. originated from this, though included some input from my ongoing ESRC work. Additional publications: 1: Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7. PubMed PMID: 29041897; PubMed Central PMCID: PMC5645932. 2: Alimbetov D, Davis T, Brook AJ, Cox LS, Faragher RG, Nurgozhin T, Zhumadilov Z, Kipling D. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology. 2016 Apr;17(2):305-15. doi: 10.1007/s10522-015-9610-z. Epub 2015 Sep 23. PubMed PMID: 26400758; PubMed Central PMCID: PMC4819486. Partners on the project have now established a spin-out building on some of the findings of the project. |
| Start Year | 2011 |
| Description | Kazakhstan project 'Small molecules' |
| Organisation | University of Brighton |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | One of a consortium of 4 institutions (Nazarbayev University, Kazakhstan; Cardiff University; University of Brighton and University of Oxford) |
| Collaborator Contribution | We jointly contributed scientific research to a collaborative project. Nazarbayev provided funds and two short term researchers to expedite the research. |
| Impact | Publication Kenessary et al 2012 N Biotech. originated from this, though included some input from my ongoing ESRC work. Additional publications: 1: Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7. PubMed PMID: 29041897; PubMed Central PMCID: PMC5645932. 2: Alimbetov D, Davis T, Brook AJ, Cox LS, Faragher RG, Nurgozhin T, Zhumadilov Z, Kipling D. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology. 2016 Apr;17(2):305-15. doi: 10.1007/s10522-015-9610-z. Epub 2015 Sep 23. PubMed PMID: 26400758; PubMed Central PMCID: PMC4819486. Partners on the project have now established a spin-out building on some of the findings of the project. |
| Start Year | 2011 |
| Description | A New Dynamic of Ageing: The NDA Programme and Age UK research showcase of the decade |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | I ran three sessions: a narrated video loop explaining our research strategy, a manned stall with questionnaires to gauge understanding of biological research on ageing and to canvass opinion on research spending, and a formal presentation in session 1: Cell to Society There was significant feedback on how perceptions had altered so that many more supported the need for basic as well as translational research on ageing, and supported funds being allocated for such work. The questionnaires also showed that there was very little initial understanding of how changes to individual cells can affect whole bodies. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.newdynamics.group.shef.ac.uk/showcase.html |
| Description | Ageing Cell conference 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk at the Ageing Cell meeting at Babraham, Cambridge. Significant discussion arose both immediately after my talk with a number of national and international audience members engaged in discussion, and I was then subsequently asked by the editor of Nature Communications to prepare a manuscript based on the work for his journal (which we are doing). |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.babraham.ac.uk/the-ageing-cell |
| Description | All Party Parliamentary Group for Longevity - strategic advisory board member, also science, genomcis and technology board member |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | I have served on the APPG for Longevity strategic advisory board since its inception (I also pitched core ideas to the Department of Health concerning the science of ageing in advance of official launch of the APPG). As an SAB member, I have attended a number of meetings in parliament and in government departments, discussing how to achieves the government's stated aim of increasing legality lifespan by 5 years by 2035. We conducted a national consultation and the SAB were involved in analysing responses and coming up with an overall strategic approach to inform a National strategy on Ageing. As a member of the Science, genomics and technology board, I was asked to author a key paper for the National strategy report (see publications) |
| Year(s) Of Engagement Activity | 2019,2020 |
| URL | https://appg-longevity.org/advisory-board |
| Description | Alliance for Healthy Aging Newcastle Sept 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Major international meeting on therapeutic strategies in ageing; discussed recent findings with global research leaders and with regulatory bodies for drug licensing; discussed possible drug trial in WS with a major drug company - further work up required. |
| Year(s) Of Engagement Activity | 2015 |
| Description | BBC Radio 4 Today interview with John Humphries |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This live radio interview on recent advances in ageing research led immediately to further requests for interviews - eg Tony Blackburn on Radio Berkshire, and I recorded an interview that was then broadcast on BBC World Service Further media interviews and broadcasts resulted. |
| Year(s) Of Engagement Activity | 2013 |
| Description | BSG conference 2013 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Audience questions concerning how biologists viewed older people allowed me to correct significant misconceptions: the audience changed their minds (on the whole) from denigrating biological ageing research to to concurring that treating ageing cells was similar to treating cancer cells, and that research into mechanisms and drugs was of value. Most importantly, it started to bridge the divide between social scientists and the natural and medical sciences in attitudes towards ageing. I was asked to speak at the 'Showcase of the decade' for the NDA |
| Year(s) Of Engagement Activity | 2013 |
| Description | BSRA conference presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk on our research to the British Society for Research on Ageing annual scientific meeting in Exeter. As a result, I have entered into a collaboration on related studies with a colleague from Durham University, and am in negotiations with a colleague at Brunel re a further collaboration. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://bsra.org.uk/wp-content/uploads/2017/02/Programme_FINAL-2017.pdf |
| Description | Birmingham University talk 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | This was an invited research seminar at the University of Birmingham, and visits/discussions with interested PIs. One outcome was the offer of access to the Queen Elizabeth hospital biobank to assess whether markers identified in our studies are robust in clinical samples. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Establishment of Oxford-wide ageing hub |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The workshop brought together researchers from across the academic divisions of the university (medical sciences, maths, physical and life sciences, social sciences and humanities) to establish an Oxford ageing hub - this also included NHS representatives, public attendees and 3rd sector organisations with an interest in ageing and later life health. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Extending lifespan and healthspan - British Science Festival talk/ panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited speaker at British Science Festival, Aston, 2010 I gave one of a series of 3 talks followed by speakers acting on an expert panel. The large number of good questions to the panel after the talks demonstrated increased understanding of the topic by the audience. |
| Year(s) Of Engagement Activity | 2010 |
| Description | FUTURE OF PHARMA - ageing |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited participant in pharma workshop with major international players including politicians to discuss new ways of developing drugs to treat age-related diseases |
| Year(s) Of Engagement Activity | 2020 |
| Description | Founders Forum panellist |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presented latest updates on ageing research to audience of company founders, and answered audience QS |
| Year(s) Of Engagement Activity | 2019 |
| Description | Geroscience masterclass |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I organised, ran and presented a number of lectures at a 4 day gerosceince masterclass workshop to a group of net high worth individuals, philanthropists, business individuals and medical practitioners. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Healthy Ageing meeting, Hinxton 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk on our research at the conference, leading to discussion of future avenues of research with colleagues and the meeting organiser. |
| Year(s) Of Engagement Activity | 2018 |
| Description | How to academy talk on ageing therapies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I gave a public lecture on how to age well - new therapeutics for the How To Academy event on Longevity as part of UK's Longevity week (Nov 14th 2019) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Human accelerated ageing disorders - Carmona 2012 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Keynote address as British Council workshop on The Biology of Ageing, Carmona, Seville, March 2012 Excellent feedback from organiser |
| Year(s) Of Engagement Activity | 2012 |
| Description | International Science Festival, Edinburgh, 2015 (L. Cox) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was a member of an expert panel of three; each of us gave a talk (mine was on progeroid diseases and ageing research), followed by a open discussion in which panel members answered audience questions. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.physoc.org/press-release/2015/forever-young-can-we-cure-ageing-%E2%80%93-edinburgh-intern... |
| Description | International cell senescence association meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk on our research to a large audience of >400 international delegates. My talk sparked considerable discussion both in the questions session immediately afterwards and in break out sessions later. As a consequence I have been asked to act on the scientific advisory board of a major player in the senescence/senolytic commercial space. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.icsa2017-senescence-on-the-seine.org |
| Description | Interview with Longevity.technology |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview by Longevity.technology describing upcoming trends in ageing research, aimed mainly at investors and business. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.longevity.technology/this-isnt-all-snake-oil-interview-with-dr-lynne-cox/ |
| Description | Invited keynote at Biopharma meeting, UCL 23rd Feb 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | I gave a 1 hour invited presentation on prospects for developing new medicines for age-related diseases through understanding cellular senescence, and then sat on a discussion panel (with 2 other scientists) to take audience questions on the entire workshop. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited keynote at Molecular Pharmacology conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | International conference to provide novel information on cell senescence to bone researchers and those researching cancer biology. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://molpharmworkshop.org/download/15/molpharmcabs-2018-programme/ |
| Description | Invited speaker, CoLab international pregnancy conference Sept 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk on the role of senescence in pregnancy and pre-term birth to the International alliance on pregnancy. Outcome: changed opinions plus request to write a review for the international journal Placenta. |
| Year(s) Of Engagement Activity | 2015 |
| Description | KS 2 science topic microorganisms 2012 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two x 1 hour presentations to combined year 5/6 classes (each ~ 30 pupils) at a local primary school to extend their undertsanding of microorgansisms as covered in the KS2 science curriculum. Format: talk with demonstrations (including samples prepared in my laboratory) and an extended interactive Q/A session. Work sheets were developed for use by class teachers on microorganisms, based on my talk and demonstration. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Launch of The Health of the Nation - a Strategy for Healthier Longer Lives (report of the All Party Parliamentary Group for Longevity) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We launched the report of the APPG describing a roadmap to achieve the government's aim of 5 additional healthy years of life by 2035 (HLE+5) at a major event headlined by the Secretary of State for Health and Social Care, the Right Honourable Matt Hancock, the shadow secretary of State Jon ash worth and various other MPs from the House of Commons and House of Lords, as well as APPG advisory group members. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.youtube.com/watch?time_continue=3&v=tl7lJ1bj2lw&feature=emb_logo |
| Description | Longevity Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I was a panellist at a longevity forum event at the Royal Institution in November 2019, presenting the latest in ageing research and taking Qs from the audience. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Longevity Leaders 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | I gave a 1 hour presentation with Q+A at this major global event. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Longevity forum: science of ageing workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Supporters |
| Results and Impact | I co-oragnised and ran a one day workshop in Oxford as part of Longevity forum's longevity week (12th Nov 2019). |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://thelongevityforum.com/the-longevity-week/ |
| Description | Microbes - 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A presentation to KS2 children at a large village primary school (250 on roll) as part of their studies on microorganisms Questionnaires pre and post the presentation showed increased understanding of the topic. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Microbes - primary school presentation 2009 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | A presentation to KS2 children at a large village primary school (250 enrolled, my talk was given to 60 combined year 5 and 6 pupils) as part of their studies on microorganisms Written questionnaires supported the teacher's assessment that understanding had imporved following the presentation. |
| Year(s) Of Engagement Activity | 2009 |
| Description | OxAgeN - establishment of the Oxford Aging Network (L. Cox) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Established a network of scientists and clinicians with an interest in ageing (research and clinical practice) to foster closer collaboration and accelerate discoveries from bench to clinic. Representatives from commercial organisations and third sector (U3A, Age UK) are also members. Impact: decision to hold scientific conference on ageing in Oxford. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.imm.ox.ac.uk/ageing |
| Description | Oxford geratology clincians training day 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was invited to give a talk on molecular mechanisms of ageing plus potential novel therapeutics to a group of clinicians (up to consultant level) as part of their CPD. Feedback showed a new appreciation of the importance of understanding underlying processes in ageing and how this can lead to rational treatments. One clinician has applied to be on the organising committee of the new Oxford Ageing Network as a consequence of this visit. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Podcast on progress in ageing therapeutics |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Podcast on ageing therapies as part of longevity week in London (14th Nov 2019) |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://thelongevityforum.com/2020/01/16/podcast-with-lynne-cox-the-longevity-forum-2019/ |
| Description | Progeroid WRN in DNA replication |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited one hour lecture at UCL on my lab's research We have forged closer academic ties with UCL and the director of the Healthy Ageing Institute is coming to Oxford to viva one of my DPhil students - we hope to pursue this to form a more direct scientific collaboration if appropriate. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Radio London interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | This was a live radio interview on the monring drive time show. I am not aware of any specific follow up Not aware of any |
| Year(s) Of Engagement Activity | 2013 |
| Description | Rapamycin BBC and ITV news |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | I was interviewed for an article boradcast on ITV 6 o'clock news (and also for BBC World Service). Further media requests for interviews flooded in - inlcuding from US and Canada. |
| Year(s) Of Engagement Activity | 2009 |
| Description | Rapamycin media interviews 2009 |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Initial written responses to media queries with reporting in all major UK print press and global online coverage of commentary. The story was picked up and run by global web media and reported in many international print newspapers |
| Year(s) Of Engagement Activity | 2009 |
| Description | School outreach visit (Oxford) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | School outreach event designed to increase awareness of Oxford University undergraduate degrees, covering all subjects but with specific reference to biochemistry and medicine. I gave 2 x30 minute presentations to a local school. There were a number of questions form both students and parents after the talks. |
| Year(s) Of Engagement Activity | 2017 |
| Description | School visit and talk (The Cherwell School, Oxford) Nov 2015 (L. Cox) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk to sixth form science students on the biology of ageing; approx. 50 attendees, with many interesting questions arising. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk, British Society for Research on Ageing conference, London July 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a talk at the annual BSRA meeting which elicited significant interest including offers to collaborate from several labs on topics raised in my talk. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.bsra.org.uk/ |
| Description | Talk, International Cell Senescence Association conference, Spain, July 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Short talk at ICSA meting, plus poster presentation. Lots of questions and interest. Collaboration with colleague from London resulting from discussions at the conference that have been followed up with joint lab meetings and support for new grant proposal. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.cellsenescence.info/ |
| Description | Talk, OxAgeN meeting July 2015 (L. Cox) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific presentation at Oxford Ageing Network meeting; outcome = agreed several collaborations and in discussion with possible industrial funders |
| Year(s) Of Engagement Activity | 2015 |
| Description | The Science Show (ABC 2010) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This was a radio interview by Robyn Williams of the Australian Boradcasting Company's The Science Show. I received various emails from listeners concerning the interview afterwards Several listeners from around the world contacted me afterwards to ask further questions on progress in ageing research. |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://www.abc.net.au/rn/scienceshow/stories/2010/3027370.htm |
| Description | The ageing society and its implications - Said Business School 2010 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | This Oxford at Said seminar was dedicated to the topic of Ageing. I was one of three academics from Oxford University discussing the social, biological and ethical implications for an ageing society. A podcast was produced from this, on the Said Business School website and on iTunesU |
| Year(s) Of Engagement Activity | 2010 |
| URL | http://podcasts.ox.ac.uk/ageing-society-and-its-implications |
| Description | The biological implications of ageing - sixth form talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk to 6th form students at a large science specialist school (1800 enrolled) as part of their general studies course The school ran a formal written feedback session. Comments were very positive that the talk had stimulated much further discussion about not only the science but the ethics of ageing research. I have been asked to give the talk to sixth forms in subsequent years. I had informal feedback from the Head of Biology that it also provided a very useful role modelling for the female students to have a female academic speaking about primary research. |
| Year(s) Of Engagement Activity | 2010 |
| Description | Towards identifying the molecular drivers of cell ageing - BSRA ASM |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited talk at the British Society for Research on Ageing Annual Scientific meeting, Aston July 2012 n/a |
| Year(s) Of Engagement Activity | 2012 |
| Description | Training session for Oxford clinical geratologists |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | I gave a presentation on ageing mechanisms to clinical geratologists in the Oxfordshire area for CPD and for some, in preparation for their MRC examinations. Feedback suggested that I had shown them new ideas and ways of looking at clinical ageing with the potential for new therapies on the horizon. |
| Year(s) Of Engagement Activity | 2017 |
| Description | WRN in DNA instability and ageing |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Invited 1 hour lecture on my lab's reserch to the Genome Stability Unit, University of Sussex There was excellent feedback and discussion as a consequence of the talk. No direct collaborations have yet resulted but ideas for future projects (eg using a novel recombinogenic cell line) were discussed. |
| Year(s) Of Engagement Activity | 2012 |
| Description | What progeroid syndromes tell us about ageing - Oxford ageing Institute seminar series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited one hour lecture to Oxford Ageing Institute (audience predominantly of economists and social scientists) Feedback from organisers was very positive that the social scientists now had a much better understanding of the biological basis of ageing. I was subsequently invited to participate in outlining a bid for LLHW by the OAI |
| Year(s) Of Engagement Activity | 2012 |
| Description | iTAC consortium meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was invited to speak at the inaugural meeting of iTAC (innovative therapeutics for ageing consortium) and to collaborate with the work of the consortium in developing a rapid drug discovery/delivery platform in the UK. I have had subsequent meetings with two key people in the consortium to take plans forward. |
| Year(s) Of Engagement Activity | 2017 |