Mechanisms of neurotoxicity of amyloid aggregates
Lead Research Organisation:
University of Cambridge
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Some of the most important but unresolved questions about the pathobiology of Alzheimers disease (AD) are: What are the neurotoxic species of Abeta? How do they injure neurons? How do they induce aggregation of intracellular proteins like tau, ?-synuclein, and TDP-43? Why are the normal mechanisms for removal of these intracellular aggregation-prone proteins overwhelmed in AD? Answers to such questions will provide both insight into the early stages of disease pathogenesis, and starting points for the discovery of novel diagnostics and therapeutics.|We hypothesize that the neurotoxicity of Abeta arises from heterogeneous mixtures of|soluble Abeta aggregates, which may have differing toxicities, but which activate complex, interlinked downstream pathways. To deconvolute this complexity we will apply an integrated suite of tools from physics, chemistry, engineering, systems biology and neurobiology to: 1) Investigate Abeta aggregation and its consequences in living cells and animals; 2) Identify its molecular targets; 3) Discover the downstream metabolic and signalling pathways activated by Abeta; 4) Identify the molecular mechanisms by which Abeta induces misprocessing of tau; and 5) Identify the regulators of autophagy (which is an important physiological mechanisms for removal of tau)|and determine why autophagy is down-regulated in AD).||
Organisations
- University of Cambridge (Lead Research Organisation)
- International Collaborative Effort for DMD (Collaboration)
- Perrigo (Collaboration)
- Korea Brain Research Institute (Collaboration)
- RIKEN (Collaboration)
- Chonnam National University Hospital (CNUH) (Collaboration)
- Korea Advanced Institute of Science and Technology (KAIST) (Collaboration)
- Seoul National University (Collaboration)
- University of Toronto (Collaboration)
- University of Leuven (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
People |
ORCID iD |
| Peter St George-Hyslop (Principal Investigator) |
Publications
Ahn M
(2012)
Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.
in PloS one
Baldwin AJ
(2011)
Metastability of native proteins and the phenomenon of amyloid formation.
in Journal of the American Chemical Society
Barnett C
(2012)
Fc? receptor polymorphisms do not predict response to intravenous immunoglobulin in myasthenia gravis.
in Journal of clinical neuromuscular disease
Bartko SJ
(2014)
Different roles for M1 and M2 receptors within perirhinal cortex in object recognition and discrimination.
in Neurobiology of learning and memory
Barucker C
(2015)
Alzheimer amyloid peptide aß42 regulates gene expression of transcription and growth factors.
in Journal of Alzheimer's disease : JAD
Bean DM
(2014)
esyN: network building, sharing and publishing.
in PloS one
Belorgey D
(2011)
Characterisation of serpin polymers in vitro and in vivo.
in Methods (San Diego, Calif.)
Bento C
(2016)
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
in Nature Communications
Bernardi L
(2012)
Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy.
in Neurobiology of aging
| Description | Dementia Advisory Panel, Biomarkers for Dementia, Cabinet Office for Life Sciences |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Advised government of work on biomarkers for dementia with implications for public health and for pharmaceutical industry |
| Description | Future Health Forum |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | Health care and social impact policy. UK-Korea governments forum |
| Description | G8 Summit - Showcasing British Successes in Dementia Research |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | Showcase event described British work on dementia biomarkers, therapeutic targets, cohorts assembled by the the Dept of Health (NOCRI, NIHR) and Medical Rsearch Council.. to encourage dementia-related business investment in UK |
| Description | MRC-KHIDI signed MOU |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Description | Ministerial Advisory Group on Dementia Research |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Improved government understanding of the research needs in Alzheimer's disease setting of G8 Dementia work |
| Description | Prime Minister David Cameron's Dementia Research Champion Group |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Provided input to MRC and government officials concerning the potential interactions between academic and industrial sites in the area of Alzheimer's disease therapies. |
| Description | Research and Health Care Policy Advice |
| Geographic Reach | Europe |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Impact | Establish research oriented hospital scheme in Korea and build UK-Korea research and health care policy forum for Dementia. |
| Description | Alzheimer's Research UK |
| Amount | £30,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 12/2017 |
| Description | Alzheimer's Research UK |
| Amount | £20,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| Description | Alzheimer's Research UK equipment grant |
| Amount | £100,000 (GBP) |
| Organisation | Alzheimer's Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| Description | Bilateral Programme |
| Amount | £14,000 (GBP) |
| Organisation | Foreign Commonwealth and Development Office (FCDO) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2017 |
| Description | CIHR / China-Canada: Alzheimer's disease |
| Amount | £630,283 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2011 |
| End | 01/2015 |
| Description | CIHR / China-Canada: Alzheimer's disease |
| Amount | £630,283 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2012 |
| End | 01/2016 |
| Description | CIHR / China-Canada: Alzheimer's disease |
| Amount | $1,000,000 (CAD) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2013 |
| End | 12/2018 |
| Description | CIHR Operating Grant |
| Amount | £942,283 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2011 |
| End | 01/2016 |
| Description | CIHR Salary Support |
| Amount | £85,000 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2012 |
| End | 01/2015 |
| Description | CIHR operating grant |
| Amount | £1,153,590 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2011 |
| End | 01/2016 |
| Description | Canadian Institutes of Health Research (CIHR) |
| Amount | £619,000 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2012 |
| Description | Canadian Institutes of Health Research (CIHR) |
| Amount | £435,900 (GBP) |
| Organisation | Canadian Institutes of Health Research |
| Sector | Public |
| Country | Canada |
| Start | 01/2012 |
| Description | Collaborative Research Grant |
| Amount | £2,200,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2021 |
| Description | Elan Pharmaceuticals PhD studentship |
| Amount | £90,000 (GBP) |
| Organisation | Perrigo |
| Department | Elan Pharmaceuticals |
| Sector | Private |
| Country | Ireland |
| Start | 01/2012 |
| Description | Engineering and Physical Sciences Research Council (EPSRC) and National Physical Laboratory (NPL) |
| Amount | £302,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2010 |
| End | 01/2013 |
| Description | Frances and Augustus Newman Foundation |
| Amount | £50,000 (GBP) |
| Organisation | The Frances and Augustus Newman Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2012 |
| Description | Fund for Translational Neuroscience |
| Amount | £300,000 (GBP) |
| Organisation | Chonnam National University Hospital (CNUH) |
| Sector | Hospitals |
| Country | Korea, Republic of |
| Start | 01/2012 |
| Description | Medical Research Council (MRC) |
| Amount | £1 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 01/2013 |
| Description | National Institutes for Health (NIH) |
| Amount | £1,286,800 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 01/2012 |
| Description | National Institutes of Health Biomedical Research in Dementia |
| Amount | £4,500,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Cambridge Biomedical Research Centre |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2012 |
| End | 12/2017 |
| Description | Network of Centres of Excellence in Neurodegeneration (COEN) |
| Amount | £100,000 (GBP) |
| Organisation | Network of Centres of Excellence in Neurodegeneration (COEN) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2012 |
| Description | PrioNET |
| Amount | £311,343 (GBP) |
| Organisation | PrioNet |
| Sector | Charity/Non Profit |
| Country | Canada |
| Start | 01/2011 |
| End | 01/2013 |
| Description | SUMOylation and Amyloid-Beta Elevation |
| Amount | $2,042,362 (USD) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | 01/2012 |
| End | 12/2017 |
| Description | UK Dementia Research Institute Professorship |
| Amount | £1,500,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 12/2023 |
| Description | UK-Korea Neuroscience Symposium |
| Amount | £20,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 07/2017 |
| Description | UK-Korea Partnering Award |
| Amount | £9,800 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2016 |
| End | 04/2017 |
| Title | esyN ( Easy Networks) |
| Description | esyN - online tool designed to make building, sharing and publishing biological networks as easy as possible. Users can build networks using the templates provided and the pathways published previously. esyN is free to use and no registration is required - projects can be saved offline. Registered users can save projects online, share projects with collaborators and publish projects - all for free. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2014 |
| Provided To Others? | Yes |
| Impact | This database was launched March 2014 but the relevant paper describing it was published only in Sept 2014. Despite being very young, esyN is starting to become populated with all sorts of biological networks, especially with ones describing processes in Alzheimer's Disease and other neurodegenerative disorders. |
| URL | http://www.esyn.org/index.php |
| Description | BSI-RIKEN |
| Organisation | RIKEN |
| Department | RIKEN Brain Science Institute |
| Country | Japan |
| Sector | Public |
| PI Contribution | Collaboration with Dr Yasunori Hayashi |
| Collaborator Contribution | Collaboration with Dr Yasunori Hayashi |
| Impact | Collaboration with Dr Yasunori Hayashi |
| Start Year | 2012 |
| Description | Bristol-BSI RIKEN |
| Organisation | RIKEN |
| Department | RIKEN Brain Science Institute |
| Country | Japan |
| Sector | Public |
| PI Contribution | Electrophysiological and molecular assays in vitro. |
| Collaborator Contribution | Tau protein constructs and vivo electrophysiology |
| Impact | Kimura K., Whitcomb D.J., Jo J., Regan R., Piers T., Heo S., Brown C., Hashikawa T., Murayama M., Seok H., Sotiropoulos I., Kim E., Collingridge G.L., Takashima A. and Cho K. (2013) Microtubule associated protein tau (MAPT) is essential for long-term depression in the hippocampus. Phil. Trans. R. Soc. B 369, 2013144. |
| Start Year | 2012 |
| Description | Bristol-Chonnam Univ Hospital |
| Organisation | Chonnam National University Hospital (CNUH) |
| Country | Korea, Republic of |
| Sector | Hospitals |
| PI Contribution | Set research lab in Chonnam Nat Univ Hospital. |
| Collaborator Contribution | Molecular biology |
| Impact | Whitehead G., Jo J., Hogg E.L., Piers T.M., Kim D.H., Seaton G., Seok H., Bru-Mercier G., Son G.H., Regan P., Hildebrandt L., Waite E., Kim B.C., Kerrigan T.L., Kim K., Whitcomb D.J., Collingridge G.L., Lightman S.L., Cho K. (2013). Acute stress causes rapid synaptic insertion of Ca2+-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Brain 136, 3753-3765. Kimura K., Whitcomb D.J., Jo J., Regan R., Piers T., Heo S., Brown C., Hashikawa T., Murayama M., Seok H., Sotiropoulos I., Kim E., Collingridge G.L., Takashima A. and Cho K. (2013) Microtubule associated protein tau (MAPT) is essential for long-term depression in the hippocampus. Phil. Trans. R. Soc. B 369, 2013144. |
| Start Year | 2013 |
| Description | Bristol-IBS collaboration |
| Organisation | Korea Advanced Institute of Science and Technology (KAIST) |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | N/A |
| Collaborator Contribution | AMPA receptor shRNA constrcuts and point mutations. |
| Impact | Whitehead G., Jo J., Hogg E.L., Piers T.M., Kim D.H., Seaton G., Seok H., Bru-Mercier G., Son G.H., Regan P., Hildebrandt L., Waite E., Kim B.C., Kerrigan T.L., Kim K., Whitcomb D.J., Collingridge G.L., Lightman S.L., Cho K. (2013). Acute stress causes rapid synaptic insertion of Ca2+-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Brain 136, 3753-3765. Kimura K., Whitcomb D.J., Jo J., Regan R., Piers T., Heo S., Brown C., Hashikawa T., Murayama M., Seok H., Sotiropoulos I., Kim E., Collingridge G.L., Takashima A. and Cho K. (2013) Microtubule associated protein tau (MAPT) is essential for long-term depression in the hippocampus. Phil. Trans. R. Soc. B 369, 2013144. |
| Start Year | 2013 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Partnership with: Prof David Ron (UCAM): In vivo fluorescent lifetime imaging of a redox-sensitive green fluorescent protein tracks disulfide bond formation in the endoplasmic reticulum. Our contribution: TCSPC imaging of redox sensors Partner contribution: Sensor Design. |
| Collaborator Contribution | Partnership with: Prof David Ron (UCAM): In vivo fluorescent lifetime imaging of a redox-sensitive green fluorescent protein tracks disulfide bond formation in the endoplasmic reticulum. Our contribution: TCSPC imaging of redox sensors Partner contribution: Sensor Design. |
| Impact | Partnership with: Prof David Ron (UCAM): In vivo fluorescent lifetime imaging of a redox-sensitive green fluorescent protein tracks disulfide bond formation in the endoplasmic reticulum. Our contribution: TCSPC imaging of redox sensors Partner contribution: Sensor Design. |
| Start Year | 2012 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with James Fawcett/Maria Spillantini looking at manipulations of extracellular matrix to increase plasticity and ameliorate cognitive symptoms in mouse models of AD |
| Collaborator Contribution | Collaboration with James Fawcett/Maria Spillantini looking at manipulations of extracellular matrix to increase plasticity and ameliorate cognitive symptoms in mouse models of AD |
| Impact | Collaboration with James Fawcett/Maria Spillantini looking at manipulations of extracellular matrix to increase plasticity and ameliorate cognitive symptoms in mouse models of AD |
| Start Year | 2012 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with: Prof. Peter St George-Hyslop (UCAM): Imaging of protein aggregation in C. elegans. We performed fluorescence lifetime imaging microscopy to monitor FUS aggregation in C.Elegans and effects and to test a toxic gain of function hypothesis of FUS aggregation. Collaborator provided Reagents, Samples and defined biological Model system |
| Collaborator Contribution | Collaboration with: Prof. Peter St George-Hyslop (UCAM): Imaging of protein aggregation in C. elegans. We performed fluorescence lifetime imaging microscopy to monitor FUS aggregation in C.Elegans and effects and to test a toxic gain of function hypothesis of FUS aggregation. Collaborator provided Reagents, Samples and defined biological Model system |
| Impact | Collaboration with: Prof. Peter St George-Hyslop (UCAM): Imaging of protein aggregation in C. elegans. We performed fluorescence lifetime imaging microscopy to monitor FUS aggregation in C.Elegans and effects and to test a toxic gain of function hypothesis of FUS aggregation. Collaborator provided Reagents, Samples and defined biological Model system |
| Start Year | 2012 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Prof. Alan Tunnacliffe (UCAM): Intrinsically Disordered Proteins As molecular shields We applied the techniques developed to study amyloidogenesis in vivo to a new problem of a similar nature: chaperone activity of intrinsically disordered proteins to prevent aggregation. Collaborator provided reagents, infrastructure, and people |
| Collaborator Contribution | Collaboration with Prof. Alan Tunnacliffe (UCAM): Intrinsically Disordered Proteins As molecular shields We applied the techniques developed to study amyloidogenesis in vivo to a new problem of a similar nature: chaperone activity of intrinsically disordered proteins to prevent aggregation. Collaborator provided reagents, infrastructure, and people |
| Impact | Collaboration with Prof. Alan Tunnacliffe (UCAM): Intrinsically Disordered Proteins As molecular shields We applied the techniques developed to study amyloidogenesis in vivo to a new problem of a similar nature: chaperone activity of intrinsically disordered proteins to prevent aggregation. Collaborator provided reagents, infrastructure, and people |
| Start Year | 2012 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with: Dr. Florian Hollfelder, UCAM: Droplet Cages as a Platform for Monitoring Amyloid Aggregation. We combined our FRET aggregation assay with their droplet cages to develop a new platform to study amyloid aggregation. Collaborators developed droplet cage assay |
| Collaborator Contribution | Collaboration with: Dr. Florian Hollfelder, UCAM: Droplet Cages as a Platform for Monitoring Amyloid Aggregation. We combined our FRET aggregation assay with their droplet cages to develop a new platform to study amyloid aggregation. Collaborators developed droplet cage assay |
| Impact | Collaboration with: Dr. Florian Hollfelder, UCAM: Droplet Cages as a Platform for Monitoring Amyloid Aggregation. We combined our FRET aggregation assay with their droplet cages to develop a new platform to study amyloid aggregation. Collaborators developed droplet cage assay |
| Start Year | 2012 |
| Description | Cambridge Institute for Medical Research, University of Cambridge |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with: Prof. Christopher Dobson: Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme. We have performed superresolution imaging of human lysozyme fibrils in situ. Collaborators produced labelled human lysozyme fibrils for analysis |
| Collaborator Contribution | Collaboration with: Prof. Christopher Dobson: Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme. We have performed superresolution imaging of human lysozyme fibrils in situ. Collaborators produced labelled human lysozyme fibrils for analysis |
| Impact | Collaboration with: Prof. Christopher Dobson: Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme. We have performed superresolution imaging of human lysozyme fibrils in situ. Collaborators produced labelled human lysozyme fibrils for analysis |
| Start Year | 2012 |
| Description | Collaboration with commercial partner |
| Organisation | Perrigo |
| Department | Elan Pharmaceuticals |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Elan Pharmaceuticals |
| Collaborator Contribution | Establishment of Cambridge-Elan Centre for Research Innovation and Drug Discovery with Elan Pharmaceuticals Inc." See http://www.cam.ac.uk/research/news/cambridge-elan-centre-for-research-innovation-and-drug-discovery-launched/ for details |
| Impact | Establishment of Cambridge-Elan Centre for Research Innovation and Drug Discovery with Elan Pharmaceuticals Inc." See http://www.cam.ac.uk/research/news/cambridge-elan-centre-for-research-innovation-and-drug-discovery-launched/ for details |
| Start Year | 2012 |
| Description | Collaboration with commercial partners - Elan Pharmaceuticals |
| Organisation | Perrigo |
| Department | Elan Pharmaceuticals |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Small molecule inhibition of protein aggregation Use of Lifetime imaging to test anti aggregation compounds in live cell models of Alzheimer's disease. |
| Collaborator Contribution | Small molecule inhibition of protein aggregation Use of Lifetime imaging to test anti aggregation compounds in live cell models of Alzheimer's disease. |
| Impact | Small molecule inhibition of protein aggregation Use of Lifetime imaging to test anti aggregation compounds in live cell models of Alzheimer's disease. |
| Start Year | 2012 |
| Description | Combining light-sheet microscopy and magnetic tweezing to probe tissue mechanics in developing Embryos (Craig Russell/Richard Adams) |
| Organisation | University of Cambridge |
| Department | Virology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Live, multicolour 3D imaging of Zebrafish developing and data analysis |
| Collaborator Contribution | Biological question, provided zebrafish, bnuilt magnetic tweezer system |
| Impact | Collaboration ongoing/paper in prep Multidisciplinary: Physics, chemistry, developmental biology |
| Start Year | 2014 |
| Description | De novo design of a biologically active amyloid (Frederic Rousseau and Joost Schymkowitz) |
| Organisation | University of Leuven |
| Department | Laboratory of Angiogenesis and Vascular Metabolism |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Verification of protein colocalisation betwen designer amyloid and native protein via two colour dSTORM imaging. Analysis of colocalisation data |
| Collaborator Contribution | Synthetic amyloid design, provision of biological questions, modelling of protein misfolding and aggregation behaviour. |
| Impact | Publication: DOI:10.1126/science.aah4949 Multidisciplinary: Physics, structural biology |
| Start Year | 2015 |
| Description | Drug discovery for Alzheimer's disease, The Korea Brain Research Institute |
| Organisation | Korea Brain Research Institute |
| Country | Korea, Republic of |
| Sector | Public |
| PI Contribution | 1. Supervise full time PhD student. 2. Provide neurophysiology and tau-pathophysiology knowledge |
| Collaborator Contribution | Vivo assays from transgenic animal model of Alzheimer's disease. |
| Impact | We established bilateral candidate search (eg, Bio-informatics and muti-omic approach) |
| Start Year | 2020 |
| Description | Graham George, Jake Pushie and Stanley Prusiner |
| Organisation | University of Cambridge |
| Department | Cambridge Institute for Medical Research (CIMR) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Graham George, Jake Pushie and Stanley Prusiner to study in vivo affects of neurodegeneration on metal homeostasis using X-Ray Fluorescence (XRF) technology |
| Collaborator Contribution | Collaboration with Graham George, Jake Pushie and Stanley Prusiner to study in vivo affects of neurodegeneration on metal homeostasis using X-Ray Fluorescence (XRF) technology |
| Impact | Collaboration with Graham George, Jake Pushie and Stanley Prusiner to study in vivo affects of neurodegeneration on metal homeostasis using X-Ray Fluorescence (XRF) technology |
| Start Year | 2012 |
| Description | Korea Alzheimer's disease research consortium |
| Organisation | Seoul National University |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | UK-Korea collaboration in Neurodegeneration under the Korean Ministry of Health and Welfare. |
| Collaborator Contribution | Research tool (miRNA) |
| Impact | Lee M., Kim K., Kwon J. H., An O. B., Ryu K., Cho, K., Suh, Y. H. and Kim, H. S. (2012) An activity-regulated microRNA, miR-188, controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2. J of Neurosci 32, 5678-5687. |
| Start Year | 2012 |
| Description | Liquid droplets and phase transitions in disease (Peter St G. Hyslop) |
| Organisation | University of Cambridge |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Performed single particle tracking in wild type and mutant hydrogels formed of FUS protein. Performed high resolution experiments in axonal growth cones of FUS distribution and phase states. Used optical technique to look at FUS phase states in live cells. |
| Collaborator Contribution | Hyslop set up protein expression system, defined experiments in biological models, supplied biological materials and helped in analysis of data. |
| Impact | Successful follow on grant with WT/MRC Multidisciplinary: neuroscience, biophysics |
| Start Year | 2012 |
| Description | Multicenter international study |
| Organisation | International Collaborative Effort for DMD |
| Country | Global |
| Sector | Academic/University |
| PI Contribution | Participation in new multicenter international clinical/genetic study to assess the role of GBA mutations in Lewy Body Dementia (DLB). We demonstrated that GBA plays a large role in the genetic etiology of DLB (OR=8) (in press) |
| Collaborator Contribution | Participation in new multicenter international clinical/genetic study to assess the role of GBA mutations in Lewy Body Dementia (DLB). We demonstrated that GBA plays a large role in the genetic etiology of DLB (OR=8) (in press) |
| Impact | Participation in new multicenter international clinical/genetic study to assess the role of GBA mutations in Lewy Body Dementia (DLB). We demonstrated that GBA plays a large role in the genetic etiology of DLB (OR=8) (in press) |
| Start Year | 2012 |
| Description | Ontario Research Fund collaboration with University of Toronto |
| Organisation | University of Toronto |
| Department | Tanz Centre for Research in Neurodegenerative Diseases |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Biophysics from Cambridge, Genetics from Toronto |
| Collaborator Contribution | Reagents and concepts |
| Impact | Multidisciplinary work oin genetics and biophysics. Has led to understanding of role of clusterin in Alzheimers disease and papers published in Nature Genetics and in press in Nature Molecular and Structural Biology |
| Start Year | 2011 |
| Description | Prof. Sir David Klenerman |
| Organisation | University of Cambridge |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Neurophysiology (long-term synaptic plasticity) assay in hippocampus. |
| Collaborator Contribution | Chemical assay for microglia-mediated neurodegeneration. |
| Impact | Joint publication: 1. Hughes C., Choi M.L., Yi J-H, Kim S-C, Drews A., St.George-Hyslop P., Bryant C., Gandhi S., Cho K. and Klenerman D. (2020) Aß aggregates induce sensitised TLR4 signalling causing LTP deficit and neuronal cell death. Nature Commun Biol.3:79 |
| Start Year | 2019 |
| Description | Protein aggregation and neurotoxicity |
| Organisation | University of Cambridge |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Using different research tools, this collaboration bring together between neurophysiology and molecular imaging in living tissue |
| Collaborator Contribution | Advanced molecular imaging tool with nano-scale resolution. |
| Impact | We are preparing research manuscript to submit. |
| Start Year | 2017 |
| Description | Research groups in Korea |
| Organisation | International Collaborative Effort for DMD |
| Country | Global |
| Sector | Academic/University |
| PI Contribution | New collaborations and interactions with groups in Korea working on dementia |
| Collaborator Contribution | New collaborations and interactions with groups in Korea working on dementia |
| Impact | New collaborations and interactions with groups in Korea working on dementia |
| Start Year | 2012 |
| Description | Single molecule translation imaging in axonal growth cones (Christine Holt) |
| Organisation | University of Cambridge |
| Department | Department of Pathology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have developed a new technique for single molecule translation imaging in neuronal growth cones. |
| Collaborator Contribution | The biological system was developed in the Holt laboratory. Sample preparation and labelling strategies were developed by Holt et al. |
| Impact | Publications: DOI:10.1016/j.neuron.2015.10.030 Multidisciplinary: Developmental biology, neuroscience, biophysics |
| Start Year | 2015 |
| Description | Study with international partners |
| Organisation | International Collaborative Effort for DMD |
| Country | Global |
| Sector | Academic/University |
| PI Contribution | We organized and led a new large international study (Canada/Europe/US) that demonstrated that the C9orf72 gene is a common cause of ALS and FTD but not of AD or PD [Xi, et al, 2012 PMID:22964832]. |
| Collaborator Contribution | We organized and led a new large international study (Canada/Europe/US) that demonstrated that the C9orf72 gene is a common cause of ALS and FTD but not of AD or PD [Xi, et al, 2012 PMID:22964832]. |
| Impact | We organized and led a new large international study (Canada/Europe/US) that demonstrated that the C9orf72 gene is a common cause of ALS and FTD but not of AD or PD [Xi, et al, 2012 PMID:22964832]. |
| Start Year | 2012 |
| Description | University of Cambridge, Department of Zoolology |
| Organisation | University of Cambridge |
| Department | Department of Zoology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Collaboration with Dr. Maria Giannakou |
| Collaborator Contribution | Collaboration with Dr. Maria Giannakou |
| Impact | Collaboration with Dr. Maria Giannakou |
| Start Year | 2012 |
| Company Name | Cantabio Pharmaceuticals |
| Description | New company identify novel therapies of Parkinson and Alzheimer Disease |
| Year Established | 2015 |
| Impact | Just started |
| Website | http://www.cantabio.com/ |
| Description | 10th UK-Korea Neuroscience Symposium in London (21-22 Aug. 2017) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | UK-Korea Neuroscientists presented their updated finding and discussed how to translate these for therapeutic applications in the future. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ukorea.ac.uk/10th-uk-korea-neuroscience-symposium-21st-22nd-august-2017-the-royal-societ... |
| Description | 15 international conferences in 2016 - speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | conference presentations at internationa; meetings: Black Forest Winter Conference: "Autophagic Membrane Trafficking & Dynamics in Ageing and Disease" (Freiburg 2016), CHDI's 11th Annual Therapeutics Conference (Palm Springs 2016), International Congress of Human Genetics (Kyoto, 2016), Neuroscience School of Advanced Studies - Autophagy and neuroprotection (Cortona - lecture course 2016), International Society for Developmental Neuroscience (2016, Juan les Pins), European Neuroscience Institute 15th Anniversary Symposium (Gottingen 2016), Keystone Autophagy symposium (Whistler, 2016), Mitochondria: balancing health and disease (London 2016), Nobel conference - The Cell Cycle and Cell Death in Disease (Stockholm, 2016), Centre for Translational Cell Research opening sympiosium (Freiburg 2016), PhD graduate Symposium Cologne Graduate School of Aging Research (2016), Cold Spring Harbor meeting: Neurodegenerative Diseases: Biology & Therapeutics (Cold Spring Harbor 2016), Milner Therapeutics Institute Symposium (Cambridge 2016), 26th Annual Meeting of the Network for European CNS Transplantation & Restoration (NECTAR), Cambridge 2016) |
| Year(s) Of Engagement Activity | 2016 |
| Description | 17th European Congress of Psychiatry, Lisbon |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion afterwards. N/A |
| Year(s) Of Engagement Activity | 2009 |
| Description | 26th Neuropharmacology Conference (San Diego) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This conference discussed about the synaptic mechanisms in various brain diseases. 100 postdoctoral researchers and 100 postgraduate students were attended and more than 100 academic profession including industry. |
| Year(s) Of Engagement Activity | 2016 |
| Description | 2nd Annual Neuroscience R&D Technologies Conference (London) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | This conference aims at creating a platform for all the stakeholders to discuss, brainstorm and find answers to the ongoing question & challenges in the neuroscience research and recent advancements in neuroscience R & D technologies. |
| Year(s) Of Engagement Activity | 2016 |
| Description | 3rd Annual Neuroscience R&D Technologies Conference, London (28-29/Sep. 2017) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | More than 100 academia and industries discussed new technology and finding for Neurodegenerative disease research. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.mnmconferences.com/3rd-Annual-Neuroscience-R-D-Technologies-Conference#Speakers |
| Description | 7th International Symposium on Geriatrics and Gerontology |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | Discussion afterwards N/A |
| Year(s) Of Engagement Activity | 2011 |
| Description | Access Employment lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Lecture by Dr. Ekaterina Rogaeva to a general audience regarding her career experience as an immigrant to Canada, and pursuing a career in neuroscience. Organized by charitable organization "Access Employment". |
| Year(s) Of Engagement Activity | 2012 |
| Description | CONNECTIONS Lecture Series: Ageing Society |
| Form Of Engagement Activity | Scientific meeting (conference/symposium etc.) |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | CONNECTIONS brings prominent speakers to Cambridge University to discuss topical issues and forge new ties between people inside and outside academia. As well as being a lecture series, CONNECTIONS links Cambridge University students with senior members of academia, government and industry. This inter-disciplinary mix of people allows the exchange of ideas and creates unique networking opportunities. |
| Year(s) Of Engagement Activity | 2012 |
| Description | Dementia Showcase |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | PM Office and department of heath sponsored showcase Industrial collaboratoins |
| Year(s) Of Engagement Activity | 2012 |
| Description | Episode of Elemental Ideas on Cambridge TV 25 Minute TV show about super-resolution microscopy |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Clemens Kaminski, Gabriele Kaminski Schierle, Colin Hockings, Florian Ströhl, Nathan Curry Episode of Elemental Ideas on Cambridge TV 25 Minute TV show about super-resolution microscopy 01/07/2016 Explaining research to the public through a video of our group's lab and research work, with interviews of the two group leaders and several postdoctoral research associates and PhD students. The videos can be accessed for free online. Elemental Ideas is Cambridge TV's science magazine programme. They've produced more than 50 programmes since August 2015, covering research topics including string theory, diabetes, exoplanets, vulcanology, epigenetics and the wildlife of New Zealand. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cambridge-tv.co.uk/super-resolution-microscopy/ |
| Description | Gladstone/DZNE Workshop for Alzheimer's disease, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion afterwards. N/A |
| Year(s) Of Engagement Activity | 2012 |
| Description | Hippocampus Conference in Sicily, Italy (2-6 June 2017) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Research conference at Sicily (June 2017), more than 200 neuroscientists joined and discussed their new findings. |
| Year(s) Of Engagement Activity | 2007 |
| URL | http://hippo.euroconferences.org/program.html |
| Description | IBRO-APRC Advanced School in Korea (18-27 Oct. 2017) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | The "IBRO-APRC Advanced School" provided an interactive platform for young aspiring neuroscientists (Ph.D students, post-doctoral fellows, and junior researchers) in the Asia-Pacific region to discuss and promote their understanding of brain functions including cellular mechanisms, synaptic connections, and dynamic patterns of activity. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.kbri.re.kr/new/pages/sub/page.html?mc=3352 |
| Description | Korea-UK Alzheimer's research symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Established UK-Korea Alzheimer's disease research consortium N/A |
| Year(s) Of Engagement Activity | 2011 |
| Description | Korea-UK Symposium for Alzheimer's disease research consortium, Seoul |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion afterwards. N/A |
| Year(s) Of Engagement Activity | 2013 |
| Description | Korean TV (KBS)-Ageing and Dementia talk |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | TV presentation live programme. N/A |
| Year(s) Of Engagement Activity | 2014 |
| Description | Lectures of community leaders at the Dominion Institute |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Lectures of community leaders at the Dominion Institute (Educational program of the Provincial Government of Ontario, Canada; "Passages to Canada"). |
| Year(s) Of Engagement Activity | 2012 |
| Description | Leibniz Institute for Neurobiology Symposium for Neural Plasticity, Germany |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Discussion afterwards N/A |
| Year(s) Of Engagement Activity | 2012 |
| Description | Research exchange meeting with DAAD students |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Organised a visit (lab tours and research lectures) for German Biophysics students funded under the "Studienstiftung" programme |
| Year(s) Of Engagement Activity | 2016 |
| Description | Royal Society-Korean Ministry of Science Forum, London |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Discussion afterwards. After my talk, established IBS (Korea)- Royal Society (UK) join symposium in Korea |
| Year(s) Of Engagement Activity | 2013 |
| Description | Showcasing research to public in a hands on manner at the Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Cambridge Science Festival Showcasing research to public in a hands on manner through various experiments organised in the dept of Chemistry including looking at neurons under a microscope. Explaining the group's research to the public Undertaken by several members of the group on a yearly basis since 2016 The Science Festival provides the public with opportunities to explore and discuss issues of scientific interest and concern and to raise aspirations by encouraging young people to consider a career in science, technology, engineering or mathematics. Each year, the Festival welcomes visitors to hundreds of events and receives extensive national and local media coverage. Over 170 event coordinators organise talks, interactive demonstrations, hands-on activities, film showings and debates with the assistance of around 1,000 staff and students from departments and organisations across the University and research institutions, charities and industry in the eastern region. In addition, over 150 people volunteer their time to act as stewards to ensure visitors have a safe and enjoyable Festival experience. |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | http://www.sciencefestival.cam.ac.uk/ |
| Description | Society for Neuroscience (USA) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 250 audience attended for scientific debate, "Synaptic pathophysiology of Alzheimer's disease". |
| Year(s) Of Engagement Activity | 2016 |
| Description | Spring Hippocampus Conference, Taomina Sicily 2019 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | More than 300 Scientists joined this conference and discussed new outcome: neuronal circuit and molecular dynamics of hippocampus in physiological and pathological condition. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Superresolution public video |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Video interview and research video to explain superresolution microscopy in medical research to a lay audience. Currently >14000 views. |
| Year(s) Of Engagement Activity | 2015 |
| URL | https://www.youtube.com/watch?v=W-0GWbOFT3w |
| Description | Talk and lab tour to funders of ARUK, Feb 2016 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Engage with funders on the research carried out thanks to their donations |
| Year(s) Of Engagement Activity | 2016 |
| Description | Talk and lab tour to funders of ARUK, May 2015 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Engage with funders on the research carried out thanks to their donations |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk on A short history of Microscopy, Cambridge |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture on A short history of Microscopy |
| Year(s) Of Engagement Activity | 2017 |
| Description | The Royal Society London LTP40 meeting, London |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk sparked questions N/A |
| Year(s) Of Engagement Activity | 2013 |
| Description | Two high school lectures |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Two lectures to students at Bishop Strachan high school in Toronto |
| Year(s) Of Engagement Activity | 2012 |
| Description | UK Age Research Forum (UKARF) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | A lecture series (three lectures) given the Royal College of Physicians to lay and professional caregivers of patients with Alzheimer's. Increased attention by the lay media, and at least one visit from a sixth form school pupil. |
| Year(s) Of Engagement Activity | 2011 |
| Description | UK-JAPAN Neuroscience Symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 80 Neuroscientists and Japanese Medical Research Funding agent (AMED) and MRC attended for UK-JAPAN Symposium for Neurodegenerative disease. Formal research presentation and debate were scheduled over two days programme (5-6/March 2018) at the Royal Society London. AMED expressed their vision and strategy for collaboration with UK funding agent (eg, MRC) and they would like to put new policy and programme. |
| Year(s) Of Engagement Activity | 2008 |
| URL | https://www.eventbrite.co.uk/e/uk-japan-neuroscience-symposium-tickets-41205943085 |
| Description | UK-Korea Spring Health Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | UK-Korea Spring Health Forum was funded by FCO and Korea Ministry of Health and Welfare. This forum aims for developing medical research and healthcare policy relationship in new fields of interest. Panel discussion concluded new policy for ageing and related R&D strategy. |
| Year(s) Of Engagement Activity | 2017 |
| Description | World Presidents' Organisation educational event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | 50 Presidents of large UK corporations. Increased interest in the support for research on Alzheimer's disease. |
| Year(s) Of Engagement Activity | 2011 |