Accelerating Precision Diagnostics – Bridging the Gap
Lead Research Organisation:
University of Glasgow
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Allan KJ
(2018)
Assessment of animal hosts of pathogenic Leptospira in northern Tanzania.
in PLoS neglected tropical diseases
Cowton VM
(2018)
Predicting the Effectiveness of Hepatitis C Virus Neutralizing Antibodies by Bioinformatic Analysis of Conserved Epitope Residues Using Public Sequence Data.
in Frontiers in immunology
Davis C
(2019)
Highly Diverse Hepatitis C Strains Detected in Sub-Saharan Africa Have Unknown Susceptibility to Direct-Acting Antiviral Treatments.
in Hepatology (Baltimore, Md.)
Dennis TPW
(2022)
Target-enrichment sequencing yields valuable genomic data for challenging-to-culture bacteria of public health importance.
in Microbial genomics
Maze MJ
(2018)
Risk factors for human acute leptospirosis in northern Tanzania.
in PLoS neglected tropical diseases
Nagy B
(2018)
Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array.
in ACS sensors
Singer JB
(2019)
Interpreting Viral Deep Sequencing Data with GLUE.
in Viruses
Singer JB
(2018)
GLUE: a flexible software system for virus sequence data.
in BMC bioinformatics
Witkowska McConnell W
(2021)
Paper microfluidic implementation of loop mediated isothermal amplification for early diagnosis of hepatitis C virus
in Nature Communications
| Description | Novel molecular approaches for understanding the epidemiology of endemic anthrax |
| Amount | £303,133 (GBP) |
| Funding ID | BB/R012075/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2021 |
| Title | Loop mediated isothermal amplification as a powerful tool for early diagnosis of hepatitis C virus |
| Description | |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | https://researchdata.gla.ac.uk/1127/ |
| Title | Target-enrichment sequencing yields valuable genomic data for difficult-to-culture bacteria of public health importance |
| Description | Metadata and sequence quality metrics of Bacillus anthracis (Table A) and Mycoplasma amphoriforme (Table B) samples included in this study. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| Impact | None to date - article under review |
| URL | https://researchdata.gla.ac.uk/1249/ |
| Description | Epigenetic stratification of rheumatoid arthritis patients for response to biological Disease Modifying anti-Rheumatic Drugs |
| Organisation | Oxford BioDynamics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | University of Glasgow will determine if an Epigenetic signature can predict whether or not patients will respond to biological disease-modifying anti-rheumatic drugs (DMARDs). |
| Collaborator Contribution | Oxford BioDynamics is carrying out the array assays and providing in kind support (wet-lab and bio-statistical / bioinformatic). |
| Impact | In development |
| Start Year | 2017 |
| Description | GLUE: Software for genotyping & drug-resistance detection in a clinical setting |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Co-development of software for genotyping & drug-resistance detection in a clinical setting. |
| Collaborator Contribution | Co-development of software for genotyping & drug-resistance detection in a clinical setting. |
| Impact | Between November 2018 and April 2019 GLUE was accessed by people in 58 countries and the online analysis tool has been run over 900 times, by people from 16 countries. |
| Start Year | 2017 |
| Title | ??????????????? |
| Description | A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites (for example cholesterol and glucose) present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | CN110662957 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | Yes |
| Impact | In development |
| Title | ???????????????? |
| Description | A CMOS-based chip has one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilize paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | CN110709699 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the diffe |
| Title | METABOLITE DETECTION APPARATUS AND CORRESPONDING DETECTION METHOD |
| Description | A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites (for example cholesterol and glucose) present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | WO2018215553 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | In development |
| Title | METABOLITE DETECTION APPARATUS AND METHOD OF DETECTING METABOLITES |
| Description | A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | WO2018215554 |
| Protection | Patent granted |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | pending |
| Title | Metabolite Detection Apparatus and Method of Detecting Metabolites |
| Description | A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites (for example cholesterol and glucose) present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | GB1708338.7 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | In development |
| Title | Metabolite Detection Apparatus and Method of Detecting Metabolites |
| Description | A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | EP18729599.3 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | In development |
| Title | Metabolite Detection Apparatus and Method of Detecting Metabolites |
| Description | A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | US 16/616765 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | In development |
| Title | Metabolite Detection Apparatus and Method of Detecting Metabolites (2) |
| Description | A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites (for example cholesterol and glucose) present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | EP18736803.0 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | In development |
| Title | Metabolite Detection Apparatus and Method of Detecting Metabolites (2) |
| Description | A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | GB1708339.5 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | In development |
| Title | Validation of a sequence capture assay for homologous recombination deficiency in pancreatic cancer |
| Description | The University of Glasgow has developed the groundbreaking new Glasgow Cancer Assays - a suite of affordable, fit-for-purpose, solid and haematological cancer genomic assays, developed specifically to address the challenges of real-world oncology, both for current and emerging routine healthcare and for therapeutic development, including participant selection for clinical trials and discovering markers of response and resistance. |
| IP Reference | |
| Protection | Protection not required |
| Year Protection Granted | 2019 |
| Licensed | Yes |
| Impact | The Glasgow Cancer Assays have been licensed on a non-exclusive basis to Agilent Technologies and are currently being evaluated by NHS labs in England and Scotland. |
| Title | • Metabolite Detection Apparatus and Method of Detecting Metabolites (2) |
| Description | A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites (for example cholesterol and glucose) present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device. |
| IP Reference | US 16/616838 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | In development |
| Description | Glasgow cancer tests hold promise of more clinical trials |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC news article on the range of tests developed in Scotland that could help cancer research and see more patients accepted onto clinical trials. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/news/uk-scotland-glasgow-west-50295587 |
| Description | International Symposium for Veterinary Epidemiology and Economics (ISVEE 15), November 2018 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at ISVEE15 |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://isvee.net/ |
| Description | New 'Glasgow cancer tests' could improve access to treatments |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | STV News article on the new range of cancer tests that has been developed which scientists hope will help research of the disease and get more patients on clinical trials. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://news.stv.tv/west-central/1442135-new-glasgow-cancer-tests-could-improve-access-to-treatments... |
| Description | Presentation at HCV meeting October 2018, Dublin |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presentation at HCV 2018 to publicise and promote GLUE. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.hcv2018.com/home |
| Description | Presentation at Wellcome Genome Campus Advanced Course on Genomics and Clinical Virology, February 2019, Hinxton |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave presentation at Wellcome Genome Campus Advanced Course on Genomics and Clinical Virology. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://coursesandconferences.wellcomegenomecampus.org/our-events/genomics-and-clinical-virology-201... |
| Description | STEP FORWARD: Glasgow University develop cancer tests to improve research into the disease and boost clinical trial patient numbers |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | News article on the new range of cancer tests aimed at improving research of the disease that have been developed at the University of Glasgow. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.thescottishsun.co.uk/news/4916816/glasgow-university-cancer-test-research-patient-diseas... |