Tropical Infectious Disease Consortium: Expanding and Accelerating Product Development
Lead Research Organisation:
Liverpool School of Tropical Medicine
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
- Liverpool School of Tropical Medicine (Lead Research Organisation)
- Francis Crick Institute (Collaboration)
- University of Manchester (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Umea University (Collaboration)
- Eisai Ltd (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- AbbVie Inc (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- Ce Bioscience Ltd (Collaboration)
- Bayer (Collaboration)
- UNIVERSITY OF GLASGOW (Collaboration)
- IVCC (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- Pasteur Institute, Paris (Collaboration)
- Liverpool School of Tropical Medicine (Collaboration)
- World Vision (Collaboration)
- Genefirst Ltd. (Collaboration)
- King Abdullah University of Science and Technology (KAUST) (Collaboration)
People |
ORCID iD |
Publications
Adolfi A
(2018)
Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors.
in Current opinion in insect science
Adolfi A
(2019)
Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae.
in Proceedings of the National Academy of Sciences of the United States of America
Barrera V
(2018)
Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina.
in eLife
Camarda G
(2019)
Antimalarial activity of primaquine operates via a two-step biochemical relay.
in Nature communications
Carrington E
(2018)
In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum.
in Scientific reports
David Hong W
(2018)
Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.
in ACS medicinal chemistry letters
Edwards T
(2018)
Speciation of common Gram-negative pathogens using a highly multiplexed high resolution melt curve assay.
in Scientific reports
Hong WD
(2017)
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.
in Journal of medicinal chemistry
| Title | Rebecca Lennon Exhibition at Dilston Grove. London |
| Description | Preparing material for a video artwork installation. High resolution video footage and recordings were made of mosquitoes feeding to provide material for an abstract and poetic art film that will provide arresting imagery for projection in the converted church gallery. |
| Type Of Art | Artistic/Creative Exhibition |
| Year Produced | 2019 |
| Impact | The video footage is being prepared for the installation and still images have been provided to the LSTM without copyright to be used for teaching and communication. |
| URL | https://www.rebeccalennon.co.uk/ |
| Title | Scientific advisor to Christine Poulson to develop ideas for novel |
| Description | Novel " An air that kills" features the use of mosquitoes for murder mystery theme for a lab based plot. Advice was given on how mosquitoes are bred, tested for infection and resistance, and consultation on the scientific authenticity of scenarios discussed. |
| Type Of Art | Creative Writing |
| Year Produced | 2019 |
| Impact | Novel published by Lion Fiction worldwide in November 2019. Available from all good book stores and Amazon. currently in the top 1000 all time selling medical thrillers on Amazon |
| URL | http://www.christinepoulson.co.uk/ |
| Description | External advice to major funder with regard to antimalarial drug discovery projects 2016 to date |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Macrofilaricide Drug Accelerator (MacDA) 2015 to date |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Member of the MMV External Scientific Advisory Board 2017 to date |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | A novel bivalent vaccine to prevent both Salmonella Typhi and Paratyphi infections: preclinical proof of concept |
| Amount | £55,000 (GBP) |
| Organisation | BactiVac Network |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 08/2019 |
| Description | Confidence in concept Oxford |
| Amount | £45,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 06/2018 |
| Description | HPLC Analysis of Insecticides for new product development |
| Amount | £81,128 (GBP) |
| Funding ID | MRA 26 Project Amendment 11 |
| Organisation | IVCC |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 12/2022 |
| Description | HPLC Analysis of Insecticides for new product development |
| Amount | £94,014 (GBP) |
| Funding ID | MRA 26 Project Amendment 12 |
| Organisation | IVCC |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 12/2023 |
| Description | IVCC contract |
| Amount | £75,000 (GBP) |
| Organisation | IVCC |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2018 |
| End | 03/2019 |
| Description | IVCC project award |
| Amount | £18,000 (GBP) |
| Organisation | IVCC |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 07/2018 |
| Description | IVCC-LITE contribution |
| Amount | £10,000 (GBP) |
| Organisation | IVCC |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 05/2018 |
| Description | Innovate UK |
| Amount | £635,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Jenner Institute Investigator |
| Amount | £3,000 (GBP) |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Description | Jenner Institute Investigator |
| Amount | £3,000 (GBP) |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2019 |
| Description | Jenner Investigator award |
| Amount | £2,000 (GBP) |
| Organisation | University of Oxford |
| Department | Jenner Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2020 |
| Description | MICA: Pre-Clinical Development of a Small Molecule anti-Wolbachia Candidate Macrofilaricide Drug |
| Amount | £1,490,692 (GBP) |
| Funding ID | MR/R025401/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 02/2020 |
| Description | MRC P2D |
| Amount | £11,700 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 09/2018 |
| Description | PhD Scheme |
| Amount | £98,000 (GBP) |
| Organisation | Redx Pharma Plc |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Preemptive discovery of insecticide cross-resistance mechanisms for next generation malaria control products |
| Amount | £769,618 (GBP) |
| Funding ID | MR/V001264/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2021 |
| End | 01/2024 |
| Description | Prostaglandin I2 and endothelial function in cerebral malaria |
| Amount | $1,000,000 (USD) |
| Funding ID | 3392.02 |
| Organisation | King Abdullah University of Science and Technology (KAUST) |
| Sector | Academic/University |
| Country | Saudi Arabia |
| Start | 04/2018 |
| End | 03/2021 |
| Description | Research Grant, BMC: DPFS Full |
| Amount | £947,594 (GBP) |
| Funding ID | MR/S00467X/1 |
| Organisation | MRC Biomedical Catalyst Developmental Pathway Funding Scheme (DPFS) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2022 |
| Description | Targeting the IL-33-inflammasome axis in therapy for cerebral malaria |
| Amount | £665,875 (GBP) |
| Funding ID | MR/R010099/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 03/2021 |
| Description | UCSF |
| Amount | £36,000 (GBP) |
| Organisation | University of Oxford |
| Department | Oxford University Innovation |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 02/2019 |
| Description | WELLCOME CLINICAL PHD PROGRAMME IN GLOBAL HEALTH RESEARCH AWARD TO KATE GASKELL |
| Amount | £320,677 (GBP) |
| Funding ID | ITCRZL79 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2022 |
| Title | DHIS-2 module for MDRTB contact registration and follow-up |
| Description | With a group in India we have developed a module in DHIS-2 for tracking MDRTB exposed household contacts which is coherent with the recently launched WHO DHIS-2 tracker for TB patients |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | The tool is still being beta tested in Peru (and hopefully soon in Bhutan) and when wrinkles have been ironed out it will be available for roll-out. |
| Title | GM mosquito with novel insecticide resistance mechanism |
| Description | We have generated a GM mosquito carrying an over expressed chemosensory protein which confers resistance to pyrethroid insecticide via a novel, presumably sequestration or enhanced transport mechanism. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | This tool is made available to the IVCC to test their new range of chemicals for mosquito vector control. |
| Title | GM mosquitoes expressing specific P450s |
| Description | Generation of GM Anopheles Gambia mosquitoes over expressing specific insecticide metabolising P450s |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | Mosquitoes are being used for commercial testing of volatile compounds in a genetic background of high P450 metabolism. The work will inform policy on the use of volatile compounds for malaria control. |
| Title | Geneticaly modified mosquito line created overexpressing Glutathione S-Transferase |
| Description | We have created mosquito lines that overexpress a GST thought to be responsible for resistance to a number of insecticide classes. These can be tested against alternative novel and repurposed compounds to gauge the likelihood of resistance already in the field or that may develop rapidly against these compounds. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | To date, the tool has shown that GST can give rise to resistance to diagnostic doses of DDT. This is the first time that a direct in vivo relationship between an insecticide and a GST has been documented |
| Title | In vivo Compound Screening Using Wax Moth larvae |
| Description | We have adapted the Galleria mellonella (wax moth) larvae model for use in screening of the compound library using M. bovis BCG. This enables testing of the compounds in an in vivo model for the first time, and identifies those that have the most effective impact on survival after infection and treatment. Galleria are infected with live bacteria and subsequently treated with experimental compounds or sterile saline. Time until death is recorded, and bacterial burden is also enumerated by colony formation unit assay. We have further exploited this model for use with a fluorescent reporter strain that allows real time in vivo imaging of infection using the IVIS camera system. Furthermore, galleria can be prepared for histological analysis of the infection resolution upon successful treatment. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | 1. Confirmation of previous cell line data 2. Identification of compounds that can increase survival in an in vivo model 3. Selection fo reduced number of lead compounds for follow on experimentaiton 4. Ability to monitor kinetics of infection at a much lower (sublethal) dose via in vivo imaging |
| Title | Method to measure the immune response to typhoid toxin |
| Description | A protocol to assess the antibody response to sub-units of the typhoid toxin in animals and humans. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | Used to support an application for funding, focusing on measuring the immune response to these antigens in a large phase III trial. |
| Title | Phage display library for Wolbachia proteins |
| Description | A phage display library has been produced that covers all of the proteins in the genome of the Wolbachia endosymbiont of the human parasite, Brugia malayi. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | The phage display library will provide another method for target identification of Wolbachia, distinct from the proteomic workflow already developed. This, therefore, will provide a means for confirming protein targets. |
| Title | Recombinant enteric antigens |
| Description | Production of recombinant proteins covering 2 sub-units of the toxin of interest that can be used in immunological assays to measure the antigen-specific immune response, including in human samples |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2018 |
| Provided To Others? | No |
| Impact | Used not only in the funded project, but also to measure the antigen-specific response in human samples to understand the immunology and pathogenesis of this antigen in infection. |
| Title | Testing of endectocide compounds in artificial feeding systems |
| Description | We have developed novel assays to taste the effect of nitisinone, a tyrosine degradation inhibitor, in blood feeder insects without the use of animals. Novel methods of artificial feeding have even developed for several blood feeder insects, including tsetse flies, mosquitoes and sand flies. This methodology allows to test different drugs without the need of using experimental animals in line with the principles of the 3R (Replacement, Reduction and Refinement) |
| Type Of Material | Biological samples |
| Year Produced | 2017 |
| Provided To Others? | No |
| Impact | And described above, this new method avoids the use of animals for testing endectocides like nitisinone, which save resources and further prevent the use of experimental animals. |
| Description | Developing the mouse model for research on cerebral malaria |
| Organisation | University of Manchester |
| Department | Division of Infection, Immunity & Respiratory Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Kevin Couper is an expert on murine models of cerebral malaria but these have recently been questioned in terms of their validity for developing human studies. My group has provided access to human in vitro models of cerebral malaria and pre-publication data for transcriptional changes associated with the interaction between the malaria parasite and human endothelium. By working together we have produced better information about the murine model and have used this to identify potential therapeutic pathways. |
| Collaborator Contribution | Dr Kevin Couper - ECM model and insights into inflammation in mammalian hosts. |
| Impact | A quantitative brain map of experimental cerebral malaria pathology. Strangward P, Haley MJ, Shaw TN, Schwartz JM, Greig R, Mironov A, de Souza JB, Cruickshank SM, Craig AG, Milner DA Jr, Allan SM, Couper KN. PLoS Pathog. 2017 Mar 8;13(3):e1006267. doi: 10.1371/journal.ppat.1006267 |
| Start Year | 2017 |
| Description | Drug target deconvolution in the obligate intracellular bacterium, Wolbachia: a chemical proteomic route to discovering novel antibacterial targets |
| Organisation | AbbVie Inc |
| Country | United States |
| Sector | Private |
| PI Contribution | We have set up regular conference calls with the team at AbbVie to discuss progress and gain insight from both the chemistry and the target enabling science and technologies teams in terms of optimising the workflow. |
| Collaborator Contribution | Abbie have provide their time and expertise to advise and assist our team in the enabling science and technological approaches to optimise the workflow. |
| Impact | Recommendations for enabling science and technology platforms to optimise the workflow |
| Start Year | 2017 |
| Description | Drug target deconvolution in the obligate intracellular bacterium, Wolbachia: a chemical proteomic route to discovering novel antibacterial targets (2) |
| Organisation | Imperial College London |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided technical expertise in Wolbachia biology and medicinal chemistry as well as the associated materials to optimise and test the chemical proteomic workflow. |
| Collaborator Contribution | Our collaborators at Imperial College have provided technical expertise and training in chemical proteomic techniques, which has allowed us to further optimise and subsequently test our workflows. |
| Impact | No outputs or outcomes yet. Collaboration is multi-disciplinary including medicinal chemistry, biology and bioinformatics expertise. |
| Start Year | 2018 |
| Description | Effect of nitisinone on susceptible and insecticide-resistant Anopheline and Aedine mosquitoes |
| Organisation | Liverpool School of Tropical Medicine |
| Department | Liverpool Insect Testing Establishment |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We tested out the killing effect that tyrosine inhibitor, nitisinone, on adult mosquitoes and oviposition (egg formation). |
| Collaborator Contribution | LITE supplied all the live mosquitoes and larvae for testing nitisinone effect. |
| Impact | Vionette-Amaral, RJ, Haines, L, Rose, C, Garcia, N, Barribeau, S, Oliveira, PL, Acosta-Serrano, A (2019). Mosquito tyrosine inhibition: an eco-friendly alternative for insecticide-based vector control. (in preparation) |
| Start Year | 2018 |
| Description | Effect of tyrosine detoxification inhibitors in sandflies |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We contribute with our experience in administering the drugs to blood feeder insects and in the general experimental design. We also supplied the drug and contribute to cover the costs of these experiments, which have been done at the LSHTM facilities. |
| Collaborator Contribution | Colleagues at LSTMH has tested the lethal effect that a tyrosine degradation inhibitor has in Lutzomyia longipalpis, vector of visceral leishmaniasis in the Americas. This is one of the two Lu. longipalpis colonies in the UK. The drug works well either in blood meals or in sugar meals, which is essential for designing new types of sugar baits. These experiments have involved the training of one MSc and BSc student. |
| Impact | No outputs yet |
| Start Year | 2017 |
| Description | Eisai compounds |
| Organisation | Eisai Ltd |
| Country | Japan |
| Sector | Private |
| PI Contribution | We have developed an in vitro assay for endothelial barrier function using human primary microvascular endotheium and Plasmodium falciparum infected erythrcytes. We have already used this to screen a series of ten PAR1 modulators from Eisai Ltd, of which three have shown good inhibition of thrombin-induced endothelial barrier loss. This work is based on our long-term interest and research on malaria cytoadherence, and access to patient isolates will provide an invaluable resource to examine the breadth of the parasite/ endothelium effect. |
| Collaborator Contribution | Eisai developed a series of PAR1 modulators as potential drugs. The ten compounds that we have access to have all been through initial lead optimisation and two have entered early stage clinical trials. |
| Impact | The work is still in progress and the CIC award will allow us to test the three Eisai compounds plus two registered PAR1 inhibitors from other companies, for their ability to block endothelial barrier loss induced by the interaction with P. falciparum-infected erythrocytes. |
| Start Year | 2013 |
| Description | GeneFirst |
| Organisation | Genefirst Ltd. |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | GeneFirst and LSTM have held joint training sessions. GeneFirst have imparted their knowledge on proprietary probe design for MLPA. |
| Collaborator Contribution | We have entered into a research agreement to develop and evaluate molecular multiplex diagnostic for anti-microbial resistance and febrile illnesses. |
| Impact | training in MLPA |
| Start Year | 2017 |
| Description | Identifying resistance liabilities to new insecticides in mosquitoes that transmit urban tropical diseases |
| Organisation | IVCC |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Supervised PhD project |
| Collaborator Contribution | Envu hosted PhD student and covered PhD student fees and research costs in Germany and involved in research development; IVCC covered UK research costs and involved in research development |
| Impact | Project has just begun, too early for outputs |
| Start Year | 2022 |
| Description | International MDRTB contact e-registry to enhance surveillance and contact management, create platform for research and generate real-time observational cohort. |
| Organisation | World Vision |
| Department | World Vision Somalia |
| Country | Kenya |
| Sector | Charity/Non Profit |
| PI Contribution | The development of an electronic interface to register and maintain under follow-up the household contacts of MDRTB patients which was coherent with the electronic module for TB reporting currently in use was facilitated by both partners through a third party who developed the application. My team created the data dictionary and logic behind the registry and adapted it for the local use of the tool |
| Collaborator Contribution | The partners ensured that the tool was appropriately configured for local usage, with linguistically, sociologically and also technically compatible with the existing platform. |
| Impact | Harriet Webster, MSc in Control of Infectious Diseases student at LSHTM undertook her MSc thesis evaluating the implementation, utility and barriers to scale-up of the tool. Her thesis, highly scored, was a direct output of this collaboration; a scientific article is being prepared for submission for publication |
| Start Year | 2017 |
| Description | Metabolomics analysis of Anopheles mosquitoes treated with tyrosine degradation inhibitors |
| Organisation | University of Glasgow |
| Department | Institute of Infection, Immunity and Inflammation |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Our team carried out with all mosquitoes assays and provided samples to the polyomics facilities (UoG) for mass-spec metabolomics analysis |
| Collaborator Contribution | Non-targeted LC-MS metabolomics analysis |
| Impact | Our teams are currently preparing a manuscript based on these analyses. |
| Start Year | 2018 |
| Description | Metabolomics analysis of tsetse flies treated with tyrosine degradation inhibitors |
| Organisation | Francis Crick Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We use Glossina (tsetse fly) as a model to understand the biochemical changes induced by nitisinone, a tyrosine degradation inhibitor that kills all blood feeder (insect) vectors. We conducted a time-course experiment are we treated tsetse flies from our LSTM colony with sublethal doses of nitisinone. All the samples were processed in Liverpool and then were analysed mass-spectrometry to determine what metabolites were affected by the drug. |
| Collaborator Contribution | Collaborators at the Crick Institute processed and analysed all samples for mass spectrometry analysis, including dataset interpretation. |
| Impact | No output yet. Manuscript in preparation: Sterkel M. et al. 'Targeting tyrosine degradation as a novel vector control tool'. |
| Start Year | 2017 |
| Description | Molecular characterisation of insecticides and combination effects against mosquitoes |
| Organisation | Bayer |
| Country | Germany |
| Sector | Private |
| PI Contribution | Created and supervised PhD project |
| Collaborator Contribution | Bayer hosted PhD student and paid research costs in Germany and UK student fees, IVCC covered UK research costs |
| Impact | 4 publications - DOI's 10.1016/j.pestbp.2022.105051 10.1016/J.CRPVBD.2021.100041 https://doi.org/10.1016/j.ibmb.2022.103813 10.1016/j.pestbp.2023.105356 multidisciplinary - molecular biology, biochemistry and pharmacology of insecticide metabolism, |
| Start Year | 2018 |
| Description | Molecular characterisation of insecticides and combination effects against mosquitoes |
| Organisation | IVCC |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Created and supervised PhD project |
| Collaborator Contribution | Bayer hosted PhD student and paid research costs in Germany and UK student fees, IVCC covered UK research costs |
| Impact | 4 publications - DOI's 10.1016/j.pestbp.2022.105051 10.1016/J.CRPVBD.2021.100041 https://doi.org/10.1016/j.ibmb.2022.103813 10.1016/j.pestbp.2023.105356 multidisciplinary - molecular biology, biochemistry and pharmacology of insecticide metabolism, |
| Start Year | 2018 |
| Description | Novel Salmonella vaccine, infection model |
| Organisation | Umea University |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Our team has created novel vaccines against Salmonella Typhi and Paratyphi infections, based on a newly discovered antigen. |
| Collaborator Contribution | The partner has established an infection model using a genetically recombinant bacterial strain, allowing to investigate the protective capacity of our vaccine. |
| Impact | Work in progress, no output yet. The collaboration is multi-disciplinary: vaccinology, immunology, bacteriology, molecular bacteriology. |
| Start Year | 2018 |
| Description | Novel bivalent vaccine to prevent both Salmonella Typhi and Paratyphi infections |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have an expertise in preclinical vaccinology and designed and proposed the project and methodologies. |
| Collaborator Contribution | Our partner has demonstrated that T-cells are induced during acute typhoid and paratyphoid fever in humans against the target antigen that we are proposing (Napolitani et al., manuscript in preparation). The partner will help in characterising the response induced by the vaccine. |
| Impact | The partner provided data that support the project and the grant application. |
| Start Year | 2017 |
| Description | PHE |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Sharing protocols. |
| Collaborator Contribution | Same. |
| Impact | Ongoing. |
| Start Year | 2019 |
| Description | PHE |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Basic and applied research to be performed in vaccine development |
| Collaborator Contribution | Use or reagents and assay development. |
| Impact | TBC |
| Start Year | 2018 |
| Description | Prospective liability of novel and repurposed compounds to metabolic resistance in An. gambiae |
| Organisation | IVCC |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Produced genetically modified mosquitoes that overexpress specific P450s that confer resistance to current insecticides |
| Collaborator Contribution | Partners provide the interface to collaborate effective with multiple industrial partners to produce and test novel compounds to control vector populations. As a partnership we are testing whether these novel compounds are susceptible to metabolism by mosquitoes, and thus likely to be effective in the field. The work also tests whether related re-purposed compounds, likely to be cheaper, are as efficient as the novel compounds |
| Impact | Interim report on the first phase of compound testing. Application for further funds to expand the work to other GM mosquito lines, |
| Start Year | 2017 |
| Description | Prospective liability of novel and repurposed compounds to metabolic resistance in An. gambiae (2) |
| Organisation | Liverpool School of Tropical Medicine |
| Department | Liverpool Insect Testing Establishment |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provide screened and sexed genetically modified mosquitoes to the facility so that they can test their resistance characteristics against novel and repurposed compounds |
| Collaborator Contribution | The LITE facility commercially tests active ingredients and compounds for toxicity and repellency against a variety of mosquito species. It is supported by the IVCC in their quest to discover new compounds for malaria control. |
| Impact | First set of assays performed that have produced an interim report on relative sensitivity to compounds. |
| Start Year | 2017 |
| Description | Prospective liability of novel and repurposed compounds to metabolic resistance in An. gambiae (3) |
| Organisation | CE Bioscience Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We lead a research project examining the genetics of insecticide resistance in msoquitoes. We perform functional genetic modification to examine the role of different gene families in resistacne phenotypes, in order to develop methods and compounds to overcome this resistance. |
| Collaborator Contribution | The partners have developed a high throughput rapid screen of larval susceptibility to compounds based on image analysis of multiwell plates of larvae to monitor behaviour and death. |
| Impact | Successful application for an MRC iCASE Studentship to develop the system further. The collaboration is multidisciplinary involving biological, physiochemcal and computational analysis to provide both qualitative and quantitative analysis. |
| Start Year | 2017 |
| Description | Role of prostacyclins in cerebral malaria |
| Organisation | King Abdullah University of Science and Technology (KAUST) |
| Country | Saudi Arabia |
| Sector | Academic/University |
| PI Contribution | This partnership uses the co-culture model developed in LSTM to understand new pathways to control endothelial inflammation. |
| Collaborator Contribution | Institut Pasteur - construction of transgenic parasites for testing in co-culture models KAUST - analysis of samples and sequencing; bioinformatics |
| Impact | None available yet |
| Start Year | 2018 |
| Description | Role of prostacyclins in cerebral malaria |
| Organisation | Pasteur Institute, Paris |
| Country | France |
| Sector | Charity/Non Profit |
| PI Contribution | This partnership uses the co-culture model developed in LSTM to understand new pathways to control endothelial inflammation. |
| Collaborator Contribution | Institut Pasteur - construction of transgenic parasites for testing in co-culture models KAUST - analysis of samples and sequencing; bioinformatics |
| Impact | None available yet |
| Start Year | 2018 |
| Description | Typhoid_PK |
| Organisation | University of Oxford |
| Department | Oxford Vaccine Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have set up and run PK assays on blood collected from patients with Typhoid fever from the Oxford Typhoid Live Challenge Model |
| Collaborator Contribution | The Oxford Vaccine Group has collected and stored these samples LSTM has analysed the data Manuscript "Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model" under revision at PLoS NTDs |
| Impact | The laboratory work has now been completed and the data are being written up for publication. The Oxford group will consider whether they might use the live challenge platform for PK studies The collaborators are also considering an application for large scale PK studies using these data |
| Start Year | 2017 |
| Description | AIMday Antimicrobial resistance |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A workshop where businesses proposed their research questions to experts, creating a discussion, brainstorming and generation of novel ideas by academics / other attendees |
| Year(s) Of Engagement Activity | 2019 |
| Description | Bluedot Festival; Can malaria be eliminated from the bluedot before we reach mars? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Bluedot is an annual music/ science festival held at Jodrell Bank that attracts 12 - 15,000 people. The talk on recent advances in malaria control held in a 200 seater auditorium was near capacity and attracted a diverse audience and age range (toddlers to retired). The presentation generated a great deal of interest and questions, particularly from teenage/ early 20's people citing interests in career opportunities in tropical medicine. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.discoverthebluedot.com/profile/can-malaria-be-eliminated-from-the-blue-dot-before-we-rea... |
| Description | Elimination 8 workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Project was presented as part of a state of the art training in current entomological methods. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://malariaelimination8.org |
| Description | Engagement with Social Mobility Foundation |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Participation in presentation on the Social Mobility Foundation to discuss mentoring of young people. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Industry visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Visit to LSTM laboratories by a group of 15 scientists, business people and funders involved in the development of new products to control mosquito vectors of disease. Include small and large companies including Mitsui, BASF, Vestergaard, Syngenta, BMGF. Discussions revolved around the application of research on new diagnostic insecticide resistance probes, transgenic mosquitoes, analytical methods for quality assurance of new products, future direction of vector control reseach |
| Year(s) Of Engagement Activity | 2023 |
| Description | Institutional visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Speaker at the Helmholtz Centre for Infection Research in Braunschweig, Germany |
| Year(s) Of Engagement Activity | 2017 |
| Description | Institutional visit |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited Speaker at the University of Saarland, Saarbrucken, Germany |
| Year(s) Of Engagement Activity | 2017 |
| Description | Invited Presentation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited presentation at International Society for Neglected Tropical Diseases. Purpose was to give an overview of the project to a more general audience. This prompted networking with personnel from industry. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited Speaker: Mosquito Research - From Sensory Biology to Vector Control |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Workshop on using research into sensory biology for vector control |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk for the Translationnal Reserach Office |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | A information meeting / workshop to provide information to research scientists on translational funding schemes (application, difficulties, further funding) |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation and participation in IVCC Stakeholder meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Poster presentation and networking discussions with members of industry, policy-makers and field operatives involved in the production of new tools to control mosquitoes and malaria |
| Year(s) Of Engagement Activity | 2019 |
| Description | Romney Street Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation and debate with the Romney Street Group, |
| Year(s) Of Engagement Activity | 2020 |
| Description | School entrepreneur visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Award winning school children that had invented and trying to market novel approaches to disease control visited the dept to examine the transgenic mosquito colonies we have generated that feature in this award. |
| Year(s) Of Engagement Activity | 2018 |
| Description | School visit (St gabriels) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | A lecture at a secondary school, intended for years 13 and above (A levels). The intended purpose was to engage / teach about vaccines and how they work, how they are developped, and what is the typical job /career of a research scientist |
| Year(s) Of Engagement Activity | 2019 |
| Description | Science Fair (Big Bang North West) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Members of the team attended the Big Bang North West, which is a STEM celebration for school children and part of a programme led by EngineeringUK. Big Bang events enable young people to discover the exciting and rewarding STEM based careers available in their local area via fun, interactive activities. As a result of our participation and discussions with students and teachers, several inquiries were made to LSTM regarding participation in future events and tours. |
| Year(s) Of Engagement Activity | 2017,2018 |
| URL | https://www.allaboutstem.co.uk/ |
| Description | Science museum display |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | We have provided genetically modified mosquitoes to the National Science museum for display in the medicine galleries, to illustrate the potential for disease control. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Series of Rational Drug Discovery lectures (Undergraduate) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | To provide a better understanding how the students can translate their science / research activities to have more impact in terms of generating and developing products such as drugs, insecticides etc. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Series of rational drug discovery lectures (Post Graduate) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | To provide a better understanding how the students can translate their science / research activities to have mor eimpact in terms of generating and developing products such as drugs, insecticides etc. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Technology discussion |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | We discussed the new technology with a spin-out company under a confidentiality agreement. We have plans to submit a patent application once we have collected more data and the company may be interested in in-licensing the technology. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Visit to research facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | To provide description of the project to heads of Yunnan Institute of Parasitic Diseases to stimulate interests of future collaborations and exchange of students between Institutes |
| Year(s) Of Engagement Activity | 2017 |
| Description | Webinar for Vellore Institute of Technology, India |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | The Webinar "Preemptive discovery of insecticide cross-resistance mechanisms for next generation malaria control products" was on the invitation of the VIT Centre for Nanobiotechnology as part of the VIT-CNBT International Webinar Series. The purpose was to present the latest research being done in my group in the area of mosquito control. Around 50 people attended and there were a number of questions and discussion around the use of chemicoproteomic approaches for mapping resistance mechanisms. |
| Year(s) Of Engagement Activity | 2021 |
| Description | pyrethrum conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Gareth Lycett: invited talk - Developing a toolkit for genetic analysis and control of malarial vectors |
| Year(s) Of Engagement Activity | 2018 |
| Description | tour to Annalisa Jenkins |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Annalisa is a biotech entrepreneur, philanthropist and President of the Court of LSHTM. opportunity to demonstrate the work of the LSTM and project specifics to a key influencer of policy and donor uptake |
| Year(s) Of Engagement Activity | 2019 |
| Description | turbo talk and poster international conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | PhD student on project Beth Poulton: turbo talk and poster - Rapid, automated insecticide resistance analysis in mosquito larvae |
| Year(s) Of Engagement Activity | 2018 |
| Description | visit by Finance staff London School of Tropical Medicine and Hygiene |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Visit by the LSTMH finance dept to provide them with an overview of the research taking place in my lab and vector group to generate cross institute interest in our respective research priorities |
| Year(s) Of Engagement Activity | 2019 |
| Description | visit by Research England |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | A visit to the insectaries to discuss the work being done in the dept under funding from UKRI, and wider issues of research policy |
| Year(s) Of Engagement Activity | 2018 |
| Description | visit by fiction author |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Visit by author Christine Poulson to discuss mosquito work as a basis for a plot in forthcoming crime novel. |
| Year(s) Of Engagement Activity | 2018 |