Investigation of cortical memory circuits in normal and disease model mice using synaptic optogenetics
Lead Research Organisation:
CARDIFF UNIVERSITY
Department Name: School of Biosciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Kevin Fox (Principal Investigator) |
Publications
Okazaki H
(2018)
Calcineurin knockout mice show a selective loss of small spines.
in Neuroscience letters
Seaton G
(2020)
Dual-Component Structural Plasticity Mediated by aCaMKII Autophosphorylation on Basal Dendrites of Cortical Layer 2/3 Neurones
in The Journal of Neuroscience
| Description | Synaptic optogenetics and spine fluctuation analysis |
| Organisation | University of Tokyo |
| Department | Graduate School of Medicine |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | We have tested the novel ASPaRac1 vector for shrinking spines in mouse barrel cortex under the control of 470nm light We have contributed to ideas on spine fluctuation as a factor controlling spine size distribution. |
| Collaborator Contribution | Our collaborators have donated the ASpaRAC1 probe and expertise in getting the synaptic optogenetics method off the ground. Our collaborators have studied spine fluctuation in a calcineurin knockout. |
| Impact | A paper on spine fluctuation analysis in a calcineurin knockout. Two symposia/workshops between UK and Japan neuroscientist on the topic of advanced imaging methods for understanding psychiatric diseases. |
| Start Year | 2015 |