The findings in the project have indirectly led to a technique for remotely measuring heart sounds (as a continuation of this project). This idea was then the basis for a spin-out company, Light Hearted AI that is led by Lucrezia Cester who completed her OPhD in the research group. The RA hired on this grant is currently providing consultancy to the spin out company.EconomicHealthcare2021Our findings are being used by Syngenta in agrochemical discovery programs. To date we have supplied them with more than 70 natural products for pesticidal screening, of which 24% showed activity. We have also received financial support from the Warwick Impact Fund to further develop some of the methods we established during the course of the project and explore their commercial potential. We have participated in ICURe, leading to the award of Innovate UK funding to establish a spin out company.EconomicAgriculture, Food and Drink,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology2014The software outputs of the grant have been used by scientists at NASA (US) to understand the effects of tides on melting in greenland glaciers: Gadi, R., Rignot, E., & Menemenlis, D. (2023). Modeling ice melt rates from seawater intrusions in the grounding zone of Petermann Gletscher, Greenland. Geophysical Research Letters, 50, e2023GL105869. https://doi.org/10.1029/2023GL105869Environment2023Prediction and model development for complex surfactant systemsEconomicAgriculture, Food and Drink,Chemicals,Healthcare2022The primary research has been published in Faraday Discussions. The software development is available through the widely-available LAMMPS molecular simulation package.EconomicChemicals2014The findings of this award led to the publication: British Standard Publically Available Specification: 198 Specification for Managing Environmental Conditions for Cultural CollectionsCulturalEconomicPolicy & public servicesEducation,Energy,Culture, Heritage, Museums and Collections2012The new facility has allowed more collaboration with researchers, with 6 major collaborations, despite COVID restrictions being in force for the early period. The stated priorities have all been advanced. The issues are large and will require significant research to initiate change within the sector. The research enabled has generated 20 peer reviewed papers, with significant additional material at publication stage and four papers in press. The award of the GoGreen project funding (the proposal was strengthened by our stronger analytical capabilities from CapCo) significantly enhanced our research ability in the areas covered by the project, sustainability and preventive conservation. The award of RIO and RiCHeS funding will dramatically increase our analytical and aging capabilities and capacity to undertake research. The main research areas from the CapCo application were; • Addressing the sector debate regarding RH fluctuations causing damage to objects, significant data produced on furniture response in real environments with acoustic emission; impact on egg tempera paintings (DVS); susceptibility of stone and ceramic objects (UV/vis/NIR, environmental chambers); requirements of miniature paintings on ivory (DVS, oxygen measurement for air exchange rates, environmental chambers); ivory response (DVS, universal tester, environmental chambers); damage mechanisms of glass and enamel objects (DVS, laser displacement measurement, environmental chambers). • Investigating mould growth and treatment: DVS analyses of both dust and cardboard storage boxes have allowed understanding of moisture- RH response which drives mould growth. • Preventing damage to archaeological materials: extensive work on archaeological iron and copper alloy (oxygen measurement, DVS), clays in stone (UV/Vis/NIR), stability of archaeological glass (DVS, UV/Vis/NIR). Environmental chambers and DVS used for archaeological bone and glass PhDs. • Testing and developing damage functions: Existing damage functions for copper and silver have been tested and compared to measurements of corrosion rate. New funding delivered (GoGreen project) to provide a post to undertake this work to generate new damage functions for glasses, iron alloys and stone. International exposures underway and materials sourced. • Treatments for outdoor objects: Internship of PhD student investigating paint treatments for twentieth century artillery in facility. PhD now awarded. • Exploring storage methods, which are key to survival of stored collections: Investigations into performance and long term stability of storage boxes for archaeological iron and copper alloy, bone and glass. Investigation into performance and long term stability of silica gels (Environmental chambers, DVS, tensile tester). New methods for much more stable storage developed and protocols for storing unstable glass investigated. The performance of portable pollution filtering devices has been investigated (UV/vis/NIR). A new grant, RIO will significantly extend our abilities to measure and determine the impact of pollution on collections and also RH fluctuations. Research has also facilitated the display of mixed archaeological objects in the new exhibitions at Richborough Roman Fort, Lindisfarne Museum and Wroxeter Roman Town. Able to support these projects with extensive testing of objects proposed for display including stability of archaeological iron objects and light stability of two prints (including the Girtin discussed below). . The re-opening of Marble Hill House was supported by the trials of air curtains to reduce air impact into the newly designed visitor route with the ultrasonic air velocity equipment. The APOLLO infra-red camera is being used as part of the paintings documentation process. Over the last year, 20 paintings have either been fully treated or prepared for loan out in the English Heritage paintings conservation studio and all are now back on display in properties across the country. A further 9 paintings will return to sites over 2025/26 once treatments are complete. The enhanced pantograph studio lighting system is in use every day, and each treatment utilised other equipment acquired through this funding stream. All paintings were examined with Infrared Reflectography using the Apollo camera, this work now forming a part of our documentation process alongside standard photography with the new camera equipment. Additionally many were examined with the microscope to answer questions relating to condition or technique, the new camera set up facilitating discussion amongst colleagues as well as enhanced documentation of findings.CulturalCulture, Heritage, Museums and Collections2022To determine the isoform of PI3Ks that are best targetted in different forms of cancer. Previous dogma and much pharmaceutical investment had being based on the concept that in tumours lacking the tumour suppressor PTEN PI3Kbeta was selectively augmented and the primary therapeutic target. Part of our study showed this is untrue. This has changed biotech PI3K targetting strategy and funding. We have shown that a well known tumour suppressor (an inhibitor of tumour progression) is a PI(3,4)P2 phosphatase in addtion to its other known roles, this has important implications for cancer progression and understanding how different mutations in cancer interact and can influence therapeutic strategy. Further work flowing from this award went to show that PTEN, a human tumour suppressor and PIP3-3-phosphatase is also a PI(3,4)P2 3-phosphatase and this is important for its cellular functions and this has led to new strategies to inhibit and modulate PI3K pathway activity.EconomicHealthcare,Pharmaceuticals and Medical Biotechnology2014Cryoprotectants are widely used as components for storage of biological and pharmaceutical products at low temperatures. Understanding the physical properties of cryoprotectants like glycerol and its potential uses is therefore very advantageous in improving our understanding of important biological processes and costly industrial processes. The completed research therefore contains the future potential of exploitation for industrial benefits, whilst advancing the knowledge of areas of current interest in the fields of physical chemistry, biophysics and biochemistry and the broader scientific community. The scientific impact of the completed research is the advancement of our understanding of protein folding in relevant solvent environments as well as improving our understanding of solvent induced denaturation and protection of proteins, areas which are receiving considerable interest in the scientific community. The development of novel experimental and computational protocols has enabled us to probe this interesting system in more detail and contribute significant scientific advancement to the physics department at Leeds and the wider scientific community. The researcher working on this project, Dr Dougan, also benefited from the cross-disciplinary nature of the work, and the collaboration opportunities with the Biological Sciences school and Prof. Alan Soper at Rutherford Appleton Laboratories. Future graduate students and postdoctoral researchers at Leeds will have the opportunity to utilize the new force-clamp instrument and benefit from its unique capabilities. The knowledge and expertise gained through this project by Dr Dougan will benefit the wider biophysics community through a number of sources. by Dr Dougan on the outcomes and progress of the research. The research was disseminated through the Astbury Centre an interdisciplinary centre at Leeds for researchers interested in aspects of structural and molecular biology. This was an excellent platform with which to broadcast and propagate the work from this grant through a combination of a weekly seminar program and experimental workshops. The new research generated from this proposal played a crucial role in educating and stimulating undergraduate and postgraduate students who are interested in biophysics. The research was presented nationally through the IOP Liquids and Complex Fluids and Biological Physics groups in the form of workshops, meeting and special Institute events. In addition, the research was presented at neutron diffraction user group meetings organized by RAL and the STFC. The research was disseminated internationally through attendance of conference such as the GRC in Protein Folding and Water and Aqueous Solutions. In addition, Dr Dougan actively wrote publications to high-impact peer-reviewed journals and book chapters for specialist issues. In addition to translating this work to an academic audience, Dr Dougan optimized the wider dissemination of the research by giving educational talks at local schools and presentations and demonstrations at physics open days. This outreach will work towards improving the profile of biophysics research in the UK and in particular with junior students.CulturalSocietalEconomicAgriculture, Food and Drink,Chemicals,Energy,Environment,Healthcare2010In: Slingo, J., Davies, P., Fowler, H. 2021. Weather Advisory Task Force. Final Report, pp77. https://www.networkrail.co.uk/wp-content/uploads/2021/03/Network-Rail-Weather-Advisory-Task-Force-Final-Report.pdf Also used in many media reports and articlesSocietalEnvironment,Transport2021This has had by facilitating knowledge and skills transfer between countries. Specifically, Dr Yanzhou Zhou returned to China and continued to publish in the area.CulturalOther2010We have documented evidence (through questionnaire data and teacher comments on our learning platform) of changes in their understanding and knowledge about teaching foreign languages. This relates directly to DELTEA since we can demonstrate changes relating to the teaching of creativity, culture and empathy which were key facets of the DELTEA digital professional development. We have exemplars of teachers using our resources and creating their own resources based on DELTEA professional learning activities and we have children's responses to some of those tasks for example, how/whether they affected their sense of confidence in reading.SocietalPolicy & public servicesEducation2023The grant holder and researchers employed on the grant have highlighted the goals and outcomes of the project as part of their outreach activities including school visits, the Oxford Science festival and an event at Oxford Natural History MuseumSocietalEducation0Preliminary findings from the project were presented at a conference convened by the Local Government Association (LGA) to share findings with a broader group of local authority stakeholders to further elaborate the evidence and test its findings. These included representatives from Public Health England (PHE), LGA, elected council members and members of public health teams. Findings from this project also informed a seminar organised by University College London (UCL) Public Policy and the UCL Centre for Behaviour Change in conjunction with NICE to discuss behaviour change and implementation support at a national level - chiefly how recommendations in evidence based guidelines could be supported by guidance on implementation. The seminar was attended by implementation researchers from across the UK and representatives from PHE and NHS. Findings from this project on barriers and facilitators to public health guideline implementation were useful in framing discussion on possible structure and content of guidance on implementation.Policy & public servicesCommunities and Social Services/Policy,Healthcare,Government, Democracy and Justice20141. Political parties in Northern Ireland have requested the datasets and according to the Policy Director of one (in a written testimonial available on request and used for the REF2021 impact case study of PI Tonge and CI Shirlow) his party has "used our election surveys to shape agendas, declaring that they "impacted significantly upon our party in understanding who votes [for the party] and why highlighted the most important issues we need to address; and helped us tailor policy development and key election messages". 2. The media published our findings (e.g. led the coverage over several pages in Northern Ireland's largest circulation newspaper) and they have been extensively debated via broadcast, press and social media. The Principal Investigator has undertaken interviews (more than 1,000) with the following - in a far-from-exhaustive list: BBC News; BBC World Service; BBC Radio 4 Today and PM programmes; BBC2 Newsnight; BBC Radio 5 Live; ITN/ITV; RTE; The Guardian; The Times; New York Times; ABC Australia; German, Spanish, Belgian and Argentinian media outlets. The PI has acted as 'studio expert' for BBC NI's television coverage of recent elections and the return of Stormont. 3. The Alliance Party, Northern Ireland's largest non-unionist and non-nationalist party, agreed to a survey of its members to be undertaken by the PI, building on some of the aspects of the growth of the centre ground which featured in the election results and data findings. This formed part of a separate 'Beyond Unionism and Nationalism' ESRC project award, completed in 2023. 4. The research has been used in oral and written evidence to parliamentary committees in the UK and Ireland and citations in their reports e.g. the House of Commons Northern Ireland Affairs Committee Report , 'The effectiveness of the institutions of the Belfast/Good Friday Agreement' (2023) (cited several times re proposals for institutional reform); the Northern Ireland Ireland (Ministers, Elections and Petitions of Concern) Bill Committee (oral presentation to the committee based upon written evidence, 30 June 2021); the Oireachtas Joint Committee on the Good Friday Agreement (GFA) (oral presentation to the committee based upon written evidence on 'An examination of the Good Friday Agreement; Strand 1) 13 July 2021. The Northern Ireland Affairs Committee asked for an oral briefing covering post-GFA electoral and other developments and this was provided in November 2024. 5. The Shadow Secretary of State for Northern Ireland asked the PI to write a training programme for all Labour Party members (400,000+) on the Good Friday Agreement and its contemporary application. This resulted in four online broadcasts and the creation of an online training pack accessible to all members. 6. The Foreign, Commonwealth and Development Office requested a briefing to senior civil servants from FCDO, NIO, and Windsor Framework team on the research findings, undertaken in Feb 2024 and dialogue is ongoing. 7. The research has led to numerous public lectures/discussions/debates. These include lectures and roundtables at the John Hewitt Summer School in Armagh (2023), the Linen Hall Library in Belfast (2023); Imagine Belfast Festival (2023 and 2024); Stonyhurst Society (2022 and 2023).CulturalSocietalEconomicPolicy & public servicesCommunities and Social Services/Policy,Education,Government, Democracy and Justice2022The technique developed is presently used by us and new groups which subsequently implemented our developments to support defense and space industry product development, as well as on government funded (UK, EC, US) research programs.EconomicAerospace, Defence and Marine,Electronics,Transport2010Findings not yet used beyond academia0the top tips (as presented in key findings) have been taken forward and used by network participants in future workCulturalSocietalCommunities and Social Services/Policy,Environment2010During the course of this fellowship I led a mission proposal (submitted 2010) to ESA's M3 Call for Medium-Class missions, promoting a new mission to Uranus. Although this proposal was not successful it did attract in-kind contributions from industry (Airbus Defence and Space, and SEA Limited) in the form of technical contributions to the proposal. Proposals were submitted in 2013 for ESA's L2/L3 mission selection, and also ESA's M4 call (2015). These were ultimately unsuccessful, but again, they attracted industrial in-kind contributions in the form of technical support for preparing the mission aspect of the proposal. In 2016 NASA setup a mission study team to look at a Uranus and/or Neptune mission which (unusually) included the participation of ESA scientists and management - partly as a result of the European effort to drive a Uranus/Neptune mission forward (and which I was a lead, enabled by this fellowship). This effort has also driven measurable increases in the science publications in this area, and also raised the public profile (as indicated by popular science articles, and interviews given to journalists by myself and other European colleagues).SocietalPolicy & public servicesAerospace, Defence and Marine2016The project was part of an industry-led consortium comprising academia (funded by EPSRC) and industry (funded by TSB). The project overall resulted in a new approach where energy use data is collected by specially developed sensors and fed into a live 3D computer model of the factory that staff can consult on their PCs, enabling them to pinpoint energy wastage. The sensors also trigger text messages reminding staff to turn off lights and equipment left on unnecessarily. The approach resulted in an estimated 20% energy saving over 6 months, and was featured as a news item on the EPSRC website (7 June 2013), which also includes a link to the project's YouTube video. The lead industry partner (Moixa) is now the main one taking the results of the overall project forward, through their commercial activities.SocietalEconomicDigital/Communication/Information Technologies (including Software),Electronics,Energy2013