STFCScience and Technologies Facilities Council (STFC)Industrial systems to examine and correlation of structure with phyisico-chemical properties and modelling studies.Access to ISIS beamline, modelling and synthetic expertise.2017-01-01ZPublicUnited KingdomNo outputs to date. This is multidisciplinary research involving maths, physics, chemistry, mechanical engineering and chemical engineeringPSESiemens Process Systems Engineering LtdNA - too earlyPSE has provided us with 5 gPROMS licences which will provides us with a suitable solver for different mathematical models and allows certain optimisation to be done.2017-01-01ZPrivateUnited KingdomNA - too earlyUniversity of CambridgeUniversity of CambridgeExperimental validation of the modelling and simulation undertaken and incorporation of the models into a broader modelling framework.Equations of state with which to link the molecular scale modelling to the longer scale modelling to enable the prediction of properties for new formulation products.2017-01-01ZAcademic/UniversityUnited KingdomNo outputs as yet. This is a multi-disciplinary collaboration involving maths, chemistry, physics, mechanical engineering and chemical engineeringAreas of mutual interest for potential future collaborationInfineon TechnologiesInfineon Technologies UKUniversity, through its Centre in Advanced Fluid Engineering for Digital Manufacturing ("CAFE4DM") has expertise in the development of modelling approaches, measurements and processes to enable a significant reduction in conventional physical experimentation of complex fluids;A. Infineum has developed and/or acquired certain confidential information relating to lubricating oils, fuels and other functional fluids, chemical additives for lubricating oils, fuels and other functional fluids, and precursors to these additives;2019-01-01ZPrivateUnited KingdomNone to date.University of Liverpool - MIFUniversity of LiverpoolProvided the samples for experiments at the Materials Innovation FactoryProvided use of HTR, FTIR and NIR at Materials Innovation Factory2018-01-01ZAcademic/UniversityUnited KingdomNo outputs as yet. This is a multi-disciplinary collaboration involving maths, chemistry, physics, mechanical engineering and chemical engineering.University of ManchesterUniversity of ManchesterWe have increased the University's strategic partnership with Unilever via the Prosperity grant and this will lead to ongoing projects across the University.The University of Manchester provides 50% of the funding for our Project Manager. The University of Manchester is committed to provide funding (fees and stipend) for eight of the project's seventeen studentships; five of which have now started. The University has also provided half of the funding needed to purchase an NMR probe which is currently being installed.2017-01-01ZAcademic/UniversityUnited KingdomNA - too earlySofia University - Surfactant TheorySofia UniversityDiscussed out ideas on further development of the theory.Established collaboration with Prof. Krassimir Danov et al. Learnt about the research and experimental work being done in Sofia University.2019-01-01ZAcademic/UniversityBulgariaNone to date.Research of viscoelastic asymmetries in static mixers and research of viscoelasticUniversity of Liverpooltbctbc2022-01-01ZAcademic/UniversityUnited KingdomtbcUnileverUnileverTechnology transfer - ideas about how we will determine the structure of the complex fluids and model that structure.Technology transfer - which are the important parameters we need to look at, the components of these mixtures and concentration. They have also provided some materials.2006-01-01ZPrivateUnited KingdomNA - too earlyCPI - Collaboration on opportunities in developing a critical mass of projects and expertiseCentre for Process Innovation (CPI)Sharing information in relation to process analyticsCapacity for partners for overcoming challenges i.e. standards / simulation and data / personalisation / stability2020-01-01ZPrivateUnited KingdomNone to dateMax Planck Institute for Intelligent SystemsMax Planck SocietyMax Planck Institute for Intelligent SystemsWe contributed to the development of the DINGO framework and software for gravitational wave data analysis (https://github.com/dingo-gw/dingo). We contributed expertise in gravitational wave data analysis and machine learning techniques, as well as co-supervision of PhD students, and coordination of the DINGO collaboration.Contributed staff time (students and a research software engineer), and expertise in machine learning techniques. Also contributed time on their GPU cluster.2020-01-01ZAcademic/UniversityGermanyThis is a multi-disciplinary collaboration to use machine learning for gravitational wave data analysis. The MPI for Intelligent Systems contributes to the machine learning components. We have published several high-profile papers (in Physical Review Letters, Nature, and ML conferences such as NeurIPS, ICLR). Since the start of the award, we have published one paper in close collaboration with MPI-IS (https://www.nature.com/articles/s41586-025-08593-z). We also maintain the open-source DINGO software (https://github.com/dingo-gw/dingo).LISA ConsortiumMax Planck SocietyStephen Green is a core member of the LISA Consortium. He is a member of the Data Analysis Research and Development Working Group. He is also a member of the LISA Council.The LISA Consortium is an international collaboration for the development, in collaboration with the European Space Agency (ESA) and NASA, of the LISA mission for the measurement of gravitational waves from space. The LISA observatory is scheduled for launch in 2037.2021-01-01ZCharity/Non ProfitGermanyContributed to the White Paper "Waveform modelling for the Laser Interferometer Space Antenna" (https://doi.org/10.1007/s41114-025-00056-1) by coordinating Section 4.4 on "Perturbation theory for post-merger waveforms (quasi-normal modes)".LIGO Scientific CollaborationLIGO Scientific CollaborationWe develop the DINGO software for gravitational-wave data analysis. We have worked with members of the LIGO-Virgo-KAGRA Parameter Estimation group to evaluate these methods and explore their integration into existing analysis workflows.The LIGO-Virgo-KAGRA Collaboration operates a global network of gravitational-wave detectors and provides the observational data, analysis infrastructure, and collaborative scientific environment that enable this research. Collaboration members contribute expertise and software frameworks used to analyze gravitational-wave signals and evaluate new data analysis methods.2018-01-01ZAcademic/UniversityUnited StatesThis collaboration contributes to a large body of scientific outputs from the LIGO-Virgo-KAGRA Collaboration, including publications reporting gravitational-wave detections and astrophysical analyses. Within this context, the partnership has supported the development of new machine-learning-based data analysis methods and software tools, including the DINGO framework (https://github.com/dingo-gw/dingo).Max Planck Institute for Gravitational PhysicsMax Planck SocietyMax Planck Institute for Gravitational PhysicsWe contributed to the development of the DINGO framework and software for gravitational wave data analysis (https://github.com/dingo-gw/dingo). We also worked with members of the LIGO-Virgo-KAGRA Collaboration to evaluate DINGO within collaboration analysis workflows. Finally we provided expertise in the use of DINGO in identifying orbital eccentricity in binary black hole mergers.The partner contributed staff time to DINGO development and to analyses of observed gravitational-wave events.2020-01-01ZAcademic/UniversityGermanyThis is a multi-disciplinary collaboration, with the MPI for Gravitational Physics providing expertise on gravitational waves, and my group providing expertise on gravitational waves and machine learning. We have published a number of high profile papers (including Physical Review Letters). Since the start of the award, the main publication led by the MPI for Gravitational Physics in this area is work on eccentric mergers (https://doi.org/10.1103/vpyp-nvfp). We jointly develop the open-source DINGO software (https://github.com/dingo-gw/dingo).MPL CollabMax Planck SocietyMax Planck Institute for the Science of LightLab workFacilites2020-01-01ZAcademic/UniversityGermanyA paperResearch consortium investigating chronic wasting disease in EuropeNational Veterinary InstituteThis consortium has been funded under an Era-Net ICRAD (International coordination of research on infectious diseases) call. I am the project leader, and my research team will be involved in developing in vitro techniques to predict the effect of sequence variants found in the prion protein gene (PRNP) of British/European cervid species on susceptibility to chronic wasting disease (CWD). CWD is a prion disease similar to scrapie in sheep and BSE in cattle, that has become widespread in North America, and was identified in Norway and other Scandinavian countries since 2016. A team from the National CJD Research and Surveillance Unit in Edinburgh will also participate in analysis of the potential for cross-species transmission of CWD using in vitro assays.The Norwegian Veterinary Institute and Swedish National Veterinary Institute will collaborate in investigating the epidemiology and projected spread of CWD in Scandinavian cervid populations, and supplying material from CWD cases to other partners. FLI, INRA and NVI will contribute to PRNP genotyping of wild cervid populations in their respective countries. INIA, INRA and FLI will investigate the potential for cross-species transmission of CWD by experimental infection of transgenic mice expressing prion protein (PrP) from the respective host species (cattle, sheep, pig, human), and in vitro amplification of CWD in brain substrate from these mice. INRA will also participate in development of in vitro techniques to predict the effect of cervid PRNP sequence variants on susceptibility to CWD.2021-01-01ZPublicSwedenPMID: 34564054; DOI: https://doi.org/10.1002/2688-8319.12203 The collaboration involves scientists with expertise in a number of disciplines, including epidemiology, wildlife ecology and disease monitoring, genetics, neuropathology, prion biology (including biochemistry, cell biology in vitro assays and rodents model of disease).Pigboost consortium- UgandaMakerere UniversityThis is an Agritec catalyst funded by Innovate UK. This projects builds on the work i do in Uganda and it is based in the same districts. It aims at developing data driven solution to support sustaibable pig production in UgandaThe three members are primary contributing expertise in breeding, quantitative data management and capture, farmer landscape mapping. This work provide the dept for me to understand the factors the drive the use of antibiotics in my study areas2020-01-01ZAcademic/UniversityUgandaIt has just startedCollaboration: The dynamics of antimicrobial resistance gene prevalence on a commercial pig farm: implications for policyUniversity of EdinburghI am collaborating with data analysis of this project, which give me the opportunity to develop the bioinformatic pipelines needed for analysing my data when it comes. My first publication on AMR from pigs will be published using this data.This would primarily be computing infra-struction to process the data. It takes about 1.6TB of space to per sample through the pipeline i am using so this sort of data would require significant robust computing infrastructure2017-01-01ZAcademic/UniversityUnited KingdomBio-informatic pipelineInactivated SARS-CoV-2 for wastewater testingScottish Environment Protection AgencyGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZCharity/Non ProfitUnited KingdomImproved testing for SARS-CoV-2Genomic Epidemiology of Atlantic salmon viruses with Pharmaq (Zoetis) and a group of aquaculture production companiesSalMarGenomic epidemiology was used to investigate genetic diversity and spread of salmonid alphavirus (SAV), the causative agent of pancreas disease (PD) in Atlantic salmon. The goal was to reconstruct SAV subtype-2 (SAV2) diversity and transmission dynamics in recent Norwegian aquaculture, including the origin of SAV2 in regions where this subtype is not tolerated under current legislation. We performed nanopore sequencing on ~100 field samples from 35 farms from 10 aquaculture production regions, shared by major aquaculture producers. Using time-calibrated phylogenetics we inferred novel genetic diversity in SAV and identified strongly supported disease transmission routes, including likely anthropogenic routes of transmission. The study demonstrated useful applications of genomic epidemiology for tracking viral disease spread in aquaculture. We are continuing the partnership through a new PhD due to start in Oct 2022 co-funded by Pharmaq, and will also seek grant funding to expand the work.For the study above, Pharmaq AS - coordinated samples from industry partners and initiated the study with Sinkaberg Hansen AS. They also provided data and input to writing of manuscript reporting findings - https://www.mdpi.com/1999-4915/13/12/2549/htm Funding contributed by the following companies (in alphabetical order): Emilsen Fisk AS, Grieg Seafood ASA, Måsøval AS, Midt-Norsk Havbruk AS, Osland Havbruk AS, Pharmaq AS, Salmar ASA, and Sinkaberg Hansen AS. Samples used in the study were provided by (in alphabetical order): Alsaker Fjordbruk, Emilsen Fisk, Grieg Seafood Rogaland, Måsøval, Midt Norsk Havbruk, Mowi, Osland Havbruk, Salmar, and Salmonor2020-01-01ZPrivateNorwayPublication on above study: https://www.mdpi.com/1999-4915/13/12/2549/htm Talks given at Pharmaqademy to industry stakeholders: - https://pharmaqademy.no/ - https://pharmaqademy.no/daniel-macqueen-genomic-epidemiology-of-sav2-in-norwegian-aquaculture-from-2018-to-2020/ Follow up funding - Pharmaq supporting PhD studentship starting Oct 2022 with £68,000 cash contribution (70% of studentship cost)Developing tools for estimating AMR in developing CountriesYale UniversitySchool of Public HealthThis group has supported my UKRI- Future Leader Fellowship application. They will be providing advance training for human microbial analysis. Through this group i also have access to the largest consortia of experts on AMR in the United State https://arlg.org this networking expertise would be much needed when the next fellowship is fundedThe contribution has mainly been in Kind and mostly intellectual input for developing the next program of research2019-01-01ZHospitalsUnited StatesThis has only just started, but i have used it write an application to the Soulsby Foundation to support efforts of developing an framework for estimating AMR in developing countries (Makerere University in Uganda, Edinburgh and Cambridge University in UK and Yale University in United States)The Global Consortium for H5N8 and Related Influenza VirusesExperimental Zooprophylactic Institute of the VenezieI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicItalyPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesHungarian Academy of Sciences (MTA)Institute for Veterinary Medical Research, Centre for Agricultural ResearchI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityHungaryPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Research consortium investigating chronic wasting disease in EuropeNorwegian Veterinary InstituteThis consortium has been funded under an Era-Net ICRAD (International coordination of research on infectious diseases) call. I am the project leader, and my research team will be involved in developing in vitro techniques to predict the effect of sequence variants found in the prion protein gene (PRNP) of British/European cervid species on susceptibility to chronic wasting disease (CWD). CWD is a prion disease similar to scrapie in sheep and BSE in cattle, that has become widespread in North America, and was identified in Norway and other Scandinavian countries since 2016. A team from the National CJD Research and Surveillance Unit in Edinburgh will also participate in analysis of the potential for cross-species transmission of CWD using in vitro assays.The Norwegian Veterinary Institute and Swedish National Veterinary Institute will collaborate in investigating the epidemiology and projected spread of CWD in Scandinavian cervid populations, and supplying material from CWD cases to other partners. FLI, INRA and NVI will contribute to PRNP genotyping of wild cervid populations in their respective countries. INIA, INRA and FLI will investigate the potential for cross-species transmission of CWD by experimental infection of transgenic mice expressing prion protein (PrP) from the respective host species (cattle, sheep, pig, human), and in vitro amplification of CWD in brain substrate from these mice. INRA will also participate in development of in vitro techniques to predict the effect of cervid PRNP sequence variants on susceptibility to CWD.2021-01-01ZPrivateNorwayPMID: 34564054; DOI: https://doi.org/10.1002/2688-8319.12203 The collaboration involves scientists with expertise in a number of disciplines, including epidemiology, wildlife ecology and disease monitoring, genetics, neuropathology, prion biology (including biochemistry, cell biology in vitro assays and rodents model of disease).Inactivated SARS-CoV-2 for wastewater testingNewcastle upon Tyne Hospitals NHS Foundation TrustGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZAcademic/UniversityUnited KingdomImproved testing for SARS-CoV-2Generation of rotaviruses expressing SARS-CoV-2 peptidesUniversity of CambridgeWe engineered and characterised rotaviruses expressing SARS-CoV-2 peptides.They engineered rotaviruses expressing some different SARS-CoV-2 peptides and performed some mouse infection experiments.2020-01-01ZAcademic/UniversityUnited KingdomPaper has been circulated to co-authorsThe Global Consortium for H5N8 and Related Influenza VirusesNational Food Chain Safety OfficeVeterinary Diagnostic DirectorateI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicHungaryPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Investigation into the prevalence and aetiology of a novel form of feline meningoencephalomyelitis; 'Robotic cat' disease.University of EdinburghRoyal School of Veterinary StudiesDeep sequencing of the brains of afflicted cats.Identification of the csyndrome, identification of afflicted cats, access to brains via liaison with owners and vet practices, histology, pathology2019-01-01ZAcademic/UniversityUnited KingdomN/AThe Global Consortium for H5N8 and Related Influenza VirusesGovernment of CanadaCanadian Food Inspection Agency (CFIA)I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicCanadaPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Flemings AMR training programme UgandaUniversity of EdinburghEdinburgh Infectious DiseasesI am co-PI on an application to the Fleming's fund administered by Mott MacDonald on behalf of the UK department of Health and social care. This grant is for training AMR stakeholders in Uganda. This application is developed directly on the basis of my fellowship in UgandaEdinburgh Infectious disease is the umbrella through which the University of Edinburgh applied to become a host institution for the Fleming's fund country training programme. The mentors for the training programme for the AMR stakeholders from Uganda(Mentees) are chose from the pool of experts in the Edinburgh infectious disease umbrella2018-01-01ZAcademic/UniversityUnited KingdomWe organised a fellow's workshop in Kampala in January this year to kick start the training activities https://www.ed.ac.uk/edinburgh-infectious-diseases/news/news/edinburgh-host-fleming-fund-fellowsInactivated SARS-CoV-2 for wastewater testing20/30 LabsGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZPrivateUnited KingdomImproved testing for SARS-CoV-2The Global Consortium for H5N8 and Related Influenza VirusesFonds de la Recherche ScientifiqueI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicBelgiumPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Identification of AMR and virulence genes in Escherichia coli from cattle by high throughput microchip PCRFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES)Expertise, provision of samples for testing, data analysis and interpretation.Expertise, screening of samples through ANSES high throughput PCR facility, data analysis and interpretation.2022-01-01ZPublicFranceNo outputs yet.Inactivated SARS-CoV-2 for wastewater testingCentre For Environment, Fisheries And Aquaculture ScienceGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZPublicUnited KingdomImproved testing for SARS-CoV-2IMCAS, BeijingInstitute of MicrobiologyThis award is a formal partnership with Dr Wenjun (Frank) Liu at IMCAS Beijing, whose research component is funded by the Chinese National Natural Science Foundation.Our colleagues in China are providing input into the modelling, epidemiology and animal challenge aspects of the project2021-01-01ZPublicChinaNo outputs or outcomes yetThe Global Consortium for H5N8 and Related Influenza VirusesAnimal Health Research InstituteI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicTaiwan, Province of ChinaPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesKonkuk UniversityAvian Disease Laboratory, College of Veterninary MedicineI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityKorea, Republic ofPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Pigboost consortium- UgandaAbacusBioAbacus bio UKThis is an Agritec catalyst funded by Innovate UK. This projects builds on the work i do in Uganda and it is based in the same districts. It aims at developing data driven solution to support sustaibable pig production in UgandaThe three members are primary contributing expertise in breeding, quantitative data management and capture, farmer landscape mapping. This work provide the dept for me to understand the factors the drive the use of antibiotics in my study areas2020-01-01ZPrivateNew ZealandIt has just startedTracking Haulage in East Africa to support COVID-19 surveillaceUniversity of EdinburghSchool of Informatics EdinburghI am the Principal investigatorCo- Principal Investigator2020-01-01ZAcademic/UniversityUnited KingdomStill early staged of the projectEPIC ConsortiumJames Hutton InstituteRoslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur).The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC.2016-01-01ZAcademic/UniversityUnited KingdomMulti-institution, multi-disciplinary collaborationIdentification of interferon stimulated genes that control Neospora caninum in bovine cells.Complutense University of MadridUsing the tools from the project, specifically ISG screening protocol using fluorescent parasites, we are currently collaborating with Prof. Luis Ortega at University of Madrid to develop and bovine ISG library to screen for genes that control Neospora in bovine cells.Prof. Luis leads the veterinary apicomplexan research at University of Madrid. He's evidence variable pathogenicity of different Neospora isolates in bovine cells and developed both fluorescent and transgenic parasites and cellular phenotypes that we can use to screen for both host and parasite genes controlling Neosporosis.2023-01-01ZAcademic/UniversitySpainThe collaboration has yet to produce an output. However, there's active research going on with a PhD student from Madrid visiting Roslin Institute and we will soon have a publication - currently under preparation.The Global Consortium for H5N8 and Related Influenza VirusesHokkaido UniversityGraduate School of Veterinary MedicineI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityJapanPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesUS Geological SurveyWildlife Disease Diagnostic Laboratories Branch, National Wildlife Health CenterI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicUnited StatesPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Exchange of ASFV DNA samples for sequencingThe Pirbright InstituteSequencing of whole genome ASFV sequences from historic samples.Provision of ASFV DNA samples.2021-01-01ZAcademic/UniversityUnited KingdomASFV sequences to aid epidemiological tracing and inform mutagenesis of the virus.Collaboration with Michael GuttmanUniversity of EdinburghInformatics ForumWe are collaborating to examine the genetic basis of the capacity to cause disease- our role is to provide sequences and phylogenetic expertiseExpertise in Machine/Deep learning techniques2020-01-01ZAcademic/UniversityUnited Kingdomn/aThe Global Consortium for H5N8 and Related Influenza VirusesErasmus MCDepartment of ViroscienceI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityNetherlandsPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Inactivated SARS-CoV-2 for wastewater testingQueen's University BelfastGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZAcademic/UniversityUnited KingdomImproved testing for SARS-CoV-2A comparative platform for strain typing CWDUniversity of AlbertaThis collaboration was funded by an award from the Alberta Prion Research Institute funding scheme. The contribution made my my team was to characterise samples from CWD infected deer.Our collaborators provided us with brain material from CWD infected deer (either experimental deer or hunter harvested wild deer).2017-01-01ZAcademic/UniversityCanadaNo outcomes to dateCollaboration with the Quadram InstituteQuadram Institute BioscienceThis is a joint project with the Quadram Institute, where the lead Principal Investigator is Dr Rob Kingsley. The BBSRC contribution to our component of the project is £123,594. It is envisaged that we will evaluate the virulence of variants of Salmonella enterica serovar Typhimurium in porcine models, both to quantify the magnitude and duration of intestinal colonisation in orally challenged pigs and the ability of strains to induce secretory and inflammatory responses in a porcine surgical model.The Quadram Institute will select Salmonella strains for testing in vivo, based on analysis of their genome sequences, transcriptomes and the phenotypes of the strains in cell-based assays.2015-01-01ZAcademic/UniversityUnited KingdomNone at this stage. We await strains for testing.In vivo challenge of genome edited deltaSRCR5 pigs with PRRSV-1Genus plcFollowing the successful generation of pigs lacking domain 5 (SRCR5) of the CD163 and the promising in vitro results, showing primary cells of these pigs to be resistant against PRRSV infection we obtained further funding from Genus plc. to conduct an in vivo study. 4 delta SRCR5 pigs and 4 wild type pigs were challenged with PRRSV-1. We conducted the study and analysed the outcomes.Genus plc contributed funding to conduct the in vivo study to assess infectability of delta SRCR5 pigs with PRRSV-12016-01-01ZPrivateUnited KingdomWe published the results of this study in a scientific publication, disseminated the results in a press release package, as well as presented the work at various scientific conferences and public engagement events.Inactivated SARS-CoV-2 for wastewater testingCardiff UniversityGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZAcademic/UniversityUnited KingdomImproved testing for SARS-CoV-2Collaboration with Jose PenadesImperial College LondonEvolutionary genomic analysis of host-adaptation, lateral transductionMechanistic analysis of host-adaptation, Lateral transduction2012-01-01ZAcademic/UniversityUnited KingdomNumerous publicationsCentre for tropical livestock genetics and health (CTLGH)Scotland's Rural CollegeMick Watson is co-leading programme 5 (informatics and bioresources) programme of CTLGH which aims to collect data on genotype and phenotype into a central database which can subsequently be mined for useful associations. So far we have ensured that scientists have access to the latest high performance computing environment for research, we have analysed and continue to analyse hundreds of farm animal genomes from LMIC countries, and we have built the data portal (http://data.ctlgh.org)The partners are involved in all programmes, which include:Program 1: Harnessing genetic variability among indigenous and exotic breeds of cattle (as well as their crosses) to develop genetic and genomic tools that will be used to improve productivity under harsh tropical conditions and to mitigate the impact of cattle on climate change. Program 2: Harnessing genetic variability in tropical productivity and adaptation among various breeds of Chickens. Program 3: Development and application of precision breeding (through novel reproductive and germplasm technologies) to achieve step changes in livestock genetic improvement. Program 4: Understanding the genetic and molecular mechanisms underlying the tolerance of certain cattle and poultry breeds to tropical diseases and pests. Program 5: A shared global data and biological sample resource to support continued research and development on tropical livestock genetics and health.2016-01-01ZAcademic/UniversityUnited KingdomThe data portal so far: http://data.ctlgh.org The collaboration is multi-disciplinary, bringing together geneticists, parasitologists, virologists, epidemiologists and data scientists together.The Global Consortium for H5N8 and Related Influenza VirusesUniversity of OxfordCentre for Tropical Medicine and Global HealthI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZHospitalsUnited KingdomPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesWageningen University & ResearchDepartment of Virology, Central Veterinary InstituteI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityNetherlandsPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Inactivated SARS-CoV-2 for wastewater testingBangor UniversityGeneration of inactivated SARS-CoV-2 virus for wastewater testing.Information2020-01-01ZAcademic/UniversityUnited KingdomImproved testing for SARS-CoV-2Knowledge exchange and primers for ASFV sequencingSokoine University of AgricultureSupport with ASFV sequencing and analysis.Archived ASFV samples sequenced at location.2022-01-01ZAcademic/UniversityTanzania, United Republic ofASFV sequences to aid epidemiological tracing and inform mutagenesis of the virus.Influence of chronic stress condition on neuroinvasion of prions and progression of prion diseaseHokkaido UniversityI was personally approached by Prof. Masaaki Murakami and Asso. Prof. Rie Hasebe at the Institute for Genetic Medicine at Hokkaido University, Sapporo, Japan to collaborate on a study to determine the influence of chronic stress condition on neuroinvasion of prions and progression of prion disease. I contributed my expertise in the study of oral prion disease pathogenesis and designed a series of in vivo studies to address the projects main aims. I also provided bioinformatics expertise and taught Asso. Prof. Rie Hasebe how to perform meta-analyses of multiple mRNA-seq data sets. During my visit I also gave an international seminar at Hokkaido University Medical School.The Japanese partners, Prof. Masaaki Murakami and Asso. Prof. Rie Hasebe hosted my visit to their department at Hokkaido University. This lab will also provide the funding and consumables and conduct the in vivo experiments.2019-01-01ZAcademic/UniversityJapanAs a consequence of this collaboration, a General Joint Research Program grant was submitted to the Institute for Genetic Medicine, Hokkaido University. The aim of the project was to study the influence of chronic stress condition on neuroinvasion of prions and progression of prion disease. This application was successful and we received JPY 650,000 (approx. £5000).The Global Consortium for H5N8 and Related Influenza VirusesHokkaido UniversityResearch Center for Zoonosis ControlI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityJapanPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesNational Veterinary InstituteI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicSwedenPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesU.S. Department of Agriculture USDANational Veterinary Services Laboratories, Veterinary Services, AmesI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicUnited StatesPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852A partnership to create a One health Living laboratory in UgandaMakerere University College of Health SciencesI have designed the project and invited the collaborative partners, this has emerged out of my BBSRC work interacting with farmers and their animals. We are propose to develop dedicated one health research similar to what we have for global health. We have received pilot funding from Edinburgh global through the Edinburgh-Africa partnerships call. This will bring together three research an training centres at Makerere University and three centres at Edinburgh UniversityOur partners own a health and demographic surveillance site that they have been managing since 2005. It has 100,000 individuals and it is this that will become the site for one health research. This is their contribution and of course the facilities we use for research ,most importantly the collaboration is fundamentally anchored on co-designing the centres have provided expertise in how this idea can and will be tested and implement elsewhere2023-01-01ZAcademic/UniversityUgandaWe have conducted several workshops including the most recent on Nanopore sequencing: https://digital-one-health.github.io/doh-ont-workshopScotland's Rural College, Epidemiology UnitScotland's Rural CollegeInverness Veterinary CentreLaboratory investigations, data analysis and interpretation, sharing of results, generation of publications.Sample and epidemiological metadata provision, expertise.2015-01-01ZAcademic/UniversityUnited Kingdomdoi: 10.3389/fvets.2021.755833. PMID: 34778436; PMCID: PMC8585936. doi: 10.1128/AEM.03142-20. PMID: 33712425; PMCID: PMC8117755.Collaboration with Texas Tech UniversityTexas Tech UniversityPartner in this BBSRC US-UK Partnering Award related to Salmonella and E. coli infections in food-producing animals.We hosted a visiting postdoctoral research fellow (Marie Bugarel from TTU) in 2015 and provided training in methods to study the basis of Salmonella virulence (inc. mutagenesis, cell-based assays & in vivo models). Drs Bugarel and Loneragan were co-authors on our manuscript describing the use of massively-parallel sequencing of polymorphic alleles to track the fate of Salmonella enterica serovars following inoculation of cattle.2014-01-01ZAcademic/UniversityUnited StatesA manuscript relating to a novel method to follow the fate of Salmonella enterica serovars during mixed infections was published in Applied and Environmental Microbiology in late 2017. This arose, in part, from the collaboration funded by a BBSRC US-UK partnering award (see tools), with resources from BBSRC- and Zoetis-funded project (BB/K015524/1) and core strategic grants to the Roslin Institute awarded in 2012 and 2017.Genomic Epidemiology of Atlantic salmon viruses with Pharmaq (Zoetis) and a group of aquaculture production companiesPharmaqGenomic epidemiology was used to investigate genetic diversity and spread of salmonid alphavirus (SAV), the causative agent of pancreas disease (PD) in Atlantic salmon. The goal was to reconstruct SAV subtype-2 (SAV2) diversity and transmission dynamics in recent Norwegian aquaculture, including the origin of SAV2 in regions where this subtype is not tolerated under current legislation. We performed nanopore sequencing on ~100 field samples from 35 farms from 10 aquaculture production regions, shared by major aquaculture producers. Using time-calibrated phylogenetics we inferred novel genetic diversity in SAV and identified strongly supported disease transmission routes, including likely anthropogenic routes of transmission. The study demonstrated useful applications of genomic epidemiology for tracking viral disease spread in aquaculture. We are continuing the partnership through a new PhD due to start in Oct 2022 co-funded by Pharmaq, and will also seek grant funding to expand the work.For the study above, Pharmaq AS - coordinated samples from industry partners and initiated the study with Sinkaberg Hansen AS. They also provided data and input to writing of manuscript reporting findings - https://www.mdpi.com/1999-4915/13/12/2549/htm Funding contributed by the following companies (in alphabetical order): Emilsen Fisk AS, Grieg Seafood ASA, Måsøval AS, Midt-Norsk Havbruk AS, Osland Havbruk AS, Pharmaq AS, Salmar ASA, and Sinkaberg Hansen AS. Samples used in the study were provided by (in alphabetical order): Alsaker Fjordbruk, Emilsen Fisk, Grieg Seafood Rogaland, Måsøval, Midt Norsk Havbruk, Mowi, Osland Havbruk, Salmar, and Salmonor2020-01-01ZPrivateNorwayPublication on above study: https://www.mdpi.com/1999-4915/13/12/2549/htm Talks given at Pharmaqademy to industry stakeholders: - https://pharmaqademy.no/ - https://pharmaqademy.no/daniel-macqueen-genomic-epidemiology-of-sav2-in-norwegian-aquaculture-from-2018-to-2020/ Follow up funding - Pharmaq supporting PhD studentship starting Oct 2022 with £68,000 cash contribution (70% of studentship cost)Collaboration with USDA NebraskaU.S. Department of Agriculture USDAExchange of STEC sequence information. Analysis of PacBio long read sequencing of human and cattle isolatesExchange of STEC sequence information. Carrying out of PacBio sequencing. Discussion of feedlot trials for E. coli O157 vaccine2014-01-01ZPublicUnited StatesPublications are provided in main listResearch consortium investigating chronic wasting disease in EuropeFriedrich Loeffler InstituteThis consortium has been funded under an Era-Net ICRAD (International coordination of research on infectious diseases) call. I am the project leader, and my research team will be involved in developing in vitro techniques to predict the effect of sequence variants found in the prion protein gene (PRNP) of British/European cervid species on susceptibility to chronic wasting disease (CWD). CWD is a prion disease similar to scrapie in sheep and BSE in cattle, that has become widespread in North America, and was identified in Norway and other Scandinavian countries since 2016. A team from the National CJD Research and Surveillance Unit in Edinburgh will also participate in analysis of the potential for cross-species transmission of CWD using in vitro assays.The Norwegian Veterinary Institute and Swedish National Veterinary Institute will collaborate in investigating the epidemiology and projected spread of CWD in Scandinavian cervid populations, and supplying material from CWD cases to other partners. FLI, INRA and NVI will contribute to PRNP genotyping of wild cervid populations in their respective countries. INIA, INRA and FLI will investigate the potential for cross-species transmission of CWD by experimental infection of transgenic mice expressing prion protein (PrP) from the respective host species (cattle, sheep, pig, human), and in vitro amplification of CWD in brain substrate from these mice. INRA will also participate in development of in vitro techniques to predict the effect of cervid PRNP sequence variants on susceptibility to CWD.2021-01-01ZAcademic/UniversityGermanyPMID: 34564054; DOI: https://doi.org/10.1002/2688-8319.12203 The collaboration involves scientists with expertise in a number of disciplines, including epidemiology, wildlife ecology and disease monitoring, genetics, neuropathology, prion biology (including biochemistry, cell biology in vitro assays and rodents model of disease).Collaboration on salmonid virus genomicsZoetisPHARMAQ ASAnalysis of salmonid virus genomes to understand disease transmission and for strain/subtype diagnosticsMarine Scotland - co-supervision of PhD, sample and data provision, intellectual input PHARMAQ AS - sample provision, intellectual input2017-01-01ZPrivateNorwayIn processEPIC ConsortiumBiomathematics and Statistics Scotland (BioSS)Roslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur).The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC.2016-01-01ZPublicUnited KingdomMulti-institution, multi-disciplinary collaborationThe Global Consortium for H5N8 and Related Influenza VirusesUtrecht UniversityDepartment of Farm Animal HealthI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityNetherlandsPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesChinese Academy of Agricultural SciencesHarbin Veterinary Research Institute (HVRI)I performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicChinaPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Silva Holtfreter- Host-adaptation by murine Staphylococcus aureusUniversity of GreifswaldPhylogenetic and sequence analysisFunctional analysis2020-01-01ZAcademic/UniversityGermanyPloS Pathogens publicationThe Global Consortium for H5N8 and Related Influenza VirusesUniversity Libre Bruxelles (Université Libre de Bruxelles ULB)Spatial Epidemiology LaboratoryI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityBelgiumPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesAnimal and Plant Quarantine AgencyI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicKorea, Republic ofPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852The Global Consortium for H5N8 and Related Influenza VirusesUniversity of OxfordDepartment of ZoologyI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZAcademic/UniversityUnited KingdomPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Collaboration ANSESFrench Agency for Food, Environmental and Occupational Health & Safety (ANSES)My research team will work in the ANSES laboratories to set up organotypic avian cultures (intestinal organoids) of chicken, turkey and Guinea fowl which will be a unique opportunity. The organoids will then be infected with a variety of coronaviruses and avian influenza viruses (low and high pathogenic) and the viral replication will be analysed at different time points post infection. The RNA will be isolated and transported back to the UK to investigate the species specific immune responses using a high throughput qPCR array. The Roslin team will train the scientist at ANSES how to culture organoids whereas the team at ANSES will train the ECRs in virological techniques and working in a high containment laboratory.The team at ANSES will contribute a lot of staff time, the animals, and will do the infection experiment in their high containment laboratory. In addition they will analyse the virus replication (RT-qPCR, egg titration and plaque assays) and we will write a joined publication describing the outcomes of this collaborative project. The data will feed in to many other projects related to avian corona and avian influenza viruses that are ongoing in the Vervelde group.2022-01-01ZPublicFranceA collaborative project with ANSES, Ploufragan laboratory (reference lab for avian influenza), was initiated and funded by the BBSRC mitigation fund. This is a multidisciplinary collaboration in which the Roslin ECRs and PI will contribute their expertise in organotypic avian cultures (organoids) and the team at ANSES will contribute their virological expertise, the capacity to work with highly pathogenic avian influenza and their access to poultry species that we do not have in the U.K. (including guinea fowl, SPF turkeys and SPF ducks). The output of this collaboration will be joined peer reviewed publications on on host specific viral entry and immune responses (avian corona viruses and avian influenza viruses), preliminary data for follow on funding and future access to a wealth of virus strains and high containment laboratory and animal facilities.Daniel Perez, University of GeorgiaUniversity of GeorgiaThis grant is a joint programme with the USA component directly funded by the USDA, with money going to colleagues (Dr Daniel Perez) at the University of Georgia and The USDA SEPRL lab (Dr Darrell Kapcyznski).Dr Perez primarily contributes to the animal challenge and viral evolution experiments2021-01-01ZAcademic/UniversityUnited StatesNone yetCollaboration with Frank AarestrupTechnical University of DenmarkAnalysis of Danish S. aureus genome sequencesProvision of bacterial isolates2018-01-01ZAcademic/UniversityDenmarkPaper in preparationCollaboration with AB VistaAB VistaWe are researching the activity of ovodefensins, naturally-occurring egg peptides with antimicrobial properties. With BBSRC LINK funding we are exploring the activity of diverse ovodefensins from multiple avian species, dissecting their structure and mode of action, and exploring their capacity to act as growth promoters and novel therapeutics.AB Vista have made a substantial cash contribution to the LINK project (c. £460k) and also provide access to natural populations of broilers for feed trials using diets supplemented (or not) with Trichoderma-expressed ovodefensins. They also support analysis of the impact of such diets on intestinal microbiota and metabolites.2012-01-01ZPrivateUnited KingdomCommercially sensitive and to be disclosed following scrutiny for Intellectual Property.Fleming Fellowship partnership for MalawiGovernment of MalawiThis collaboration, is similar to the one in Uganda. The application that attracted these funds is build on the one in Uganda which was developed around my fellowship. I am the deputy director for these fellowships at the University of EdinburghMalawi will be supported by the Fleming fund where we shall train stakeholders in AMR, the grant is ~£520,0002019-01-01ZPublicMalawiThis only started in January 2020, therefore we do not have any outcomes as yetCollaboration on salmonid virus genomicsMarine Scotland Science (MSS)Analysis of salmonid virus genomes to understand disease transmission and for strain/subtype diagnosticsMarine Scotland - co-supervision of PhD, sample and data provision, intellectual input PHARMAQ AS - sample provision, intellectual input2017-01-01ZPublicUnited KingdomIn processEpidemiology of integron genes in Scottish cattleUniversity of LimogesInvestigation of integron gene carriage by Scottish cattle through PCR and epidemiological analysis.Provision of control strains and method expertise.2019-01-01ZAcademic/UniversityFrancedoi: 10.3389/fvets.2021.755833. PMID: 34778436; PMCID: PMC8585936.EPIC ConsortiumMoredun Research InstituteRoslin Institute leads on improving veterinary surveillance (Prof Mark Bronsvoort, Dr Sam Lycett), analyses of disease control options (Dr Thibaud Porphyre) and horizon scanning for disease threats (Dr Paul Bessell). Through EPIC, Roslin staff will be providing expertise and the scientific evidence to policy makers, including during animal disease emergencies (should one occur).The EPIC consortium delivers advice about livestock diseases to the Scottish Government under 5 themes: Topic 1 - Preparedness, Topic 2 - Risk, Topic 3 - Surveillance, Topic 4 - Control, Topic 5 - Futures. All Topics are co-lead with different combinations of partners from the collaborating institutes: Glasgow, Moredun, Roslin, James Hutton, BioSS, SRUC.2016-01-01ZCharity/Non ProfitUnited KingdomMulti-institution, multi-disciplinary collaborationEvaluation of potential diagnostic tests for preclinical prion diseaseNational Veterinary School of ToulouseThe collaboration was funded by an award to me from the UK Department of Health and Social Care. The contribution from my team is the adaptation of potential tests to sheep blood, and application of the tests to blinded panels of preclinical blood samples generated in a previous project. We have also supplied panels of samples from the same archive to our collaborators.Our partners at ENVT have inoculated a panel of blood samples from sheep preclinically infected with BSE into a sensitive transgenic mouse model to determine infectious prion titres. The samples are identical aliquots of those tested in the blinded panels with potential diagnostic assays to determine comparative sensitivity and specificity. They are also supplying us with frozen transgenic mouse brains expressing sheep PrP for use in one of the assays under investigation. Our partners at EFS are testing an identical panel of preclinical BSE-infected sheep blood samples using their sensitive protein misfolding amplification assay (PMCA) developed for detection of variant Creutzfeldt-Jakob disease in human patients.2017-01-01ZAcademic/UniversityFranceNo outcomes to dateThe Global Consortium for H5N8 and Related Influenza VirusesAnimal Health ServiceI performed phylogeographic analysis on avian influenza sequence data from the 2014/2015 highly pathogenic bird flu outbreaks supplied by the collaborators, resulting in a paper in Science. Since then I have also been performing analysis on the 2016/2017 outbreaks and investigating the generation of reassortments by phylodynamic (computational) methods. This work has now been submitted to a journal and we are doing the revisions (Feb 2020). Following on from this, many of the partners (including Roslin) are now in a recently (2020) funded European collaborative grant (details reported separately).The partners contributed sequence data from avian influenza cases, other avian influenza case data and expertise relating to bird migration. This collaboration was mediated through GISAID http://platform.gisaid.org/epi3/frontend The main collaborators are Erasmus Medical Centre, University of Utrecht and Friedrich Loeffler Institute.2014-01-01ZPublicNetherlandsPaper: "Role for migratory wild birds in the global spread of avian influenza H5N8" The Global Consortium for H5N8 and Related Influenza Viruses: S Lycett, R Bodewes, (many others), .. M Woolhouse, T Kuiken Science 14 Oct 2016: Vol. 354, Issue 6309, pp. 213-217 DOI: 10.1126/science.aaf8852Collaborative research with Public Health EnglandPublic Health EnglandWe provide samples and analysis of bacteria that are present in livestock that are the potential source of infections in humansPHE analyse bacterial infections in humans and so by working in partnership we can improve our capacity to determine the source of particular infections in humans and hopefully prevent or limit these to improve public health2015-01-01ZPublicUnited KingdomOutputs are publications as defined elsewhere as well as improved value to PHE surveillanceFleming Fund fellowship Kenya (Policy fellows)Fleming FundI am the co-director of this fellowship scheme at the University of Edinburgh. My work in Uganda was the foundation on which the initial award was made and now we have Kenya awarded following Malawi Last YearWe use some the tools and study designs developed from my fellowship in the training and indeed this has been recognised globally see link https://icars-global.org/cta-resources/2021-01-01ZCharity/Non Profithttps://icars-global.org/cta-resources/Research consortium investigating chronic wasting disease in EuropeFrench National Institute of Agricultural ResearchThis consortium has been funded under an Era-Net ICRAD (International coordination of research on infectious diseases) call. I am the project leader, and my research team will be involved in developing in vitro techniques to predict the effect of sequence variants found in the prion protein gene (PRNP) of British/European cervid species on susceptibility to chronic wasting disease (CWD). CWD is a prion disease similar to scrapie in sheep and BSE in cattle, that has become widespread in North America, and was identified in Norway and other Scandinavian countries since 2016. A team from the National CJD Research and Surveillance Unit in Edinburgh will also participate in analysis of the potential for cross-species transmission of CWD using in vitro assays.The Norwegian Veterinary Institute and Swedish National Veterinary Institute will collaborate in investigating the epidemiology and projected spread of CWD in Scandinavian cervid populations, and supplying material from CWD cases to other partners. FLI, INRA and NVI will contribute to PRNP genotyping of wild cervid populations in their respective countries. INIA, INRA and FLI will investigate the potential for cross-species transmission of CWD by experimental infection of transgenic mice expressing prion protein (PrP) from the respective host species (cattle, sheep, pig, human), and in vitro amplification of CWD in brain substrate from these mice. INRA will also participate in development of in vitro techniques to predict the effect of cervid PRNP sequence variants on susceptibility to CWD.2021-01-01ZAcademic/UniversityFrancePMID: 34564054; DOI: https://doi.org/10.1002/2688-8319.12203 The collaboration involves scientists with expertise in a number of disciplines, including epidemiology, wildlife ecology and disease monitoring, genetics, neuropathology, prion biology (including biochemistry, cell biology in vitro assays and rodents model of disease).Using taxonomic patterns and phylogenetic signals to enrich assessments of environmental monitoring of radionuclidesCentre For Environment, Fisheries And Aquaculture ScienceSupervising a PhD student.Supervising a PhD student and access to facilities2021-01-01ZPublicUnited KingdomNone so far.Morphometric and growth analysis of Arabidopsis plants exposed to ionising radiationBelgian Nuclear Research CentreBiosphereTwo visits to SCK during which TREE PhD student helped to train researchers at SCK how to use LAMINA softwareTwo visits to SCK, including one for a week, during which they training a TREE PhD student (Nicol Caplin) to model growth in MatLab and how to analyse for antioxidant activity in Arabidopsis using an array of enzyme assays. I then acted as external examiner for a doctoral candidate as a result of the contacts made.2016-01-01ZPublicBelgiumA publication in Frontiers in Plant ScienceTREEUniversity of PortsmouthSchool of Earth & Environmental SciencesWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZAcademic/UniversityUnited Kingdomas in outputsTREEUK Centre for Ecology & HydrologyWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZPublicUnited Kingdomas in outputsTREEUniversity of SalfordWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZAcademic/UniversityUnited Kingdomas in outputsTREEUniversity of Nottinghamagriculture and environmental sciencesWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZAcademic/UniversityUnited Kingdomas in outputsTREEUniversity of StirlingBiological and Environmental SciencesWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZAcademic/UniversityUnited Kingdomas in outputsTREEUniversity of PlymouthWe contribute to work packages with these collaborators on the TREE consortium. Collaborate at multiple levels - sharing expertise, joint planning, joint supervision and joint publishing. reciprocal lab visits.As above2013-01-01ZAcademic/UniversityUnited Kingdomas in outputsJournal Article co-authoredUniversity of SouthamptonSchool of Electronics and Computer Science SouthamptonA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the projectA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the project2010-01-01ZAcademic/UniversityUnited KingdomBehaviour change potential for energy saving in non-domestic buildings: Development and pilot-testing of a benchmarking tool DOI: 10.1177/0143624412466559 Keywords: energy use, behaviour, benchmarking, workplace available at http://bse.sagepub.com/content/early/2012/11/10/0143624412466559 . The journal article describes the development and pilot-testing of a novel questionnaire-based benchmarking tool for the assessment of behaviour change potential for energy saving in office and industrial settings. Its application to a case-study from the manufacturing sector demonstrates that the tool is easy to use, and it provides valuable insights on areas for improvement in energy use within non-domestic buildings, with a focus on user behaviour and management approaches. The tool can be used in applied research, for example in intervention studies for comparison within the same organisation (before and after), and/or for benchmarking against the performance of similar organisations.Journal Article co-authoredVitamins DesignA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the projectA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the project2010-01-01ZPrivateUnited KingdomBehaviour change potential for energy saving in non-domestic buildings: Development and pilot-testing of a benchmarking tool DOI: 10.1177/0143624412466559 Keywords: energy use, behaviour, benchmarking, workplace available at http://bse.sagepub.com/content/early/2012/11/10/0143624412466559 . The journal article describes the development and pilot-testing of a novel questionnaire-based benchmarking tool for the assessment of behaviour change potential for energy saving in office and industrial settings. Its application to a case-study from the manufacturing sector demonstrates that the tool is easy to use, and it provides valuable insights on areas for improvement in energy use within non-domestic buildings, with a focus on user behaviour and management approaches. The tool can be used in applied research, for example in intervention studies for comparison within the same organisation (before and after), and/or for benchmarking against the performance of similar organisations.Journal Article co-authoredUniversity College LondonBartlett School of Graduate StudiesA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the projectA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the project2010-01-01ZAcademic/UniversityUnited KingdomBehaviour change potential for energy saving in non-domestic buildings: Development and pilot-testing of a benchmarking tool DOI: 10.1177/0143624412466559 Keywords: energy use, behaviour, benchmarking, workplace available at http://bse.sagepub.com/content/early/2012/11/10/0143624412466559 . The journal article describes the development and pilot-testing of a novel questionnaire-based benchmarking tool for the assessment of behaviour change potential for energy saving in office and industrial settings. Its application to a case-study from the manufacturing sector demonstrates that the tool is easy to use, and it provides valuable insights on areas for improvement in energy use within non-domestic buildings, with a focus on user behaviour and management approaches. The tool can be used in applied research, for example in intervention studies for comparison within the same organisation (before and after), and/or for benchmarking against the performance of similar organisations.Journal Article co-authoredArup GroupA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the projectA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the project2010-01-01ZPrivateUnited KingdomBehaviour change potential for energy saving in non-domestic buildings: Development and pilot-testing of a benchmarking tool DOI: 10.1177/0143624412466559 Keywords: energy use, behaviour, benchmarking, workplace available at http://bse.sagepub.com/content/early/2012/11/10/0143624412466559 . The journal article describes the development and pilot-testing of a novel questionnaire-based benchmarking tool for the assessment of behaviour change potential for energy saving in office and industrial settings. Its application to a case-study from the manufacturing sector demonstrates that the tool is easy to use, and it provides valuable insights on areas for improvement in energy use within non-domestic buildings, with a focus on user behaviour and management approaches. The tool can be used in applied research, for example in intervention studies for comparison within the same organisation (before and after), and/or for benchmarking against the performance of similar organisations.Journal Article co-authoredMoixa EnergyA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the projectA Milligan _University of Dundee_leading the literature search, data gathering and research and investigation into pro-environmental behaviour change, user centred design and draft report summary in collaboration with Moxia and ARUP. C Wright_ Moixa Energy Holdings_Building Banter PI, project lead and technology R&D in terms of software and hardware development and data systems. T Whitely _ARUP, low carbon consultant and leading the energy user questionnaires and the commercialisation and dissemination phase with Moixa Energy M Ucci_ Bartlett / UCL University College London, is an Environmental and Healthy Buildings expert at the Bartlett Faculty of the Built Environment who lead the benchmarking and Energy Assessment and the Quantitative & Qualitative Analysis in collaboration with Moixa and ARUP. A Westater, [with D Fitzsimmons and C Gaggero] _Vitamins Design Ltd led the design and testing of several Energy Interventions and Technologies and the user centred workshops. A Rogers_ University of Southhampton_ led the computational strategy early in the the project2010-01-01ZPrivateUnited KingdomBehaviour change potential for energy saving in non-domestic buildings: Development and pilot-testing of a benchmarking tool DOI: 10.1177/0143624412466559 Keywords: energy use, behaviour, benchmarking, workplace available at http://bse.sagepub.com/content/early/2012/11/10/0143624412466559 . The journal article describes the development and pilot-testing of a novel questionnaire-based benchmarking tool for the assessment of behaviour change potential for energy saving in office and industrial settings. Its application to a case-study from the manufacturing sector demonstrates that the tool is easy to use, and it provides valuable insights on areas for improvement in energy use within non-domestic buildings, with a focus on user behaviour and management approaches. The tool can be used in applied research, for example in intervention studies for comparison within the same organisation (before and after), and/or for benchmarking against the performance of similar organisations.Kinetics of yeast CcO mutantsStockholm UniversitySupply of purified mutant enzymesFast kinetic measurements2012-01-01ZAcademic/UniversitySwedenPublicationGeneration of yeast CcO mutantsUniversity of JaffnaCentre de Génétique Moléculaire CNRSBiophysical characterisation of mutantsGeneration of mutantsAcademic/UniversitySri LankaSeveral papersEvolution of meiotic genes in wheatGenetics, Diversity and Ecophysiology of CerealsWe identified several meiotic genes with signature of evolution in tetraploid and hexaploid wheat lines. We have strong expertise in genetics and meiotic recombination but needed some insights from experts in wheat genome evolution. We decided to contact members of INRAE, UCA Genetics, Diversity & Ecophysiology of Cereals (France) and shared our finding to collaborate with them on this project. Members of INRAE have expertise in the field of plant genome evolution having published some work on the "evolution of recombination landscapes in diverging populations of bread wheat". We are continuing our analysis on the change of function of meiotic genes during evolution and are benefiting from this collaboration.Members of INRAE have extensive knowledge and technical expertise in the study of wheat meiosis. They shared information on their unpublished work, biological material (wheat mutant lines), and genomic expertise that we can use to further study the evolution of meiotic genes in wheat and experimentally test hypotheses. We are particularly interested to understand if and how meiotic genes have changed function to adapt to ploidy change. To further stimulate discussion and strengthen the collaboration, they invited me to visit their department and give a talk.2022-01-01ZPublicFranceThe collaboration lead to an invitation by members of INRAE for me to visit their department and give a seminar in 2023. We also submitted a joint PhD project to an INRAE funding call (pending). The research work is ongoing and will lead to a publication upon completion of the experiments.Ghanaian CollaboratorsForestry Research Institute of GhanaCollaborators will support fieldwork at three locations in GhanaThey are the support base for our measurements in forests in Ghana2024-01-01ZPublicGhananoneVP-AMRUniversity of ManilaProf Leslie Michelle M. Dalmacio, UP ManilaProject partner2025-01-01ZAcademic/UniversityPhilippinesN/ACo-production of research outputNational Institute for Health and Care ResearchINVOLVEPartners attended a co-production workshop where they inputted into the research agenda of the project. They also completed a consultation survey on the research. Following this, they were invited to co-author a paper which is a write up for the workshop and survey. The paper is now drafted, and all members contributed to the draft and each wrote a 'policy/practice perspective' short section in relation to their professional roles. The contributions made by the research team were sharing of knowledge and expertise around intersectionality and the current cutting edge methods, approaches, and conceptual issues, and offers of authorship on an academic paper.Following the above, the partners' contribution was their professional stakeholder insight on a new theoretical/conceptual approach to inequalities, which is actively shaping the research agenda, plans for follow on work, and more concretely the academic paper to be submitted soon.2019-01-01ZPublicUnited KingdomThe drafted paper is entitled 'Can intersectionality help with understanding and tackling health inequalities? Perspectives from research, policy and practice'.Collaboration with Sport England (research attachment)Sport EnglandProvided expertise knowledge in intersectionality and intersectional analysis to Sport England's dataset on physical activity over the pandemic. This was via a medical student's research attached, supervised by myself and Prof Liddy Goyder (ScHARR). We are now working on a joint journal publication together. Sport England became aware of my work in this area via the website.Sport England have shared access to a restricted dataset. Our analysis is generating novel and highly topical insights from this dataset which will form the basis of a publication.2021-01-01ZPublicUnited KingdomA paper was in preparation led by the student but they have since moved on and are not pursuing this further.Collaboration with Rabiya Gangreker (Public Health Knowledge Analyst)Blackburn With Darwen CouncilThis collaboration involved working together to develop an intersectionality and health workshop for the National Institute for Public Health School for Public Health Research annual meeting. Rabiya is a public health practitioner (Public Health Knowledge Analyst). We were keen to involved a non-academic in the workshop to boost audience engagement. Unfortunately, though we developed plans and materials for the workshop it was cancelled due to Covid. We are exploring the possibility of running the workshop virtually at this year's annual meeting.Rabiya provided feedback on the workshop slides and produced her own slides. She was due to help facilitate some of the session.2020-01-01ZPublicUnited KingdomN/A as noted this was cancelled due to Covid.Co-production of research outputPublic Health EnglandPartners attended a co-production workshop where they inputted into the research agenda of the project. They also completed a consultation survey on the research. Following this, they were invited to co-author a paper which is a write up for the workshop and survey. The paper is now drafted, and all members contributed to the draft and each wrote a 'policy/practice perspective' short section in relation to their professional roles. The contributions made by the research team were sharing of knowledge and expertise around intersectionality and the current cutting edge methods, approaches, and conceptual issues, and offers of authorship on an academic paper.Following the above, the partners' contribution was their professional stakeholder insight on a new theoretical/conceptual approach to inequalities, which is actively shaping the research agenda, plans for follow on work, and more concretely the academic paper to be submitted soon.2019-01-01ZPublicUnited KingdomThe drafted paper is entitled 'Can intersectionality help with understanding and tackling health inequalities? Perspectives from research, policy and practice'.Co-production of research outputRace Equality FoundationPartners attended a co-production workshop where they inputted into the research agenda of the project. They also completed a consultation survey on the research. Following this, they were invited to co-author a paper which is a write up for the workshop and survey. The paper is now drafted, and all members contributed to the draft and each wrote a 'policy/practice perspective' short section in relation to their professional roles. The contributions made by the research team were sharing of knowledge and expertise around intersectionality and the current cutting edge methods, approaches, and conceptual issues, and offers of authorship on an academic paper.Following the above, the partners' contribution was their professional stakeholder insight on a new theoretical/conceptual approach to inequalities, which is actively shaping the research agenda, plans for follow on work, and more concretely the academic paper to be submitted soon.2019-01-01ZCharity/Non ProfitUnited KingdomThe drafted paper is entitled 'Can intersectionality help with understanding and tackling health inequalities? Perspectives from research, policy and practice'.Participation in World University Network on intersectional methodologiesUniversity of AlbertaThis work has resulted in co-authoring two scoping reviews of intersectional methodologies. The publications have been submitted.As per above we have co-authored scoping reviews together.2021-01-01ZAcademic/UniversityCanadaIn progress.Co-production of research outputInternational Longevity Centre (ILC-UK)Partners attended a co-production workshop where they inputted into the research agenda of the project. They also completed a consultation survey on the research. Following this, they were invited to co-author a paper which is a write up for the workshop and survey. The paper is now drafted, and all members contributed to the draft and each wrote a 'policy/practice perspective' short section in relation to their professional roles. The contributions made by the research team were sharing of knowledge and expertise around intersectionality and the current cutting edge methods, approaches, and conceptual issues, and offers of authorship on an academic paper.Following the above, the partners' contribution was their professional stakeholder insight on a new theoretical/conceptual approach to inequalities, which is actively shaping the research agenda, plans for follow on work, and more concretely the academic paper to be submitted soon.2019-01-01ZCharity/Non ProfitUnited KingdomThe drafted paper is entitled 'Can intersectionality help with understanding and tackling health inequalities? Perspectives from research, policy and practice'.Collaboration with Chelsea Technologies GroupChelsea Technologies GroupKnowledge exchange, contribution of data and development of data analysis routinesLoan of equipment. Advice on opperationPrivateUnited KingdomCo-written paper: Oxborough et al. 2012IIASAInternational Institute for Applied Systems AnalysisThe fellowship is a collaborative fellowship with IIASAThe fellowship is a collaborative fellowship with IIASA2020-01-01ZAcademic/UniversityAustriaPapers forthcoming PhD co-supervisionDvojba_Exploring morphological doubletism in CroatianUniversity of ZagrebOur research team established collaboration with several scientists from other institutions in order to explore the phenomena of overabundance in Croatian on a larger scale (e.g. from a diachronic perspective). Our team contributed with a database being developed during the course of this award.Our partners contributed with specialized knowledge on the overabundance in Croatian with their scientific work based on the data retrieved from the database built within Feast and Famine project.2020-01-01ZAcademic/UniversityCroatiaThis collaboration resulted in several talks. One paper has been submitted to a linguistic journal.Collaboration with WIDEEberhard Karls University of TübingenAs part of our investigation of defectiveness we collaborated with Prof. Harald Baayen's WIDE project (ERC grant 742545). This has led to an article in a special edition of the Mental Lexicon (listed in the project outputs).Work on vector based models of defectiveness in Russian nouns.2023-01-01ZAcademic/UniversityGermanyBaayen, H, Brown, D & Chuang, Y-Y 2023, 'Explorations of morphological structure in distributional space', The Mental Lexicon. https://doi.org/10.1075/ml.00021.baa Chuang, Y-Y., Brown, D., Baayen, H., & Evans, R. (2023). Paradigm gaps are associated with weird "distributional semantics" properties: Russian defective nouns and their case and number paradigms. The Mental Lexicon. Advance online publication. https://doi.org/10.1075/ml.22013.chuCollaboration between Feast and Famine: Confronting Overabundance and Defectivity in Language and Kreas: Creativity and adaptability as conditions for the success of Europe in an interrelated worldCharles UniversityDominika Kováríková, PhD., co-investigator of Feast and Famine project, is a member of the Kreas team at Charles University. She focuses on creating online tools that offer pre-processed data for linguistic research, as well as on the research of the shared data. One example of such tool is GramatiKat created for the Feast and Famine project research. Dr. Kováríková regularly presents the possible uses of the online tools in various areas of linguistics.The Kreas project provided the training and networking to the team members. The online tool GramatiKat that is created within the Feast and Famine project, is based on the premise of sharing preprocessed corpus data for further linguistic research. The premise is an intersection between Dr. Kováríková's work in both projects. Prof. Václav Cvrcek, PhD., a member of the Kreas team, is also a member of the Feast and Famine advisory board, offering his linguistic knowledge and his vast experience with corpus data processing.2020-01-01ZAcademic/UniversityCzech RepublicThe main output that has resulted from this collaboration is the online tool GramatiKat for research of grammatical categories in Czech.Visiting schollar at the Max Planck Institute for Evolutionary AnthropologyMax Planck SocietyMax Planck Institute for Evolutionary AnthropologyI was able to access some books that I needed for my work, as well as promoting my work to the people at the Department of Linguistic and Cultural Evolution. Moreover, while I was waiting to get my UK visa, I was able to start doing research from the office space they lent me.I was invited to be a visiting schollar at the Max Planck Institute for Evolutionary Anthropology (at the Department of Linguistic and Cultural Evolution). I was given full access to all the facilities and an office space to work, as well as further development courses and funded Golden Open Access to a large selection of journals.2022-01-01ZAcademic/UniversityGermanyI was able to complete the revisions for a chapter on an edited volume on Caucasian languages which is in press (though not related to this project). Additionally, while I was getting my visa, I was able to start with this current project.Visiting scholars: Dr Radek Cech and Ms Michaela Hanušková, University of OstravaUniversity of OstravaProvided working environment for staff and consultations with Ms Hanušková for her PhD. Provided an interview for the podcast series at their department.Provided funding for the trip and delivered a seminar for our linguistics lunchtime lecture series on 16 November 2022. The topic (emerging language structures in non-native Czech) is highly relevant to the subject of our project.2022-01-01ZAcademic/UniversityCzech RepublicSeminar delivered: Quantitative analysis of texts written by non-native Czech speakersVisiting scholar: Dr Adrian Zasina, Institute of the Czech National Corpus, Faculty of Arts, Charles University, PragueCharles UniversityFaculty of ArtsSheffield and the Feast and Famine project were the hosts for Dr Zasina's five-month research stay at our institution. He participated in our project research meetings and submitted a proposal with us for a conference panel next summer; and the PI provided feedback on his plans and outputs. The PI and the project administrator facilitated his data collection amongst foreign-language learners of Czech and arranged seminars at which he presented his research and gained feedback.Dr Zasina received funding from his home institution to undertake the research stay: it covered his salary, living and travel expenses for the duration. He developed a project that dovetailed with our project aims, expanding them into the realm of second-language acquisition.2022-01-01ZAcademic/UniversityCzech RepublicOne article already published: Zasina, Adrian. 2022. Designing a Corpus Workbook for Students of Czech as a Foreign Language. Studie z aplikované lingvistiky 19(2), 125-132. Two talks delivered at Sheffield: LingLunch seminar series, 7 December 2022. Can low proficiency level learners produce diverse texts? A multidimensional approach to Czech as a foreign language. Modern Languages Teaching Centre, 13 December 2022. How to be more native-like in a foreign language? Using corpora in language teaching.Guest lecturer to summer school on research methods in ParisNational Institute for Oriental Languages and CivilizationsBased on recent fieldwork experience for the project I have given students an updated lecture on research methods in a post pandemic world.I was invited to present and assess students' work.2022-01-01ZAcademic/UniversityFranceCourse on linguistic fieldwork methods.Cambridge Broadband LtdCambridge Broadband NetworksInvestigation concerning the feasibility and performance gain available from a virtual multiple input multiple output (MIMO) enhanced broadband fixed wireless access (FWA) system.Access to radio channel measurements and models.2007-01-01ZPrivateUnited KingdomSystem simulations and analysis for optimum power control for a distributed antenna collaborative fixed wireless access (FWA) system.Prison Literacies Partnership with HMP Edinburgh and Fife CollegeHM Prison ServiceHMP EdinburghI set up a partnership with Fife (formerly Carnegie) College and HMP Edinburgh, involving student volunteers from Edinburgh Napier's English programme in the prison's learning centre.Scottish Prison Service provides induction and training for student volunteers; learning centre staff at HMP Edinburgh guide student volunteers during the placement period.2011-01-01ZPublicUnited KingdomThis partnership formed the basis of an Impact Case Study for REF 2014, UoA29 English: "Promoting Literacy and Creative Writing Skills at HMP Edinburgh" http://impact.ref.ac.uk/CaseStudies/CaseStudy.aspx?Id=43947 Article in Prisoners' Education Trust Learning Matters Newsletter, which includes impact on individual participants: http://www.prisonerseducation.org.uk/case-studies/hmp-edinburgh-supports-learning-through-literacy-and-creative-writing-volunteers The partnership was mentioned favourably in the Edinburgh Prison Visiting Committee's Annual Report for the year ending 31 March 2012: http://avc.bpweb.net/images/EdinburghVC12.pdf?zenid=68323fefd93ca29684501fdc1b9f%20fcc9 This is a cross-sector partnership involving partners in higher education (Edinburgh Napier University), further education (Fife College) and the Scottish Prison Service (an executive agency of the Scottish Government).Characterization of HDAC1/2 in embryonic haematopoiesisUniversity of ManchesterFaculty of Life SciencesWe have generated conditional knockout cells in which we can simultaneously inactivate the highly related histone deacetylase enzymes, Hdac1 and Hdac2.Dr Georges Lacaud has been using the Hdac1/2 double knockout cells to determine their roles in haematopoiesis.2012-01-01ZAcademic/UniversityUnited KingdomThe work is still underway, but initial data looks good and we would expect to publish in then next 12 months.Chromsome segregation in HDAC1/2 DKO cellsUniversity of LeicesterWe provided HDAC1/2 double knocjout cells to the Fry lab for them to analyze chromosome segregation.The Fry lab was able to take HDAC1/2 DKO cells and quantitate aberrant chromosome segregation using an immunofluoresence microscopy approach.2013-01-01ZAcademic/UniversityUnited KingdomThis collaboration was instrumental in the publication of Jamaladdin et al. (2014) in PNASUnderstanding the regulation of the 'acetylome' in embryonic stem cellsUniversity of SheffieldNational Centre for III-V TechnologiesWe have provided cells, labelled with SILAC amino acids, in which individual HDAC enzymes have been deleted to address the regulation of Lysine-acetylation across all protein in stem cells.My collaborator at Sheffield has performed the mass-spectrometry analysis of complex samples and then informatics analysis of the data.2016-01-01ZAcademic/UniversityUnited KingdomWe have generated proteome-wide dataset for individual sites of lysine-acetylation and the degree to which levels change following HDAC deletion. We intend to write up these findings and submit a manuscript in 2017.Characterizing the Sin3A/HDAC1 complex: an alternative strategy for the precise inhibition of deacetylase activity in cells.LifeArcCharacterization of the Sin3/HDAC1 complex. In particular the PAH domains of Sin3A, a unique protein-protein interaction motif which could be targeted as a more precise way of inhibiting HDAC activity in cells.Knowledge of drug development and converting basic research into therapeutics.2017-01-01ZCharity/Non ProfitUnited KingdomCollaboration was able to secure a BBSRC iCASE PhD studentshipUnderstanding the role of HDAC3 in stem cell differentiationSanford-Burnham Medical Research InstituteGenomic Control of MetabolismWe have generated a conditional HDAC3 knock-out cell line which has been used in ChIP-seq to examine the relations ship between retinoid signalling and the pluripotent factor Oct4.Our collaborators have used our cells to confirm the role of the HDAC3/SMRT co-repressor complex in early embryonic stem cell differentiation.2015-01-01ZCharity/Non ProfitUnited StatesA manuscript "Oct4 acts as an integrator of pluripotency and signal-induced differentiation" has recently been written and submitted.UK Deep-Sea Mining NetworkDepartment For Environment, Food And Rural Affairs (DEFRA)Attended a workshop on deep-sea mining.Organised network, workshop.2024-01-01ZPublicUnited KingdomMulti-disciplinary network involves scientists, policy makers, solicitors. Scientists from variety of backgrounds including: biology, chemistry, physics, social sciences.Industrial Research InternshipNVIDIAProvided mathematical modelling of industrial hardware specifications.Industrial internship to work on research related to my thesis.2018-01-01ZPrivateGlobalSubmitted a paper to leading academic conference.Scottish Government partnershipGovernment of ScotlandExtensive collaboration in context of UKRI/ESRC Policy Fellowship.Close partnership relating to academic contribution to policy/strategy development and departmental work relating to multilateral trade issues, and policy input into academic research.2022-01-01ZPublicUnited KingdomSee details elsewhere in report, inc. re.: - Academic research - Cross-sector policy/strategy stakeholder engagement - Support for Scottish Government strategy/policy development - Specialist capacity development/trainingYaMCATSUniversity of LeicesterDepartment of MathematicsThis collaboration set up an LMS Scheme 3 network between Leeds, Leicester and Sheffield called YaMCATS (Yorkshire and Midlands Category Theory Seminar) that is now in its second year of operation. I helped write the proposal, plan the meetings and organise the meetings that have been held in Sheffield.My partners have performed similar roles at their respective universities.2014-01-01ZAcademic/UniversityUnited KingdomWe have held 6 meetings so far, with 2 more to come in the 2015-16 academic year.K-theory for 2-categoriesOhio State UniversityI continue to participate in a joint research project in which my particular research background plays a key role in our progress.My partners also contribute their own skills and knowledge to the project, and we were hosted at Ohio State for a week in October to pursue this joint project. I presented some of our findings at a local seminar in Ohio as an invited speaker.2014-01-01ZAcademic/UniversityUnited StatesWe submitted two papers in 2015 and expect to submit a further two papers in 2016.YaMCATSUniversity of LeedsSchool of Mathematics LeedsThis collaboration set up an LMS Scheme 3 network between Leeds, Leicester and Sheffield called YaMCATS (Yorkshire and Midlands Category Theory Seminar) that is now in its second year of operation. I helped write the proposal, plan the meetings and organise the meetings that have been held in Sheffield.My partners have performed similar roles at their respective universities.2014-01-01ZAcademic/UniversityUnited KingdomWe have held 6 meetings so far, with 2 more to come in the 2015-16 academic year.K-theory for 2-categoriesReed CollegeI continue to participate in a joint research project in which my particular research background plays a key role in our progress.My partners also contribute their own skills and knowledge to the project, and we were hosted at Ohio State for a week in October to pursue this joint project. I presented some of our findings at a local seminar in Ohio as an invited speaker.2014-01-01ZAcademic/UniversityUnited StatesWe submitted two papers in 2015 and expect to submit a further two papers in 2016.Gray tensor productsMasaryk UniversityDepartment of MathematicsThis collaboration has explored some foundational questions in higher dimensional algebra. I have provided insight into these questions as well as helping to shape some of the central features of our outputs.My collaborator posed some of the initial questions and showed how some classic techniques could be updated to address them.2013-01-01ZAcademic/UniversityCzech RepublicJ. Bourke and N. Gurski, The Gray tensor product via factorisation J. Bourke and N. Gurski, A cocategorical obstruction to tensor products of Gray-categoriesModules over braided monoidal categoriesUniversity of HamburgDepartment of Computer ScienceI have helped shape the research by providing expertise and linking discoveries with other areas of category theory.Manuel Barenz (Bamberg) provided the original direction of the research, while David Yetter (Kansas State) has provided extensive background knowledge. We have all contributed to content of the research equally.2015-01-01ZAcademic/UniversityGermanyNone yet.Action operadsUniversity of SheffieldSchool of Mathematics and StatisticsThis collaboration involves ongoing work with two of my post-graduate research students. It has motivated new applications of ideas in my research to solve problems they were studying as part of their PhD research. I have provided direction as well as key background knowledge.My partners (Alex Corner and Edward Prior) have postulated some key problems for us to attack, and helped apply methods I have helped develop to those problems.2014-01-01ZAcademic/UniversityUnited KingdomThe preprint "Operads with general groups of equivariance, and some 2-categorical aspects of operads in Cat" is a direct outcome of this collaboration, as is "Operads, tensor products, and the categorical Borel construction." We expect another submitted paper in 2016.Daniel SchaeppiUniversity of SheffieldSchool of Mathematics and StatisticsI mentored Daniel Schaeppi as an RA in Sheffield during 2014-15, and we began a joint research project.Daniel suggested the topic of research which also led to a series of seminar talks.2014-01-01ZAcademic/UniversityUnited KingdomNone yet.YaMCATSLondon Mathematical SocietyThis collaboration set up an LMS Scheme 3 network between Leeds, Leicester and Sheffield called YaMCATS (Yorkshire and Midlands Category Theory Seminar) that is now in its second year of operation. I helped write the proposal, plan the meetings and organise the meetings that have been held in Sheffield.My partners have performed similar roles at their respective universities.2014-01-01ZAcademic/UniversityUnited KingdomWe have held 6 meetings so far, with 2 more to come in the 2015-16 academic year.Modules over braided monoidal categoriesKansas State UniversityDepartment of MathematicsI have helped shape the research by providing expertise and linking discoveries with other areas of category theory.Manuel Barenz (Bamberg) provided the original direction of the research, while David Yetter (Kansas State) has provided extensive background knowledge. We have all contributed to content of the research equally.2015-01-01ZAcademic/UniversityUnited StatesNone yet.A visit to Manchester University (UoM) and London School of Hygiene and Tropical Medicine (LSHTM)London School of Hygiene and Tropical Medicine (LSHTM)Department of Global Health and DevelopmentA team of three researchers, including an ARL, from Ifakara Health Institute (IHI) was invited to present the project research to academicians and researchers at the UoM and LSHTM. One supervisor of ARL is from the LSHTM and one advisor of the advisory committee is from the UoM. We were able to share the project research and plan activities for 3 years (2023-2025). This happened in October 2023.The partners from UoM and LSHTM provided constructive comments and suggestions for improving the research project. This included methodological insights and shared some opportunities for short courses including a Discrete Choice Experiment (DCE) in Calgary, Canada.2023-01-01ZAcademic/UniversityUnited Kingdom-Improvement in proposed methodology of the research project. -Applied and participated in a DCE short course in Calgary, Canada. -Received some softcopies of relevant books to read.A visit to Manchester University (UoM) and London School of Hygiene and Tropical Medicine (LSHTM)University of ManchesterA team of three researchers, including an ARL, from Ifakara Health Institute (IHI) was invited to present the project research to academicians and researchers at the UoM and LSHTM. One supervisor of ARL is from the LSHTM and one advisor of the advisory committee is from the UoM. We were able to share the project research and plan activities for 3 years (2023-2025). This happened in October 2023.The partners from UoM and LSHTM provided constructive comments and suggestions for improving the research project. This included methodological insights and shared some opportunities for short courses including a Discrete Choice Experiment (DCE) in Calgary, Canada.2023-01-01ZAcademic/UniversityUnited Kingdom-Improvement in proposed methodology of the research project. -Applied and participated in a DCE short course in Calgary, Canada. -Received some softcopies of relevant books to read.Collaboration with Guangdong University of Technology, ChinaGuangdong University of TechnologyInstitute of Biomedical and Pharmaceutical SciencesProvide research facilities to express, purify and label protein. Host a postdoctoral researcher form the partner organisation to carry out single molecule fluorescence measurement.Salary of the postdoctoral researcher2017-01-01ZAcademic/UniversityChinaMulti-disciplinary: biochemistry, biophysics, drug discoveryApplication of CRISPR-Cas9 Technology in Fast Detection of Transgenic ProductsChinese Academy of SciencesInstitute for Nutritional SciencesInvestigate the molecular mechanisms and corresponding thermodynamic parameters of the detection system using single-molecule and other biophysical techniques.1. Prepare main components of the detection system, including Spy-dCas9 protein, specific sgRNA, double-stranded target DNA, DNA-RNA hybrid antibody, and so on. 2. Confirm the effectiveness of the detection system by in vitro approaches, and modify the reaction conditions. 3. In cooperation with the partner, further improve the specificity and sensitivity of the detection system based on its molecular mechanisms. 4. Quantitatively detect the heterologous gene fragments in samples from transgenic products by applying the system.2016-01-01ZLearned SocietyChinamulti-disciplinary, biosensor/biophysics/spectroscopyStructural and functional characterisation of a G-quadruplex in the promoter of ß1-adrenergic receptorChinese Academy of SciencesShenzhen Institute of Advanced Integration TechnologyProvide guidance for the project and carry out single molecule FRET measurements.Cell biology and other biophysical measurements2016-01-01ZAcademic/UniversityChinaMulti-disciplinary, biophysics/biochemistry/cell biology/cardiovascular scienceCollaboration with Research Group of Prof. VlassovNovosibirsk State UniversityInstitute of Chemical Biology and Fundamental MedicineParticipation in the International Grant Award-2014 'New generation of RNA-targeting agents based on oligonucleotide derivatives: a platform for generation of novel therapeutics; Federal State Institution of Science Institute of Chemical Biology and Fundamental Medicine , Siberian Branch of the Russian Academy of Sciences, Grant REF: 14-44-00068. Scientific contribution: medicinal and analytical chemistry, spectroscopy (NMR, fluorescence & UV and mass spectrometry) structural biology and biophysics.Principal Applicant in the International Grant Award-2014 'New generation of RNA-targeting agents based on oligonucleotide derivatives: a platform for generation of novel therapeutics; Federal State Institution of Science Institute of Chemical Biology and Fundamental Medicine , Siberian Branch of the Russian Academy of Sciences, Grant REF: 14-44-00068. Scientific contribution: biochemistry, molecular biology and chemistry of nucleic acids.2006-01-01ZAcademic/UniversityRussian Federation1. M. A. Zenkova, D. V. Pyshnyi, W. A. Zalloum, M. B. Gebrezgiabher and E. V. Bichenkova. 'New Approaches for the Development of Nucleic Acid-based Therapeutics: Challenges and Opportunities in RNA Targeting.' International Drug Discovery. (2011) 2011, 1-5. 2. N.G. Beloglazova, M. M. Fabani, N. N. Polushin, V. V. Sil'nikov, V.V. Vlassov, E.V. Bichenkova and M. A. Zenkova. 'Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain'. Journal of Nucleic Acids. (2011) doi:10.4061/2011/748632 3. Miles S.M., Gebrezgiabher M. B., Pyshnyi D. V., Mironova N. L., Zenkova M. A., Vlassov V. V. and Bichenkova E. V. (2009). 'Structural Aspects of oligonucleotide-mediated artificial ribonucleases'. Presented at Conversation 16 on Biomolecular Structure and Dynamics. Suny, Albany: Adenine Press, NY, USA. Published in J. Biomol. Struct. Dyn. 2009, 26, 847. 4. Miles S.M., Gebrezgiabher M.B, Zalloum W.A, Pyshnyi D.V., Mironova N.L., Zenkova M.A., Vlassov V.V and Bichenkova E.V. (2009). 'Oligonucleotide-based chemical nucleases: opportunities and challenges in RNA targeting'. Presented at 13 European Conference on the Spectroscopy of Biological Molecules. Palmero, Italy: IOS Press NL. 13th ECSBM, Palermo, Book of Abstracts, p. 32. Mengisteab B. Gebrezgiabher, Steven M. Miles, Dmitrii V. Pyshnyi, Nadezhda L. Mironova, Marina A. Zenkova, Valentin V. Vlassov, Elena V. Bichenkova, 'Structural Aspects of novel Artificial Ribonucleases by 2D NMR spectroscopy'. J. Biomol. NMR (2008), 41 (2), 209.The Collaborative Research Framework Agreement with SOLVAYSolvaySOLVAY is an early partner interested in the synthesis and production of the nucleic acid-peptide catalytic structures, developed in our research funded by EPSRC. The success in the research funded by EPSRC was significant to promote collaborations with this commercial partner and lead to the Collaborative Research Framework Agreement between the University of Manchester and SOLVAY. Funding body: SOLVAY. Bichenkova: £105,704 (as a part of a £1.3M research program together with Drs A. Miller, A. Saiani, C. Merry, J. Gough, R. Goodacre, L. Majewski and Prof. Mike Turner). Oct 2011 - March 2015. Our success in the research previously funded by EPSRC (2006-2009) has triggered the collaborations with Solvay, an early commercial partner, and lead to the Collaborative Research Framework Agreement between the University of Manchester and SOLVAY. Funding body: SOLVAY. Bichenkova: £105,704 (as a part of a £1.3M research program together with Drs A. Miller, A. Saiani, C. Merry, J. Gough, R. Goodacre, L. Majewski and Prof. Mike Turner). Oct 2011 - March 2015. This work programme provides full financial support for one PhD student for 3.5 years (Aled Williams; started from October 2011).Solvay contributes in financial support of this research project (£105,704 (as a part of a £1.3M research program together with Drs A. Miller, A. Saiani, C. Merry, J. Gough, R. Goodacre, L. Majewski and Prof. Mike Turner) and provides expertise in peptide chemistry.2011-01-01ZPrivateGlobalNow Nano Summer Conference - June 9-11th 2014 - Cranage Hall, Cheshire - 15 minute Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic activities'. Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; University of Manchester Postgraduate Summer Research Showcase - June 24th 2014 - UoM - Poster Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic properties against biologically relevant RNA.' Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; Nucleic Acids Group Research Conference (RSC) - July 4th 2014 - Royal Society of Chemistry, Burlington House, London - Poster Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic properties against biologically relevant RNA.'Collaboration with the research group of Prof. Marina V. Zenkova, Novosibirsk, RussiaNovosibirsk State UniversityInstitute of Chemical Biology and Fundamental MedicineOur research outcomes in the area of structure-based rational design of oligonucleotide-mediated chemical ribonucleases (previously funded by EPSRC) triggered a new collaborative initiative with the research group of Prof. Marina V. Zenkova Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia). Recently we received BBSRC DTP studentship award for 3.5-years to initiate the project 'Enzyme-free, spontaneous recombination of RNAs'. A new PhD student, Catherine Watson, has been selected by the Faculty panel (The University of Manchester) and started her postgraduate research & training program in September 2012.The research group of Prof. Marina A. Zenkova (Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia) provides an expertise in biochemistry, molecular biology and artificial ribonucleases.2006-01-01ZAcademic/UniversityRussian FederationStructural aspects of non-enzymatic recombination in viral RNAs' by Catherine Watson, Richard A. Bryce, Elena V. Bichenkova. Presented at Symposium 'The 10th Nucleic Acids Forum' in July 2014 at the RSC Chemistry Centre, Burlington House, London'. (Poster presentation by Catherine Watson). Now Nano Summer Conference - June 9-11th 2014 - Cranage Hall, Cheshire - 15 minute Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic activities'. Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; University of Manchester Postgraduate Summer Research Showcase - June 24th 2014 - UoM - Poster Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic properties against biologically relevant RNA' Aled Williams, Yaroslav Staroseletz, Laurent Jeannin, Marina A. Zenkova, Harmesh Aojula and Elena V. Bichenkova; Nucleic Acids Group Research Conference (RSC) - July 4th 2014 - Royal Society of Chemistry, Burlington House, London - Poster Presentation - 'Developing a new generation of peptidyl-oligonucleotide conjugates with desired biocatalytic properties against biologically relevant RNA.' 1. M. A. Zenkova, D. V. Pyshnyi, W. A. Zalloum, M. B. Gebrezgiabher and E. V. Bichenkova. 'New Approaches for the Development of Nucleic Acid-based Therapeutics: Challenges and Opportunities in RNA Targeting.' International Drug Discovery. (2011) 2011, 1-5. N.G. Beloglazova, M. M. Fabani, N. N. Polushin, V. V. Sil'nikov, V.V. Vlassov, E.V. Bichenkova and M. A. Zenkova. 'Site-Selective Artificial Ribonucleases: Oligonucleotide Conjugates Containing Multiple Imidazole Residues in the Catalytic Domain'. Journal of Nucleic Acids. (2011) doi:10.4061/2011/748632 Miles S.M., Gebrezgiabher M. B., Pyshnyi D. V., Mironova N. L., Zenkova M. A., Vlassov V. V. and Bichenkova E. V. (2009). 'Structural Aspects of oligonucleotide-mediated artificial ribonucleases'. Presented at Conversation 16 on Biomolecular Structure and Dynamics. Suny, Albany: Adenine Press, NY, USA. Published in J. Biomol. Struct. Dyn. 2009, 26, 847. Miles S.M., Gebrezgiabher M.B, Zalloum W.A, Pyshnyi D.V., Mironova N.L., Zenkova M.A., Vlassov V.V and Bichenkova E.V. (2009). 'Oligonucleotide-based chemical nucleases: opportunities and challenges in RNA targeting'. Presented at 13 European Conference on the Spectroscopy of Biological Molecules. Palmero, Italy: IOS Press NL. 13th ECSBM, Palermo, Book of Abstracts, p. 32. Mengisteab B. Gebrezgiabher, Steven M. Miles, Dmitrii V. Pyshnyi, Nadezhda L. Mironova, Marina A. Zenkova, Valentin V. Vlassov, Elena V. Bichenkova, 'Structural Aspects of novel Artificial Ribonucleases by 2D NMR spectroscopy'. J. Biomol. NMR (2008), 41 (2), 209.Collaboration with Conformetrix Ltd (currently C4X Discovery)C4X Discovery LtdCollaboration with Conformetrix Ltd (currently C4X Discovery) ) led to BBSRC Industrial CASE Studentship Award (E.V. Bichenkova (PI) and H. Aojula (co-applicant) with Conformetrix Ltd) to support 4-year studentship at the interface of academia and industry. £96,604 (2013-2017)Collaboration with Conformetrix Ltd (currently C4X Discovery) ) led to BBSRC Industrial CASE Studentship Award (E.V. Bichenkova (PI) and H. Aojula (co-applicant) with Conformetrix Ltd) to support 4-year studentship at the interface of academia and industry. £96,604 (2013-2017)2013-01-01ZAcademic/UniversityUnited Kingdom'Complete 3D description of dynamic behaviour of enzyme mimics: role of various structural elements in catalysis and interactions with bio-target.' BBSRC Industrial CASE Studentship Award (BB/K012622/1). E.V. Bichenkova (PI) and H. Aojula (co-applicant) with Conformetrix Ltd. to support 4-year studentship at the interface of academia and industry. £96,604 (2013-2017)Professor Tuomas KnowlesUniversity of CambridgeDepartment of ChemistryThe Narita lab showed the first functional relevance for autophagy in senescence in culture. Now the lab has generated a highly unique autophagy mouse model, Atg5i (Autophagy, 2018), which will be utilised in this proposal. The Narita lab also identified cell-cell direct contacts as an effector mechanism of senescence, driving senescence diversity.Prof. Knowles (UK Co-Investigator, BBSRC-JSPS grant; Dept Chemistry, University of Cambridge) is a world expert on biophysics and microfluidics. The Knowles lab has developed a microfluidic inDrop single-cell RNA-sequencing system, which we will adapt to our high-throughput single-cell Chromatin Integreation & Labelling (scChIL) technology. Their microfluidics technology is also utilised to dissect the diversity of senescence and its impact on tumorigenesis.2018-01-01ZAcademic/UniversityUnited KingdomThe primary impact of the project will be to increase knowledge of the genetic and epigenetic alterations that occur during ageing and age-reversal. This project will be of direct benefit to researchers working in the fields of ageing and age-related disorders as well as epigenetics. Since our mouse model uses autophagy perturbation, this will also be benefit to researchers in the field of autophagy. We will utilise microfluidics to develop high throughput epigenomic techniques, which will also inspire microfluidics and microgel researchers. Publications include: Zhu et al. Core-shell spheroid-laden microgels crosslinked under biocompatible conditions for probing cancer-stromal communication. Adv Biomed Res. 2, 2200138. doi.org/10.1002/anbr.202200138Professor Yasuyuki OhkawaKyushu UniversityThe Narita lab showed the first functional relevance for autophagy in senescence in culture. Now the lab has generated a highly unique autophagy mouse model, Atg5i (Autophagy, 2018), which will be utilised in this proposal.Low-throughput manual single-cell Chromatin Integration & Labelling (scChIL) has been successfully developed by the Ohkawa/Kimura team. Also, the Ohkawa lab has constant access to 26 months old mice (1-17M old mice are commercially available in Japan).2018-01-01ZAcademic/UniversityJapanThe primary impact of the project will be to increase knowledge of the genetic and epigenetic alterations that occur during ageing and age-reversal. This project will be of direct benefit to researchers working in the fields of ageing and age-related disorders as well as epigenetics. Since our mouse model uses autophagy perturbation, this will also be benefit to researchers in the field of autophagy. We will utilise microfluidics to develop high throughput epigenomic techniques, which will also inspire microfluidics and microgel researchers.HiroshiOsaka UniversityGraduate School of Frontier BiosciencesUsing the monoclonal antibodies provided in our research on senescence. Dr. Kimura and I regularly discuss epigenetics projects and indeed, I will stay with him for a month as a vising scientist this year (2017).My group shares our experimental resources (published and unpublished) with Dr. Narita, these include ChIP-grade monoclonal antibodies against various chromatin factors and genetically encoded probes for specific histone modifications. Dr. Narita and I regularly discuss epigenetics projects and indeed, he stays with us for a month as a vising scientist this year.2009-01-01ZAcademic/UniversityJapanPublication. Mol Cell 2012.Large area solar cell fabricationUniversity of PretoriaWe got a UKRI research grant (collaborative) to develop large area perovskite solar cellsThe will do the defect characterisation of the samples prepared2024-01-01ZAcademic/UniversitySouth AfricaNot yetCollaboration on Carbon electrode with Dr Yu HueUniversity of EdinburghSchool of ChemistryWe have written a combined collaborative grant to develop an in-house carbon paste to overcome the challenges of the existing onesWe submitted a combined collaborative research grant2025-01-01ZAcademic/UniversityUnited KingdomNo output yetCollaboration with computational physicist to study the interfacesUniversity of DundeeWe will be providing the samples to this collaboration and try to understand the charge transfer processesThe partners will be doing some computational calculations to understand the interface charge transport properties in multi-layered heterostructures2025-01-01ZAcademic/UniversityUnited KingdomNo, the collaboration just started.Hyperpolarization collaborationCambridge Cancer CentreNMR techniques, materials, theory, simulationsMRI techniques, materials, methodology2010-01-01ZAcademic/UniversityUnited KingdomToo complex to report here.Hyperpolarization collaborationSwiss Federal Institute of Technology in Lausanne (EPFL)NMR techniques, materials, theory, simulationsMRI techniques, materials, methodology2010-01-01ZPublicSwitzerlandToo complex to report here.Hyperpolarization collaborationUniversity of CopenhagenNMR techniques, materials, theory, simulationsMRI techniques, materials, methodology2010-01-01ZAcademic/UniversityDenmarkToo complex to report here.Hyperpolarization collaborationÉcole normale supérieure de Lyon (ENS Lyon)NMR techniques, materials, theory, simulationsMRI techniques, materials, methodology2010-01-01ZAcademic/UniversityFranceToo complex to report here.Hyperpolarization collaborationUniversity of PennsylvaniaUniversity of Pennsylvania School of MedicineNMR techniques, materials, theory, simulationsMRI techniques, materials, methodology2010-01-01ZAcademic/UniversityUnited StatesToo complex to report here.University of British ColumbiaUniversity of British ColumbiaImplementation of xenon MRI pulse sequences on UBC scannesEvaluation of Sheffield MRI protocols at a new clinical site2020-01-01ZAcademic/UniversityCanadaResearch ongoingXenon clinical trails consortiumCincinnati Children's Hospital Medical CenterDivision of RheumatologyFounding member of consortium for development , evaluation and standardisation of imaging methods for outcome measures for clinical trials of respiratory therapeuticsevaluation and standardisation of imaging methods for outcome measures for clinical trials of respiratory therapeutic2015-01-01ZHospitalsUnited Statesnone yetCollaboration with Imperial CollegeImperial College LondonProvision of xenon polariser to a new siteProvision of xenon polariser to a new site2025-01-01ZAcademic/UniversityUnited KingdomProvision of xenon polariser to a new clinical site for lung MRIPHOSP COVID /CMORE projectUniversity of LeicesterLeicester Medical SchoolCoordinator on lung imaging WP Coordinator for CMORE multi organ sub studyLarge UK national COVID clinical study2020-01-01ZAcademic/UniversityUnited Kingdomconference abstractsXenon MRI technology enablingUniversity Hospitals of Leicester NHS TrustLeicester Royal InfirmaryEnabled xenon MRI technology with installation of Sheffield xenon polarisers at Addenbrookes and Papworth hospitals in Cambridge, UCL, Columbia University, NYC, Kiel University , University of Oxford, AArhus university , Manchester University / Wyhenshawe Hospital, Leicester NIHR BRC,Engineering expertise Xenon hyperppolarisation MRI sequence integration to scanners2015-01-01ZHospitalsUnited KingdomFirst xenon lung images acquired at papworth 2020 first images at Aarhus 2020 first images at Columbia 2020 first COVID images at Oxford 2025 first xenon images at Manchester 2023 first xenon images at UCLUK Pulmonary Hypertension MR imaging collaborationUniversity of GlasgowSchool of Medicine GlasgowI have been proactive in standardising and translating MRI protocols for pulmonary disease across all UK centres. I was asked by Prof Nick Morrell in Cambridge, to lead an imaging study with a standardised MR protocol based around the MRC funded national pulmonary arterial hypertension cohort study of which he is the PI. A cardio-pulmonary MR protocol has been drawn up and I am currently in the process of implementing this MR protocol in all of the UK PH clinical centres.Input on MR protocol design Patient recruitment2014-01-01ZAcademic/UniversityUnited KingdomStandardised UK Pulmonary Hypertension MRI protocol Basis for clinical trials of new therapies for PH with imaging outcomesRHINOCardiff UniversityOur technology formed an essential component of the MRC award to Prof. Sailesh Kotecha for the RHINO (Respiratory Health Outcomes in Neonates) study. Pilot study from this study inidicates sub-clinical ventilation heterogeneity and microstructural differences in small airways of teenagers born pre-term.RHINO have recruited 40+ subjects that we have scanned in order for us to collect this data.2017-01-01ZAcademic/UniversityUnited KingdomN/AUoS / GE Healthcare prosperity partnershipGE Healthcare LimitedAcademic IP and knowhow for low TRL physics and engineering research for hyperpolarised, lung and MRI technologiesEngineering knowhow and IP for MRI scannner engineering2012-01-01ZAcademic/UniversityUnited KingdomEPSRC prosperity partnership awardLeicester University and NIHR BRCUniversity Hospitals of Leicester NHS TrustLeicester Royal InfirmarySupply of a hyperpolariser for xenon MRI and technical support for a new clinical siteSupply of a hyperpolariser for xenon MRI and technical support for a new clinical site2024-01-01ZHospitalsUnited KingdomSupply of a bespoke Sheffield POLARIS xenon polariser for imaging in LeicesterCHANGE-MRIHannover Medical SchoolRadiology CentreDefinition and implementation of a multi site clinical evaluation of MRI perfusion imaging for screening of Chronic Thromboembolic Lung DiseaseSole UK partner - acquisition of imaging data and methodology development2016-01-01ZAcademic/UniversityGermanyNone yetXenon MRI technology enablingColumbia UniversityEnabled xenon MRI technology with installation of Sheffield xenon polarisers at Addenbrookes and Papworth hospitals in Cambridge, UCL, Columbia University, NYC, Kiel University , University of Oxford, AArhus university , Manchester University / Wyhenshawe Hospital, Leicester NIHR BRC,Engineering expertise Xenon hyperppolarisation MRI sequence integration to scanners2015-01-01ZAcademic/UniversityUnited StatesFirst xenon lung images acquired at papworth 2020 first images at Aarhus 2020 first images at Columbia 2020 first COVID images at Oxford 2025 first xenon images at Manchester 2023 first xenon images at UCLXenon MRI technology enablingUniversity College LondonEnabled xenon MRI technology with installation of Sheffield xenon polarisers at Addenbrookes and Papworth hospitals in Cambridge, UCL, Columbia University, NYC, Kiel University , University of Oxford, AArhus university , Manchester University / Wyhenshawe Hospital, Leicester NIHR BRC,Engineering expertise Xenon hyperppolarisation MRI sequence integration to scanners2015-01-01ZAcademic/UniversityUnited KingdomFirst xenon lung images acquired at papworth 2020 first images at Aarhus 2020 first images at Columbia 2020 first COVID images at Oxford 2025 first xenon images at Manchester 2023 first xenon images at UCLUniversity of Manchester /Wythenshawe Hospital xenon polariser and MRI infrastructure collaborationUniversity of ManchesterManchester Business SchoolLoan of a xenon polariser and expertise setting up a new clinical site in xenon MRIRecipeint clinical site keen to establish technology for lung imaging2019-01-01ZAcademic/UniversityUnited KingdomNone yetXenon MRI technology enablingUniversity of KielNeuropediatric Department KielEnabled xenon MRI technology with installation of Sheffield xenon polarisers at Addenbrookes and Papworth hospitals in Cambridge, UCL, Columbia University, NYC, Kiel University , University of Oxford, AArhus university , Manchester University / Wyhenshawe Hospital, Leicester NIHR BRC,Engineering expertise Xenon hyperppolarisation MRI sequence integration to scanners2015-01-01ZAcademic/UniversityGermanyFirst xenon lung images acquired at papworth 2020 first images at Aarhus 2020 first images at Columbia 2020 first COVID images at Oxford 2025 first xenon images at Manchester 2023 first xenon images at UCLGalapagos pharmaceuticalsGalapagos NVUse of UoS 129Xe lung MRI as outcome measure in a clinical trial of an ILD drugAppended an imaging outcome measure sub study to an existing clinical trial of a new therapeutic for IPF - https://www.glpg.com/IPF2019-01-01ZPrivateBelgiumNone yetColumbia University NYC polariser collaborationColumbia University Medical CenterInstalled POLARIS xenon polariser and POLARIS pulse sequences for MRI of xenonNew clinical site for xenon MRI2020-01-01ZAcademic/UniversityUnited StatesXenon MRI enabled in clinical site in US leading medical centreXenon MRI technology enablingRoyal Papworth Hospital NHS Foundation TrustRadiologyEnabled xenon MRI technology with installation of Sheffield xenon polarisers at Addenbrookes and Papworth hospitals in Cambridge, UCL, Columbia University, NYC, Kiel University , University of Oxford, AArhus university , Manchester University / Wyhenshawe Hospital, Leicester NIHR BRC,Engineering expertise Xenon hyperppolarisation MRI sequence integration to scanners2015-01-01ZPublicUnited KingdomFirst xenon lung images acquired at papworth 2020 first images at Aarhus 2020 first images at Columbia 2020 first COVID images at Oxford 2025 first xenon images at Manchester 2023 first xenon images at UCLSloan Kettering, New YorkMemorial Sloan Kettering Cancer CenterBuilt RF coil for hyeperpolarised 13C breast MRI for group of Kayvan KavaniProvided definition of clinical need for new coil2019-01-01ZAcademic/UniversityUnited StatesISMRM abstract Draft paper to MRM Novel RF coil design IP owned by University of SheffieldUCL NIHR BRCUniversity College LondonBuild of a xenon polariser for UCL NIHR BRCContract to build of a xenon polariser for UCL NIHR BRC2019-01-01ZAcademic/UniversityUnited KingdomNA yetUK Pulmonary Hypertension MR imaging collaborationRoyal Papworth Hospital NHS Foundation TrustI have been proactive in standardising and translating MRI protocols for pulmonary disease across all UK centres. I was asked by Prof Nick Morrell in Cambridge, to lead an imaging study with a standardised MR protocol based around the MRC funded national pulmonary arterial hypertension cohort study of which he is the PI. A cardio-pulmonary MR protocol has been drawn up and I am currently in the process of implementing this MR protocol in all of the UK PH clinical centres.Input on MR protocol design Patient recruitment2014-01-01ZPublicUnited KingdomStandardised UK Pulmonary Hypertension MRI protocol Basis for clinical trials of new therapies for PH with imaging outcomesUniversity of Kiel xenon MRIUniversity Hospital Schleswig-Holstein -KielEnabled xenon polariser at Kiel university for medical and porous media researchNew site for xenon MRI2020-01-01ZAcademic/UniversityGermanyMember of German porous media NMR researhc consortiumUK Pulmonary Hypertension MR imaging collaborationNewcastle UniversityI have been proactive in standardising and translating MRI protocols for pulmonary disease across all UK centres. I was asked by Prof Nick Morrell in Cambridge, to lead an imaging study with a standardised MR protocol based around the MRC funded national pulmonary arterial hypertension cohort study of which he is the PI. A cardio-pulmonary MR protocol has been drawn up and I am currently in the process of implementing this MR protocol in all of the UK PH clinical centres.Input on MR protocol design Patient recruitment2014-01-01ZUnited KingdomStandardised UK Pulmonary Hypertension MRI protocol Basis for clinical trials of new therapies for PH with imaging outcomesAarhus University xenon poalriser and MRI pulse sequencesAarhus UniversityEnabled xenon MRI in Danish medical centre with POLARIS xenon polariser and mRI pulse sequencesNew collaboration for xenon lung MRI in Denmark , co supervision of PhD student2021-01-01ZAcademic/UniversityDenmarkJoint PhD student New site enabled for xenon multi centre imagingAstra Zeneca NOVELTY AdPRO studyAstraZenecaPerforming a xenon MRI and lung function deep phenotyping sub-study on the asthma COPD NOVELTY studyLead on lung MRI2020-01-01ZPrivateUnited KingdomERS abstractsEXPLAIN - NIHR LONG COVID XENION MRI STUDYUniversity of OxfordOxford HubMy group provide the xenon lung MRI methodology that underpins this studyEnabled scanning techniques for xenon MRI in Oxford Act as central image processing hub Sheffield is the second clincial recruitment site2021-01-01ZAcademic/UniversityUnited Kingdompaper in RadiologyCOVID-ILDImperial College LondonLead on lung MRI study central to this UKRI multi centre clinical study evaluating the incidence of interstitial lung disease post COVIDLarge national clinical research cosnortium2020-01-01ZAcademic/UniversityUnited KingdomEstablished first UK multi centre platform study for xenon MRIUK Pulmonary Hypertension MR imaging collaborationImperial College LondonImperial College of Science Technology and Medicine (ICSTM)I have been proactive in standardising and translating MRI protocols for pulmonary disease across all UK centres. I was asked by Prof Nick Morrell in Cambridge, to lead an imaging study with a standardised MR protocol based around the MRC funded national pulmonary arterial hypertension cohort study of which he is the PI. A cardio-pulmonary MR protocol has been drawn up and I am currently in the process of implementing this MR protocol in all of the UK PH clinical centres.Input on MR protocol design Patient recruitment2014-01-01ZAcademic/UniversityUnited KingdomStandardised UK Pulmonary Hypertension MRI protocol Basis for clinical trials of new therapies for PH with imaging outcomesUK Pulmonary Hypertension MR imaging collaborationUniversity of CambridgeSchool of Clinical MedicineI have been proactive in standardising and translating MRI protocols for pulmonary disease across all UK centres. I was asked by Prof Nick Morrell in Cambridge, to lead an imaging study with a standardised MR protocol based around the MRC funded national pulmonary arterial hypertension cohort study of which he is the PI. A cardio-pulmonary MR protocol has been drawn up and I am currently in the process of implementing this MR protocol in all of the UK PH clinical centres.Input on MR protocol design Patient recruitment2014-01-01ZAcademic/UniversityUnited KingdomStandardised UK Pulmonary Hypertension MRI protocol Basis for clinical trials of new therapies for PH with imaging outcomesMc Master University CanadaMcMaster UniversityImplementation of Sheffield lung xenon MRI protocols at a new siteClinical evaluation of Sheffield lung MRI protocols2021-01-01ZAcademic/UniversityCanadaOngoing collaborative researchFibre micro-robot (electrothermally actuated)Bispebjerg HospitalOur research team develops Fibre micro-robot (electrothermally actuated) in-house, aiming to precise tissue mapping and laser ablation with continuous diagnostics until no tumour detected.Our collaborators provide their professional advices to support our research development. Brain: - Mr Dipankar Nandi, Professor of Practice (Neurosurgery), Department of Brain Sciences, ICL and Neurosurgery Consultant, Charing Cross Hospital - Dr Hanifa Koguna: junior neurosurgeon, ICL Breast - Daniel Leff, Clinical Senior Lecturer, ICL Colorectal - James Kinross, Clinical Senior Lecturer in Colorectal Surgery, ICL Head and Neck - tumour removal / tumour cavity scan - James Higgins - NIHR Doctoral Fellow, ICL Skin - Dr Catharina M. Lerche, senior scientist at Department of Dermatology, Bispebjerg Hospital, University of Copenhagen2019-01-01ZHospitalsDenmarkN/ADevelopment of fibre-optic SERS probes using two-photon polymerisation for rapid in vivo detection of bacteriaImperial College LondonDr Jang Ah Kim is leading the project by designing experiments; developing protocols; fabricating devices; conducting experiments; collecting, plotting and analysing data; writing papers.Dr Dominic Wales, who is an internal collaborator at the Hamlyn Centre, contributes to characterisation and improvement of surface chemistry of the developed devices; discussions on the experiments and data analysis; writing papers. Dr Alex Thompson, who is a lecturer in Department of Surgery and Cancer, contributes to designing and building optical systems and devices; providing access to microbiological/clinical samples and facilities; discussions on the experiments and data analysis; writing papers.2018-01-01ZAcademic/UniversityUnited KingdomA conference presentation/proceeding was out in 2019 and a journal article was published in 2020. Details available in the Publications section.MicroElectroMechanical Multimaterial fibresMassachusetts Institute of TechnologyDepartment of Materials Science and EngineeringApplication of fibres to Medical Robotics and Confocal EndomicroscopeFabrication of fibres with piezoelectric polymers for actuation. They supported EPSRC programme grant "Micro-Robotics for Surgery" application.2017-01-01ZAcademic/UniversityUnited StatesMulti-dicipllinary: Materials Science, Engineering, Physics, Robotics, SurgeryMiniature pressure sensor made of P(VDF-TrFE) for medical catheter and implantable deviceImperial College LondonDivision of Brain SciencesOur researcher, Dr Bruno Miguel Gil Rosa, works on the development of the electronic interface for signal acquisition from the P(VDF-TrFE) sensor, amplification, and transmission to a recording platform (computer, smartphone) through a tethered or untethered (wireless) communication.Our collaborator, Dr. Bing Li (Edmond and Lily Safra Research Fellow, independent PI) works on the development, fabrication, and transference of the P(VDF-TrFE) sensor.2019-01-01ZAcademic/UniversityUnited KingdomN/AMultimaterial fibres for biosensingSwiss Federal Institute of Technology in Lausanne (EPFL)Department of Materials Science (IMX)(1) Functionalisation of fibres for bio-sensing, animal and clinical studies (2) Design and optical characterization of fibres, applications such as mass spectrometryFabrication of fibres with novel metal electrodes (1) or waveguides (2)2017-01-01ZPublicSwitzerlandthey supported EPSRC programme grant "Micro-robotics for surgery" application. There is a patent application (pending) they supported, led by our team. Disciplines involved: Materials science, Chemistry, Physics, Engineering, Microbiology, SurgeryMaterial Characterization: novel materials for flexible batteries, oxygen plasma processing, contact angle measurements and mechanical characterisation of devicesImperial College LondonDepartment of BioengineeringOur researcher, Dr Panagiotis Kassanos, collaborates with Chandramohan George (Dyson School of Design Engineering), Rosalia Moreddu (Chemical Engineering), Nuria Oliva Jorge (Bioengineering), Michael Bruyns-Haylett (Bioengineering) for material characterisation on novel materials for flexible batteries, oxygen plasma processing, contact angle measurements and mechanical characterisation of devices.Dr Panagiotis Kassanos's collaboration with Dyson and Chemical Engineering are focused on material characterisation. The former on sheet resistance measurements of novel materials for flexible batteries and the latter on oxygen plasma processing, contact angle measurements and mechanical characterisation of devices. His collaboration with Bioengineering was first through a Julia Higgins Imperial postdoc research award together with Dr Meysam Keshavarz (another researcher in our team) and currently through a Rosetrees Seedcorn 2020 award as Co-I's for the development of cartilage regeneration technologies.2019-01-01ZAcademic/UniversityUnited KingdomPublication: 'Scalable Route to Electroactive and Light Active Perylene Diimide Dye Polymer Binder for Lithium-Ion Batteries', ACS Applied Energy Materials, February, 2020. DOI: 10.1021/acsaem.9b01225Neuro interface with multimaterial fibresVirginia TechWe are working with Prof Xiaoting Jia on advancing the interface to neurons using multimaterial fibre combined with our sensor capabilities.Her previous work and expertise on neural interface, listening / triggering to single neuron activity with her probes.2018-01-01ZAcademic/UniversityUnited StatesThis is a multidisciplinary work of physics, chemistry and material science to advance probes for neural interface. Work ongoing,'Biohybrid prosthetic for nerve regeneration based on multi-functional fibre' Clinical Colaboration with Renji hospital in ShanghaiRenji HospitalThe Hamlyn Centre is developing a new generation of microfabrication techniques, based on multi-functional fibre could improve the rehabilitation of patient by allowing for the implants to directly reconnect severed nerves. To achieve this, the growth of cultured nervous cells along an implant axes will be induced and enhanced by the mean of topological, electrical and chemical stimulations. A unique set of techniques has been developed in the Hamlyn Centre for the fabrication, functionalisation, electrical connection and fluid delivery capability of fibre designed and realised on site. Those fibres of tuneable diameter and length can be used to meet the requirement of nerve regeneration implants. Our research teams brought our current research results regarding neuro-regeneration, robotic assisted surgery for spinal cord surgery and wearable devices to our collaborators for further discussion.The collaborators from Renji Hospital offered their advices to our research issues. This collaboration will be used to set up an experimental framework adapted toward our long term goal of in vivo study.2019-01-01ZHospitalsChinaN/ADetection of biomarkers in biological fluids and breathUniversity College LondonDr. Bing Li (UCL) has been supporting in the fabrication of multiplexed electrochemical sensors deposited on a single silicon array for detection of several biomarkers in neurodegenerative diseases, whereas our research team at the Hamlyn Centre is responsible for providing the multiplexed electronic interface for signal acquisition, processing, and visualization. A post-doc researcher from Prof. Norbert Klein (Dr. Sami Ramadhan, ICL) is developing fast screening tools for detection of biomarkers in cancer diseases and COVID-19 infection, whereas our research team is responsible for providing the multiplexed electronic interface connected to the functionalized GFETs.Dr. Bing Li (UCL) is designing and functionalizing the electrochemical sensors for detection of lactate, pH, and amyloid biomarkers in biological samples. Dr. Sami Ramadhan (ICL) is involved on the functionalization of GFETs with antibodies for the detection of the spike protein from virus-like-particles of COVID-19 and also specific exosomes from different types of cancer. The cancer cell samples for this latter study are provided by Dr. Bing Li (UCL).2021-01-01ZAcademic/UniversityUnited KingdomTwo review papers on the journals Carbon and Biosensors & Bioelectronics entitled "Clinical detection of neurodegenerative blood biomarkers using graphene immunosensor" and "Multiplexed immunosensors for point-of-care diagnostic applications", respectively.Medical robotic design, fabricating, integration and controlShanghai Jiao Tong UniversityJoint Design: Our researcher, Dr Weibang Bai, developed rough ball joints, Wuzhou developed gear joints, Andreas developed rolling joints. Modelling: Dr Weibang Bai works on traditional DH model and learning based LSTM models for the miniaturized instruments, Francesco Cursi works on traditional DH model and some learning models on Micro-IGES robot arm.For the joint design and updating, Dr Wuzhou Hong, Dr Andreas Schmitz and Dr Weibang Bai worked together and helped each other to fabricate the instruments and prepare for the integration and test (ended). For the modelling using DH and learning models, Francesco Cursi and Dr Weibang Bai discuss and test the models together (still active).2019-01-01ZAcademic/UniversityChinaN/AFibre micro-robot (electrothermally actuated)Imperial College LondonOur research team develops Fibre micro-robot (electrothermally actuated) in-house, aiming to precise tissue mapping and laser ablation with continuous diagnostics until no tumour detected.Our collaborators provide their professional advices to support our research development. Brain: - Mr Dipankar Nandi, Professor of Practice (Neurosurgery), Department of Brain Sciences, ICL and Neurosurgery Consultant, Charing Cross Hospital - Dr Hanifa Koguna: junior neurosurgeon, ICL Breast - Daniel Leff, Clinical Senior Lecturer, ICL Colorectal - James Kinross, Clinical Senior Lecturer in Colorectal Surgery, ICL Head and Neck - tumour removal / tumour cavity scan - James Higgins - NIHR Doctoral Fellow, ICL Skin - Dr Catharina M. Lerche, senior scientist at Department of Dermatology, Bispebjerg Hospital, University of Copenhagen2019-01-01ZAcademic/UniversityUnited KingdomN/AModelling and control of tendon-driven surgical robotsSapienza University of RomeOur researcher, Francesco Cursi, collaborates with researchers from Sapienza university of Rome on improving the modelling and control of tendon-driven surgical robots.Our collaborators provide their professional advices for supporting our research.2019-01-01ZAcademic/UniversityItalyPublication: Francesco Cursi, Valerio Modugno, Petar Kormushev, 2021. Model Predictive Control for a Tendon-Driven Surgical Robot with Safety Constraints in Kinematics and Dynamics, 2020 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS).MR safe steerable catheterAlbert Ludwig University of FreiburgOur research team made the MR safe steerable catheter.Our collaborators, Professor Michael Bock and his team at the Albert Ludwig University of Freiburg, tested this device under MRI in phantom and pig.2020-01-01ZAcademic/UniversityGermanyA conference presentation with a publication of an extended abstract: To be presented in 2021 ISMRM & SMRT Annual Meeting & Exhibition, abstract to be published in the proceedings. - M. E. M. K. Abdelaziz, L. Tian, T. Lottner, S. Reiss, K. Düring, G-Z. Yang, M. Bock and B. Temelkuran, "An MR Safe Steerable Catheter for MR-guided Endovascular Interventions", Accepted to be published in proceedings of ISMRM & SMRT Annual Meeting & Exhibition 2021.Fabrication of fibre-based IL-8 protein immune-sensor based on functionalised grapheneFranche-Comté Électronique Mécanique Thermique et Optique - Sciences et TechnologiesAutomatic Control and Micro Mechatronic Systems (AS2M)Leading by Dr Haijie Tan, our research team works on fabrication of fibre-based IL-8 protein immune-sensor based on functionalised graphene. Dr Haijie Tan contributes to the experimental design, fabrication and integration of the graphene biosensing platform, by coordinating colleagues with expertise from electronics, biology and chemistry. he also helps with interpretation of our experimental results building upon knowledge about semi-conducting materials. Dr. Bruno Gil Rosa develops the sensor platform that is dealing with the signal read-out, processing and communication. Dr. Dominic Wales is responsible for carrying out chemistry-related experiments. Dr. Burak Temelkuran and Mohamed Abdelaziz work on the multi-functional fibre platform and map out the process for drawing of customisable multi-material fibres.Our collaborator, Dr. Antoine Barbot (CNRS researcher at FEMTO-ST INSTITUTE), works on developing a wet transfer platform by utilising magnetic micro-robots for precise wet transfer. Dr. Bing Li (Edmond and Lily Safra Research Fellow, independent PI), on the other hand, develops graphene functionalisation steps for immobilising specified antibodies on graphene.2019-01-01ZAcademic/UniversityFranceN/AMicrofluidics at Fibre Tip for Nanolitre Delivery and SamplingFranche-Comté Électronique Mécanique Thermique et Optique - Sciences et TechnologiesAutomatic Control and Micro Mechatronic Systems (AS2M)Our research teams collaborate with Dr Antione Barbot on the development of microfluidics at fibre tip for nanolitre delivery and sampling. Our researchers aim to realise a fibre-based sensor for biomarker detection using electrochemistry, optics and micro fluidic based biopsy, to assist and accelerate diagnosis of lung disease during bronchoscopy procedures.Our external collaborator, Dr Antione Barbot (CNRS researcher at FEMTO-ST INSTITUTE), works with our researchers to improve the fibre-optic sensors performance and enhance imaging quality of imaging probes, as well as localise treatment.2020-01-01ZAcademic/UniversityFrancePublication: Antoine Barbot, Maura Power, Florent Seichepine and Guang-Zhong Yang, 2020. 'Liquid seal for compact micropiston actuation at the capillary tip', Science Advances, 6(22), eaba5660. DOI: 10.1126/sciadv.aba5660A functional atraumatic self-shaping cochlear implantQueen Elizabeth Hospital BirminghamOur research team conducted the experiments.Our partner gave feedback on clinical relevance, clinical requirements and design requirements.2020-01-01ZHospitalsUnited Kingdom- Journal contribution: https://doi.org/10.1002/mame.202100620 - Cover highlight: https://doi.org/10.1002/mame.202270002 - Conference poster: https://hamlynsymposium.org/app/uploads/2021/05/HS21Poster_DBS.pdfM-bots fabrication, characterisation and magnetic actuation developmentImperial College LondonOur researcher Dr Meysam Keshavarz works on conceptualisation, methodology, validation, formal analysis, investigation, resources, writing - Original Draft, writing - Review & Editing, visualisation, supervision, project administration, funding acquisitionCollaborators are Dr Jang Ah Kim and Dr Ali Anil Demircali. Dr Jang Ah Kim works on methodology, fabrication, characterisation and Dr Ali Anil Demircali works on magnetic actuation and characterisation.2021-01-01ZAcademic/UniversityUnited KingdomThe research teams are working on publication.Development of graphene-based biosensors for the detection of lung disease biomarkersImperial College LondonOur researcher, Dr Haijie Tan, collaborate with Dr Bing Li (Edmond and Lily Safra Research Fellow, independent PI) from Department of Brain Sciences, Imperial College London on the development of graphene-based biosensors for the detection of lung disease biomarkers.Dr Bing Li (Edmond and Lily Safra Research Fellow, independent PI) from Department of Brain Sciences, Imperial College London works with our research team to develop graphene-based biosensors for the detection of lung disease biomarkers.2019-01-01ZAcademic/UniversityUnited KingdomN/AFibre Robot Animal StudyCelal Bayar UniversityOur research team brought our fibre robot instrument to be tested in an animal study,Collaboration with Dr Huseyin Uvet from Yildiz Technical University and Dr Gulsum Gencoglan from Celal Bayar University. They helped organize the animal lab and the study.2021-01-01ZAcademic/UniversityTurkeyThe research teams are working on publication.Prof Zoltan Takats, Molecularly Aware Robitic Surgery (MARS)Imperial College LondonWe contribute with the fibre robot and a fibre-delivered surgical laser.Prof Takats contributes with his Ambient Mass Spectrometry - iKnife, for intraoperative tissue identification.2018-01-01ZAcademic/UniversityUnited KingdomThe fibre robot developed under this programme, integrated with the diagnostic (iKnife) and therapeutic (surgical laser) instruments, is being advanced to achieve semi-autonomous surgery in various clinical indications: Skin cancer (EPSRC THT phase1 EP/W004798/1), Lower GI track (EPSRC THT phase2 - recently granted), cervical cancer (The Eve Appeal). Working together with the leading robotic company Intuitive Surgical, the fibre robot has been successfully tested in a cadaver study for transoral robotic surgery (TORS).Fibre Robot Animal StudyYildiz Technical UniversityOur research team brought our fibre robot instrument to be tested in an animal study,Collaboration with Dr Huseyin Uvet from Yildiz Technical University and Dr Gulsum Gencoglan from Celal Bayar University. They helped organize the animal lab and the study.2021-01-01ZAcademic/UniversityTurkeyThe research teams are working on publication.Fabrication of fibre-based IL-8 protein immune-sensor based on functionalised grapheneImperial College LondonDivision of Brain SciencesLeading by Dr Haijie Tan, our research team works on fabrication of fibre-based IL-8 protein immune-sensor based on functionalised graphene. Dr Haijie Tan contributes to the experimental design, fabrication and integration of the graphene biosensing platform, by coordinating colleagues with expertise from electronics, biology and chemistry. he also helps with interpretation of our experimental results building upon knowledge about semi-conducting materials. Dr. Bruno Gil Rosa develops the sensor platform that is dealing with the signal read-out, processing and communication. Dr. Dominic Wales is responsible for carrying out chemistry-related experiments. Dr. Burak Temelkuran and Mohamed Abdelaziz work on the multi-functional fibre platform and map out the process for drawing of customisable multi-material fibres.Our collaborator, Dr. Antoine Barbot (CNRS researcher at FEMTO-ST INSTITUTE), works on developing a wet transfer platform by utilising magnetic micro-robots for precise wet transfer. Dr. Bing Li (Edmond and Lily Safra Research Fellow, independent PI), on the other hand, develops graphene functionalisation steps for immobilising specified antibodies on graphene.2019-01-01ZAcademic/UniversityUnited KingdomN/AMR-Guided Endovascular InterventionsUniversity Medical Center FreiburgOur research team develops multi-material fibre steerable catheter and other surgical instruments for MR-Guided Endovascular Interventions.Our collaborators provide their professional advices to support our research development. University Medical Center Freiburg: - Michael Bock (Professor for Experimental Radiology) - Prof. Dr Med. Constantin von zur Mühlen (Chief Senior Physician, Head of Interventional Cardiology) - Prof. Dr Med. Constantin von zur Mühlen (Chief Senior Physician, Head of Interventional Cardiology) - PD Dr Med. Timo Heidt Imperial College London: - Celia Theodoreli Riga (Consultant Vascular Surgeon, Honorary Clinical Senior Lecturer) - Colin Bicknell (Clinical Senior Lecturer, Hon Consultant Vascular Surgeon) - Dr Mohamad S Hamady (Honorary Senior Lecturer)2019-01-01ZHospitalsGermanyN/AMR-Guided Endovascular InterventionsImperial College Healthcare NHS TrustImperial College Healthcare NHS CharityOur research team develops multi-material fibre steerable catheter and other surgical instruments for MR-Guided Endovascular Interventions.Our collaborators provide their professional advices to support our research development. University Medical Center Freiburg: - Michael Bock (Professor for Experimental Radiology) - Prof. Dr Med. Constantin von zur Mühlen (Chief Senior Physician, Head of Interventional Cardiology) - Prof. Dr Med. Constantin von zur Mühlen (Chief Senior Physician, Head of Interventional Cardiology) - PD Dr Med. Timo Heidt Imperial College London: - Celia Theodoreli Riga (Consultant Vascular Surgeon, Honorary Clinical Senior Lecturer) - Colin Bicknell (Clinical Senior Lecturer, Hon Consultant Vascular Surgeon) - Dr Mohamad S Hamady (Honorary Senior Lecturer)2019-01-01ZCharity/Non ProfitUnited KingdomN/AMIT magnetic robots and low friction materialsMassachusetts Institute of TechnologyOur team suggesting applications for the developed magnetic as well as low friction materials MIT team developed under Prof Xuanhe Zhao.3D printed magnetic materials and low friction materials.2018-01-01ZAcademic/UniversityUnited StatesCollaboration at early stage for any output.Development of multiplexed force sensors for the medical catheterImperial College LondonOur researcher Dr Bruno Gil Rosa collaborates with Dr Bing Li (Edmond and Lily Safra Research Fellow, independent PI), Department of Brain Sciences, Imperial College London) on the development of multiplexed force sensors for the medical catheter.Dr Bing Li (Edmond and Lily Safra Research Fellow, independent PI), Department of Brain Sciences, Imperial College London) works with our researcher to develop multiplexed force sensors for the medical catheter.2019-01-01ZAcademic/UniversityUnited KingdomBruno Gil, Bing Li, Anzhu Gao, Guang-Zhong Yang, Miniaturized Piezo Force Sensor for Medical Catheter and Implantable Device, ACS Applied Electronic Materials, 2, 2669, 2020. (ACS Editor's Choice and Most Read of the Year) DOI: 10.1021/acsaelm.0c00538 Bing Li, Bruno Gil Rosa, Maura Power, Anzhu Gao, Guang-Zhong Yang. Controllable Fabrication of Carbon Nanotube-coated Micro-spring Pressure Sensor for Medical Applications. ACS Applied Materials & Interfaces, 11, 35577, 2019. (Q1, IF=8.76) DOI: 10.1021/acsami.9b12237ECREA Science and Environment SectionEuropean Communication Research and Education AssociationThis grant allowed me to remain as the Vice-Chair of the Science and Environment Section of ECREA for the duration of the grant.As part of the collaboration, the section members contributed to the symposium Reframing Water and Climate Resilience. In addition, I co-organized the online pre-conference event Misinformation, Science Populism and the Role of Citizens.2022-01-01ZCharity/Non ProfitBelgiumPreconference - Misinformation, Science Populism and the Role of Citizens. Symposium - Reframing Water and Climate Resilience.Visiting Fellow at Waterwise UKWaterwiseDestination of knowledge among the charity network of partners.One-on-one mentorship; workshop facilitation, lecturing, conference panel presentation and charing.2022-01-01ZCharity/Non ProfitUnited KingdomWaterwise annual conference presentationVisiting Fellowship at the Institute for Development StudiesInstitute of Development StudiesUnder the mentorship of Dr. Amber Huff I joined the Resource Politics Cluster of IDS.As part of the fellowship, the cluster took part in the organization of the symposium - Reframing Water and Climate Resilience (see networking)2022-01-01ZAcademic/UniversityUnited KingdomThe symposium Reframing Water and Climate ResilienceCollaboration with Pennington Biomedical Research CentreLouisiana State UniversityPennington Biomedical Research CentreWorking relationship on the analysis of population specific data.Working relationship on the analysis of population specific data.2025-01-01ZAcademic/UniversityUnited StatesNAZEPUniversity of WaterlooIn NERC FLOODMAL we developed flood mapping and flood modelling of the Upper Zambezi floodplain and related these to malaria transmission risk. Clinical rates of malaria incidence recorded in health facilities in Western Province (1.1m people, high levels of extreme poverty) is denominated by the number of people in the facility catchment and their access to the facility. This is determined by annual flood levels that are becoming increasingly erratic with climate change. This new project (22-25) led by U Waterloo, with UK FLOODMAL investigators as co-Is (Thomas and Smith) has been funded by CIHR (Canadian Institutes for Health Research), will integrate our spatial process modelling of water and disease with physical geographic, social science and public health studies of peoples' access to health facilities and their health seeking behaviour. The project aims to provide a) population calibrations of monthly health data recorded in facilities and collated nationally for use in risk modelling; b) leading to adapted health service provision in the face of climate change. As in NERC FLOODMAL we work closely with the Zambian Ministry of Health as partners. The NERC FLOODMAL derived UK research team will contribute space-time process modelling of access routes and transportation, data on flooding (remote sensing products, Zambezi hydraulic modelling), mapping access routes and GIS analysis. We coordinate research activities and impact generation in the partnership through a Zambian registered NGO the Zambezi EcoHealth partnership, of which I was a founding member through NERC FLOODMAL.U.Waterloo is a team of public health anthropologists contributing social science data and understanding on travel decisions and health seeking behaviour, as well as project coordination2019-01-01ZAcademic/UniversityCanadamulti-displinaryPromoting reading for meaning for young children in some selected schools in Limpopo ProvinceUniversity of LimpopoThe University of Limpopo, under the auspices of the DSI-NRF South African Research Chair Initiative (SARChI) in Schools as Enabling Environments, seeks to scale up an intervention to promote reading for learners in the Foundation phase in a partnership study. Prof Mahlapahlapana will be the Principal Investigator, with Professors Liesel Ebersöhn (University of Pretoria) and Qing Gu (University College London) as Research Advisors and Co-Principal Investigators. The national Department for Basic Education (DBE) in South Africa and Department for Education (DfE) in the Province of Limpopo are partners and key stakeholders of this project. The Enabling Schools Toolkit was created and piloted in ten primary schools in the Northwest Province - as a result of this ESRC funded research on Enabling Schools that was led by Professors Qing Gu and Liesel Ebersöhn. The Toolkit represents a proof of concept that through reading, creative arts and creative writing, Foundation Phase children can benefit from a whole child education approach to learning, improving reading as well as mental health and wellbeing outcomes. Professor Ebersöhn and Professor Gu have been working with Prof Mahlapahlapana and his research team, in partnership with the national Department for Basic Education and the Provincial Department for Education, on the scaling up project over the last year. Schools have been recruited and training sessions and materials have been set up. The team is current setting up research instruments in preparation of data collection.The efficacy (scaling-up) phase of the Enabling Schools Toolkit in the Limpopo Province will purposively sample up to 30 primary schools in consultation with officials from the national DBE and provincial DfE. DBE and DfE are strategic drivers of this efficacy project who ensures buy-in and participation from schools in Limpopo and secures the research team's access to schools. The primary sponsor will be NRF through the SARChI Chair at the University of Limpopo. Other partners are to support in human and physical resources such as research expertise, and in-kind capacity with details to be finalised in a proposal being drafted. The programme will involve school principals, relevant SMT-members, and foundation phase teachers, learners, and parents in selected 30 schools, as well as researchers from the three participating universities. In 2024-5, Professor Ebersöhn and Professor Gu have been supporting the Limpopo research team to prepare training for recruited schools (including their principals and teachers) and set up research instruments in preparation for data collection.2023-01-01ZAcademic/UniversitySouth AfricaThe partnership is scaling up the Enabling Schools Toolkit - the main output of this ESRC funded Enabling School research. The research team at the University of Limpopo are preparing for the fieldwork and training of school principals and teachers. The Toolkit, reading materials and research instruments created from the ESRC Enabling Project are essential resources for this scaling up project. The Enabling Schools Toolkit developed by a multi-disciplinary team including education, psychology, philosophy, and sociology of education.African Research Universities Alliance partnershipsUniversity of the WitwatersrandThis partnership builds on our existing collaborations through the ESRC project and aims to strengthen a cross-disciplinary understanding of the links between poverty, family choices and child development. To this end, we will collect unique household data and strengthen ties between Wits (School of Economics and Finance), University of Pretoria (UP, Centre for the Study of Resilience) and UCL (Institute for Global Health and the Institute for Education) - as a springboard for future innovative work on poverty, family behaviour and child development. The activities to be carried out through this partnership complements the ongoing South African Enabling Schools Project (ESP) led by UCL and UP, and funded by the UK Economic and Social Research Council. The ESP has developed a school-level intervention to improve education and health outcomes among primary school children in rural South Africa. Currently, the home environment is not examined as an input to study outcomes and Wits is an unfunded member of the ESP consortium. The following four activities will thus be conducted through the proposed ARUA-UCL-Wits project to significantly extend ESP work. The UCL research team will lead the design and execution of the household survey (May-June 2022): The development of a survey to be administered to 350-400 Enabling Schools Project (ESP) participants' households. This will contain items on: (1) multi-dimensional poverty, (2) child/adult time preferences, (3) child/adult time allocation, (4) vulnerability/resilience, (5) household expenditure, (6) child/adult mental and physical health. UCL researchers will participate in the first week of data collection and piloting to facilitate the three-way sharing of expertise. An ethics amendment will be submitted and Covid-19 protocols adhered to, similarly to ongoing ESP data collection activities. Additionally, the UCL research team will also lead the data collection from a sub-sample of children using photovoice methodology.Training and capacity-building (April-May 2022): A week-long workshop, jointly hosted by Wits, UCL and UP. This will cover fundamentals of statistics for research, survey data collection and concepts in behavourial health economics, educational leadership, resilience and vulnerability. The workshop will reflect on available local data and information gaps that necessitate primary data collection in South Africa. UP Partner will also facilitate the execution of the household survey and the data collection through photovoice methodology.2022-01-01ZAcademic/UniversitySouth AfricaThis multi-disciplinary collaboration is new, funded by the UCL in January 2022. The collaborative activities are informed by knowledge and methodology from health economics, mental health, education, and educational psychology. The intended outcomes of this collaboration are as follows: 1. Build research capacity in the UK and South Africa to carry out this project and develop a future body of work on child development in complex settings. 2. Develop a household survey for use in this and future projects, focussing on the understudied aspects of time preferences, time poverty, vulnerability and resilience. 3. Collect household data to enable several high-impact analyses of household poverty, economic behaviour, vulnerability and resilience. 4. Academic and non-academic dissemination, with at least one high-impact journal article and conference presentation. 5. Build a new body of knowledge on the impact of time preferences, time poverty and resilience on child development in vulnerable communities.African Research Universities Alliance partnershipsUniversity College LondonThis partnership builds on our existing collaborations through the ESRC project and aims to strengthen a cross-disciplinary understanding of the links between poverty, family choices and child development. To this end, we will collect unique household data and strengthen ties between Wits (School of Economics and Finance), University of Pretoria (UP, Centre for the Study of Resilience) and UCL (Institute for Global Health and the Institute for Education) - as a springboard for future innovative work on poverty, family behaviour and child development. The activities to be carried out through this partnership complements the ongoing South African Enabling Schools Project (ESP) led by UCL and UP, and funded by the UK Economic and Social Research Council. The ESP has developed a school-level intervention to improve education and health outcomes among primary school children in rural South Africa. Currently, the home environment is not examined as an input to study outcomes and Wits is an unfunded member of the ESP consortium. The following four activities will thus be conducted through the proposed ARUA-UCL-Wits project to significantly extend ESP work. The UCL research team will lead the design and execution of the household survey (May-June 2022): The development of a survey to be administered to 350-400 Enabling Schools Project (ESP) participants' households. This will contain items on: (1) multi-dimensional poverty, (2) child/adult time preferences, (3) child/adult time allocation, (4) vulnerability/resilience, (5) household expenditure, (6) child/adult mental and physical health. UCL researchers will participate in the first week of data collection and piloting to facilitate the three-way sharing of expertise. An ethics amendment will be submitted and Covid-19 protocols adhered to, similarly to ongoing ESP data collection activities. Additionally, the UCL research team will also lead the data collection from a sub-sample of children using photovoice methodology.Training and capacity-building (April-May 2022): A week-long workshop, jointly hosted by Wits, UCL and UP. This will cover fundamentals of statistics for research, survey data collection and concepts in behavourial health economics, educational leadership, resilience and vulnerability. The workshop will reflect on available local data and information gaps that necessitate primary data collection in South Africa. UP Partner will also facilitate the execution of the household survey and the data collection through photovoice methodology.2022-01-01ZAcademic/UniversityUnited KingdomThis multi-disciplinary collaboration is new, funded by the UCL in January 2022. The collaborative activities are informed by knowledge and methodology from health economics, mental health, education, and educational psychology. The intended outcomes of this collaboration are as follows: 1. Build research capacity in the UK and South Africa to carry out this project and develop a future body of work on child development in complex settings. 2. Develop a household survey for use in this and future projects, focussing on the understudied aspects of time preferences, time poverty, vulnerability and resilience. 3. Collect household data to enable several high-impact analyses of household poverty, economic behaviour, vulnerability and resilience. 4. Academic and non-academic dissemination, with at least one high-impact journal article and conference presentation. 5. Build a new body of knowledge on the impact of time preferences, time poverty and resilience on child development in vulnerable communities.African Research Universities Alliance partnershipsUniversity of PretoriaThis partnership builds on our existing collaborations through the ESRC project and aims to strengthen a cross-disciplinary understanding of the links between poverty, family choices and child development. To this end, we will collect unique household data and strengthen ties between Wits (School of Economics and Finance), University of Pretoria (UP, Centre for the Study of Resilience) and UCL (Institute for Global Health and the Institute for Education) - as a springboard for future innovative work on poverty, family behaviour and child development. The activities to be carried out through this partnership complements the ongoing South African Enabling Schools Project (ESP) led by UCL and UP, and funded by the UK Economic and Social Research Council. The ESP has developed a school-level intervention to improve education and health outcomes among primary school children in rural South Africa. Currently, the home environment is not examined as an input to study outcomes and Wits is an unfunded member of the ESP consortium. The following four activities will thus be conducted through the proposed ARUA-UCL-Wits project to significantly extend ESP work. The UCL research team will lead the design and execution of the household survey (May-June 2022): The development of a survey to be administered to 350-400 Enabling Schools Project (ESP) participants' households. This will contain items on: (1) multi-dimensional poverty, (2) child/adult time preferences, (3) child/adult time allocation, (4) vulnerability/resilience, (5) household expenditure, (6) child/adult mental and physical health. UCL researchers will participate in the first week of data collection and piloting to facilitate the three-way sharing of expertise. An ethics amendment will be submitted and Covid-19 protocols adhered to, similarly to ongoing ESP data collection activities. Additionally, the UCL research team will also lead the data collection from a sub-sample of children using photovoice methodology.Training and capacity-building (April-May 2022): A week-long workshop, jointly hosted by Wits, UCL and UP. This will cover fundamentals of statistics for research, survey data collection and concepts in behavourial health economics, educational leadership, resilience and vulnerability. The workshop will reflect on available local data and information gaps that necessitate primary data collection in South Africa. UP Partner will also facilitate the execution of the household survey and the data collection through photovoice methodology.2022-01-01ZAcademic/UniversitySouth AfricaThis multi-disciplinary collaboration is new, funded by the UCL in January 2022. The collaborative activities are informed by knowledge and methodology from health economics, mental health, education, and educational psychology. The intended outcomes of this collaboration are as follows: 1. Build research capacity in the UK and South Africa to carry out this project and develop a future body of work on child development in complex settings. 2. Develop a household survey for use in this and future projects, focussing on the understudied aspects of time preferences, time poverty, vulnerability and resilience. 3. Collect household data to enable several high-impact analyses of household poverty, economic behaviour, vulnerability and resilience. 4. Academic and non-academic dissemination, with at least one high-impact journal article and conference presentation. 5. Build a new body of knowledge on the impact of time preferences, time poverty and resilience on child development in vulnerable communities.African Research Universities Alliance partnershipsLondon South Bank UniversityThis partnership builds on our existing collaborations through the ESRC project and aims to strengthen a cross-disciplinary understanding of the links between poverty, family choices and child development. To this end, we will collect unique household data and strengthen ties between Wits (School of Economics and Finance), University of Pretoria (UP, Centre for the Study of Resilience) and UCL (Institute for Global Health and the Institute for Education) - as a springboard for future innovative work on poverty, family behaviour and child development. The activities to be carried out through this partnership complements the ongoing South African Enabling Schools Project (ESP) led by UCL and UP, and funded by the UK Economic and Social Research Council. The ESP has developed a school-level intervention to improve education and health outcomes among primary school children in rural South Africa. Currently, the home environment is not examined as an input to study outcomes and Wits is an unfunded member of the ESP consortium. The following four activities will thus be conducted through the proposed ARUA-UCL-Wits project to significantly extend ESP work. The UCL research team will lead the design and execution of the household survey (May-June 2022): The development of a survey to be administered to 350-400 Enabling Schools Project (ESP) participants' households. This will contain items on: (1) multi-dimensional poverty, (2) child/adult time preferences, (3) child/adult time allocation, (4) vulnerability/resilience, (5) household expenditure, (6) child/adult mental and physical health. UCL researchers will participate in the first week of data collection and piloting to facilitate the three-way sharing of expertise. An ethics amendment will be submitted and Covid-19 protocols adhered to, similarly to ongoing ESP data collection activities. Additionally, the UCL research team will also lead the data collection from a sub-sample of children using photovoice methodology.Training and capacity-building (April-May 2022): A week-long workshop, jointly hosted by Wits, UCL and UP. This will cover fundamentals of statistics for research, survey data collection and concepts in behavourial health economics, educational leadership, resilience and vulnerability. The workshop will reflect on available local data and information gaps that necessitate primary data collection in South Africa. UP Partner will also facilitate the execution of the household survey and the data collection through photovoice methodology.2022-01-01ZAcademic/UniversityUnited KingdomThis multi-disciplinary collaboration is new, funded by the UCL in January 2022. The collaborative activities are informed by knowledge and methodology from health economics, mental health, education, and educational psychology. The intended outcomes of this collaboration are as follows: 1. Build research capacity in the UK and South Africa to carry out this project and develop a future body of work on child development in complex settings. 2. Develop a household survey for use in this and future projects, focussing on the understudied aspects of time preferences, time poverty, vulnerability and resilience. 3. Collect household data to enable several high-impact analyses of household poverty, economic behaviour, vulnerability and resilience. 4. Academic and non-academic dissemination, with at least one high-impact journal article and conference presentation. 5. Build a new body of knowledge on the impact of time preferences, time poverty and resilience on child development in vulnerable communities.Collaboration with colleagues in continental EuropeWageningen University & ResearchI organised an online meeting in November 2024 https://warwick.ac.uk/fac/sci/lifesci/wcc/events/aphidmeeting/ for members of the European Vegetable Research Institutes' Network (EUVRIN) and the IOBC Working Group on Integrated Protection of Field Vegetable Crops. This was to discuss issues around management of aphids in outdoor vegetable and salad crops. There were 6 presentations and some useful discussion about current research.As a result of the meeting, our Dutch partners at Wageningen University followed up an opportunity to apply for a small amount of Dutch funding to further discussions/collaboration. This is about "Stacking" biological control with other integrated management tactics for sustainable aphid control in open field vegetables. It is for 50k€ and is basically a scoping project as outlined below: A1. Have a start-up meeting with focus on a few key vegetables (e.g. lettuce, crucifers, legumes). Break-out sessions will help identify integrative aspects of addressing aphid solutions. Prioritise on which crop-aphid combinations activities of partners will focus. A2. Formulate scenarios per crop, identify where new tactics, combinations or biocontrol products are needed. Create an inventory of all available tactics, with cross-pollination across crop species, define novel aphid management packages. A3. Feasibility studies. Identify caveats per package. Identify areas of R&D, applied and basic research, rank solutions for feasibility (status & progress meeting, and establish a research agenda). A4. Identify funding opportunities (national and international), organise, and align research initiatives with calls and start working out proposal(s). The industry partner is Biobest and there are partners from the Netherlands, UK, Belgium, Austria, Switzerland, Germany. It ties in closely with some of the PhD projects we have at the moment (focused on companion plants and other approaches) and a recent small project with BBSRC funding on lettuce - and also the interests of some UK growers. The application was successful and the meeting took place in summer 2025. We are now working with colleagues to identify European funding opportunities.2024-01-01ZAcademic/UniversityNetherlandsNo outcomes or outputs yet.OPTAMOTUniversity of NottinghamTested and determined the best alloys to use to achieve UHV with 3d-printed structures. Used conducting 3d-printed structures to create magnetic fields' landscapes for neutral atoms trapping. Contributed to the design of various 3d-printed UHV chambers. Tested the UHV compatibility of various 3d-printed UHV chambers. Determined the mechanical strength of the alloy.ASL - Project management; - Demonstrated AM material capable of meeting structural and outgassing requirements to construct UHV capable chambers; - Designed UHV chambers following input from academic partners; - Market analysis and commercialisation; University of Nottingham - Participated in the design of UHV chambers; - Tested the performances of the UHV chamber; - Measured the outgassing profile as a function of a temperature;2017-01-01ZAcademic/UniversityUnited Kingdom- Publication in peer review journal; - Exhibition in a showcase; This is multidisciplinary collaboration, the lead partner, Added Scientific Ltd., has an engineering background while the two academic partners (the University of Sussex and University of Nottingham) are in the area of physics.OPTAMOTAdded Scientific LtdTested and determined the best alloys to use to achieve UHV with 3d-printed structures. Used conducting 3d-printed structures to create magnetic fields' landscapes for neutral atoms trapping. Contributed to the design of various 3d-printed UHV chambers. Tested the UHV compatibility of various 3d-printed UHV chambers. Determined the mechanical strength of the alloy.ASL - Project management; - Demonstrated AM material capable of meeting structural and outgassing requirements to construct UHV capable chambers; - Designed UHV chambers following input from academic partners; - Market analysis and commercialisation; University of Nottingham - Participated in the design of UHV chambers; - Tested the performances of the UHV chamber; - Measured the outgassing profile as a function of a temperature;2017-01-01ZPrivateUnited Kingdom- Publication in peer review journal; - Exhibition in a showcase; This is multidisciplinary collaboration, the lead partner, Added Scientific Ltd., has an engineering background while the two academic partners (the University of Sussex and University of Nottingham) are in the area of physics.Pacific partnersUniversity of QueenslandThis projects builds on a long-standing association with the Co-I Professor Corrin at Queensland, and this funding on research in the region which had long been of interest to the Co-I. Collaboration also materialised in an article recently submitted for publication.This project has been facilitated by the Co-I Professor Jennifer Corrin who has assisted in briefing and co-ordinating the field work in Solomon Islands, and in co-authoring an article (COMPARATIVE PERSPECTIVES ON PLURAL LEGAL GOVERNANCE OF MARINE RESOURCES IN THE PACIFIC) which has been submitted for publication to the Comparative Law Journal of the Pacific.2020-01-01ZAcademic/UniversityAustraliaA research conference paper 2020 at the Society of Legal Scholars Conference, durham, UK An article in the Environmental Law Review Journal The submission of a further co-authored article to the Comparative Law Journal of the Pacific, University of Victoria, Wellington New ZealandProject's partnershipLoughborough UniversityDepartment of EngineeringI and my team contributed to the collaboration by the training of the staff working on the project (postdoc), and the creation of a shared account for data storage on SurfSara, so to allow access to partners for data exchange.Sandia National Laboratories: Intellectual input and the provision of two highly-valuable direct numerical simulation (DNS) datasets of two conditions relevant for the project. These DNS have been used to benchmark the numerical methodology used in our work. Rolls-Royce has contributed to the partnership via intellectual inputs at the project's meeting. Loughborough University (LU) has also participated to the project's meetings and provided intellectual input. In addition, a PhD studentship has been allocated by LU (estimated to start April 2022) and tied with the present project, under a formal agreement established between LU and TU Delft.2021-01-01ZAcademic/UniversityUnited KingdomThis collaboration has not yet lead to any output. However, a paper has been recently submitted to the International Combustion Symposium.Detection of flashback in hydrogen combustion towards decarbonizationIndian Institute of Science BangaloreWe simulated with large eddy simulations a reheat geometry where hydrogen is used as fuel, and tested different techniques for the stabilization of the hydrogen flame. This collaboration led to further fundings (5000 eur via joint TU Delft & IISc/IIT seed fund scheme) for travel exchange to the IIS Bangalore.The partners provided a DNS database to validate the results2021-01-01ZAcademic/UniversityIndia- Award of joint TU Delft & IISc/IIT seed fund scheme (5000 eur). The new project is titled "Detection of flashback in hydrogen combustion towards decarbonization" - Research findings expected end of 2023Project's partnershipSandia National Laboratories CaliforniaI and my team contributed to the collaboration by the training of the staff working on the project (postdoc), and the creation of a shared account for data storage on SurfSara, so to allow access to partners for data exchange.Sandia National Laboratories: Intellectual input and the provision of two highly-valuable direct numerical simulation (DNS) datasets of two conditions relevant for the project. These DNS have been used to benchmark the numerical methodology used in our work. Rolls-Royce has contributed to the partnership via intellectual inputs at the project's meeting. Loughborough University (LU) has also participated to the project's meetings and provided intellectual input. In addition, a PhD studentship has been allocated by LU (estimated to start April 2022) and tied with the present project, under a formal agreement established between LU and TU Delft.2021-01-01ZPublicUnited StatesThis collaboration has not yet lead to any output. However, a paper has been recently submitted to the International Combustion Symposium.Project's partnershipRolls Royce Group PlcI and my team contributed to the collaboration by the training of the staff working on the project (postdoc), and the creation of a shared account for data storage on SurfSara, so to allow access to partners for data exchange.Sandia National Laboratories: Intellectual input and the provision of two highly-valuable direct numerical simulation (DNS) datasets of two conditions relevant for the project. These DNS have been used to benchmark the numerical methodology used in our work. Rolls-Royce has contributed to the partnership via intellectual inputs at the project's meeting. Loughborough University (LU) has also participated to the project's meetings and provided intellectual input. In addition, a PhD studentship has been allocated by LU (estimated to start April 2022) and tied with the present project, under a formal agreement established between LU and TU Delft.2021-01-01ZPrivateUnited KingdomThis collaboration has not yet lead to any output. However, a paper has been recently submitted to the International Combustion Symposium.DPAGUniversity of OxfordDepartment of Physiology, Anatomy and GeneticsNew adaptive microscope technology for deep tissue imaging.Expertise in neuroscience and in vivo imaging.2023-01-01ZAcademic/UniversityUnited KingdomOutputs are in preparation.COST Action CA22136 - PANGEOSUniversity of BarcelonaI lead Working Group 3 within the PANGEOS COST Action. The COST Action is a networking collaboration which brings together researchers from all over Europe. I recently organised a workshop in Lisbon which was attended by 20 people to discuss research on remote sensing and vegetation modelling.Other members of the COST Action come together to share knowledge and research with the objective of writing publications.2024-01-01ZAcademic/UniversitySpainOne training school, a workshop and a small conferenceUKCEHUK Centre for Ecology & HydrologyWe worked with UKCEH at UK agricultural flux towers to measure coupled eddy-covariance and remote sensing data. We contributed the remote sensing measurements and expertise. The collaboration has led to 2 masters projects.UKCEH provided processed flux tower data and offered expert guidance.2022-01-01ZPublicUnited KingdomN/AADASADASWe collected plant physiology measurements and remote sensing measurements at a ADAS field trial, measuring the impacts of different nitrogen fertiliser application rates on plant health, yields and investigating if we can measure these differences from drone platforms.ADAS were responsible for planning and managing the field trials and for collecting some agricultural field data (e.g. green leaf area index, yields).2020-01-01ZPrivateUnited KingdomThe results from this work were presented at the British Ecological Survey meeting in Edinburgh (December, 2022) and a COST-Action (SENSECO) working group meeting in Romania (October, 2021).Ian TomlinsonUniversity of EdinburghInstitute of Genetics & Molecular MedicineAnalysis of RNA and DNA from patient samples collected by Ian Tomlinson to investigate allele specific MLH1 mRNA expression and promoter methylationSharing of patient sample sets. Sharing of data from analyses of these sample sets.2017-01-01ZAcademic/UniversityUnited KingdomSome data still under analysis. The collaboration has contributed to 3 publications (Thomas et al., 2019; Rayner et al., 2019 and Russell et al., 2020)Laura Thomas - Patient derived intestinal organoids from normal, colon cancer and FAP/MAP/LYNCH patientsSwansea UniversitySwansea University Medical SchoolWe will use organoids derived by these collaborators to investigate the effect of secreted intestinal growth factors on the growth and development of organoids derived from normal and cancer tissues.The lab of Laura Thomas participate in a large NHS study which enables them to collect tissue biopsies from consenting patients with colon cancer and use these to derive intestinal organoid lines.2023-01-01ZAcademic/UniversityUnited KingdomNone as yet, this is a new collaboration.Marcia Hall, Mount Vernon Cancer HospitalEast and North Hertfordshire NHS TrustMount Vernon Cancer CentreThe investigation of circulating tumour cells and cell free DNA in MSI+ cancers.Prof Marcia Hall has established the CICATRIx study, which collects blood samples from patients with advanced cancer attending Mount Vernon Hospital (West Midlands-South Birmingham Ethics Committee (reference 16/WM/0196; protocol number RD2016- 08)). These samples are already shared with Brunel researchers with full ethical approval and Prof Hall has agreed that we can share in the use of RNA and DNA extracted from relevant samples, specifically colorectal and endometrial cancers.2022-01-01ZHospitalsUnited KingdomNo outputs yetDavid Church and laboratoryUniversity of OxfordNuffield Department of MedicineWe have generated a mouse model of microsatellite unstable colorectal cancer by breeding mice containing a conditional BRAFV600E oncogenic mutation with MLH1 conditional knockout mice. These mutations have been activated specifically in the intestine and result in increased numbers of polyps and faster growth than those found in mice carrying the BRAFV600E mutation alone. Preliminary analysis shows that these polyps are have microsatellite instability.Dr Church and his group are generating further MLH1 mouse crosses with APC mutated and POLE mutated strains. They are also developing methods to assess and compare immune activity in tumours from all three crosses.2019-01-01ZAcademic/UniversityUnited KingdomA new mouse model of MSI+ colorectal cancer with the potential for two further models of hypermutated colorectal cancer. This project is very much a work in progress at the moment with encouraging preliminary results.Tracy O'Mara and other members of the ECAC consortiumQIMR Berghofer Medical Research InstituteUsing patient genotyping data provided by Tracy O'Mara and colleagues, we have carried out a candidate SNP analysis on the effect of rs1800734 on the risk of mismatch repair deficient endometrial cancer. We have shown that, in contrast to our published work on colorectal cancer (Thomas et al, 2019), this SNP has no effect on endometrial cancer risk which ties in with our own in vitro studies. We now have a manuscript including this data ready for submission to Clinical EpigeneticsT racy A. O'Mara, Daniel D. Buchanan, Emma Tham, Miriam Mints, Anne Keränen and Amanda B. Spurdle have previously collected and analysed several large cohorts of endometrial cancer patient genotyping data for use in genome wide association studies. For this collaboration they provided additional analyses on the mismatch repair status of each patient allowing the cohorts to be stratified. This allowed us to carry out the analysis of the effect of rs1800734 risk on MMR deficient endometrial cancer which now forms part of a manuscript in preparation.2019-01-01ZAcademic/UniversityAustraliaThe collaboration has contributed to 1 publications (Russell et al., 2020) and ongoing planning for a future grant proposal.Ian TomlinsonUniversity of BirminghamInstitute of Cancer and Genomic ScienceAnalysis of RNA and DNA from patient samples collected by Ian Tomlinson to investigate allele specific MLH1 mRNA expression and promoter methylationSharing of patient sample sets. Sharing of data from analyses of these sample sets.2017-01-01ZAcademic/UniversityUnited KingdomSome data still under analysis. The collaboration has contributed to 3 publications (Thomas et al., 2019; Rayner et al., 2019 and Russell et al., 2020)Emmanouil Karteris, Brunel University LondonBrunel University LondonDivision of BiosciencesInitiating a collaboration to investigate drivers of promoter hypermethylation in Endometrial CancerEndometrial cancer and liquid biopsy collection and biomarker analysis2021-01-01ZAcademic/UniversityUnited KingdomCollaboration just initiated - sharing of ideas and resources.Timothy Maughan and the S:CORT consortiumUniversity of OxfordDepartment of OncologyWe have used samples and data collected by the S:CORT consortium to analyse the effect of the SNP rs1800734 on MLH1 expression and methylation in early colorectal lesionsProviding data and DNA and RNA from early colorectal cancer lesions as well as regular meetings offering support and advice on this sub-project and the project as a whole.2017-01-01ZAcademic/UniversityUnited KingdomThe collaboration has contributed to 1 publications (Thomas et al., 2019).Visiting Industrial Researcher from the Taisei Corporation, JapanTaisei CorporationProvision of research equipment and advanced physical modelling techniques to simulate offshore cable plough performance in a laboratory environment. Training of visiting researcher in advanced modelling techniquesFinancial support of visiting researcher2017-01-01ZPrivateJapanCreating of a data set looking at cable plough perfroamcne modelling suring centrifuge testing as well as a study (data) on how plough share geometry affects plough performance.Jeanne SaljeUniversity of OxfordWolfson CollegeThis is a scientific collaboration with Jeanne Salje on pathogenic intracellular bacterial. We contributed our expertise in bacterial cell wall structure and biosynthesis.The partner contributed their expertise in the biology of intracellular bacteria.2017-01-01ZCharity/Non ProfitUnited KingdomPublication in scientific journal: PMID: 29178391SME collaborationBicycle TherapeuticsKnowledge Transfer Fundamental molecular microbiology and mechanistic understanding Reagents and assaysPhD suport, internship support, reagent support, financial support2018-01-01ZPrivateUnited KingdomJoint Innovate Uk Anti-Infectives funding https://www.bicycletherapeutics.com/beyond-oncology/Tanneke den BlaauwenUniversity of AmsterdamThis is a long-term scientific collaboration with Tanneke den Blaauwen on cell envelope biogenesis in E. coli. We contribute our expertise in bacterial cell wall structure and biosynthesis, provided research tools and performed experiments.The partner contributed their expertise in bacterial cell biogenesis and cellular localization of proteins, provided research tools and performed experiments.Academic/UniversityNetherlandsPublications in scientific journals: PMID: 30233559 PMID: 26124755 PMID: 25951518 PMID: 23387922 PMID: 22606933 PMID: 21472954 PMID: 21183073 PMID: 20545860 PMID: 16803586Joseph MougousUniversity of WashingtonDivision of Medical GeneticsExpertise in bacterial cell wall. Experiments to determine peptidoglycan composition and enzymatic assays of peptidoglycan enzymes.Expertise in a the molecular biology of a variety of bacterial species, and in bacterial secretion systems. Experimental work on bacterial secretion systems.2011-01-01ZAcademic/UniversityUnited StatesScientific publications: PMID: 28696203 PMID: 25470067 PMID: 23878199 PMID: 22813741 PMID: 22607806 PMID: 21776080Rick LewisNewcastle UniversityNewcastle University Medical SchoolThis is a long-term scientific collaboration with Rick Lewis on bacterial cell wall proteins. We contributed our expertise in bacterial cell wall structure and biosynthesis, provided research tools and performed experiments.The partner contributed their expertise in x-ray crystallography for the analysis for protein structure determination, provided research tools and performed experiments.2007-01-01ZAcademic/UniversityUnited KingdomPublications in scientific journals: PMID: 27862967 PMID: 27329754 PMID: 27257764 PMID: 25403286 PMID: 24954617 PMID: 24909784 PMID: 22432711 PMID: 21964069 PMID: 19074383Oxfrod chemistryUniversity of OxfordChemistry Research LaboratoryWe have discussed this project and set up a collaboration with Professor Chris Schofield at Oxford to look at the affinity of beta-lactam dimers and polymers with Beta-lactamase enzymes.They will provide access to equipment and reagents to support this collaboration as well as host the student2017-01-01ZAcademic/UniversityUnited Kingdomtoo earlyH3D drug discovery University of Cape TownUniversity of Cape TownH3DInput of reagents assays and protein structuresInput of medicinal chemistry know-how and chemical matter2017-01-01ZAcademic/UniversitySouth AfricaInterpersonal exchange of postdocs and to be PhD studentsMichael VanNieuwenhzeUniversity of IndianapolisThis is a long-term scientific collaboration with Michael VanNieuwenhze on bacterial cell wall synthesis. We contributed our expertise in bacterial cell wall structure and biosynthesis, provided research tools and performed experiments.The partner contributed their expertise in chemical probes for bacterial cell wall labelling, provided research tools and performed experiments.2014-01-01ZAcademic/UniversityUnited StatesMulti-disciplinary collaboration: chemistry, microbiology Publications in scientific journals: PMID: 31916938 PMID: 31743648 PMID: 31419110 PMID: 30504892 PMID: 30275297 PMID: 30233559 PMID: 30046664 PMID: 29765094 PMID: 29311645 PMID: 28974693 PMID: 24292151Paula SalgadoNewcastle UniversityNewcastle 85+ StudyThis is a scientific collaboration with Paula Salgado on the biochemistry of cell wall enzymes based on our common interest in the bacterial cell wall. We contributed our expertise in bacterial cell wall structure and biosynthesis, provided research tools and performed experiments.The partner contributed their expertise in the biology and sporulation in chlostridia, and x-ray crystallography, provided research tools and performed experiments. .2014-01-01ZAcademic/UniversityUnited KingdomPublication in peer reviewed journal: PMID: 30066424Joe GrayNewcastle UniversityNewcastle University Medical SchoolThis is a long-term scientific collaboration with Joe Gray on bacterial cell walls and proteins. We contributed our expertise in bacterial cell wall structure and biosynthesis, provided research tools and performed experiments.The partner contributed their expertise in mass spectrometry for the analysis of bacterial cell walls and proteins, provided research tools and performed experiments.2007-01-01ZAcademic/UniversityUnited KingdomPublications in scientific journals: PMID: 31916938 PMID: 31209025 PMID: 30713527 PMID: 30102748 PMID: 30066424 PMID: 29311645 PMID: 28974693 PMID: 28581639 PMID: 27506799 PMID: 26537571 PMID: 26010014 PMID: 25424554 PMID: 24292151 PMID: 18996994Wuhan UniversityWuhan UniversitySince 2021, Lijing, the PI of this project, has begun hosting three doctoral students from the School of Public Health at Wuhan University.Since 2021, three doctoral students from the School of Public Health at Wuhan University have been involved in the project. They are dedicated to further data analysis, economic evaluation, and additional follow-up work. It is anticipated that all three of them will utilize the data generated during the project's research period and extended follow-up to develop their doctoral dissertations and obtain their doctoral degrees.2021-01-01ZAcademic/UniversityChinaNot applicable.Wuhan UniversityWuhan UniversitySince 2021, Lijing, the PI of this project, has begun hosting three doctoral students from the School of Public Health at Wuhan University.Since 2021, three doctoral students from the School of Public Health at Wuhan University have been involved in the project. They are dedicated to further data analysis, economic evaluation, and additional follow-up work. It is anticipated that all three of them will utilize the data generated during the project's research period and extended follow-up to develop their doctoral dissertations and obtain their doctoral degrees.2021-01-01ZAcademic/UniversityChinaNot applicable.Beijing Tiantan HospitalBeijing Tiantan HospitalWe coordinated and assisted with designing the content of the intervention and training.They designed the content of the intervention, such as steps of follow-up and medication prescription. They also designed the content of training session for village and township doctors.2016-01-01ZHospitalsChinaThe content of intervention and training, and the Manual of Operation for village and township doctors.China MobileChina MobileMhealth and Smart Healthcare Research CenterWe cooperated with China Mobile to develop the APP of our study: 1) We provided the idea and details of designing the APP, such as modules and indicators. 2) We answer their questions during the development of the APP. 3) We monitored the process and did the quality control. 4) We came out the data management and security plan, and build the security network. 5) We coordinated the testing of the demo APP.They developed the APP based on our requirements and assisted with building the security network. Also, they develop the demo APP and tested it.2016-01-01ZPublicChinaWe have developed a demo APP. Disciplines involved: global health, information technologyPeking Union Medical CollegePeking Union Medical CollegeThe PI, Prof. Yan and Dr. Gong jointly supervised all the work of extended follow-up.Dr. Enying Gong is one of the core members of this project and currently works at Peking Union Medical College. She is also one of the main persons in charge of the extended follow-up of this project.2021-01-01ZAcademic/UniversityChinaNot applicableCollaboration with NUSNational University of SingaporeResearch stay at NUS in July 2015 with on-going collaboration since then.Research stay at NUS in July 2015 with on-going collaboration since then.2015-01-01ZAcademic/UniversitySingapore1) An invited paper Y. Zeng, B. Clerckx and R. Zhang, "Communications and Signals Design for Wireless Power Transmission" accepted to IEEE Trans. on Comm, to be published in 2017 is an output of the collaboration. 2) Preparation of a special issue on wireless information and power transmission in IEEE Journal on Selected Areas in Communications, and following publications: B. Clerckx, R. Zhang, R. Schober, D. W. K. Ng, D. I. Kim, and H. V. Poor, "Guest Editorial Wireless Transmission of Information and Power-Part I," IEEE Journal on Selected Areas in Communications, vol. 37, no. 1, pp. 1-3, Jan 2019. B. Clerckx, R. Zhang, R. Schober, D. W. K. Ng, D. I. Kim, and H. V. Poor, "Fundamentals of Wireless Information and Power Transfer: From RF Energy Harvester Models to Signal and System Designs," IEEE Journal on Selected Areas in Communications, vol. 37, no. 1, pp. 4-33, Jan 2019. B. Clerckx, R. Zhang, R. Schober, D. W. K. Ng, D. I. Kim, and H. V. Poor, "Guest Editorial Wireless Transmission of Information and Power-Part II," IEEE Journal on Selected Areas in Communications, Feb 2019.Colin RobinsonUniversity of Kentmolecular biology expertise and proteomics expertise in terms of glycosylationmolecular biology of protein transport in E.coli2010-01-01ZUnited Kingdommultidisciplinary: biology:engineeringNPIF Award PartnershipDeluxeLocalisation Access ServicesThe research aims to fill a gap in academic contributions to subtitling process research. Thanks to the collaborative partnership established with Deluxe Media, one of the major audiovisual service providers in Europe, it has been possible to conduct a workplace study focused on observation and analysis of the current workplace and the subtitling production process.Deluxe has provided access to their Localisation facilities in the London office. The rest of the agreement is bound by confidentiality.2017-01-01ZPrivateUnited StatesAt present, the outcomes resulting from this collaboration consist in the chapters 4 and 6 of my PhD Thesis, referring to the quality of production processes in subtitling, and the quality of social environment in the AVT industry, respectively.Marmot Project PartnershipUniversity of California, Los Angeles (UCLA)The Aberdeen side of the project provides some statistical and modelling analysis of the long-term data in addition to laboratory analyses of the blood samples shipped to our institution.The Yellow-bellied Marmot Project, run by Prof. Dan Blumstein of the EEB department UCLA, provides access to long-term data and blood samples collected on their field-site. The Rocky Mountain Biological Laboratory provides access to facilities on the research site as well as use of long-term weather data.2017-01-01ZAcademic/UniversityUnited StatesThere are no concrete outcomes so far but new manuscripts should result from the partnership in 2020. This collaboration is multi-disciplinary as it combines behavioural and field ecology studies from UCLA with physiology studies in the University of Aberdeen and climate studies at the Rocky Mountain Biological Laboratory.Marmot Project PartnershipRocky Mountain Biological LaboratoryRocky Mountain Biological LaboratoryThe Aberdeen side of the project provides some statistical and modelling analysis of the long-term data in addition to laboratory analyses of the blood samples shipped to our institution.The Yellow-bellied Marmot Project, run by Prof. Dan Blumstein of the EEB department UCLA, provides access to long-term data and blood samples collected on their field-site. The Rocky Mountain Biological Laboratory provides access to facilities on the research site as well as use of long-term weather data.2017-01-01ZCharity/Non ProfitUnited StatesThere are no concrete outcomes so far but new manuscripts should result from the partnership in 2020. This collaboration is multi-disciplinary as it combines behavioural and field ecology studies from UCLA with physiology studies in the University of Aberdeen and climate studies at the Rocky Mountain Biological Laboratory.ELM-BrazilFederal University of Sao CarlosMathematicsIntellectualIntellectual2012-01-01ZAcademic/UniversityBrazilOn going series of papers with TMN Goncalves, now in BrazilTP-CreteUniversity of CreteDuring this time TP was part of the Archimedes Center for Modeling, Analysis and Computation. TP undertook research on the topic of energy conservative numerical methods for dispersive fluid flow PDEs.Collaborative research2012-01-01ZAcademic/UniversityGreeceThis collaboration yielded a pair of research partners with whom I still collaborateELM-SurreyUniversity of SurreyMathematicsIntellectual input, training of PhD studentIntellectual inputAcademic/UniversityUnited KingdomJournal papers co-authored by Elizabeth Mansfield and Peter Hydon. One paper close to submission also co-authored by Linyu Peng.GAVI Chikungunya vaccine investment caseBill and Melinda Gates FoundationGlobal Alliance for Vaccination and Immunisation (GAVI)I co-supervise a PhD student and am involved in discussions with a wider team at LSHTM with GAVI about building evidence to make internal investment decisions within GAVI about prioritising the newly available chikungunya vaccine for donor funding.We have generated new estimates of force of infection globally which is a key precursor to estimating disease burden and likely impact of vaccination campaigns.2022-01-01ZCharity/Non ProfitSwitzerlandKang, Hyolim, et al. "Chikungunya seroprevalence, force of infection, and prevalence of chronic disability after infection in endemic and epidemic settings: a systematic review, meta-analysis, and modelling study." The Lancet Infectious Diseases (2024).Covid-19 impact on dengue collaborationBeijing Normal UniversityWe have jointly worked on two papers assessing the impact of COVID-19 restrictions on dengue transmission in China and globally. Myself and Huaiyu Tian designed the experiments, analysis strategy and wrote the manuscript, while Huaiyu's team collected the data and conducted the analyses.We have jointly worked on two papers assessing the impact of COVID-19 restrictions on dengue transmission in China and globally. Myself and Huaiyu Tian designed the experiments, analysis strategy and wrote the manuscript, while Huaiyu's team collected the data and conducted the analyses.2021-01-01ZAcademic/UniversityChinaTwo main publications (both listed under publications): 1. Assessing the impact of border closures on dengue in China: Li, Naizhe, et al. "Assessing the impact of COVID-19 border restrictions on dengue transmission in Yunnan Province, China: an observational epidemiological and phylogenetic analysis." The Lancet Regional Health-Western Pacific 14 (2021): 100259. 2. Assessing the global impact of COVID-19 restrictions on dengue burden: Chen, Yuyang, et al. "Measuring the effects of COVID-19-related disruption on dengue transmission in southeast Asia and Latin America: a statistical modelling study." The Lancet infectious diseases 22.5 (2022): 657-667.Neglected Tropical Diseases Modelling consortiumNeglected Tropical Diseases Modelling ConsortiumI was invited to chair a session on dengue at the annual meeting of the NTD consortium in Geneva, Switzerland. I organised discussions, took notes and produced a summary of discussion on future research needs for dengue control which will form part of a wider publication by the NTD modelling consortium.The NTD modelling consortium brought together modellers, implementation researchers and country programme managers to discuss unmet needs across different NTDs. They aim to produce a combined publication using the outputs from our separate discussion groups.2022-01-01ZCharity/Non ProfitManuscript under preparation. Involved researchers and governmental personnel from modelling, epidemiology, clinicians and implementation research disciplines.Global Arbovirus InitiativeWorld Health Organization (WHO)As part oft he Global Arbovirus initiative we have convened an international group of modellers to: i) review the drivers of spatial variations in transmission risk for arboviruses (published) ii) produce new global arbovirus risk maps for dengue, Chikungunya, Zika and yellow fever (completed, submission imminent) iii) meet with WHO arbovirus technical advisory group experts and country representatives to validate and improve the risk maps (in progress)The GAI secretariat set up the meeting and has convened the attendees and overall helped shape all these new collaborators into an effective working group. They also provide direct financial contributions to our activities that funds personnel to conduct the work.2022-01-01ZPublicSwitzerlandreview the drivers of spatial variations in transmission risk for arboviruses Lim, Ah-Young, et al. "A systematic review of the data, methods and environmental covariates used to map Aedes-borne arbovirus transmission risk." BMC infectious diseases 23.1 (2023): 708.ISSI Team: Solving the Prominence ParadoxInternational Space Science Institute (ISSI)I am a member of the ISSI team: Solving the Prominence Paradox led by Dr Nicolas Labrosse. The team met for a 4 day meeting last February in Bern, Switzerland and are meeting again this March. In the meeting I presented my research into mm/sub-mm modelling of solar prominences. I also contributed to discussions that took place and planning for future collaborations.Each member of the ISSI team has presented their personal research and taken part in discussions and future planning for collaboration.2017-01-01ZAcademic/UniversitySwitzerlandWorks are ongoing.Long Term Attachment at Institute of Theoretical Astrophysics, OsloUniversity of OsloInstitute of Theoretical AstrophysicsI partook in a long-term attachment to the institute of theoretical astrophysics at the University of Oslo from January to May 2017. Whilst there I worked as part of the SolarALMA group ran by Dr Sven Wedemeyer in investigating ALMA data analysis and reduction as well as 3D modelling of the solar atmosphere in the mm/sub-mm regime. Some of this work has resulted in my writing of a journal article that is currently in submission.During my stay at the Institute of Theoretical Astrophysics in Oslo I was able to work under the supervision of Dr Sven Wedemeyer and other experts in my field of study. This was a very useful process where I was able to learn much, whilst still furthering my research.2017-01-01ZAcademic/UniversityNorwayPublication: First Spectral Analysis of a Solar Plasma Eruption using ALMA, A.S. Rodger (in press)Feasibility Study: Modular tooling and control for tactile manipulation of pastesFANUC UKIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futurePhD students exchange with the National Institute of Industrial Engineering (NITIE), Mumbai, IndiaNational Institute of Industrial EngineeringThe NITIE will send 3 PhD students who will spend 2 years at teh University of Warwick to conduct research in the area of simulations of collaborative robotic assembly system in context of these being part of production systems (ie with embedded uncertainties of production by linking AI/data mining with physics-based simulation to support augmented decision making.(i) Exchange of three PhD students who will spend two years at your university to work on the projects related to the CESCIR research. (i) Support development of training and educational programs with a focus on augmented decision making for smart Human-Robots Collaborative Systems. The NITIE estimated financial contribution is around £80k over 4 years2021-01-01ZAcademic/UniversityIndiaNot yet.Feasibility Study: Flexible dextrous grasping of complex higher payload partsRolls Royce Group PlcResearch team looked at the Industry challenge: design a gripper that can handle a specified range of parts without the need for custom tooling. This study's specific focus is on the 10kg+ weight range and the diverse shapes and sizes within that range sets it apart. The study's emphasis on designing a gripper that eliminates the need for custom tooling and provides flexibility and adaptability aligns with the industry's evolving demands for cost-effective, agile, and efficient manufacturing solutions.staff time and access to premises to look at current systems and develop grippers and manipulation systems for aerospace parts.2024-01-01ZPrivateUnited Kingdomstill ongoing, papers will be producedFeasibility Study: Flexible dextrous grasping of complex higher payload partsAirbus GroupAirbus OperationsResearch team looked at the Industry challenge: design a gripper that can handle a specified range of parts without the need for custom tooling. This study's specific focus is on the 10kg+ weight range and the diverse shapes and sizes within that range sets it apart. The study's emphasis on designing a gripper that eliminates the need for custom tooling and provides flexibility and adaptability aligns with the industry's evolving demands for cost-effective, agile, and efficient manufacturing solutions.staff time and access to premises to look at current systems and develop grippers and manipulation systems for aerospace parts.2024-01-01ZPrivateUnited Kingdomstill ongoing, papers will be producedResearcher in Residence (Visiting Researcher Fellowship) with AMRC SheffieldUniversity of SheffieldAdvanced Manufacturing Research Centre (AMRC)As a Researcher in Residence (April 2024 - April 2026), my contributions to this collaboration have been focused on robot calibration on the network and Factory 2050 cloud infrastructure, with the goal of pushing these advancements towards industrial standards. My work integrates real-time robotic calibration, digital twin technologies, and AI-driven automation, ensuring that robotic systems achieve higher precision, repeatability, and adaptability for advanced manufacturing applications. A key aspect of my contribution has been the development and deployment of a networked calibration framework, allowing robots across Factory 2050 and connected industrial facilities to self-calibrate in real-time. This involves leveraging cloud-based digital twins, AI-driven sensor fusion, and machine learning algorithms to continuously refine robotic accuracy. The integration of real-time data analytics and predictive maintenance ensures that robotic systems can adapt dynamically to changes in the manufacturing environment, reducing downtime and improving efficiency. Beyond technical development, I have led efforts to standardize robotic calibration protocols, working closely with industrial partners, research institutions, and policy-makers to ensure that these innovations align with international manufacturing and automation standards. This includes engaging with standardization bodies and contributing to guidelines for networked robotic calibration, positioning Cranfield University as a leader in AI-driven robotic standardization and industrial automation. Additionally, I have facilitated collaborations with key stakeholders, including AMRC Factory 2050, Airbus, and the ROS-Industrial Consortium, ensuring that our research translates into industry-wide best practices. By securing funding for joint research initiatives and organizing knowledge-sharing workshops, I am actively driving the adoption of cloud-based robotic calibration as a standardized industrial solution, further reinforcing Cranfield's leadership in intelligent automation and digital manufacturing.AMRC Factory 2050: The Advanced Manufacturing Research Centre (AMRC) at Factory 2050 has provided state-of-the-art testbeds, infrastructure, and industrial integration support for the deployment and validation of cloud-based robotic calibration frameworks. Their expertise in robotic automation, metrology, and digital manufacturing ecosystems has facilitated real-world testing and refinement of AI-driven calibration methodologies, ensuring seamless integration with Industry 4.0 principles.2024-01-01ZAcademic/UniversityUnited KingdomIEEE ICASCS Special Session Chair (2025) AI & RoboticsFeasibility Study: Collaborative human and robot simulation for crop collection in a farming environmentAgri-EPI Centre LtdCollaboration with 3 academic partner institutions to address an industry challenge that materialised from Industry/Academic project workshops. Industry challenge: companies develop ad hoc robotic systems, with limited reliability. Integration of these systems is also complicated by a lack of standardisation of the key component used in these systems. The development of farming applications using robots, through simulation, therefore needs to be validated to ensure their robustness with different hardware configurations.  Gathering data and producing a digital twin (dt) for manufacturing process diagnostic, also human-centric dt for a real vineyard by applying the user needs and requirements during the dt development for a vineyardBoth industrial partners have provided access to real-time environments to enable data collation by the academic partner institutions, ongoing dialogue to ensure human-centric considerations, aiming for completion prior to the end of this project.2024-01-01ZPrivateUnited KingdomStudy aims: to design and set up, as an example, a simulation framework of a reconfigurable robot/cobot system for crop collection in a farming environment, such as polytunnels or other harvesting conditions. This is aimed to form the basis of a Design Studio for human robot collaboration design and simulation. The specific tasks include rover path and motion planning, motion planning for a human model and arm/gripper in simulation.Feasibility Study: Modular tooling and control for tactile manipulation of pastesFAR-UK LtdIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futureFeasibility Study: Modular tooling and control for tactile manipulation of pastesSamworth BrothersBradgate BakeryIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futureFeasibility Study: Modular tooling and control for tactile manipulation of pastesExpert Tooling & Automation LtdIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futureWMG/Constellium research collaborationConstelliumConstellium UK LtdDevelopment of Closed-loop in-process (CLIP) digital twin fir defect resolution and defect classification using CAE simulation and Machine learning.Partners provided the necessary material and components for testing which includes sheet metal, full scale battery enclosure and performed crash safety testing in their lab. They also bring their industrial expertise in the form of regular meetings and visits.2021-01-01ZPrivateUnited KingdomJournal papers are the main outcomes from the collaboration as listed below: (1) https://doi.org/10.1016/j.jmrt.2022.10.055 (2) https://doi.org/10.2351/7.0001150 (3) https://doi.org/10.1080/13621718.2022.2163341. It also leads to a development of Industrial Digital Technologies (IDT) : Prediction and analyses of thermal-induced distortionFeasibility Study: Modular tooling and control for tactile manipulation of pastesFord Motor CompanyFord UKIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futureFeasibility Study: Modular tooling and control for tactile manipulation of pastesSamworth BrothersIndustry challenge materialised from a workshop in 2023. Industry challenge: An automated way of spreading various pastes on surfaces. Pastes can be defined as liquid substances with suspended solid particles. Their mechanical properties vary with applied force. Food spreads are a good representative for this category as they introduce uncertainties in chunkiness and viscosity. The ability to spread food items on surfaces like bread would likely be transferable not just to other food products, but also across industry in the spreading of any paste (e.g., cements, coatings, textiles, adhesives) onto a wide variety of surfaces. Researchers developed digital twin of new manipulation methods for tools that interact with difficult materials like pastes, etcPartners have regular update meetings to review workplan and to review if an automation system can spread paste-like substance (with uncertain material properties and composition) evenly and delicately across an uncertain surface. Staff time, access to premises and provision of a conveyor belt.2024-01-01ZPrivateUnited Kingdomthis is a sensitive feasibility study and will be reported in the futurePaccou collaborationUniversity of LilleI initiated the UK Biobank studies to analyse bone marrow adiposity on a population scale. My team then implemented the methods to do this, including deep learning and MRI analyses.In 2020 we began collaborating with Prof Julien Paccou at the University of Lille and CHU Lille. Prof Paccou provided expertise in analysis of our UK Biobank MRI data, particularly ensuring that we analysed clinically relevant skeletal sites. He and his colleague, Dr Sammy Badr, are co-authors on our initial study.2020-01-01ZAcademic/UniversityFranceThree published papers: https://doi.org/10.1038/s41467-025-63395-1 https://doi.org/10.1038/s41467-024-55422-4 https://doi.org/10.1016/j.csbj.2023.12.029 Two preprints (now published, above): https://doi.org/10.31219/osf.io/n25tk_v1 https://www.medrxiv.org/content/10.1101/2022.12.06.22283151v1.full-text And also the invited seminars and other talks related to this work. The collaboration is multi-disciplinary, including radiology, artificial intelligence, musculoskeletal biology, metabolism and endocrinology, gerontology, genomics, epidemiology, immunology, and sex differences.Fowler collaborationUniversity of EdinburghCentre for Discovery Brain SciencesI co-supervised a Master's student in Dr Jill Fowler's lab (University of Edinburgh), with the research focusing on sex differences in the ability of caloric restriction (CR) to protect against cerebral ischaemia, and whether adiponectin knockout influences this effect of CR. Due to the COVID restrictions we had to modify the approach to this project, and therefore adapted it to use UK Biobank data to investigate the relationship between circulating adiponectin (a hormone produced from bone marrow adipose tissue) and stroke. In this project I provided expertise in use of the UK Biobank data, and also connections with my University of Edinburgh collaborators who have further expertise in these analyses.Dr Fowler secured funding for the Master's student and was lead supervisor on the initial project. Dr Fowler provided expertise in analysis of brain samples for pathways relating to ischaemic injury and neuroprotection.2019-01-01ZAcademic/UniversityUnited KingdomNone so far. We are working on a manuscript reporting the impact of adiponectin on stroke.MacDougald collaborationUniversity of MichiganUniversity of Michigan Medical SchoolMy team analysed results of rat and rabbit studies that were done in Prof Ormond MacDougald's lab at the University of Michigan, including work led by Dr Erica Scheller. We have also continued to collaborate with Prof MacDougald, including investigating how BMFF in UK Biobank is associated with other factors (e.g. plasma metabolites)Prof MacDougald's lab coordinated the studies in these animal models, including microarray analysis of rabbit samples, and in vivo studies in rats to assess the responsiveness of bone marrow adipose tissue to insulin.2016-01-01ZAcademic/UniversityUnited StatesSome outcomes of this collaboration are reported in the following publication: https://www.nature.com/articles/s41467-020-16878-2 Other work is ongoing.Kilpeläinen collaborationUniversity of CopenhagenMy team and I travelled to Copenhagen in June 2024 to discuss future research and funding opportunities with Tuomas Kilpeläinen and his group. We shared with them our findings about the genetics and clinical associates of bone marrow adiposity and discussed including these in their pipelines that test how body composition impacts human health.The Kilpeläinen group shared with us their expertise in body composition profiling for genetic epidemiology studies.2024-01-01ZAcademic/UniversityDenmarkNone so far.Theodoratou collaborationUniversity of EdinburghUsher Institute of Population Health Sciences and InformaticsMy team has established a new deep learning method and used this to measure bone marrow adiposity in the UK Biobank. This has led to multiple publications and some follow-on fundingOur collaborator, Prof Evropi Theodoratou, and her team has provided expertise in molecular epidemiology, particularly Genome-Wide and Phenome-Wide Association Studies using our data.2020-01-01ZAcademic/UniversityUnited KingdomTwo publications as of March 2026: doi 10.1038/s41467-024-55422-4 and doi 10.1038/s41467-025-63395-1.Paccou collaborationLille University HospitalMy team is leading the analysis of bone marrow adiposity (BMA) in MRI data from the UK Biobank, including development of new machine learning methods to identify bone marrow regions of interest from these MRI data.Prof Julien Paccou and his colleague, Dr Sammy Badr, are experts in MRI analysis of BMA. They have assisted with identifying the bone marrow sites of interest for our analyses.2020-01-01ZHospitalsFranceNo outputs so far.Medix BiochemicaMedix BiochemicaWe have developed monoclonal antibodies to the human lung serine protease inhibitor, elafin. These antibodies are now being evaluated for diagnostic development by Medix Biochemica (Espoo, Finland) as a diagnostic for pre-term birth delivery and were developed as part of a Proof of Concept grant funded by InvestNI (PoC 409). The collaboration is at an early stage of development and we hope to move towards a licencing agreement with Medix Biochemica in the near futureMedix Biochemica are currently evaluating the value of the elafin antibodies as a pre-term birth diagnostic. This research is ongoing2016-01-01ZPrivateFinlandNone as yetKnowledge Transfer SchemeBelfast Health and Social Care TrustTransfer of knowledge from university laboratory to hospital laboratory. Dr Nicolas Camper spent time working in Prof Moore's laboratory in the Belfast City Hospital. The objective was to evaluate the effect of nanoparticle-delivered drugs to planktonic and biofilm bacteria compared to 'naked' delivery of these drugs.2012-01-01ZPublicUnited KingdomCollaboration with Prof Marcus Mall, Charité Universitätsmedizin BerlinCharité - University of Medicine BerlinWe have carried out assays for Dr Mall which have contributed to publicationsDr Mall has provided training in his laboratory in Germany for researchers from my laboratory since 2012. he has also carried out experiments and assays for us in his lab which has contributed to publications and funding opportunities2012-01-01ZAcademic/UniversityGermany1. Taggart CC, Weldon S, Mall MA. At the forefront of cystic fibrosis Basic Science research: 16th ECFS Basic Science Conference. J Cyst Fibros. 2020 Feb 13. pii: S1569-1993(20)30047-3. 2. McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC. Targeting Proteases in Cystic Fibrosis Lung Disease. Paradigms, Progress, and Potential. Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147 3. Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA. Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease. Am J Respir Cell Mol Biol. 2019 Sep 9 4. Small DM, Brown RR, Doherty DF, Abladey A, Zhou-Suckow Z, Delaney RJ, Kerrigan L, Dougan CM, Borensztajn KS, Holsinger L, Booth R, Scott CJ, López-Campos G, Elborn JS, Mall MA, Weldon S, Taggart CC. Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease. Eur Respir J. 2019 Jan 17. pii: 1801523. 5. Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA. Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis. Eur Respir J. 2018 Mar 29;51(3). pii: 1701910 6. Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS. Protean proteases: at the cutting edge of lung diseases. Eur Respir J. 2017 Feb 8;49(2). pii: 1501200Polyphor collaborationPolyphor AGWe have established a collaboration with Polyphor, a Swiss biotech company. We have begun evaluating an anti-elastase inhibitor for them in our assaysThey have provided us with their anti-elastase inhibitor, POL6014. We have visited with Polyphor and have commenced drafting of an Horizon 2020 grant application with them. The H2020 application successfully progressed to Phase 2 of the application process (January 2017). However, in late February 2017, Polyphor decided to withdraw the application from the phase 2 process due to a change in the company focus.2015-01-01ZPrivateSwitzerlandNoneCF MATTERSUniversity College CorkMedicineWork Package leader on Host Defense research studyOur partners will run a clinical trial in CF patients and we will evaluate the host defense response in sputum samples obtained from these patients2013-01-01ZAcademic/UniversityIreland0Consultancy with Albumedix (Nottingham, UK)Albumedix LtdI have provided expert advice via consultancy to the Albumedix teamAlbumedix are developing a variant of alpha 1 antitrypsin for the treatment of Cystic Fibrosis lung disease and I have provided them with advice regarding the pre-clinical evaluation of their Alpha 1 antitrypsin molecule2017-01-01ZPrivateUnited KingdomNothing so farKTP RandoxRandox LaboratoriesWe have generated an antibody to a novel biomarker in the lung which is now being developed by Randox into an imunoassayRandox will develop the antibody on several of their testing matrices to sell initially as a Research Only ELISA followed by development into a near patient assay. As of March 2017 the Research Use Only ELISA had not been released by Randox due to unforeseen technical issues.2013-01-01ZPrivateGlobalA patent application has been filed to the UK Intellectual Property Office (1414079.2)Collaboration with Chiesi Farmaceutici SpA, Parma, Italy to develop cell therapy to treat limbal stem cell deficiencyChiesiResearch and Development & clinical trialsSetup a clinical trial and a registry with Chiesi using cell therapy to treat patients with unilateral and bilateral limbal stem cell deficiencyProvide the IMP, clinical protocol and financial support.2020-01-01ZPrivateItalySetup a clinical trial and registry to treat patients with limbal stem cell deficiency using autologous cell therapy.Collaboration with Dr Julie Glanville on a NIHR grant application to the Research for Patient Benefit Programme on: "A systematic literature review and meta-analysis of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes"University of YorkWriting a joint grant application to the NIHR RfPB Programme on: "A systematic literature review and meta-analysis of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes".As above2017-01-01ZAcademic/UniversityUnited KingdomNIHR Grant Application submission deadline: 15 March 2016.The use of new animal origin-free cell culture suplements known as HKSdaFREE, HKGE2, HEGE and CRYOVIVE for LSC cultureAvan BiotechWe are currently growing ex vivo limbal stem cells (LSC) using the above animal-free culture medium to compare with our normal epithelial medium.The aim is to potentially use a better clinical grade/animal free culture medium that will be commercially availble to grow limbal stem cells for transplantation.2011-01-01ZPrivateCanadaThe collaboration is at an early stage and there is no output yet.Cryopreservation of cultured human limbal epitheliumFlinders UniversityOphthalmologyOptimization of a protocol for cryopreservation of human limbal epithelial cell cultures based on cell survival. The development of appropriate assays to determine the survival of cells after freezing and thawing are crucial to the successful outcome of the project. In addition to investigate potentially harmful effects of cryoprotectants on Limbal Stem Cells in the absence of freezing and to determine the optimum cooling and warming rates.The Collaborator is an internatinally known expert in cryobiology, he has been instrumental in setting up the projectThe Collaborator will assist on analysis and interpretation of Quality of Life instruments including the NEI-VFQ25 quality of vision subscale and pain/visual impairment scores. The Collaborator will assist to characterize changes in pre-corneal fluid before and after stem cell transplantation in patients with unilateral total limbal stem cell deficiency.2015-01-01ZAcademic/UniversityAustraliaWe have just started this project 6 months ago therefore not in a position to report any substantive outcome yet.Assessment of pre-corneal tear film in patients with unilateral total limbal stem cell deficeincy before and after autologous limbal stem cell transplantation.University of BristolSchool of Clinical SciencesAssited in original grant application.The Collaborator will assist to characterize changes in pre-corneal fluid before and after stem cell transplantation for the treatment of unilateral total limbal stem cell deficeincy.2017-01-01ZAcademic/UniversityUnited KingdomNo output yet as this component of the project is due to start in the new year.collaboration with Dr. Tor Utheim's group, NorwayUniversity of OsloDepartment of Medical BiochemistryWe are sharing with Dr. Utheim's group our culture system for the ex vivo expansion of LSCs on human amniotic membrane.Dr.Utheim's team is sharing data with our group with regard to transport conditions for limbal biopsies as well as ex vivo cultured LSCs.2019-01-01ZAcademic/UniversityNorwaynot yetCollaboration with Dr Ruby Shalom-Feuerstein, Rappaport Faculty of Medicine of the Technion, Haifa, israel on a grabt application to BIRAX Third Call for Proposal (Deadline 12 May 2016)Technion - Israel Institute of TechnologyRuth and Bruce Rappaport Faculty of MedicineProfessor Majlinda Lako has been working together with Professor Figueiredo and Dr Ruby Shalom-Feuerstein on a grant application to BIRAX 3rd Call for a collaborative research proposal looking at limbal stem cell heterogeneity.Jointly writng a grant proposal to BIRAX 3rd Call (Deadline: 12 May 2016).2017-01-01ZAcademic/UniversityIsraelWriting grant application to BIRAX 3rd call (deadline 12 May 2016).Cryopreservation of cultured human limbal epitheliumUniversity of BristolSchool of Clinical SciencesOptimization of a protocol for cryopreservation of human limbal epithelial cell cultures based on cell survival. The development of appropriate assays to determine the survival of cells after freezing and thawing are crucial to the successful outcome of the project. In addition to investigate potentially harmful effects of cryoprotectants on Limbal Stem Cells in the absence of freezing and to determine the optimum cooling and warming rates.The Collaborator is an internatinally known expert in cryobiology, he has been instrumental in setting up the projectThe Collaborator will assist on analysis and interpretation of Quality of Life instruments including the NEI-VFQ25 quality of vision subscale and pain/visual impairment scores. The Collaborator will assist to characterize changes in pre-corneal fluid before and after stem cell transplantation in patients with unilateral total limbal stem cell deficiency.2015-01-01ZAcademic/UniversityUnited KingdomWe have just started this project 6 months ago therefore not in a position to report any substantive outcome yet.Collaboration with HDBR and Prof. Lindsay's groupNewcastle UniversityInstitute of Genetic MedicineWe are using embryonic and fetal eye tissue for immunofluorescence and RNA-seq studies.Prof. Lindsay's group is providing the HDBR embryonic and fetal eye tissue for our research.2009-01-01ZAcademic/UniversityUnited Kingdommanuscripts, scientific collaborationCryopreservation of cultured human limbal epitheliumUniversity of BristolSchool of Clinical SciencesOptimization of a protocol for cryopreservation of human limbal epithelial cell cultures based on cell survival. The development of appropriate assays to determine the survival of cells after freezing and thawing are crucial to the successful outcome of the project. In addition to investigate potentially harmful effects of cryoprotectants on Limbal Stem Cells in the absence of freezing and to determine the optimum cooling and warming rates.The Collaborator is an internatinally known expert in cryobiology, he has been instrumental in setting up the projectThe Collaborator will assist on analysis and interpretation of Quality of Life instruments including the NEI-VFQ25 quality of vision subscale and pain/visual impairment scores. The Collaborator will assist to characterize changes in pre-corneal fluid before and after stem cell transplantation in patients with unilateral total limbal stem cell deficiency.2015-01-01ZAcademic/UniversityUnited KingdomWe have just started this project 6 months ago therefore not in a position to report any substantive outcome yet.collaboration with dr. Christopher Duncan and his groupNewcastle Universitywe are optimising an ocular surface model for SARS-COv2 Infectionthe collaborating group is providing the virus and sharing us with key techniques for assessing viral replication and cells's immune response2020-01-01ZUnited Kingdomn/aInvestigation of inflammatory and immune cell biomarkers on superficial keratotomy tissue excised at the time of ex vivo expanded autologous limbal stem cell transplantation in patients with unilateral total limbal stem cell deficiencyNewcastle UniversityInstitute of Cellular MedicineInvolved in concept, design and methodology of the project; but also data analysis and interpretation of findings.Professor Simi Ali will perform the immunostaining, microarray and elisa based analysis for inflamatory and immune markers2016-01-01ZAcademic/UniversityUnited KingdomStill collecting samples (n=7). Due to start project in the new year.Quality of Life analysis of limbal stem cell transplantation for the treatment of total unilateral limbal stem cell deficiency.Flinders UniversityOphthalmologyThe collaborator wil asssit on data anlysis and interpretation of quality of life questionnaires, inclusing NEI-VFQ25 quality of vision subscale and pain/visual impairment scoresThe Collaborator will assist on data analysis and interpretation of Quality of Life Questionnaires, inlcuding NEI-VFQ25 quality of vision subscale and pain/visual impairment scores2017-01-01ZAcademic/UniversityAustraliaNo output yet as this part of the project is due to start in the new year.Investigatigation of increased incidence of "Acid Attacks" in Newcastle upon TyneNorthumbria PoliceI have instigated this collaboration with Northumbria Police to investigate the increased incidence of "Acid Attacks" in Newcastle upon Tyne over the last 5 years. This initiative has shown an increased incidence of more than doubled over the last 4 years. We are currently setting up a more extensive collaboration in our region trying to understand the problem and also to develop initiatives to prevent such events.Northumbria Police has investigated form the Police point of view what has been the numbers of "Acid Attacks" over the last 4 years and has shown similarly increased numbers. Northumbria Police and I are currently setting up a more extensive collaboration in our region trying to understand the problem and also to develop initiatives to prevent such events.2018-01-01ZPublicUnited KingdomWe have been able to determine the increasd incidence of " Acid Attacks" in our region and are currently establishing furtherr collabroation with ASTI (Acid SurvivorsTrust International) cahrity, based in London setting up a joint programme aiming to "Early prevention: acid violence reduction and changing attitude in teh communit".SIPHER ConsortiumGreater Manchester Combined AuthorityDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZPublicUnited KingdomNot yet disclosableReal-World Applications Track Chair at GECCO 2019Leiden UniversityCo-chairing the prestigious real-world applications track at GECCO 2019Co-chairing the prestigious real-world applications track at GECCO 20192018-01-01ZAcademic/UniversityNetherlandsNone yetEMO 2019 ConferenceMichigan State UniversityMarketing Chair; Posters Competition Panel MemberOrganising the EMO 2019 conference, East Lansing, USA2018-01-01ZAcademic/UniversityUnited StatesConference is being held 10-13 March 2019SIPHER ConsortiumGovernment of ScotlandDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZPublicUnited KingdomNot yet disclosableSIPHER ConsortiumUniversity of LeedsDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZAcademic/UniversityUnited KingdomNot yet disclosable2019 Lorentz Center workshop on many-objective optimizationThe National Institute for Research in Computer Science and Control (INRIA)Writing the proposal and preparing the workshopWriting the proposal and preparing the workshop2017-01-01ZPublicFranceProposal documentSupport to product pricing optimization projectShop DirectData ScienceWe contributed free technical consultancy to an ESRC Consumer Data Research Centre masters research project being undertaken within Shop Direct. We also made available a community version of our Liger optimization workflow software and provided free technical support to the installation and use of this tool on the project.Shop Direct provided the research placement opportunity, including pricing models and data science expertise.2017-01-01ZPrivateUnited KingdomProof-of-concept pricing optimization results; Masters dissertation2019 Lorentz Center workshop on many-objective optimizationUniversity of CologneWriting the proposal and preparing the workshopWriting the proposal and preparing the workshop2017-01-01ZAcademic/UniversityGermanyProposal document2019 Lorentz Center workshop on many-objective optimizationLeiden UniversityWriting the proposal and preparing the workshopWriting the proposal and preparing the workshop2017-01-01ZAcademic/UniversityNetherlandsProposal documentSIPHER ConsortiumUniversity of EdinburghDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZAcademic/UniversityUnited KingdomNot yet disclosableSIPHER ConsortiumNewcastle UniversityDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZUnited KingdomNot yet disclosableSIPHER ConsortiumSheffield City CouncilDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZPublicUnited KingdomNot yet disclosableSIPHER ConsortiumUniversity of ManchesterDeveloping consortium proposal to UKPRPDeveloping consortium proposal to UKPRP2017-01-01ZAcademic/UniversityUnited KingdomNot yet disclosableThe COBRA StudyVU University Medical CenterWe provide the statistical support for the COBRA study, which also incorporates data from participants in the UK CHIC StudyNeuroimaging, clinical medicine, biomarkers, immunology, virology, genetics, statistics, epidemiology2013-01-01ZAcademic/UniversityNetherlandsOne publication to date (listed in the form)The POPPY StudyImperial College School of MedicineData from the UK CHIC study feeds into the POPPY Study (a cohort of HIV and ageing in the UK). The POPPY study has received funding from several funders, including the NIH, the British HIV Association and pharmaceutical companies, with around £200,000 coming to UCL over the next 3 years.Clinical management, neuroimaging, biomarker studies, HIV medicine, sleep medicine2013-01-01ZAcademic/UniversityUnited KingdomTo date, two publications (listed on the form) have arisen from this collaboration. The collaboration is multi-disciplinary including HIV clinicians, neuroimagers, biomarker analysts, epidemiologists and statisticians.The COBRA StudyImperial College School of MedicineWe provide the statistical support for the COBRA study, which also incorporates data from participants in the UK CHIC StudyNeuroimaging, clinical medicine, biomarkers, immunology, virology, genetics, statistics, epidemiology2013-01-01ZAcademic/UniversityUnited KingdomOne publication to date (listed in the form)UK HIV Drug Resistance DatabaseMedical Research Council (MRC)MRC Clinical Trials UnitThe studies have provided joint scientific leadership and have equally contributed to statistical analysesThrough collaboration with this study we have successfully applied for a new five-year programme grant from the MRC (G0900274)Academic/UniversityUnited KingdomPublications as listed in section 2 and further grant funding (described above)HIV-CAUSAL (Harvard University plus others)Harvard UniversityIntellectual input into study design and analysis; provision of datasets; writing manuscripts2009-01-01ZAcademic/UniversityUnited StatesSeveral publications in high impact journals, all are listed in appropriate sectionAgreement between collaborating partner to recruit a PhD student to assist in this EPSRC funded projectCumminsFollowing the appointment of a research associate to work on this EPSRC funded project, an agreement has been made between myself (PI) and Cummins Turbo technology (Industrial collaborator of this project) to recruit a PhD student to help the existing team. The PhD was funded by EPSRC DTA - Swansea univerity grant for 3 years. All the mechanical testing, microstructure characterisation and experiments will be carried out in Swansea University. It is also our responsibility to support and fund the student for 3 years and provide technical and scientific expertise throughout this project.Cummins supplying all the materials required for this project.2014-01-01ZPrivateUnited StatesN/AAdjunct Professor at Griffith University, Queensland AustraliaGriffith UniversityINSTITUTE FOR INTEGRATED AND INTELLIGENT SYSTEMSAndrew Martin has been appointed Adjunct Professor in the INSTITUTE FOR INTEGRATED AND INTELLIGENT SYSTEMS in Griffith University. He has visited twice, giving four research seminars so far, and undertaken a variety of research discussions - not yet leading to funded projects, but which are anticipated in future.Prof. Dong, who is a formal collaborator for the Smart Grid Security and Privacy project (the project was established in a joint call with Sinagpore; he is PI for that side of the project, at the National University of Singapore) now divides his time between Singapore and Griffith University, where he directs the Institute. He has facilitated this collaboration, and informally brings his research team there into the project.2017-01-01ZAcademic/UniversityAustraliaFour research seminars at Griffith University and, sponsored by Griffith, for the Queensland Government.Optically detected Magnetic Resonance for quantum sensing using molecular spinsUniversity of GlasgowI manufacture the materials used as samples of interest in this collaboration and conduct some fundamental characterisation.Dr Sam Bayliss and his research team perform advanced continuous wave and pulsed optically detected magnetic resonance studies on samples we provide.2022-01-01ZAcademic/UniversityUnited KingdomPre-print submitted to Nature MaterialsAccess to Transient Absorption Spectroscopy experiments and expertiseImperial College LondonDepartment of ChemistryIn collaboration with the Bauklin and Ingle groups, we have the ability to probe how the transient optical behaviour of our materials links to their potential as maser devices. As part of the ICL "Maser group", I have supplied samples of organic materials.The Bauklin and Ingle group measure our samples and return the data. Our analysis is then informed by experts in the group.2022-01-01ZAcademic/UniversityUnited KingdomAs a result of this collaboration, we were able to advance our analysis to form hitherto two beautiful papers covering new maser materials. The resulting papers have been accepted for publication by Advanced Materials (IF: 32.09, https://onlinelibrary.wiley.com/doi/10.1002/adma.202300441) and Chemistry for Materials (IF: 14, https://pubs.acs.org/doi/10.1021/acs.chemmater.3c00640).University of SurreyUniversity of SurreyIon Beam CentreWe have been making solar cell samples for Ion Beam Analysis measurements. We have published two papers from this work.The Surrey Ion Beam Centre has been performing time-of-flight elastic recoil analysis (ToF-ERDA) measurements.2023-01-01ZPublicUnited KingdomWe have published two papers and have been invited to submit a paper for the 15th Silicon PV conference.Commonwealth Science and Industrial Research OrganisationCommonwealth Scientific and Industrial Research OrganisationCSIRO EnergyWe are working in collaboration on several projects, including the stability of AZO passivation as well as an analysis of the specific power of PV modules.We are working in collaboration on several projects, including the stability of AZO passivation as well as an analysis of the specific power of PV modules.2023-01-01ZPublicAustraliaN/AEPFL PV Lab / CSEMSwiss Federal Institute of Technology in Lausanne (EPFL)We have worked on joint publications in the area of passivating contacts for silicon solar cells. This collaboration has leveraged the complementary experimental capabilities of the two institutes.They have provided support to experiments by allowing access to their unique capacbilities. This is particularly related to the industrial high-temperature furnace.2024-01-01ZPublicSwitzerlandS. McNab, A. Morisset, S. Libraro, E. Genç, X. Niu, J. Swallow, R. Weatherup, F. Josef-Haug, M. Wright, PR Wilshaw, RS Bonilla, "SiNX and AlOX Interface Nanolayers for Hole-selective Polysilicon Contacts in High Efficiency Solar Cells", ACS Applied Energy Materials 7 (2024) 10259-10270. M. Sharpe, M. Wright, C. D. McAleese, Y. Wang, T. Hobson, X. Niu, A. Morisset, RS Bonilla, " Characterisation of solar cell nanolayer interfaces using time-of-flight elastic recoil detection analysis", Solar Energy Materials and Solar Cells 296 (2026) 114074.University of New South WalesUniversity of New South WalesWe are working on studying the stability of AZO passivation layers. I fabricated the samples at Oxford and travelled to UNSW to do measurements.Providing facilities for stability measurements.2023-01-01ZAcademic/UniversityAustraliaN/ACardiff UniversityCardiff University2007-01-01ZAcademic/UniversityUnited KingdomDual Doctorate between University of Troyes and Loughborough UniversityGeneral Santos National School of Arts & TradeI co-supervised a PhD studentship funded by the Chinese Science Coucil with Prof. F. Pierron (UTT) towards a dual doctoral degreeProf. F. Pierron (UTT) co-supervised same PhD student with me.2010-01-01ZAcademic/UniversityPhilippinesFu, J., et al. Assessment of Corneal Deformation Using Optical Coherence Tomography and Digital Volume Correlation. in SEM XII: Congress & Exposition on Experimental and Applied Mechanics. 2012. Costa Mesa, California, USA: SEM Fu, J., F. Pierron, and P.D. Ruiz, Elastic stiffness characterization using 3-D full-field deformation fields obtained with optical coherence tomography and digital volume correlation. Journal of Biomedical Optics, 2013. 18(12): p. 16 Fu, J., F. Pierron, and P.D. Ruiz. 3-D strain measurement towards identification of mechanical properties in the bulk. in ICEM 16. 2014. Cambridge, UK. Fu, J., P.D. Ruiz, and F. Pierron. Correction of refraction induced distortion in optical coherence tomography corneal reconstructions for volume deformation measurements. in Photomechanics 2013. 2013. Montpellier, France. Multidisciplinary: bringing Experimental Mechanics and Inversion Numerical methods into a single project.Wheat rust modelling partnershipChinese Academy of Agricultural SciencesInstitute of Plant ProtectionWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZAcademic/UniversityChinaData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCWheat rust modelling partnershipRothamsted ResearchWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZAcademic/UniversityUnited KingdomData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCWheat rust modelling partnershipUniversity of Chinese Academy of SciencesInstitute of Remote Sensing and Digital EarthWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZCharity/Non ProfitChinaData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCWheat rust modelling partnershipZhejiang UniversityWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZAcademic/UniversityChinaData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCWheat rust modelling partnershipKing's College LondonWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZAcademic/UniversityUnited KingdomData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCWheat rust modelling partnershipAssimila LtdWorking with RADI and Assimila to develop a model for predicting wheat rust spread. CABI and IPP carried out a literature review on the current state of wheat rust modelling. For the locust and biopesticide development models ZJU and IPP, CAAS worked to collect ground truthing data and developed models. CABI assisted with the ground truthing data collection and model development with Assimila.IPP and RADI carried out field work to ground truth data. RADI and Assimila worked on developing models for wheat rust prediction and spread. KCL are working on Land Surface Temperature (LST) and how that data fits into the various models while Rothamsted Research are determining the biodiversity of insects affected by locust control insecticides. Assimila are also developing models to predict locust development and time for the biopesticide to kill locusts. IPP, CAAS are also working on biopesticide survival in the environment in Inner Mongolia and ZJU are looking at soil moisture effects in Inner Mongolia.2016-01-01ZPrivateUnited KingdomData Product and Land Surface Temperature Algorithm Report delivered by KCL; Desk study for preparing baseline of current locust and wheat rust expectations of relevant players delivered jointly by CABI and NATESCSOLEIL synchrotronSOLEIL SynchrotronHermes BeamlineThis collaboration has been established with Hermes Beamline of SOLEIL synchrotron, in order to investigate via X-ray photoelectron magnetic microscopy. Our team has fabricated 3D magnetic nanostructures, which have been sent to SOLEIL for characterisation.The group of Rachid Belkhou at SOLEIL are magnetic imaging the 3D nanostructures that we sent them, using their own time to use the HERMES beamline. This is essential for standard beamtime that we'll have in June-2018.2017-01-01ZAcademic/UniversityFranceFor the moment, the main outcome of the collaboration is preliminary results regarding magnetic imaging of 3D nanostructures using photoelectron X-ray microscopy.ALBA SynchrotronALBA SynchrotronThis collaboration has been established with CIRCE beamline of ALBA synchrotron, in order to investigate via X-ray photoelectron magnetic microscopy. Our team has fabricated 3D magnetic nanostructures, which have been sent to ALBA for characterisation.The group at the CIRCE facility are imaging the 3D nanostructures that we sent them. They used their own time to use CIRCE beamline as part of the preparation for the beamtime.2020-01-01ZAcademic/UniversitySpainWe have very promising results regarding magnetic imaging of 3D nanostructures and spontaneous motion of magnetic textures due to the 3D geometry. We are working on processing the data preparing it for publication.School of Economics, University of Nairobi, KenyaUniversity of NairobiThe Centre is configured as a hub and spoke model. The University of Cape Town hosts the hub, with the two strong research centres based at the University of Ghana and the University of Nairobi as (initial) nodes. The research groups and members of the three research nodes bring together internationally eminent African scholars who are influential researchers in their country contexts and have excellent research connections to their respective national statistical offices. The UCT-based hub provides administrative support to a range of activities related to the production of outputs. At the rime of preparing this report, the Kenyan team is also supported by the South African team in the completion of its Inequality Trends Report, scheduled for release in April 2020. The South African-based team is also responsible for the provision of training and training opportunities to our partners, and includes providing training facilities for these activities.Our partners at the University of Nairobi are the eminent Prof Germano Mwabu and Prof Damiano Manda, both strong African development economists and senior members of the School of Economics at the University of Nairobi. The Kenyan team actively participate in the research activities of the Centre. This next phase of the project will see active collaboration across joint projects and capacity-development initiatives.2018-01-01ZAcademic/UniversityKenyaOutcomes and outputs will be listed as they are completed.ISSER, University of Ghana, Legon, GhanaUniversity of GhanaAt present, the Ghanaian team is finalising the production of Ghana's Inequality Trends Report (ITR). As with the Kenyan ITR, this is scheduled for release in April 2020. Members of the South African node have provided intellectual inputs into the process, and recommendations have been taken on board in the production of the final document. The South African-based team is also responsible for the administration of the partnership. This includes the provision of training and training opportunities to our partners, and the provision of training facilities for each training activity.At this stage of the project's life cycle, there have been few opportunities for engagement across the nodes in respect of joint-deliverables. Thus, while there have been numerous, fruitful engagements in respect of research, the value of these discussions in terms of tangible outputs, has been minimal. This will however change, as the project progresses - and will be reported on in due course.2018-01-01ZAcademic/UniversityGhanaLike the South African Inequality Trends Report, the Ghanaian report uses a wide range of data sources to present a broad overview of various dimensions of inequality including on household income and expenditure, assets, earnings, employment, education, health, access to basic services, and social mobility. This report will serve as a baseline diagnostic to assist the country to track its performance in ensuring that all people in Ghana share the same opportunities and have equal access in realising those opportunities.Statistics South AfricaStatistics South AfricaThe African Centre of Excellence for Inequality Research (ACEIR) was established to build capacity for frontier African data scholarship and to contribute to deep, multidimensional and interdisciplinary understandings of inequality that can help inform policies that address inequality. One of the first tasks of the Centre was for each of the three country nodes - Ghana, Kenya and South Africa - to undertake textured analyses of inequality (in these respective countries) in collaboration with their national statistical agencies. In November, the first country report on inequality trends was released by the South African node. The report, which was launched by the South African Statistician-General, and was the product of a close collaboration between Statistics South Africa, ACEIR, and the Agence Française de Développement. The South African-based team is also responsible for the administration of the partnership, which includes the provision of training and training opportunities to our partners, and also the provision of training facilities.At this stage of the project cycle, the substantive engagement is between the South African node of ACEIR, and Statistics South Africa. As the work programme unfolds, engagement between project partners - specifically amongst the statistical agencies of the node countries, will increase. In particular as the Centre hones its work around the SDGs.PublicSouth AfricaIn November 2019, the first country report on inequality trends was released by the South African node. This Inequality Trends Report was launched by the Statistician-General, and is a product of the collaboration between Statistics South Africa, ACEIR, and the Agence Française de Développement. The launch of the report in November was followed by a multi-stakeholder event hosted in Cape Town in February 2020, at which participants from government, NGO's, and the private and academic sectors were provide with an opportunity to engage constructively on ideas and strategies to tackle the country's monumental inequality challenges.Kenya National Bureau of StatisticsKenya National Bureau of StatisticsAt this stage in the project, the contributions by ACEIR's South African team, have been minimal. As the project progresses, any new contributions will be appropriately reported on.The School of Economics at the University of Nairobi has an informal relationship with the Kenya National Bureau of Statistics (KNBS). The provision of access to the KNBS data set by students enrolled in Doctoral and Masters research programmes, requires letters of support from the School. However, access to data by teaching and research staff is more challenging. A number of the members of the School of Economics participate in technical working groups of the KNBS, and in the past, the former Director of School of Economics was a member of the KNBS Board of Management. At present, the Kenyan node of ACEIR enjoys the privilege of having a senior officer in the KNBS as a team member on a(n inequality) project funded by the Agence Française de Devéloppement (AFD). His primary role is managing the relationship with the KNBS, and facilitating the processes for data access. In respect of access to data housed by the KNBS, once access has been granted to the data sets, the members of the Kenyan node of ACEIR will have unrestricted use for research purposes. Data sharing will require approval from the KNBS; at this stage, this not being pursued by the Kenyan node.2018-01-01ZPublicKenyaIn process: the production of Kenya's first Inequality Trends Report. This multi-dimensional diagnostic provides a textured analyses of inequality, which is intended to contribute to deep, multidimensional and interdisciplinary understandings of inequality that could help inform policies that address inequality.University of BristolUniversity of BristolThe partnerships programme has allowed the Centre to build on existing collaborations with key partners in the UK. A key prong of the Centre's emerging work programme in each of our African nodes (including in SA) is a focus on spatial inequality. Dave Gordon and his team in the Townsend Centre for International Poverty Research and the Bristol Poverty Institute are world class researchers in all aspects of the spatial analysis of well-being. They consult with statistical agencies and national governments around the world, including in a number of African countries. Analysis of spatial inequality requires access to census data and government administrative data in order to get down to the local level. A key strength of ACEIR and a central plank in our theory of change in contributing to evidence informed policy making is the very good working relations that we enjoy in each of our nodes (South Africa, Ghana and Kenya) with our respective National Statistical Offices. They are participating as researchers in our country profiling exercises and, as trainees, in our capacity building programmes. There is particular interest within these agencies for capacity building in spatial mapping and analysis. To be more specific, the South African work programme has already started an ambitious work programme with Statistics South Africa on inequality in access to basic services and migration as part of its set-up work programme. The other two nodes (and Ethiopia) are keen to undertake similar exercises with their NSOs. The World Bank has undertaken a number of these exercises in African countries but with a conspicuous lack of success in building local capacity. Our nodes are strong enough to take on this responsibility, both in our launch countries and in our respective regions. Mapping multidimensional inequality in each of the three node countries is almost complete. This work is mostly focussed on the derivation of a set of maps that can be used to announce the national hubs and the need for a national research programme and engagement on inequality and poverty.The University of Bristol is a key partner to our a capacity building initiative (with specific reference to training in spatial inequality mapping), and we are planning to seed this through this partnerships grant.2019-01-01ZAcademic/UniversityUnited KingdomOutputs will be listed as they are completed.London School of EconomicsLondon School of Economics and Political Science (University of London)International Inequalities InstituteThis partnership with the LSE presents an opportunity for ACEIR to make a purposeful contribution towards building a body of knowledge that reflects an inter-disciplinary approach whereby perspectives of other disciplines complement the prevailing economic understandings of inequality. This will be done through the development of two review papers, one focused on economic strategies the other on community strategies. The strength of the papers are derived from the expertise of the UK-based and South African teams. The South African team has been responsible for leading the administrative and intellectual processes for the production of the two papers.The leadership and research community within the III are internationally eminent contributors in the areas of policy responses as well as community strategies to address inequality; thus they have much to bring to the framing and writing of the two papers that are in process of being produced. Prof Mike Savage is an eminent Sociologist and is currently the Director of the International Inequalities Institute at the LSE. He and his team are bringing two strengths to the work programme. First, they bring skills in strategies to overcome inequalities including the analysis of civil society movements and community mobilisation. Second, they bring strength in the collection of wealth data and in the analysis of how the distribution of wealth and assets leads to persistent inequalities. Collectively the papers will make a substantive contribution towards sharpening the discussion of policies and strategies to overcome inequality.2018-01-01ZAcademic/UniversityUnited KingdomOutputs and outcomes will be be listed once they have been completed. To date, there are none.Agence Française de DéveloppementFrench Development AgencyThe Centre is configured as a hub and spoke model. The University of Cape Town hosts the hub, and has a team of young, talented researchers, led and supported by the eminent Prof Murray Leibbrandt. This team has been responsible for the project's outputs. The South African-based team is also responsible for the administration of the grant associated with the partnership. This includes the provision of training and training opportunities to our partners, and includes the provision of training facilities.ACEIR builds off well-established research entities and researchers, and thus there are excellent fundraising possibilities. The Agence Française de Développement (AFD) have been very enthusiastic about the Centre and have made a start-up investment in ACEIR that contributes to the activities of the ACEIR hub and then further investments to each of the three nodes; South Africa, Ghana and Kenya. An additional investment has been made to include Côte d'Ivoire. The contribution from the AFD has however not been limited to the awarding of funding: the research projects have benefited from a substantial intellectual contribution from the Research Facility at the AFD. AFD researchers actively contribute to the design and content of the research outputs.2016-01-01ZPublicFranceTwo outputs have been produced as a direct result of this partnership: 1) In 2018, with the establishment of the Centre, researchers from the country nodes - Ghana, Kenya and South Africa - and affiliate scholars in Côte d'Ivoire embarked on textured analyses of inequality in their respective countries. To build capacity for this undertaking, a Handbook on Inequality Measurement for Country Studies was developed by researchers at the University of Cape Town, where ACEIR's hub and the South African node are located. Released in October 2019, the handbook was developed specifically as an intermediate guide for the ACEIR members; it may also be useful for researchers who are planning an inequality study within a particular country. In addition, the handbook was written with a meta objective in mind: namely to facilitate the comparability of results and findings across countries. This externality represents one of the major motivations for a multi-country collaboration such as ACEIR. 2) Funded by a grant from the AFD (which is partially funded through the European Union's Research Facility on Inequalities), the Inequality Trends Report is the product of a partnership between Statistics South Africa, the Agence Française de Développement, and ACEIR. Released in November 2019, the report uses a wide range of data sources to present a broad overview of various dimensions of inequality including on household income and expenditure, assets, earnings, employment, education, health, access to basic services, and social mobility. The report serves as a baseline diagnostic to assist the country to track its performance in ensuring that all people in South Africa share the same opportunities and have equal access in realising those opportunities.AucklandUniversity of AucklandDepartment of PhysicsPayment of NZ$17,191 for the assay of blood samples from the Children of SCOPE cohort study, to measure lipids and insulin. I am now cleaning the data in preparation for analysing the association of fetal and child growth measures with these assay results.Access to data from the Children of SCOPE cohort; provision of intellectual expertise in obstetrics and pediatrics2015-01-01ZAcademic/UniversityNew ZealandAssays completed, no academic publications yet - analysis ongoingMRC LHAUniversity College LondonMRC Unit for Lifelong Health and AgeingI have been working on, supervising and collaborating on analyses of the NSHD cohort in relation to pathways from early life exposures to healthy ageingData sharing - NSHD data - and collaboration in terms of providing expertise in measures of healthy ageing2015-01-01ZAcademic/UniversityUnited KingdomPMID:27681097Continuing collaborations with the Seismic Research Centre, University of the West IndiesUniversity of West IndiesSeismic Research CentreWe continue to work together on elements of the volcanic activity of the La Soufriere volcano, on St Vincent.Collaboration, sharing of ideas, co-production of papers and reports and sharing of samples.2012-01-01ZAcademic/UniversityTrinidad and TobagoMultiple papers from earlier phases of the collaboration; one new joint paper on the 2021 eruption.PhD student long term attachmentBielefeld UniversityCarolyn Mills applied for an STFC LTA award to visit Cora Uhlemann for 6 months in Germany. Cora helped with the applicationCora will advise Carolyn for the 6 months on their project2025-01-01ZAcademic/UniversityGermanynone yet4D Star collaborationUniversity of LeuvenDepartment of Physics and AstronomyCollaboration with Prof. Conny Aerts' observational program under the Synergy Grant 4D star Our team provides numerical simulations with which to compare observational results.Our team provides numerical simulations with which to compare observational results.2015-01-01ZAcademic/UniversityBelgiumMany joint publications listed in publications.Biomass processing collaborationMcGill UniversityThe RAM Facility has supported the work of a visiting post-graduate student from McGill University and a post-doctoral researcher from the University of Birmingham.They have provided the materials for processing and dedicated supervisor (Prof. Audrey Moores, McGill University) and student time.2026-01-01ZAcademic/UniversityCanadaDevelopment of a clearer understanding of how RAM technology can be used to process chitin-based biomass.Flexible Page-level Memory Access Monitoring Based on Virtualization HardwareNational University of Defense TechnologyProf Lu Kai, Dr Wenzhe ZhangPage protection is often used to achieve memory access monitoring in many applications, dealing with programanalysis, checkpoint-based failure recovery, and garbage collection in managed runtime systems. Typically, low overhead access monitoring is limited by the relatively large page-level granularity of memory management unit hardware support for virtual memory protection. In this paper, we improve upon traditional page-level mechanisms by additionally using hardware support for virtualization in order to achieve fine and flexible granularities that can be smaller than a page. We first introduce a memory allocator based on page protection that can achieve fine-grained monitoring. Second, we explain how virtualization hardware support can be used to achieve dynamic adjustment of the monitoring granularity. In all, we propose a process-level virtual machine to achieve dynamic and fine-grained monitoring. Any application can run on our process-level virtual machine without modification. Experimental results for an incremental checkpoint tool provide a use-case to demonstrate our work. Comparing with traditional page-based checkpoint, our work can effectively reduce the amount of checkpoint data and improve performance.Page protection is often used to achieve memory access monitoring in many applications, dealing with programanalysis, checkpoint-based failure recovery, and garbage collection in managed runtime systems. Typically, low overhead access monitoring is limited by the relatively large page-level granularity of memory management unit hardware support for virtual memory protection. In this paper, we improve upon traditional page-level mechanisms by additionally using hardware support for virtualization in order to achieve fine and flexible granularities that can be smaller than a page. We first introduce a memory allocator based on page protection that can achieve fine-grained monitoring. Second, we explain how virtualization hardware support can be used to achieve dynamic adjustment of the monitoring granularity. In all, we propose a process-level virtual machine to achieve dynamic and fine-grained monitoring. Any application can run on our process-level virtual machine without modification. Experimental results for an incremental checkpoint tool provide a use-case to demonstrate our work. Comparing with traditional page-based checkpoint, our work can effectively reduce the amount of checkpoint data and improve performance.2016-01-01ZAcademic/UniversityChinahttp://delivery.acm.org/10.1145/3060000/3050751/p201-Lu.pdfCollaboration with Monash University, AustraliaMonash UniversityI provided surgical expertise gained from this award, and used equipment from this award. We shared compatible data, co-wrote, and co-edited papers.They provided data from additional cohorts of animals. They provided analysis methods and expertise. We shared compatible data, co-wrote and co-edited papers.2016-01-01ZAcademic/UniversityAustraliadoi: 10.1093/cercor/bhz072 doi.org/10.1523/JNEUROSCI.0330-19.2019 10.1038/s41583-020-0364-5 10.1038/nrn.2017.111 10.1016/j.tins.2016.11.001imaging of the cochleaNational Institutes of Health (NIH)In collaboration with Dr Harri Shroff at NIBIB and Dr Douglas Forrest lab at NIDDK, Bethesda, Maryland I established novel imaging techniques for the mammalian cochlea. The project has opened up new ways of analysis of the cochlea and how it may deteriorate in diseased statesDr Harri Shroff provided imaging facilities and training needed to use the equipment, as well as laboratory space and all chemicals and reagents needed for performing the experiments. Dr Douglas Forrest provided animals needed for the project.2018-01-01ZPublicUnited StatesThis collaboration is multidisciplinary, and includes imaging, physiology and cellular biology approaches.CatalucciInstitute of Genetic and Biomedical ResearchAnalysis of effect of micro RNA on heart growthProvision of hearts from mice injected with miRNA inhibitor.2011-01-01ZAcademic/UniversityUnited Kingdom23166348Norway RatsUniversity of OsloInstitute for Experimental Medical ResearchAnalysis of Cardiac Myocyte proteome, transcriptome and epigenome.Provision and phenotyping of hearts hypertrophic due to exercise, aortic banding or ageing.2009-01-01ZAcademic/UniversityNorwayPublication in JCB in 2012 27893464 23166348UT SWUniversity of Texas Southwestern Medical CenterSouthwestern Medical CenterAnalysis of Tissue from miR-133 DKO animalsProvision of tissue and mRNA from miR-133 double knockout animals2010-01-01ZAcademic/UniversityUnited StatesPublication in JCB in 2012: 23166348RitterUniversity of WurzburgAnalysis of Cardiac tissue from aortically constricted mice. Analysis of effect of cell permeant peptide that prevents calcineurin nuclear import upon NFAT accumulation in the nucleus.Provision of tissue from surgically prepared mice. Provision of cell permeant peptide. Provision of GFP-tagged calcineurin expression vectors.2007-01-01ZAcademic/UniversityGermanyPublication in Mol Cell: 19250908 Publication in PNAS: 19549843MIkoshibaRIKENRIKEN Brain Science InstituteAnalysis of tissue from itpr2 KO animals Use of IP3R2 monoclonal AntibodyProvision of IP3R2 monoclonal antibody. Provision of heart tissue from IP3R2 KO animalsPublicJapanPublication in JCB: 23166348 Publication in Mol Cell: 19250908MolkentinCincinnati Children's Hospital Medical CenterDepartment of PediatricsAnalysed the miceThe collaborator provided hearts from control and aortically constricted mice transgenic for the IP3R Ligand binding domain and for type 2 IP3 receptors.2011-01-01ZAcademic/UniversityUnited StatesPublication in Journal of Cell Biology in 2012 23166348ConwayUniversity of OxfordDepartment of ChemistryUSe and testing of cell permeant IP3 analoguesProvision of Cell permeant IP3 analoguesAcademic/UniversityUnited Kingdom23166348 20106523 19934645 19549843 19250908 18407350 18250332 17692540 17585817 17574672 16882691 16814379 15561771 15263017 14685260 12767897State switching and emotion regulation during infancy and early childhood.King's CollegeCollaboration with Professor Edmund Sonuga-Barke, funded by a £300,000 start-up grant from King's College University, to look at state switching and emotion regulation during infancy and early childhood. For this I am hosting and supervising two researchers, Dr Kasia Kostyrka-Allchorne and Zeynep Suata, in running testing with young children in our labs at the University of East London. The researchers are taking advantage of research equipment available there which was purchased from this FRL Fellowship.The two researchers, Dr Kasia Kostyrka-Allchorne and Zeynep Suata, are employees at King's College. The funding comes from a start-up grant given to Professor Edmund Sonuga-Barke.2017-01-01ZAcademic/UniversityUnited StatesTwo testing projects are currently at piloting stage.Eye movements in infants born prematurelyUniversity of EdinburghI have collaborated with Dr Sue Fletcher-Watson by helping her to analyse some eyetracking data that she collected as part of a project at the University of Edinburgh.The project is analysing data that they have collected.2017-01-01ZAcademic/UniversityUnited KingdomWe are analysing the data and shall be writing it up shortly.Professor Ingo DreyerUniversity of TalcaMy contribution to this collaboration has been primarily intellectual, providing biological expertise to guide the development of mathematical models. I worked closely with the mathematical modeller and physicist to help define the key biological questions, interpret experimental observations, and ensure that the modelling framework accurately reflects the underlying biological processes. This interdisciplinary exchange enabled the integration of biological knowledge with quantitative modelling approaches, helping to develop models that can address biologically relevant questions and generate testable hypotheses. The collaboration strengthened the connection between experimental plant biology and theoretical modelling, supporting a more mechanistic understanding of the biological system under study.The collaborator contributed expertise in mathematical modelling and quantitative analysis to support the development of theoretical frameworks addressing the biological questions underpinning the project. They developed and implemented mathematical models to explore the dynamics of the biological system and to test hypotheses arising from experimental observations.2025-01-01ZAcademic/UniversityChileThis collaboration has resulted in the submission of a joint manuscript that integrates experimental biological data with quantitative modelling approaches. The work represents a key outcome of the partnership and reflects the close interaction between experimental and theoretical perspectives developed during the project. The collaboration is multidisciplinary, bringing together expertise from plant biology, mathematical modelling, and physics.Latent profiles of people with convictions for sexual offencesMinistry of JusticeThis part of the project aimed to identify subtypes of people with convictions for sexual offences that go beyond distinctions based on victim type. Analyses are based on existing data used under licence from the Ministry of Justice. The PI (SG) formulated the research question, and jointly submitted an application to conduct research to the Ministry of Justice National Research Committee, designed the project and wrote the article. The final report has been shared with the Ministry of Justice together with feedback for practice. Other analyses have documented pathways between different risk factors using network analyses. The findings of this work are currently being written up for publication and will be shared with the Ministry of Justice upon completion.The Partner was responsible for data analysis and contributed to drafting the final published article. Analyses were carried out to identify indicators of different domains of risk for sexual offending from psychological test data for participants who were assessed for eligibility for the prison based Core Sexual Offender Treatment Programme. Based on these analyses, indicators of different risk domains were used in latent profile analyses to identify psychological profiles of people with convictions for sexual offences. Further analyses examined differences between these profiles based on individual characteristics (age, IQ), offence histories, victim preference, and level of risk.2021-01-01ZPublicUnited KingdomOne output has been published in the British Journal of Psychiatry, a high impact peer reviewed scientific journal. A report has also been shared with the Ministry of Justice, and our finings have been shared with the Centre of Expertise on Child Sexual Abuse. One further output is anticipated for publication based on these data.Ari Waisman / University of MainzJohannes Gutenberg University of MainzProfessor Ari Waisman discussed reporter construct strategiesMade a reporter transgenic2010-01-01ZAcademic/UniversityGermanyNone to dateLiver on a chip commercilisationStemnovate LimitedStemnovate have non exclusively licensed our stem cell derived hepatocyte technology. We will provide know how and training.Financial contribution to a PhD programme - *BBSRC EASTBIO* Modelling foetal liver development and disruption using pluripotent stem cells (iCase)2017-01-01ZPrivateUnited KingdomIn the process of interviewingcomparing hPSC-cartilage to limb cartilageWellcome Sanger InstituteMaterials protocols dataProtocols data2020-01-01ZCharity/Non ProfitUnited KingdomData and a paper will resultKCL Stem Cell Hotel Concierge PositionPerkin ElmerEstablishment of Stem Cell Hotel within Centre for Stem Cells and Regenerative Medicine at KCL.Funding for Stem Cell Hotel Concierge (technician) plus equipment maintenance and servicing contracts.2016-01-01ZPrivateUnited StatesSkills and expertise provided to KCL.Collaboration between Prof Stuart Forbes and Novartis Institute of Biomedical ResearchNovartis Institutes for BioMedical Research (NIBR)Cell lines and methods generated using UKRMP funded research are being provided to Novartis.In house expertise from NIBR2016-01-01ZPrivateUnited StatesNo outcomes as yet but the aim is to produce a screen for regeneration cues for HPCs using a CRISPR-Cas9 assisted system.Collaboration Tamir Rashid & NPSCNational Phenotypic Screening CentreRashid group are transferring their assay for alpha-trypsin-1 deficiency to NPSC for HTS purposesNational Phenotypic Screening Centre and Janssen are providing high through put capabilities and compound libraries.2017-01-01ZCharity/Non ProfitUnited KingdomOngoing - no outputs as yet.GSKGlaxoSmithKline (GSK)Idea Screening New modelFinances small molecules2014-01-01ZPrivateGlobalToo earlyCollaboration Tamir Rashid & NPSCJanssen Research & DevelopmentRashid group are transferring their assay for alpha-trypsin-1 deficiency to NPSC for HTS purposesNational Phenotypic Screening Centre and Janssen are providing high through put capabilities and compound libraries.2017-01-01ZPrivateGlobalOngoing - no outputs as yet.GAG analysis with Keele/OswestryKeele UniversitySchool of LawWe have a protocol for chondrogenesis . Nicky Kuipper at Keele Oswestry will analyse GAGS in medium and cells for preliminary data for a grant applicationFACE and other analyses2016-01-01ZAcademic/UniversityUnited Kingdomanalyses of samples in progressCollaboration with Xintela SwedenXintela ABCollaboration to enhance chondrogeneis from hESCs using extracellular matrix modulationWe have the protocol and cells they have specific required antibodies2014-01-01ZPrivateSwedenOnly just initiatedKCL and Materiomics Topochip StudyMateriomicsDevelopment of screen for features that promote differentiation of human epidermal keratinocytes.Provision of platform technology.2016-01-01ZPrivateNetherlandsScreen which potential clinical applicationsOPC migration assaysUniversity of StrathclydeDepartment of Civil and Environmental EngineeringInstigator We have the biological idea and Michele Zagnoni has the technology to do the work. cells to put in the assay. Knowledge on biology.Microfluidics technology to do the work.2015-01-01ZAcademic/UniversityUnited KingdomARUK pilot grant FISM fellowship to Roberta Felici FISM small project grant to Michele Zagnoni (co-applicant)Astellas Institute for Regenerative Medicine CollaborationAstellas PharmaAstellas Pharma UKScreening small molecule librariesProvision of library2018-01-01ZPrivateUnited KingdomConfidentialGeneration of dynamic substrates that mimic changed in the epidermal/dermal interfaceKeele UniversityMy BBSRC-funded research assistant is working with Alicia El Haj's team to develop the substrates. My lab benefits from Alicia's expertise and access to her workshop to manufacture components of the experimental setup.See above.2015-01-01ZAcademic/UniversityUnited KingdomResearch in progressCollaboration with TocrisBio-Techne LtdTocrisPlanned collaboration to develop high though put screening for drugs enhancing chondrogenesisTargeted drug libraries, screening support and advice; Modified compounds2019-01-01ZPrivateUnited KingdomSeeking joint fundingAstraZeneca and Dave Hay Collaboration: Toxicity TestingAstraZenecaToxicology SciencesProvided screening platform/technology that had been developed during UKRMP funded research.AZ provided a library of compounds for testing as well as AZ generated data for comparative purposes2016-01-01ZPrivateUnited KingdomPlans for joint publication of results. Screening platform currently being investigated a spin out opportunity. PDRA has been awarded an RSE Fellowship to pursue this opportunity.SnRNAseqKarolinska InstituteCollaboration between us (MS neuropathology and biology experts) and Goncalo Castelo-Branco (experts in snRNAseq and analysis)Collaboration between us (MS neuropathology and biology experts) and Goncalo Castelo-Branco (experts in snRNAseq and analysis)2017-01-01ZAcademic/UniversitySwedenNature Medicine and Nature paper 2018 and 2019Genzyme and Scott WebsterSanofiGenzyme CorporationScientific idea Drug targetHigh throughput screening technology Assay development2014-01-01ZPrivateUnited StatesProject moved to LifearcMiltenyiMiltenyi Biotec GmBHWe have submitted a large grant application to Arthritis Research Uk with Miltenyi. If successful they will contribute in kind support with cell sorting and GMP translationof our protocol for clinical therapyCell sorting expertise and kits/antibodies/plates for FACs based cell sorting for enrichment of chondroprogenitors2017-01-01ZPrivateGermanyToo earlyIs GDF11 causative of ineffective erythropoiesis of beta thalassemia, and the target of luspatercept?University College LondonStudied the effect of GDF11 on differentiation of normal and beta thalassemia erythroid cells, determining if GDF11 causes or exacerbates ineffective erythropoiesis.Provided clinical and intellectual input to project. Enabled funding for project.2020-01-01ZAcademic/UniversityUnited KingdomFunding from Celgene Paper in preparationCulture and analysis of beta thalassemia patient erythroid cellsKing's College LondonWe are creating am immortalised cell line from patient with rare blood cell disease enabling exploration of the underlying molecular defectsProviding patient sample and bringing expertise in alpha thalassemia and genome technologies2024-01-01ZAcademic/UniversityUnited KingdomClinical Haematology Molecular and cell Biology researchOutreach Network for Gene Drive ResearchOutreach Network for Gene Drive ResearchInput to policy discussionsNetwork is engaged in briefing national and international entities, e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive. Outreach also relates to general public (directly and via media) as well as policymakers, regulators and practitioners. The Pirbright Institute is now a member of the Network2019-01-01ZCharity/Non ProfitBriefing and media comment regarding gene drives and gene drive research to multiple agencies e.g. EU/EC, European Parliament, IUCN, Convention on Biological Diversity, on issues related to gene drive.Collaboration with ESRC Centre for Competition PolicyUniversity of East AngliaCentre for Competition PolicyWe presented our work to the Centre - including at their annual conference in 2012 - and also funded some of their PhD students to attend the annual CRESSE Workshop on Competition Policy Enforcement that we funded through our ESRC grantThey hosted us and we benefitted from interaction with a group with very considerable experience in Competition Policy Issues. They also provided Discussants to some of our Workshops2011-01-01ZAcademic/UniversityUnited KingdomThe collaboration was multi-disciplinary. CCP has a mixture of economists and lawyers and we particularly benefitted from discussions with one of their legal experts.Improving the information literacy of early careers researchers - focus on biomedical reseachersAnnual ReviewsEQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. She is shaping the focus and future plans for the collaboration, using her expertise as an information specialist. All team members contributed towards conducting and writing up the systematic review.EQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. All team members contributed towards conducting and writing up the systematic review.2016-01-01ZCharity/Non ProfitUnited StatesThe collaboration is multi-disciplinary with involvement of both librarians and a publisher. A conference abstract has been submitted to the Canadian Health Libraries Association Conference. The team have completed work on a literature review to identify problems and barriers that early career researchers face when undertaking a systematic review. The review was submitted for publication in January 2020. The conclusions of the review will inform development of an early career researcher needs and barriers identification survey. Work on the survey will begin in the summer of 2020.French EQUATOR CentreUniversity of Paris - DescartesOne of the goals of the EQUATOR Network is to achieve global presence to support responsible research reporting efficiently. In 201 we started setting up centres in other countries. EQUATOR team based in the UK (HQ of the Network) supports teams in other countries and collaborates on various projects including research studies and organisation of conferences, meetings and workshops.EQUATOR Centres work together to promote responsible reporting of health research studies. Centre members collaborate on research projects, teaching and promotion activities.2014-01-01ZAcademic/UniversityFrance1. Meetings. For example, Doug Altman was invited to speak at the University of Paris Descartes in 2016 about the quality of methods and reporting in the medical research literature. 2. Research collaboration 3. TeachingGoodReports Template projectPenelope ResearchThis collaboration grew out of an existing collaboration with Penelope Research (Penelope Research Scientific Manuscript Review Software and EQUATOR Wizard). The UK EQUATOR Centre's Caroline Struthers conceived the project. She initially built a matrix that integrates and harmonises all of items from 16 main reporting guidelines and extensions for clinical research, which formed the base of the GoodReports tool. The tool makes it much easier for authors of research articles to identify and use all available reporting guidance relevant to their research at the point of writing it up, without having to find and use several separate documents. The UK EQUATOR Centre team is now contributing expertise in trial design, good reporting and academic writing, and experience in working with early-career researchers towards the further development and testing of the GoodReports tool, with Caroline Struthers continuing to take the lead on this project.Penelope Research brings software development expertise to the collaboration. In initial stages of this collaboration, a second software developer was involved. However, this involvement ended before any outputs were realised. The team has integrated the Penelope/EQUATOR Wizard for finding the correct reporting guideline with the matrix created by EQUATOR to create the GoodReports web app, which displays the appropriate online fillable reporting checklist for an author's study. Authors can either annotate where in their manuscript they have reported each checklist item online, or download the blank checklist in Word and fill it in offline. The filled checklist can then be submitted to a journal alongside the manuscript. The team is now further developing the GoodReports tool, to include more reporting guidelines, more examples of good reporting, and templates for guiding article writing.2016-01-01ZPrivateUnited KingdomThe GoodReports web app, including the updated wizard and online reporting guideline generator, has been available since January 2018. It can be accessed independently from the EQUATOR website and as part of the Penelope manuscript checking software. BMJ Open piloted GoodReports as part of the full Penelope package in its submission process in 2018. The results of this pilot are currently being written up. As of March 2020, GoodReports has had 30,517 users. A third of the users have downloaded a blank or completed checklist. Penelope generates an email survey to ask for feedback from users. 702 people have responded so far, with 667 answering the rating question and giving an average rating of 8/10. In September 2019, the team began a three year MRC award to further develop GoodReports and test it in a randomised trial.Collaboration with the Pan American Health Organization to raise standards of health research reporting in the Pan American regionsPan American Health OrganizationPAHO Research Promotion and DevelopmentThe main aim of the collaboration is to raise research reporting standards in South America. The initial phase of this collaboration was a translation of the EQUATOR Network's online Library for Health Research Reporting into Spanish. EQUATOR team members developed and maintain our Library, and produce regular newsletters that are now being translated into Spanish under this collaboration. We also heavily contribute to the direct and indirect dissemination of our work to South American journal editors. EQUATOR's Caroline Struthers, Jennifer de Beyer and Iveta Simera wrote and edited a significant proportion of a four-module online course on enhancing the value and use of research, which was published on the PAHO's CITI Training Platform in June 2017. EQUATOR's Michael Schlussel contributed a Portuguese promotional video. EQUATOR's Michael Schlussel and Patricia Logullo created a Portuguese translation of the modules.PAHO has contributed translations, dissemination contacts and practical help with dissemination of the outputs of our collaborative work. PAHO contributed organisational, authorship, editorial and translation expertise to create a four-module online course on enhancing the value and use of research. PAHo translated the modules into Spanish and made them available on its Virtual Campus alongside the English version. PAHO supported the addition of automatic translation for the EQUATOR website (2022).2010-01-01ZCharity/Non ProfitUnited StatesSpanish translation of the English EQUATOR Network website that hosts the online Library for Health Research Reporting. Portuguese translation of the English EQUATOR Network website that hosts the online Library for Health Research Reporting. Regular Spanish EQUATOR Newsletters Promotion campaign targetting South American health research journals Iveta Simera presented at the 4th University Internationalization Seminar organised by PAHO, the Organisation of American States and COIMBRA Group for high representatives of Brazilian Universities in 2016. In 2017, four published online modules were made available via the CITI Program in English, Portguguese and Spanish. The modules are also freely available to all PAHO-supported scholars via the PAHO Virtual Campus. Promotional videos in English, Portuguese and Spanish were also created. (https://www.campusvirtualsp.org/en) The modules have been translated in Spanish and Portuguese.Oxford University Clinical Graduate School (OUCAGS), University of OxfordUniversity of OxfordThe EQUATOR team developed a 4-module course, "Introduction to medical research:essential skills" at the request of the Oxford University Clinical Graduate School (OUCAGS) to address the needs of their young doctors in training. The EQUATOR team now delivers this training twice a year and contributes organisation of the academic side of the course.The OUCAGS team contributes the organisional aspects of the course.2013-01-01ZAcademic/UniversityUnited KingdomA 4-module course "Introduction to medical research:essential skills" has been developed and is run twice a year (2013 until present), reaching around 20 junior doctors with an interest in research each time.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)University of MinnesotaShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZAcademic/UniversityUnited StatesThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.Collaboration with the Health Research Authority, UKNHS Health Research AuthorityThe EQUATOR Network reviewed guidance on titles of research projects to propose recommendations to improve the clarity of titles of research proposals submitted to the Health Research Authority for ethical approval. The EQUATOR Network has undertaken public consultations on the HRA's behalf on steps that the HRA can take to promote good publication practice to improve transparency.Practical implementation of proposed recommendations2012-01-01ZPublicUnited Kingdom1. Study report on titles of research projects submitted to the Health Research Authority, UK 2. Public survey conducted by the EQUATOR Network on proposed changes to IRAS question A51, to promote good research dissemination practices.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)University of FloridaShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZAcademic/UniversityUnited StatesThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.Canadian EQUATOR CentreOttawa Hospital Research InstituteOne of the goals of the EQUATOR Network is to achieve global presence to support responsible research reporting efficiently. In 2014 we started setting up centres in other countries. EQUATOR team based in the UK (HQ of the Network) supports teams in other countries and collaborates on various projects including research studies and organisation of conferences, meetings and workshops.EQUATOR Centres work together to promote responsible reporting of health research studies. Centre members collaborate on research projects, teaching and promotion activities.2014-01-01ZAcademic/UniversityCanadaConference, teaching collaborationAustralian EQUATOR CentreBond UniversityOne of the goals of the EQUATOR Network is to achieve global presence to support responsible research reporting efficiently. In 201 we started setting up centres in other countries. EQUATOR team based in the UK (HQ of the Network) supports teams in other countries and collaborates on various projects including research studies and organisation of conferences, meetings and workshops.EQUATOR Centres work together to promote responsible reporting of health research studies. Centre members collaborate on research projects, teaching and promotion activities.2015-01-01ZAcademic/UniversityAustralia1. Launch meeting 2. Elaine Beller of the Australian Centre joined the 2016 EQUATOR Publication School as a facilitator 3. The Australian Centre has run a short, 2-day version of the EQUATOR Publication School (December 2016), using their experiences of the EQUATOR Publication School in Oxford.Penelope Research Scientific Manuscript Review Software and EQUATOR WizardPenelope ResearchThe EQUATOR Network provided expertise and input into an algorithm/decision tree to develop an online tool to enable authors of research reports identify the appropriate reporting guideline for manuscripts submitted to scientific journals. We also created a database of key reporting guidelines to populate an online tool called GoodReports, which allows authors to identify the appropriate reporting guideline and delivers an online version of the checklist for the guideline identified.Penelope Research developed the software for the GoodReports online tool. The decision tree questions have been integrated into Penelope's main product which is which is automated manuscript review software http://www.peneloperesearch.com/#home-penelope-section. The Penelope feedback report includes a link to the GoodReports tool and the appropriate checklist.2015-01-01ZPrivateUnited Kingdom1. The EQUATOR Decision Tree was created 2. The EQUATOR Wizard was developed, using the Decision Tree as a basis. It has been accessed over 5000 times since 2016 and is one of the most viewed items on the EQUATOR Network website. 3. The prototype Wizard was piloted in February 2016. http://www.equator-network.org/2016/02/17/its-a-kind-of-magic-how-to-improve-adherence-to-reporting-guidelines/ In a before-after analysis, BioMed Central embedded the decision-tree tool in the submission system for four journals in the BMC series. In total, 590 manuscripts were included in this analysis - 300 in the before cohort and 290 in the after. There was a significant increase in manuscripts where authors had identified the correct reporting guidelines for their study type - 16% in the before cohort and 25% in the after cohort. There was also a significant decrease in manuscripts where authors incorrectly stated that there were no relevant guidelines - 27% in the before cohort and 16% in the after cohort. These results suggest that providing authors with a tool to assist in identifying the correct reporting guidelines for their study improved the identification of the correct reporting guidelines. 4. The results of the pilot were presented at a conference of journal editors. 5. The Wizard has been updated and version 1.5 has been released. 6. The updated Wizard has been integrated into the GoodReports online tool and a link to the tool integrated into the Penelope Research manuscript checker. This multidisciplinary collaboration combines the software development skills of Penelope Research with EQUATOR Network's expertise in good reporting.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)University of OttawaOttawa Health Research InstituteShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZAcademic/UniversityCanadaThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.EQUATOR Network / REWARD Alliance collaborationThe LancetThe EQUATOR Network promotes and educates about the REWARD principles through its online presence.The REWARD Alliance promotes and educates about the EQUATOR programme through its online presence2015-01-01ZPrivateUnited Kingdom1. An international conference was held in September 2015 in Edinburgh, Scotland. 2. An international conference was held in February 2020 in Berlin, Germany. The conference was hosted by a local centre (QUEST Berlin).Improving the information literacy of early careers researchers - focus on biomedical reseachersUniversity of CambridgeEQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. She is shaping the focus and future plans for the collaboration, using her expertise as an information specialist. All team members contributed towards conducting and writing up the systematic review.EQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. All team members contributed towards conducting and writing up the systematic review.2016-01-01ZAcademic/UniversityUnited KingdomThe collaboration is multi-disciplinary with involvement of both librarians and a publisher. A conference abstract has been submitted to the Canadian Health Libraries Association Conference. The team have completed work on a literature review to identify problems and barriers that early career researchers face when undertaking a systematic review. The review was submitted for publication in January 2020. The conclusions of the review will inform development of an early career researcher needs and barriers identification survey. Work on the survey will begin in the summer of 2020.Improving the information literacy of early careers researchers - focus on biomedical reseachersUniversity of OttawaEQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. She is shaping the focus and future plans for the collaboration, using her expertise as an information specialist. All team members contributed towards conducting and writing up the systematic review.EQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. All team members contributed towards conducting and writing up the systematic review.2016-01-01ZAcademic/UniversityCanadaThe collaboration is multi-disciplinary with involvement of both librarians and a publisher. A conference abstract has been submitted to the Canadian Health Libraries Association Conference. The team have completed work on a literature review to identify problems and barriers that early career researchers face when undertaking a systematic review. The review was submitted for publication in January 2020. The conclusions of the review will inform development of an early career researcher needs and barriers identification survey. Work on the survey will begin in the summer of 2020.Improving the information literacy of early careers researchers - focus on biomedical reseachersUniversity of TorontoEQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. She is shaping the focus and future plans for the collaboration, using her expertise as an information specialist. All team members contributed towards conducting and writing up the systematic review.EQUATOR Network's Shona Kirtley and her collaborators play an equal role in this partnership to improve the information literacy of early careers researchers. All team members contributed towards conducting and writing up the systematic review.2016-01-01ZAcademic/UniversityCanadaThe collaboration is multi-disciplinary with involvement of both librarians and a publisher. A conference abstract has been submitted to the Canadian Health Libraries Association Conference. The team have completed work on a literature review to identify problems and barriers that early career researchers face when undertaking a systematic review. The review was submitted for publication in January 2020. The conclusions of the review will inform development of an early career researcher needs and barriers identification survey. Work on the survey will begin in the summer of 2020.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)Institute for Quality and Efficiency in Health CareShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZPrivateGermanyThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)Monash UniversityShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZAcademic/UniversityAustraliaThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.Member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search)University of TorontoShona Kirtley is a member of guideline development group to develop an extension to the PRISMA reporting guideline for reporting literature searches in systematic reviews (PRISMA-Search). The group is leading the development of this much-needed reporting guidance, which is nearing completion. The background research, Delphi rounds, face-to-face meetings, public comment and guideline writing have all been completed and the manuscript has been submitted for publication. All collaborators play an equal role in this guideline development group.All collaborators play an equal role in this guideline development group.2015-01-01ZAcademic/UniversityCanadaThree rounds of Delphi exercise were completed and one face-to-face meeting was held. The list of items identified during the Delphi rounds was refined and draft guidance released as a preprint on OSF and presented as a poster at the MLA conference in May 2019. The group has now revised the guideline following the feedback gathered from the public consultation. The guideline was submitted for publication on 27 February 2020 and was published in January 2021.EQUATOR Network / African Journal Partnership ProjectAfrican Journal Partnership ProgramThe EQUATOR Network provides training and resources on research publication and reporting guidelinesThe African Journal Partnership Project implements resources and reporting guidelines in African journals.2015-01-01ZCharity/Non ProfitUnknownA workshop was conducted with the Partnership in Malawi in 2015, resulting in changes in participating journals' policies.Global Health Network, University of OxfordUniversity of OxfordCollaborative development of online learning, promoting online resources to improve publication of researchCollaborative development of online learning, promoting online resources to improve publication of research2013-01-01ZAcademic/UniversityUnited KingdomOnline learning module: Introduction to responsible publication of clinical researchMemorandum CLIMATE JUSTICE AND AI COMPUTING LAB Digital Worlds Institute, University of FloridaUniversity of FloridaIn conversation with THE CLIMATE JUSTICE AND AI COMPUTING LAB's principal investigator (Amelia Winger-Bearskin, Digital Worlds Institute, University of Florida) and THE CREATIVE AI LAB'S team (Eva Jäger, Mercedes Bunz), it is clear that we share a similar commitment to including artists and the artistic R&D process in the development of AI technologies. Furthermore, this collaboration will be part of our ongoing research into building public interest technological infrastructure for Web3 with global ecology at the center. Through King's College London's Digital Humanities department's scholarship and the Serpentine's Art Technologies artist network, we plan to co-create artist-led prototypes that can serve as test-beds for future AI technologies.The AI Climate Justice Lab shared with us insights for prototypes of sustainable technologies during workshops and provide advice to prototypes developed in the lab.2022-01-01ZAcademic/UniversityUnited Statesn/a yet.Collaboration with Novartis Research Institution - Boston USANovartis Institutes for BioMedical Research (NIBR)We have received a small molecule inhibitor from Novartis under MTA, and tested this compound to validate our genetic dataNovartis provided a small molecule inhibitor against the vps34 Pi 3-kinase under MTA,2016-01-01ZPrivateUnited StatesA manuscript describing the results of these studies has now been published (Bilanges et al - Nature Communications 2017)Tumanov - LtbRTrudeau InstituteConducting experiments using transgenic mice supplied by collaboratorProvided Lymphotoxin-beta receptor floxed transgenic mice.2015-01-01ZCharity/Non ProfitUnited StatesNone yetBASBritish Antarctic SurveyProvision of the drill hardware for testing.Provision of the appropriate rock samples and test environment.2016-01-01ZAcademic/UniversityUnited KingdomWe are working together to create a uniquely deployable and capable subglacial sampling system.Application of Signal Amplification by Reversible Exchange (SABRE) for hyperpolarisation in NMRPfizer IncResearch undertaken to probe the characterization of drug scaffold conjugates by NMRKnowledge and 3 weekly meetings where results are discussed and progress planned.2022-01-01ZPrivateUnited StatesOutputs at the moment are internal reports but publications are expected.Collaboration with the Permaculture AssociationPermaculture AssociationMarch 27, 2025 - the PI shared a short input introducing the SDLL project to the community of school representatives interested in the course launched by the Permaculture Association for schools in England, Designing Sustainable Schools. We have shared project updates and the importance of languages in permaculture frameworks via two exchange meetings since the beginning of the project.Permaculture Association have developed a bespoke Introduction to Permaculture Course offered to ±70 teachers in three primary schools, three artists involved in the project and a Post-doctoral Researcher. Two additional video-recorded inputs were offered to the project community to facilitate the development of the project.2025-01-01ZCharity/Non ProfitUnited KingdomBespoke course for teachers and artists - Introduction to Permaculture (online). Two video-recorded inputs complimentary to the online course - shared with teachers during in-service days with follow-up discussions facilitated by the project team. Multi-disciplinary collaboration: permaculture + applied linguistics and language educationAnimal behaviour influence on N2O emissionsUniversity of TexasTexas A&M University-Kingsville, Caesar Kleberg Wildlife Research InstituteThe idea of relating emissions of nitrous oxide to animal behaviour, joining my expertise in atmospheric emissions with the behaviour knowledge of the colleague in TexasThe understanding of animal behaviour2016-01-01ZAcademic/UniversityUnited StatesPresentations in conferences as listed in the relevant section of this awardConservation agriculture collaborationShimpling Park FarmWe visited Shimpling Park Farms to see how conservation agriculture practises were being used to add value to farmingOwner of Shimpling Park Farms contributed to the development of a subsequent workshop on Conservation Agriculture2017-01-01ZPrivateUnited KingdomA workshop was held at the John Innes Centre involving farmers and researchers, including scientists from the USACapturing novel quality and soil health traits for sustainable barley productionNew Heritage Barley Limitedthis is a collaborative project to characterise novel traits in barley for the brewing and distilling industries. Our contribution is to provide seed and field trial facilities as well as expertise in barley growingThey provide expertise in association genetics and mapping. They also provide facilities and expertise for metabolomics analysis. New heritage barley is a spin-out company from the John Innes Centre that is investing in this project2018-01-01ZPrivateUnited KingdomThe collaboration only started in October 2018, with a student being recruited to the projectCapturing novel quality and soil health traits for sustainable barley productionUniversity of Liverpoolthis is a collaborative project to characterise novel traits in barley for the brewing and distilling industries. Our contribution is to provide seed and field trial facilities as well as expertise in barley growingThey provide expertise in association genetics and mapping. They also provide facilities and expertise for metabolomics analysis. New heritage barley is a spin-out company from the John Innes Centre that is investing in this project2018-01-01ZAcademic/UniversityUnited KingdomThe collaboration only started in October 2018, with a student being recruited to the projectIdentifying the genetic determinants of barley colonisation by the growth-promoting biocontrol agent Pseudomonas fluorescensNew Heritage Barley LimitedThis is a collaborative project led by Jacob Malone at the John Innes Centre, and I am a partner in the project. I provide expertise in barley growing and production, and on measurement of phenotypic traitsNew Heritage Barley Ltd is a start-up company from the John Innes Centre, providing expertise in barley production for the malting and brewing industries. They also provide access to commercial trials and malting facilities2017-01-01ZPrivateUnited KingdomThe collaboration started in 2017 when the student was recruited to the project. A presentation was made at the JIC 50th anniversary exhibition in 2017Development of natural, environmental friendly varraocideVita (Europe) LtdEmploying gene-knockdown in a previous BBSRC-LINK project we identified a critical target in Varroa. Employing the in vitro feeding system developed through further BBSRC funding, we demonstrated that is target was druggable by three human medical drugs in common use, but these drugs were totally benign to honey bees. We proceeded to identify two readily available and commonly used plant-based human health supplements that had reports of potentially acting on this target, at least in humans and mammals. Using the in vitro system we validated that both of these compounds were totally benign to honey bees but lethal when fed to varroa. Because of their good safety profile as sold for human supplements and their potent varroacidal properties it was thought these compounds could be developed as next-generation varroacides. Consequently, we contacted Vita (Europe) Ltd as the next step in the development and commercialisation of these novel varroacides.Vita (Europe) Ltd are a well established bee health business selling in 60+ countries worldwide with a large focus on controlling varroa. A Licensing Option and Evaluation Agreement has been drawn up and signed between Uni Aberdeen and Vita. Vita are proceeding with lab and field studies for efficacy testing; toxicology expert report; environmental risk assessments; residue expert report and other necessary requirements before product registration in various regional domains. Though we will provide our research expertise knowledge to the product development where required, the product development and testing requires the expertise and contacts/contracts of Vita.2026-01-01ZPrivateUnited KingdomJust starting / still on-going.Protest Camps NetworkUniversity of LeicesterManagementThe Protest Camps Network was established by a group of researchers looking at the recent phenomenon of protest camps and the use of public space. From my research I contributed knowledge on creative forms of protest and organisation. I organised a one day public workshop funded by the ESRC Festival of Social Science.My partners have contributed room space, advertising and marketing resources, and opportunities for international networking and idea exchange.2012-01-01ZAcademic/UniversityUnited Kingdom'Creating worlds together: A workshop on Experimentations and Protest Camps'. Public workshop. Birkbeck College, University of London, 2 November, 2013 'The Politics of the Social in Contemporary Art'. Tate Modern, London, 16 February 2013 'Creating worlds: The affective spaces of experimental politics'. Day conference. Royal Holloway, Bedford Square, London, 14 January, 2013Protest Camps NetworkBournemouth UniversityMediaThe Protest Camps Network was established by a group of researchers looking at the recent phenomenon of protest camps and the use of public space. From my research I contributed knowledge on creative forms of protest and organisation. I organised a one day public workshop funded by the ESRC Festival of Social Science.My partners have contributed room space, advertising and marketing resources, and opportunities for international networking and idea exchange.2012-01-01ZAcademic/UniversityUnited Kingdom'Creating worlds together: A workshop on Experimentations and Protest Camps'. Public workshop. Birkbeck College, University of London, 2 November, 2013 'The Politics of the Social in Contemporary Art'. Tate Modern, London, 16 February 2013 'Creating worlds: The affective spaces of experimental politics'. Day conference. Royal Holloway, Bedford Square, London, 14 January, 2013Application of single cell multiomic data analysis pipeline in adult zebrafish hypothalamic cellsUniversity of ExeterBiosciencesWe have made a fruitful collaboration with Dr. Jordi Solana's group to apply single cell multiomic data analysis that his lab has developed in our zebrafish hypothalamic dataset.The collaborator provided custom-made code and carried out consultations and provided feedbacks for applying his analysis tools to our dataset.2025-01-01ZAcademic/UniversityUnited KingdomManuscript is being prepared based on this collaboration.Sharing Parental Experiences (SHAPE)Fatherhood InstituteWe have engaged a wide network of local and national stakeholders - including the Fatherhood Institute, the Coram Foundation, Home Start, One Plus One, Dadvengers, Cambridgeshire County Council, Pinpoint, and Addenbrookes Hospital. Our discussions with these stakeholders have helped us to prepare three videos and three related audio archives that will be released at the Cambridge Festival later this monthThe stakeholder meetings have been useful in highlighting the priorities and interests of their communities - they were also helpful in shaping the format of the resources (e.g., linking the videos to the audio archives) - and facilitating communication with wider and more diverse audiences.2025-01-01ZCharity/Non ProfitUnited Kingdomwork in progressSharing Parental Experiences (SHAPE)Addenbrooke's HospitalWe have engaged a wide network of local and national stakeholders - including the Fatherhood Institute, the Coram Foundation, Home Start, One Plus One, Dadvengers, Cambridgeshire County Council, Pinpoint, and Addenbrookes Hospital. Our discussions with these stakeholders have helped us to prepare three videos and three related audio archives that will be released at the Cambridge Festival later this monthThe stakeholder meetings have been useful in highlighting the priorities and interests of their communities - they were also helpful in shaping the format of the resources (e.g., linking the videos to the audio archives) - and facilitating communication with wider and more diverse audiences.2025-01-01ZHospitalsUnited Kingdomwork in progressSharing Parental Experiences (SHAPE)One Plus OneWe have engaged a wide network of local and national stakeholders - including the Fatherhood Institute, the Coram Foundation, Home Start, One Plus One, Dadvengers, Cambridgeshire County Council, Pinpoint, and Addenbrookes Hospital. Our discussions with these stakeholders have helped us to prepare three videos and three related audio archives that will be released at the Cambridge Festival later this monthThe stakeholder meetings have been useful in highlighting the priorities and interests of their communities - they were also helpful in shaping the format of the resources (e.g., linking the videos to the audio archives) - and facilitating communication with wider and more diverse audiences.2025-01-01ZCharity/Non ProfitUnited Kingdomwork in progressSharing Parental Experiences (SHAPE)Cambridgeshire County CouncilWe have engaged a wide network of local and national stakeholders - including the Fatherhood Institute, the Coram Foundation, Home Start, One Plus One, Dadvengers, Cambridgeshire County Council, Pinpoint, and Addenbrookes Hospital. Our discussions with these stakeholders have helped us to prepare three videos and three related audio archives that will be released at the Cambridge Festival later this monthThe stakeholder meetings have been useful in highlighting the priorities and interests of their communities - they were also helpful in shaping the format of the resources (e.g., linking the videos to the audio archives) - and facilitating communication with wider and more diverse audiences.2025-01-01ZPublicUnited Kingdomwork in progressBi-lateral investigation of commercial crop seed production viability under future climate change scenariosKWS UKA collaboration is now underway using the new ClimGen version supported by NE/N012569/1 to investigate climate extremes and their impacts upon a major agritech company 'KWS' who operate seed production facilities in southern and central Europe.Provisin of crop seed climate sensitivities; provision of crop seed production locations. In confidence2016-01-01ZPrivateUnited KingdomThe experiments are still underway. Completion of the experiments will provide KWS with a demonstrator of new climate probabilities for crop seed perishment under extreme maximum temperatures. The project is a demonstrator only. If KWS wish to proceed with a full analysis, the UEA and KWS will agree appropriate license terms for the use of the new version of the ClimGen software.AstraZeneca CollaborationAstraZenecaModelling of dataAccess to data2020-01-01ZPrivateUnited KingdomIn progressRoche_TuringRoche PharmaceuticalsAdvisory boardNA2021-01-01ZPrivateGlobalN/AKPMG-Cambridge Future of Work Mental Wellbeing PillarKPMG International CooperativeKPMG LeedsThis partnership will build on the work of Prof. Aston and the CMIH. The aim is to understand and enhance KPMG data collection and collation methods/strategies to enable building and benefits from resilient data systems. This will be through examining causal inference testing, identifying mechanisms that underlie directional associations ('causal' links), and noting mechanisms as key to effective interventions/strategies.The collaborators have provided new datasets, the analyses of which will build upon the work of the CMIH.2023-01-01ZPrivateUnited KingdomNone yet.Collaboration with dementia experts in SingaporeNanyang Technological UniversityWe develop AI-based tools for the analysis of clinical data from memory clinics in SingaporeThe partners have opened data from memory clinics to our team in Cambridge for further analysis2019-01-01ZAcademic/UniversitySingaporepreliminary results in early prediction of dementia using AI-guided tools on clinical dataCollaboration with the Tokyo Institute of TechnologyTokyo Institute of TechnologyThe research carried out in this project was of particular interest to the group of Prof Joon-Wan Kim, who is an expert in the the fabrication of micro pumps and actuators. He supported this project by providing expert advice and both Prof Joon-Wan Kim and one of his PhD students have been making samples to support our work.Prof Joon-Wan Kim and his research students have been processing silicon wafers using a series of MEMS processing techniques to create both micro pumps and batteries. This allows us to apply the techniques from this project to new types of applications. Also, the research student is applying for a fully funded fellowship to visit my research group, again with the view to support our work and create new exciting applicaitons.2021-01-01ZAcademic/UniversityJapan- Follow-up exchange project with exchange PhD student currently under revision - Joint publications are under way - This may lead to more exchange projects with Japan that can lead to better scientific training and broader cultural exposure of our studentsNot-Equal: Digital Security for AllNewcastle UniversityOpen LabThe broader theoretical position on digital security developed through the ESSfES award that enables a bridging between digital security and digital inclusion policy has been used as the foundation for the Digital Security For All strand of the Not-Equal Digital Economy Network+ inititiative that is run by Open Lab at Newcastle University. This broader theoretical position has been used as the basis for the first call for projects that has been issued by the Not-Equal network.Not-Equal provides administrative support for ESSfES related engagements and activities. I have calculated 10 days at £350 per day to reflect this.2018-01-01ZAcademic/UniversityUnited KingdomThe output to date has been a call for project proposals that sit within the broader interpretation of digital security that has been developed through ESSfES. Disciplines involved: Computer Science, Design and Sociology.Collaboration with Dr Amanda TatlerUniversity of NottinghamFaculty of Medicine & Health SciencesWe have provided our stem cell model of respiratory fibrosiswe have contributed our stem cell model of respiratory fibrosis, while Dr Tatlers group has bought experience in viral infection modelling2021-01-01ZAcademic/UniversityUnited KingdomWe are now using this collaboration as a mechanism to better understand how respiratory infection contributes to respiratory fibrosisCollaboration with Amanda GoodwinUniversity of NottinghamAmanda would like to use our hISPC derived TII AECs for her own research and we have provided access to thesereagents/consumables as part of training as well as experimental outputs2022-01-01ZAcademic/UniversityUnited Kingdomnone yetCollaboration with Dr Cathy MerryUniversity of NottinghamSchool of MedicineWe have provided the model cell lines that have a genetic background that causes IPF - these cell form the basis of the IPF model while Prof Merrys hydrogels form the basis of the ECM modelProf Merry has provided her hydrogel2020-01-01ZAcademic/UniversityUnited KingdomThis is multidisiplanary as we are using stem cells and biomaterials to model fibrosis.IkarovecIkarovec LimitedAUC was used to analyse phage samples obtained by ikarovec in order to determine the quality of their potential products. We have continued to build relationships with this and aim to target this expertise with outer gene therapy companies for future KTP and commercial opportunities.Ikarovec provided samples of phages for analysis.2025-01-01ZPrivateUnited Kingdomno major outcomes have been obtained yet, but are likely to come in the future as Ikarovec moves towards commecialisation.Taipei National University of the ArtsTaipei National University of the ArtsDepartment of Dancetbc1. 2011(Taipei): NT$1,200,000 2. 2012(Beijing): NT$250,000 3. 2013(London): NT$700,000 4. 2014(Beijing): NT$150,000 These contributions were for accommodation, flights, Per-diem, facilities hire, documentation, and conference.2011-01-01ZAcademic/UniversityTaiwan, Province of ChinatbcBeijing Dance AcademyBeijing Dance Academytbctbc2009-01-01ZAcademic/UniversityChinatbcThe Place, London UKThe Place, LondonTheatre and Artist DevelopmenttbcThe Place contributed in-kind supports of rehearsal spaces, seminar rooms and administrative support for three weeks period during the London project.2012-01-01ZCharity/Non ProfitUnited KingdomtbcANCCHORSUniversity of AveiroDepartment of Civil EngineeringFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZAcademic/UniversityPortugalNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.DRAM - Digital Research Atlas of the Mack research proposalGlasgow School of ArtDigital Design StudioWe (UWS) were invited to become Co-I on this proposal to the AHRC for funding research into the digital representation of the Mackintosh Building at the Glasgow. Following the fire in 2014, a great deal of research and information gathering has taken, and is still taking place. This proposal seeks to integrate these sources of knowledge and interpretation within a single model, that will aid understanding and interpretation of the building in the future. The contribution of UWS is to advise and represent the area of materials heritage science during the creation of this model. This grew from involvement with the MAV project, as MAV served as an introduction to the humanities and social aspects of heritage. In addition Prof Jones is also a co-I on the new DRAM proposal, as an expert in cultural significance and authenticity.The partner (GSA) is the PI for this project, so has coordinated and composed all materials associated with the funding proposal.2015-01-01ZAcademic/UniversityUnited KingdomNo outputs to date, except the research proposal documents.ANCCHORSStichting Restauratie Atelier LimburgFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZCharity/Non ProfitNetherlandsNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSNational Research CouncilInstitute of Atmospheric Sciences and ClimateFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZAcademic/UniversityItalyNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.HERICULTUniversity of Novi SadDepartment of Materials EngineeringWe collaborated with the Uni of Novi Sad, on two submissions of a Marie Sklodowska-Curie Action, an Innovative Training Network (ITN) bid under call: H2020-MSCA-ITN-2016. THis involved collaboration with 17 organisations, with Nov Sad as coordinator, but also with Prof Jones (Co-I on the MAV project), at her new insitution the University of Stirling. We contributed proposals for ESR training and doctoral studies.The collaborators performed a similar role to UWS, and the Uni of Novi Sad coordinated the entire effort.2014-01-01ZAcademic/UniversitySerbiaTwo iterations of a full Marie Sklodowska-Curie ITN Action Bid were produced and submitted to the European Commission.ANCCHORSNansen Environmental and Remote Sensing CenterFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZCharity/Non ProfitNorwayNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSNorwegian Institute for Cultural Heritage Research (NIKU)Funding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZAcademic/UniversityNorwayNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSGovernment of ScotlandHistoric ScotlandFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZPublicUnited KingdomNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSUniversity of the Highlands and IslandsEnvironmental Research InstituteFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZAcademic/UniversityUnited KingdomNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSBaltic Sea Cultural Centre in GdanskFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZCharity/Non ProfitPolandNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSArteria AssociationFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZPublicPolandNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.ANCCHORSSigninumFunding bid made to H2020 workprogramme "Cultural heritage of European coastal and maritime regions", call H2020-SC6-CULT-COOP-2016-2017; "Europe in a changing world". The proposal was called ANCCHORS:A Network of Coastal Communities: Heritage Opportunities and Research for Sustainability. We at UWS coordinated this first stage proposal.All partners collaborated on the formulation of the funding bid, contributing case study and methodological materials.2016-01-01ZPrivateSpainNone as yet, awaiting decision on entry to stage two of the scheme. Update Feb 2018- the proposal application was unsuccessful, notified in mid 2017.Phoenix Tribology LtdPhoenix Tribology LtdThe PDRA was able to spend time with the company, learning about their software and electronics and contributing to the development of a commercial product based on the project.Phoenix Tribology Ltd provided facilities and equipment to allow testing of the concepts behind the project, leading to successful commercialisation of the scientific concepts behind the project.2017-01-01ZPrivateUnited KingdomPhoenix Tribology Ltd were able to develop a commercial in-situ profilometer based on the outputs of this project. The PDRA became skilled in the use of their software and electronics, such that a 3D profilometer could be integrated into their equipment at the University of Southampton.NPL - EPSRC IAA SecondmentNational Physical LaboratoryWe have hosted Dr Timothy Kamps, a higher research scientist from NPL, on a secondment to further develop the concepts that arose from this grant around the area of metrology measurements in challenging environments. This was made possible by an EPSRC Impact Acceleration Account grant from the University of Southampton.Dr Kamps has contributed to research around the area of using alternative approaches to facilitate metrology measurements in challenging environments.2019-01-01ZAcademic/UniversityUnited KingdomThe secondment facilitated the comparison of this technology with similar methods being undertaken at NPL through the EURAMET Multifunctional ultrafast microprobes for on-the-machine measurements projectPrecision cut tissue slices to study early immune responses and viral replicationRoyal Veterinary College (RVC)Pathobiology and Population SciencesPrecision cut tissue slices (PCTS) from porcine lymph nodes and tonsils are prepared with support from the collaborators at RVC, transported to Pirbright and infected with either African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV) or foot and mouth disease virus (FMDV).Collaborators at the RVC provide the infrastructure to prepare PCTS and provide training on the tissue slicing process.2024-01-01ZAcademic/UniversityUnited KingdomAim of the project is to establish methodology and workflow to infect cells types permissive for these viruses and measure the innate immune response in the local tissue microenvironment.Effects of co-infections on Marek's disease in poultry, and development of novel recombinant Marek's disease virus vector vaccinesMoy ParkThis is a joint BBSRC funded project on investigation "Effects of co-infections on Marek's disease in poultry, and development of novel recombinant Marek's disease virus vector vaccines" between Pirbright, Moy Park and Slate Hall Veterinary Practice. Pirbright team works on the detailed investigation of prevalence of naturally occurring MDV-2 (Marek's disease virus serotype 2) infection in the field in UK; isolation and characterisation of MDV-2 field strains and development of novel MDV-2-based recombinant vaccine MDV2-IBD-ND which will protect chickens against Marek's disease, infectious bursal disease and Newcastle disease.Moy Park will collect the field samples and investigate the effect of MDV-2 on flock productivity and disease.2023-01-01ZPrivateUnited KingdomToo earlyProfessor Stephen GrahamUniversity of CambridgeDepartment of PathologyFunctional assays of virus-host interactions, joint supervision of PhD student (Hannah Arnold).Structural biology and biophysical assays of virus-host protein-protein interactions, joint supervision of PhD student (Hannah Arnold).2024-01-01ZAcademic/UniversityUnited KingdomDetermining the molecular determinants of virus-host interactions underpinning the host preferences of capripoxviruses.Population genetics of myelomaImperial College LondonDivision of Immunology and InflammationStatistical analysis and machine learning on large publicly available datasets.Expert knowledge of myeloma biology and bioinformatics management and first phase analytics of the datasets.2023-01-01ZAcademic/UniversityUnited KingdomThere are currently no published outputs. There are 3 disciplines involved: medicine (biology of Myeloma, Prof Karadimitris) AI (machine learning, Dr Angelopoulos) and bioinformatics (data management and standard analyses, Dr Huang, bioinformatician with Prof Karadimitris).Intern supervision (2025)The Pirbright InstituteSupervision of intern project Sept 2024 to Aug 2025. Supporting training & research.Internal partners only2024-01-01ZAcademic/UniversityUnited KingdomOngoing work that will be published this yearWessex One Health (WOH) Doctoral Landscape AwardUniversity of SussexBrighton and Sussex Medical SchoolTD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZAcademic/UniversityUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Infection of pigs with FMDV by intraoropharyngeal inoculationFriedrich Loeffler InstituteFederal Research Institute for Animal HealthIntraoropharyngeal (IOP) inoculation of pigs with FMDV is considered as a route of infection close to field conditions. We have tried to establish this route of infection in collaboration with colleagues from the Friedrich-Loeffler Institute (FLI) in Germany. We shared our information on our housing and experimental condtions with colleagues at the FLI.Reciprocally, FLI colleagues shared information on their attempts to establish this infection route.2024-01-01ZAcademic/UniversityGermanyA joint manuscript on the challenges of FMMDV IOP infection in pigs is in preparation.Wessex One Health (WOH) Doctoral Landscape AwardUniversity of SurreyTD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZAcademic/UniversityUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Understanding the genetic resistant to Marek's diseaseUniversity of SurreyWe have provided the sequencing data of resistant and susceptible inbred chicken lines and crosses to be analyzed using AI for understanding the genetic resistant to Marek's disease.The collaborators contribution is to use AI for analysis to explore the determinants associated with the distinct resistance phenotype.2023-01-01ZAcademic/UniversityUnited KingdomPublication: 10.1016/j.psj.2025.106311CambridgeUniversity of CambridgeCollaborative research on epitope display systems and use of functional genetic screens.Collaborative research on epitope display systems and use of functional genetic screens.2022-01-01ZAcademic/UniversityUnited KingdomCollaborative research on epitope display systems and use of functional genetic screens.Wessex One Health (WOH) Doctoral Landscape AwardDefence Science & Technology Laboratory (DSTL)TD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZPublicUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Wessex One Health (WOH) Doctoral Landscape AwardUniversity of ExeterTD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZAcademic/UniversityUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Advancing ASF Research Capacity in Thailand: Skill-Building in Immunology and VirologyNational Center for Genetic Engineering and Biotechnology (BIOTEC)Two early career researchers visited Pirbright for a month where the BBSRC Discovery Fellow hosted within the ASF Vaccinology group provided hands-on technical training to establish sustainable ASF research capacity at the collaborator's research group. Key contributions: The fellow redesigned the collaborator's primary immunological workflows by applying human factors engineering principles. The fellow transitioned their protocols from a manual, tube-based 3-step format (5-hour duration) to an optimised 96-well plate system (3-hour duration). This resulted in a 40% reduction in time-to-result and a 90% reduction in reagent costs per sample, despite increasing assay complexity to 5 steps. The fellow provided intensive, hands-on training in virology and immunology, including virus culture, primary cell extraction, and high-dimensional data analysis (FlowJo/t-SNE and R). This included a specific focus on biosafety protocols, resulting in the adoption of disinfection methods established at the Institute. The fellow also facilitated the generation of preliminary co-infection data using the institute's high-parameter equipment and facilitated new cross-sector partnership links for the collaborators. Furthermore, the transfer of a validated antigen-specific immunoassay (luciferase linked antibody capture assays) and a joint bid for internal funding to host a regional training workshop are ongoing.They contribute complementary laboratory expertise and access to invaluable region-specific field-derived data that are not available within our setting. As ASF is not present in the UK, their datasets and contextual knowledge are essential to ensuring that our research is grounded in real-world epidemiological conditions. They have provided technical input that strengthens the scientific design and enhances the translational relevance of our work, and their insights into regional research priorities and operational considerations help ensure that proposed methods are appropriately aligned with field realities. They have also expressed strong institutional commitment through planned in-kind support for technical exchange and joint capacity-building activities in Southeast Asia, contingent on funding. This partnership integrates laboratory-based innovation with field-informed evidence, creating a level of relevance and applicability that would not be achievable independently.2025-01-01ZPublicThailandIn addition to the jointly developed grant proposal to organise a regional ASF workshop (outcome pending), the collaboration has resulted in the initiation of technical transfer activities. This includes the structured transfer of a laboratory assay, and harmonisation of protocols are currently underway. The partner laboratory has begun implementing key methods developed through the collaboration, including adoption of the disinfection protocols, virus growth methods, and staining protocols through titration studies. These activities represent early-stage technology uptake and local capacity strengthening.Joint PhD project on "Exploring ultrastructural features of the virus-host interactions of MDV"Diamond Light SourcePirbright team provided expertise on MDV biology part of the project.Diamond team provided expertise on using the state-of-the-art tools to gain structural biology insights into the distinct features of MDV-host cell interactions.2022-01-01ZPrivateUnited KingdomNo outputs yet.Joint PhD project on "Using Marek's Disease Virus to understand the RNA world of alphaherpesviruses"University of SurreySurrey team has provided expertise on characterization of Marek's disease virus encoded vhs protein function in vitro.Pirbright team has provided expertise in making the mutant virus of vhs deleted MDV and study the role of vhs in the context of infection in vitro and in vivo.2022-01-01ZAcademic/UniversityUnited KingdomThe student Sophie Cutts has abstract accepted for oral presentation in both Microbiology Society Annual Conference 2024 to be held in Edinburgh 8-11 April and 14th International Symposium on Marek's Disease and Avian Herpesvirus to be held at St. Louis, USA from 12th-14th July, 2024.Use of AI to understand virus diversityAston UniversityComputer ScienceWe have provided high quality data to be used to explore relationships between virus diversity and outcomes of infection.The collaborators have utilized a t-SNE approach to increase the likelihood of identifying particular mutations that are associated with outcomes of viral infections. Their contribution is the ability to analyse and identify the patterns in viral mutations that are biologically important.2023-01-01ZAcademic/UniversityUnited KingdomGrant Submission to BBSRC - Uncovering the role of viral diversity in sustaining endemic virus transmission. Grant Submission to NIH - Using lab-in-the-loop machine learning to model alphavirus neuroinvasionProfessor Michael WeekesUniversity of CambridgeVirus-host interactions.Proteomics.2023-01-01ZAcademic/UniversityUnited KingdomIn progress.Wessex One Health (WOH) Doctoral Landscape AwardAnimal and Plant Health AgencyTD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZPublicUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Construction of Bayesian networks from GenePy matrices.University of SouthamptonSouthampton Medical SchoolMachine learning of Bayesian Networks for IBD matrices inscribing GenePy scores.Sharing of their IBD and control datasets which are construed of GenePy matrices, which provide mutational load of genes and regions. Interpretation of the constructed networks.2024-01-01ZAcademic/UniversityUnited Kingdom(discipline Medicine) Improved understanding of mutational burden patterns in the pathogenesis of IBD. (discipline Artificial Intelligence) Communication clues and visual annotation of explainable structured statistical models (Bayesian Networks) for biomedical data.Wessex One Health (WOH) Doctoral Landscape AwardUK Health Security AgencyTD is co-lead from the Pirbright Institute in this multi-partner award led by the University of Surrey. Nicolas Locker is the official lead from the Pirbright Institute. Yvonne Walsh from the Pirbright Institute provides academic and student support. The Pirbright Communications teams assist with advertisements and communications.This BBSRC-funded doctoral programme will train students in interdisciplinary approaches to Infection Biosciences across all classes of pathogens, to combat existing and future disease threats to human and animal health, including emerging infections, vector-borne diseases, antimicrobial resistance and food insecurity. Wessex One Health (WOH) brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and research experience for students, with the following highlights: -Cross-institutional supervisory teams -Opportunities to train at high containment -Cohort training in genomics, bioinformatics, applied AI -Cohort-building activities across all partners -Opportunities for studentships working with industry (CASE) -Wide range of short industrial placement opportunities. The Partners -University of Surrey (Guildford) -University of Sussex, Including Brighton and Sussex Medical School (Brighton) -University of Exeter, MRC Centre for Medical Mycology -The Pirbright Institute (Woking, Surrey) -Animal and Plant Health Agency (APHA) (Weybridge, Surrey), -UK Health Security Agency (UKHSA) (Porton Down, Wiltshire or Colindale, London) -Defence Science Technology Laboratory (Dstl) (Porton Down, Wiltshire)2024-01-01ZPublicUnited KingdomOutcomes so far: -Design of 20 collaborative PhD projects between the Pirbright Institute with the partners (APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex). -Closer links between the Pirbright Insitute and the APHA, DSTL, UKHSA, University of Surrey, University of Exeter, University of Sussex in terms of building the DLA, planning training and discussing facilities (such as containment). The awards runs 2025-2033.Collaboration with lab of Martin Booth, Oxford UniversityUniversity of OxfordDepartment of Engineering ScienceSuper-resolution imaging of NusG and RNAP using a 4pi-SMS 3D super-res microscopeInstrument, data acquisition and data analysis.2024-01-01ZAcademic/UniversityUnited KingdomA draft manuscript is in preparationCollaboration with lab of Abhishek Mazumder, Ashoka UniversityAshoka UniversityIn vitro studies of phase separation of NusG.Material preparation, Experiments, interpretation.2024-01-01ZAcademic/UniversityIndiaA poster presentation for Biophysical Society Meeting in San Fransisco, CA.Raytheon Strategic PartnerhsipRaytheon Systems LtdThis is a formal collaborative agreement between the university and RSL which resulted from the fact the university has been accredited as an ACE-CSR. We have worked closely on knowledge exchange, public engagement and teaching engagement activities over the period of the partnership.RSL have inputted into teaching, public engagement and knowledge exchange activities. We have hosted research teams on several occasions who have actively engaged with our research work.2017-01-01ZPrivateUnited KingdomN/AGreater Manchester Cyber FoundryUniversity of SalfordThis partnership was developed on the back of the reputation of being an ACE-CSR. It has went forward and was successful in receiving an ERDF award with a total project cost of circa £6M. This project provides a knowledge exchange pathway for the four universities around the core concept of Cyber Innovation. It is a strategically important project within the Greater Manchester Combine Authority and supports their overall digital strategy. Lancaster's contribution to this project is two fold: to provide a programme of support to companies to embed the practice of cyber innovation and inculcate a culture of higher education collaboration: to provide research input to knowledge exchange projects with companies to exploit cyber security research knowledge based in the ACE-CSR.MMU are the project lead and provide overall project management. MMU, University of Manchester and Salford university are responsible for business recruitment and also for providing knowledge exchange projects.2018-01-01ZAcademic/UniversityUnited KingdomThis project has worked with 60 companies to provide business support. There are currently 10 companies currently engaged in knowledge exchange projects, which have yet to be completed. This is a multi-disciplinary collaboration.Fujitsu Threat Intelligence PlatformFujitsuFujitsu Laboratories of EuropeLancaster provides research input and technical capability to provide a threat intelligence research platform. This is a secure network location run on the university's digital estate to capture a range of malicious traffic, and monitor malicious activity for threat analysis. This platform is used by academic (Staff and students) and industrial researchers. Lancaster also contributed equipment and capital resources to this test environment to establish and run the platform.Fujitsu have provided considerable input in terms of human resource and equipment provided to the university.2017-01-01ZPrivateUnited KingdomThis has resulted in a number of academic publications.Greater Manchester Cyber FoundryManchester Metropolitan UniversityThis partnership was developed on the back of the reputation of being an ACE-CSR. It has went forward and was successful in receiving an ERDF award with a total project cost of circa £6M. This project provides a knowledge exchange pathway for the four universities around the core concept of Cyber Innovation. It is a strategically important project within the Greater Manchester Combine Authority and supports their overall digital strategy. Lancaster's contribution to this project is two fold: to provide a programme of support to companies to embed the practice of cyber innovation and inculcate a culture of higher education collaboration: to provide research input to knowledge exchange projects with companies to exploit cyber security research knowledge based in the ACE-CSR.MMU are the project lead and provide overall project management. MMU, University of Manchester and Salford university are responsible for business recruitment and also for providing knowledge exchange projects.2018-01-01ZAcademic/UniversityUnited KingdomThis project has worked with 60 companies to provide business support. There are currently 10 companies currently engaged in knowledge exchange projects, which have yet to be completed. This is a multi-disciplinary collaboration.Greater Manchester Cyber FoundryUniversity of ManchesterThis partnership was developed on the back of the reputation of being an ACE-CSR. It has went forward and was successful in receiving an ERDF award with a total project cost of circa £6M. This project provides a knowledge exchange pathway for the four universities around the core concept of Cyber Innovation. It is a strategically important project within the Greater Manchester Combine Authority and supports their overall digital strategy. Lancaster's contribution to this project is two fold: to provide a programme of support to companies to embed the practice of cyber innovation and inculcate a culture of higher education collaboration: to provide research input to knowledge exchange projects with companies to exploit cyber security research knowledge based in the ACE-CSR.MMU are the project lead and provide overall project management. MMU, University of Manchester and Salford university are responsible for business recruitment and also for providing knowledge exchange projects.2018-01-01ZAcademic/UniversityUnited KingdomThis project has worked with 60 companies to provide business support. There are currently 10 companies currently engaged in knowledge exchange projects, which have yet to be completed. This is a multi-disciplinary collaboration.GCHQ/NCSC partnershipGovernment Communications Headquarters (GCHQ)This partnership has resulted in the direct award of the ACE-CSR collaboration. It includes a number of research activities focusing on the specialisms in cyber security and networking. We have provided knowledge exchange activities as well as collaborating directly with various business units on internal projects. The partnership has seen activities from small projects to support infrastructure development, all the way through to phd sponsorship and co-supervision.The partners have contributed to teaching, research and public engagement activities.2017-01-01ZPublicUnited KingdomN/ACollaboration with Laboratoire Océanologique Villefranche-sur-mer FranceVillefranche Oceanographic LaboratoryTo date, Marine Frontiers research team is contributing the most advanced multi-plankton functional types global marine ecosystem model PlankTOM, and providing new developments in the areas of: 1) modelling the complexity of zooplankton life cycles and marine snow; 2) linkages between surface ecosystems and sinking of organic carbon; 3) introducing a virus in a global ecosystem model.To date, contributions to Marine Frontiers project have included: 1) participations/ contributions to GreenOcean workshop including participation in organisation, steering committee members, session conveyors, presentations contributions and scientific ideas + discussions; 2) hosts for research work visits by Marine Frontiers project P-I, and project researcher Racault; 3) contribution of cutting-edge expertise in global in-situ observations, including from TARA Oceans expeditions (2013-present) with most comprehensive imagery and metagenomic data; 4) contribution of cutting-edge expertise in advanced statistical methods for large datasets' analyses; and 5) contributions to successful funding application for the development of new research activities stemming from Marine Frontiers project (see Schmidt Futures in ResearchFish section on Funding).2022-01-01ZCharity/Non ProfitFranceMulti-disciplinary collaboration including marine ecosystem modellers, observationalists and data analysts. To date, outcomes for Marine Frontiers project have included: 1) improving understanding and research practice on the linkages between surface ecosystems and sinking of organic carbon; 2) hosting of collaborative research visits by Marine Frontiers project P-I, and project researcher Racault; 3) contributing cutting-edge expertise in global in-situ observations, including from TARA Oceans expeditions (2013-present) with most comprehensive imagery and metagenomic data; 4) contributing cutting-edge expertise in advanced statistical methods for large datasets' analyses; 5) applying with Marine Frontiers P-I Prof. le Quéré to funding call Schmidt Futures to further develop research stemming from Marine Frontiers project (see Schmidt Futures in ResearchFish section on Funding); 6) applying with Marine Frontiers research Racault to UKRI Future Leaders Fellowship round #7 (application submitted Dec 2022) to develop new research on marine viruses in collaboration with colleagues at LOV France.Collaboration with the Ecole Nationale Suppérieure (ENS) ParisÉcole Normale Supérieure, ParisI have visited ENS in February 2022 and will be going back in May 2022. I have given a seminar and exchanged with researchers on a daily basis. I have given a policy presentation to two groups of graduate students.ENS has hosted me and provided insights into the research on marine carbon cycle ongoing in their institutions and among their partners in Paris. They have provided a single office for one month and technical support. They are helping with the organisation of a workshop which will be held at ENS.2021-01-01ZAcademic/UniversityFranceENS has given Corinne Le Quéré the honorary title of Extraordinary Professor for a period of 5 years. As part of this I am welcomed at ENS for 5 weeks per year to foster collaborations with the marine biogeochemistry community. I spent 4 weeks in February 2022, where I engaged with a range of researchers on a daily basis. We planned a workshop at ENS in May 2022 on the topic of modelling marine ecosystems and the carbon cycle.