08DC2362-B8F7-4E0B-B1FC-001FB7AF5B94ENGLISH HERITAGE TRUST CONSERVATION AND HERITAGE SCIENCE FACILITY - RANGER'S HOUSE, GREENWICH, LONDONClosedAH/V01241X/1Research GrantThe English Heritage Trust (EHT) cares for the National Heritage Collection of 400 historic sites and 3/4 million associated artefacts. The Facility The heritage science and conservation facility at Ranger's House acts as a central hub for core research and conservation activities carried out by EHT. The facility itself comprises five rooms in the apartment adjacent to the publicly accessible house (home to the Wernher Collection), the fine art conservation studio, and an outbuilding used as a store. The facility has grown organically and has reached a point where the scale of work outstrips the capacity of the facility - both due to space and the quality of equipment within. The Beneficiaries - People and Collections The English Heritage Conservation Science team has been leading the way in research on the environmental response of objects in historic environments. This work has been critical in allowing for the safe display and storage of the collection in historic buildings. Its novelty lies in the combination of close object/ building examination and analysis, with an epidemiological approach. We have been able to develop this novel approach because we look after similar objects that are exposed to a range of very different environments. The practical methods we have devised as a result of our research have enabled us to reduce the carbon footprint of conservation activities by 40%. The sector's interest in this work is demonstrated by an impressive 70 publications in competitive forums, the oversubscription to a series of 8 international courses covering management of showcases and an invitation to the 2018 Gordon conference on Scientific Methods in Cultural Heritage Research. We have also supported six PhDs - looking at response of lined canvas paintings, archaeological bone, archaeological glass and outdoor artillery - through the CPD scheme, SEAHA doctoral training scheme, AHRC Collaborative Doctoral Program and the Science and Heritage Programme. This research would not be possible without the Ranger's facility and its equipment, but it has been severely restrained by lack of space and outdated equipment - with constant failures or issues with software compatibility. The conservation studio at Ranger's House, often guided by scientific advice from the conservation science team, carries out practical treatments and technical analysis of the English Heritage collection of over 1500 easel paintings, many of international significance, and their associated frames. Technical examination advances our understanding of an artist's materials and methodology. Over the last five years our work has resulted in the reattribution of several paintings, notably to Botticelli and Titian, and much associated publicity for English Heritage has followed. Art historical findings relating to paintings by Rembrandt, Titian, Weenix and Beuckelaer have been presented at several national and international conferences and published in postprints and journals. To allow this treatment and research to continue, we need to update equipment in line with technological advances and remedy issues with the studio space, previously adapted from an old coach house The Project The amount of research needed, both within the EHT strategy and to support the sector, is not possible within the confines of the existing facility, nor with equipment more than 10 years old and suffering constant failures (and not supported by the manufacturers due to its age). We will redevelop the interiors of the facility and upgrade the store into a workshop in order to house equipment, and provide space for sample preparation and wood working for fine art conservation. We will also replace the most outdated pieces of equipment, to significantly improve the efficiency for research undertaken in the facility.2021-04-2947E8D760-6F07-4F7F-9D2B-1E1CDDEBBAA4Infrastructure Fund2020-12-08INCOME_ACTUAL622959National TrustUnited Kingdominfra red scannign at National Trust Knowle paintings studio8289DD9D-219B-49D6-B276-1EC235FFFF52The collaboration allowed us to build a good working relationship between EH and the relatively new paintings conservation provision at the NT studio.63e0c3b1906776.18648353-1none as yetUndertaking the IRR of the National Trust painting at the Knole House conservation studios enabled EH to establish the practicalities of off-site working with the new equipment in a safe space. The National Trust do not have access to IRR internally and the analysis of the painting, provided a clearer image of an indistinct area of text, potentially important for clarification of the sitter and date of the work.Charity/Non Profit2022-01-01Birkbeck, University of LondonUnited KingdomDepartment of Biological Scienceswork on PhD in archaeological bone deterioration6F8C283D-4239-4776-81A6-C9FECE86E52CPhD awarded63d80d8aa67a13.59722698-1Analysis of bone samples from EHT collectionAccess and training in dynamic vapour sorption.Academic/University2021-01-01University College LondonUnited KingdomInstitute of ArchaeologyWork on PhD into glass deteriorationB804F425-F597-4A7D-8FBD-CE5CF87DB7A7none as yet63d80e7983bca6.60493723-1analysis of ancient glass samples from EHT collectionTraining and use of dynamic vapour sorption, use of aging chambers to condition silica gelAcademic/University2022-01-01Victoria and Albert MuseumUnited Kingdomacoustic emission analysis of 7th century wooden pillarE3B9685C-2BC1-4E41-B250-26F4122C67C9non as yet, paper accepted for conference67c6b5dbe33560.13699182-1long term monitoring of the pillar, recording and collection of losses, environmental monitoring, building support to hold acoustic emission sensors in place, checking and downloading acoustic emission.deployed acoustic emission analysis kit to wooden pillar, undertaken DVS analysis of fragments from the pillarPublic2025-01-01National TrustUnited Kingdomanalysis of earliest cricket ball3C3DEA76-AE15-433E-950E-3987FE6D4116none yet679a40109ee472.68273534-1historical research on itemFTIR and Raman analysisCharity/Non Profit2025-01-01Cardiff UniversityUnited KingdomEIS for PhDF9669154-C1C2-4891-B25B-98A5193E7F41none yet679a407cb15b36.52711717-1aging of coatings on steelprovision of electrochemical impedance spectroscopyAcademic/University2025-01-01Imperial College LondonUnited KingdomPhD clear coatings for steelC91C9FA8-CED4-4D9E-BBFA-B43AE24082FCnone yet679a4464d8ba59.25462461-1access to Imperial tribology and engineering labs,supervision of PhD, provision of exposure sites, information on metal composition and degradation rate, environmental data, pollution data, previous coatings usedAcademic/University2024-01-01Daresbury LaboratoryUnited KingdomXPS glassB7D414F4-27FF-4769-937B-C72B5918730Dnone yet679a43908fbdf4.95281840-1tunnelling XPS analysisproduction of historic glass samples, exposure at international sitesPrivate2024-01-01Polish Academy of SciencesPolandInstitute of Physicsinteraction with IKIFP on paintings970B72F2-EBEF-458A-87B4-C05B54FA742Fnone as yet653103f3a0cd01.59722271-1PhD student prepared the samples, travelled to Lab to run them over a four week period.Ran thirty paint samples on Dynamic Vapour Sorption, interpreted resultsAcademic/University2023-01-01Cranfield UniversityUnited Kingdomacoustic emission from wood borersCA98DE18-2FE7-4B22-BD49-73F11734BA11none as yet65f432cc2caa09.83428178-1undertaking tests at Royal Botanic Gardens Kew, undertaking tests on HMS Victorytesting application of acoustic emission methodology to detect active wood boring insects in wooden timbers located HMS Victory, loan of acoustic emission equipment, training in equipment use, interpretation of signalsAcademic/University2024-01-01Birkbeck, University of LondonUnited KingdomDepartment of Biological Sciencesanalytical collaboration with birkbeck college4CB73B56-1678-4537-BB06-7D78A04301DCIdentification of wallpainting efflorescneces as predominantly calcite (TGA) was pivotal in conservation decisions. Quantification of amounts of akaganeite, iron, magnetite adn other corrosion products in observed degradation allowed interpretation of DVS curves measured in facility. The purity of the polymer boxes was determined by DSC along with glass transition temperature to aid in accelerated aging decisions. Interdisciplinary materials science adn conservation research.63ff4b60771ff0.37362576-1provision of lead coated PQCs and logger, thermogravimetric analysis, FTIR analysis, thermomagnetometry and differential scanning calorimetry.provision of showcases to test lead piezo electric quartz crystal (PQC) technology, provision of standard environments for same, provision of samples from Lullingstone wall painting deterioration and archaeological iron deterioration, provision of aged polypropylene and polyethylene storage boxesAcademic/University2022-01-01visit by ICON internsParticipation in an open day or visit at my research institutionNationalE6F44914-994A-4C67-9677-B4BD7ACEABF5Interns from Institute of Conservation scheme visited the science lab and paintings studio63d80f70274563.89089357falseProfessional Practitioners2022English Heritage Members eventA talk or presentationNational0BF03E58-803F-4108-BA0A-54FE2279BF27Visit to Ranger's House for English Heritage members that included presentation of the technical analysis of paintings carried out in the paintings conservation studio during paintings conservation.651bf2ba31bc67.35121261falseSupporters2023Technical discussion of Bateman Master PaintingA formal working group, expert panel or dialogueNational49F88D7B-4E65-4147-84B7-BFC7496283B0Infrared reflectography images discussed and aided technical analysis and new attribution and working practices of the Bateman Master (contemporary of Canaletto) painting651bf205ec3af4.44657554falseProfessional Practitioners2023National Maritime Museum Conservation Staff visitParticipation in an open day or visit at my research institutionLocalF64CA910-345D-4080-B8F4-BF54DAA756B6Conservation staff from National Maritime Museum visited the conservation studio and conservation science lab to see the CapCo funded improvements and hear more about the team's work and research.656861bd6840a1.72579208falseProfessional Practitioners2023Metropolitan Police Museum staff visitParticipation in an open day or visit at my research institutionRegional63853891-2469-47E1-84EE-F4AAAB130180Staff from the Metropolitan Police Museum visited the conservation studio and conservation science lab to find out about the work of the Collections Conservation Team and similarities to their own work.651bd0f5794b72.17135258falseProfessional Practitioners2023Reynolds research dayA formal working group, expert panel or dialogueNational8E3E7B64-7C3C-4360-8DB7-2027C9A2D164Technical findings of Reynolds paintings analysis including Infrared Reflectography (IRR) imaging and microscopy results discussed with other paintings conservators working on Reynolds paintings.651bf000c4a801.17188217falseProfessional Practitionershttps://www.youtube.com/watch?v=JscF6JMDC4Q2023Intern and student visit to Ranger's labParticipation in an open day or visit at my research institutionInternational9C59C0BE-AC8E-4007-97BA-3CF689147F2FGave lab tour to Intern from Metropolitan Police Heritage Centre (who was completing postgraduate studies at University of Leicester and the internship formed part of studies) and student from City and Guilds of London Art School Conservation course. Gave awareness of conservation and especially conservation science and sparked interest in further study for undergraduate student.67976d8230f779.39042909falsePostgraduate students2024Tour for visiting professor from KU LeuvenParticipation in an open day or visit at my research institutionInternational4EADEEF0-D09F-4566-9D74-E2B7A8CF1184Visiting professor from KU Leuwen had tour of lab and studio facilities, with questiions and discussions on similar research and areas of work.67976fed155e83.41651871falseProfessional Practitioners2024Historic Estate Conservation Committee visit to lab and studioParticipation in an open day or visit at my research institutionNationalFD174AF2-361C-45A0-875B-454ED8D513D7Historic England's Historic Environment Conservation Committee toured the conservation studio and conservation science lab facilities to see the CapCo funded improvements and hear more about the Collections Conservation Team's work.651bd016b6a469.44008534falseProfessional Practitioners2023Filming for Ormiston Academies Trust (OAT) careers pages OAT futuresA broadcast e.g. TV/radio/film/podcast (other than news/press)NationalA45886B1-8D16-44CF-9466-7230E0321C59Conservation Scientist and Paintings Conservator filmed in the conservation science lab and conservation studio for careers videos. These will be put on the OAT futures website for the pupils at Ormiston Academies Trust to view. The trust has over 30,000 pupils in over 40 schools, 32 of which are secondary schools, spread across the country.651bd3cf808760.87832255falseSchoolshttps://oatfutures.co.uk/2023Reynolds exhibitionParticipation in an activity, workshop or similarInternational059A3420-094F-4B73-99D9-FD1159ECA058Technical analysis of four paintings and conservation treatment of two works including use of Infrared Reflectography and microscopy to investigate Reynolds painting techniques and materials. Information used as part of the exhibition &quot;Spotlight on Reynolds: Lord Iveagh's Favourite Artist at 300&quot;, at Kenwood House. Technical analysis included in Bloomberg Connects audio tour of the exhibition, and associated video https://www.youtube.com/watch?v=JscF6JMDC4Q. National and international press coverage.651c004596ba86.28814866falsePublic/other audienceshttps://www.english-heritage.org.uk/visit/places/kenwood/things-to-do/spotlight-on-reynolds2023Kenwood volunteers visit to conservation studioParticipation in an open day or visit at my research institutionRegional5CC07DCF-96F4-43D4-9AD2-2BBB1A1A1930Tour of the paintings conservation studio for volunteers from Kenwood House, sparked questions and discussion on paintings conservation and Kenwood paintings.651bf0dabc5e89.44866310falsePublic/other audiences2023marble hill house revived lecture seriesA broadcast e.g. TV/radio/film/podcast (other than news/press)NationalD420610E-A062-48C2-B176-BBA9B201177Electure on YouTube on infra-red camera results on paintings at Marble Hill House63d8132dad64e4.53574325falsePublic/other audiences2022articl ein EH members magazine about refurbishment of painting studioA magazine, newsletter or online publicationNationalED4C4D36-BF23-452D-8EC4-876EC81CB22Darticle in English Heritage members magazine describing refurbishment of paintings studio and some of work undertaken63d80baa930a53.31021587falsePublic/other audiences2022career taster session for local schoolParticipation in an open day or visit at my research institutionLocal549BEF76-2CB5-4F6C-9453-1847BB680F328 pupils form Thomas Tallis school attended for visit focussing on STEM careers, which sparked questions and discussion afterwards63d810178acbc6.88219386falseSchools2022Tour for donorsParticipation in an open day or visit at my research institutionNationalC7DA08B2-B9D7-41F3-A83A-A6FAEE414181Tour of studio for donors to discuss analysis and treatment approaches.67979932c12542.77662700falseSupporters2024public talkA talk or presentationLocalB669AC89-C626-45C8-A499-B41D079E9584Public talk Conservation science at English heritage to Sevenoaks U3A science group, sparked questions and discussion afterwards. Two attendees volunteered at English Heritage sites afterwards.63d055f3b9e0d6.97192981falsePublic/other audiences2022materials testing seminarParticipation in an activity, workshop or similarInternationalC9F5F8B5-4F1B-43A2-9194-8EEA29ED28FFseminar discussing approaches to materials testing and pratcical demonstrations679a429a59c571.82554270falseProfessional Practitioners2024workshop on use of oxygen depletion measurements for conservationParticipation in an activity, workshop or similarInternational179C0231-D530-4F81-BC3A-FA86ECCED9E326 participants took part in workshop to show use of oxygen depletion measurements. Over half have made follow up inquiries and purchased the equipment.63d0554736bcd1.99637070falseProfessional Practitioners2022article in EH members magazine about new conservation science labA magazine, newsletter or online publicationNationalC5998964-33FD-4CE1-8123-9B615D09A577article in English Heritage Members magazine, circulation over 3000, several subsequent enquiries related to the article63d80b514e8476.66715520falsePublic/other audiences2022Tate conservation staff visitParticipation in an open day or visit at my research institutionNational6F02D44F-4B6B-479E-97E0-2FBE4184105BConservation staff from Tate visited the conservation studio and conservation science lab to see the CapCo funded improvements and hear more about the team's work651bd1b0d0e299.16042448falseProfessional Practitioners2023Tour for donorsParticipation in an open day or visit at my research institutionRegional29E37974-BF6B-4CA1-9485-F5C87A4CC9BEGave studio tour to donors, discussing analysis of donated paintings, informing attribution.6797982eb0b3f3.21794797falseSupporters2024articl ein EH members magazine about refurbishment of painting studioA magazine, newsletter or online publicationNationalB59E4BEF-0336-4F2C-84C7-FCCC4D786A8Darticle in English Heritage members magazine describing refurbishment of paintings studio and some of work undertaken63d80c547e0a12.20638219falsePublic/other audiences2022ICON staff and trustees visitParticipation in an open day or visit at my research institutionNational9470E5FA-1096-448E-A5A0-9F4687215578Institute of Conservation (ICON) staff and trustees visited lab and studio facilities, with questions and discussion.65e1bbc1ef2df4.81312345falseProfessional Practitioners2024VIP tourParticipation in an open day or visit at my research institutionNational7B284DA4-6109-412F-AAB5-6D6AD7E12989Tour of the studio for VIP guest at Chair's reception.679798d4756002.76016049falseProfessional Practitioners2024Visit by Arts Council England, Government Indemnity Scheme staffParticipation in an open day or visit at my research institutionNationalA3EBBEB6-270D-48BE-A251-143BF2589CB8Arts Council England (ACE), Government Indemnity Scheme (GIS) staff visited Ranger's House, including the lab and studio facilities. Discussion on how the equipment facilitated work and understanding for collections and feeds into environmental control and our annual reports for GIS / ACE.67976bd7f37611.26345322falsePolicymakers/politicians2024Diana Cecil by Cornelius JohnsonParticipation in an activity, workshop or similarInternational5E04A006-A2F8-437A-8D6F-AFBD7D3BBC3ACompleted technical analysis and conservation treatment, including use of Infrared Reflectography and microscopy to investigate painting technique and materials. National and international press coverage, as well as social media video https://www.instagram.com/p/C0BgzyOMQmQ/ and painting back on display 30th November 2023656f03ef866543.08315053falsePublic/other audienceshttps://www.english-heritage.org.uk/about-us/search-news/pr-fashion-for-fuller-lips-not-a-modern-phenomenon--english-heritage-reveals-jacobean-ladys-original-beauty/20233999950BelgiumEURAustriade_ATGoGreen2026-11-02European Commission H2020F6F08FC0-B254-4EA1-A1A6-FC03725D50B76230c4088ad338.99607916Public2022-11-011000000United KingdomGBPUnited Kingdomen_GBCreating a national integrated mobile and fixed lab for collections, historic buildings and sites2026-07-01Arts & Humanities Research Council (AHRC)AH/Z506242/1E43BB73A-4C84-45BF-AE24-2FF94E7AA603679a3f084dc1d9.94042761Public2024-07-31The new facility has allowed more collaboration with researchers, with 6 major collaborations, despite COVID restrictions being in force for the early period. The stated priorities have all been advanced. The issues are large and will require significant research to initiate change within the sector. The research enabled has generated 20 peer reviewed papers, with significant additional material at publication stage and four papers in press. The award of the GoGreen project funding (the proposal was strengthened by our stronger analytical capabilities from CapCo) significantly enhanced our research ability in the areas covered by the project, sustainability and preventive conservation. The award of RIO and RiCHeS funding will dramatically increase our analytical and aging capabilities and capacity to undertake research. The main research areas from the CapCo application were; • Addressing the sector debate regarding RH fluctuations causing damage to objects, significant data produced on furniture response in real environments with acoustic emission; impact on egg tempera paintings (DVS); susceptibility of stone and ceramic objects (UV/vis/NIR, environmental chambers); requirements of miniature paintings on ivory (DVS, oxygen measurement for air exchange rates, environmental chambers); ivory response (DVS, universal tester, environmental chambers); damage mechanisms of glass and enamel objects (DVS, laser displacement measurement, environmental chambers). • Investigating mould growth and treatment: DVS analyses of both dust and cardboard storage boxes have allowed understanding of moisture- RH response which drives mould growth. • Preventing damage to archaeological materials: extensive work on archaeological iron and copper alloy (oxygen measurement, DVS), clays in stone (UV/Vis/NIR), stability of archaeological glass (DVS, UV/Vis/NIR). Environmental chambers and DVS used for archaeological bone and glass PhDs. • Testing and developing damage functions: Existing damage functions for copper and silver have been tested and compared to measurements of corrosion rate. New funding delivered (GoGreen project) to provide a post to undertake this work to generate new damage functions for glasses, iron alloys and stone. International exposures underway and materials sourced. • Treatments for outdoor objects: Internship of PhD student investigating paint treatments for twentieth century artillery in facility. PhD now awarded. • Exploring storage methods, which are key to survival of stored collections: Investigations into performance and long term stability of storage boxes for archaeological iron and copper alloy, bone and glass. Investigation into performance and long term stability of silica gels (Environmental chambers, DVS, tensile tester). New methods for much more stable storage developed and protocols for storing unstable glass investigated. The performance of portable pollution filtering devices has been investigated (UV/vis/NIR). A new grant, RIO will significantly extend our abilities to measure and determine the impact of pollution on collections and also RH fluctuations. Research has also facilitated the display of mixed archaeological objects in the new exhibitions at Richborough Roman Fort, Lindisfarne Museum and Wroxeter Roman Town. Able to support these projects with extensive testing of objects proposed for display including stability of archaeological iron objects and light stability of two prints (including the Girtin discussed below). . The re-opening of Marble Hill House was supported by the trials of air curtains to reduce air impact into the newly designed visitor route with the ultrasonic air velocity equipment. The APOLLO infra-red camera is being used as part of the paintings documentation process. Over the last year, 20 paintings have either been fully treated or prepared for loan out in the English Heritage paintings conservation studio and all are now back on display in properties across the country. A further 9 paintings will return to sites over 2025/26 once treatments are complete. The enhanced pantograph studio lighting system is in use every day, and each treatment utilised other equipment acquired through this funding stream. All paintings were examined with Infrared Reflectography using the Apollo camera, this work now forming a part of our documentation process alongside standard photography with the new camera equipment. Additionally many were examined with the microscope to answer questions relating to condition or technique, the new camera set up facilitating discussion amongst colleagues as well as enhanced documentation of findings.202263DC3AEA-C520-4F7B-A79A-EDC6A3B1ADC9Cultural6233261ff2ab77.80769525Culture, Heritage, Museums and CollectionsDevelopment of calculations to predict showcase conditioning efficiency relating to humidity control which has informed showcase design (environmental chambers, balance and DVS), presented in 3 publications. Combined with energy use measurements and life cycle assessment this has produced a model for the carbon footprint of showcases in heritage institutions, presented in 2 publications and 2 others under review. A method to determine the stability and measure the corrosion rate of archaeological iron and copper alloys has been developed (oxygen meters) and published (2 papers). This has allowed significant epidemiological research on English Heritages archaeological metals collection including discovery of a group of objects that deteriorate frighteningly rapidly at very low RH values. Developed a low cost method to estimate acetic acid in enclosures, replacing expensive instrumental analyses, that have been beyond the resources of many cultural heritage institutions and reported to be a significant limitation in surveys (UV/Vis/NIR, environmental chambers). One publication under peer review. Studies into the degradation of daguerreotypes of the Darwin family have allowed improvements for their safe display at Down House (environmental chambers), The lessons have been transferred to the field in a paper. The environmental chambers and DVS have been used extensively in two collaborative PhD projects. A new phenomena in the isotherms of archaeological glass has been discovered, that will have important impacts on its preventive conservation. The behaviour of furniture and wooden sculpture under fluctuating RH conditions has been studied with the acoustic emission equipment, indicating the safety of some environments and identifying others that need improving. The long term nature of such studies, to account for seasonal variations means publication is just beginning. One paper has been accepted but not yet appeared.Showcase humidity calculations already in use by 15 institutions (conservators, scientists, designers). Acetic acid adopted by 15 conservators and scientists. Oxygen depletion method used by 12 researchers, including in two major research projects and 20 others have been trained. For a small field such as conservation research, this is an exceptionally high take up rate. Results from daguerreotype glass deterioration is already informing other institutions displays and archaeological glass results will alter display and storage approaches.2073FDA7-C5C3-4CFD-B981-EEF0B1D0C8996233249dec0783.48520029Culture Heritage Museums and Collectionsresults fed into drafting of CEN BS 15999 part 2 and rewriet of CEN BS 15999 part 1Europe5BF818AE-D8F3-4B25-AC16-6EA8AFDCD452The existing standard EN BS 15999 part 1 has been purchased over by over 3000 professionals (EN data) and is much more widely used by individuals with subscription services. Part 2 is due for publication in 2022 and deals with many technical aspects, which have generated a number of papers reporting failures in showcase performance. The two areas have been through robust review and been accepted by the technical committee and will significantly improve RH and pollution performance.6231bdc4124480.09149449Contribution to new or Improved professional practiceIn 2021 the Fine Art Conservator implemented a simple method to measure the carbon footprint of an easel painting conservation treatment, including monitoring energy use, materials, object transport and staff travel. It uses widely available tools and resources, without requiring the help of a specialist sustainability expert. It represents a walk-through of the steps lay persons could take to replicate the study.34C259E4-5DB1-42DA-86E0-0F712372F1CAAdditional painting conservation treatments have been assessed to determine the carbon footprint. Information has been shared with wider ICON Sustainability Network and led to further research on sustainable packing materials for paintings.656f075035e707.70733678trueHow to Calculate the Carbon Footprint of a Paintings Conservation treatmentImprovements to research infrastructurehttps://www.english-heritage.org.uk/siteassets/home/learn/conservation/collections-advice--guidance/how-to-calcluate-the-carbon-footprint-of-a-painting-conservation-treatment_alice-tate-harte_david_thickett.pdf2023carbon calculator for different methods of interventive and preventive conservation for silver collectionF47E5F1D-7DD4-4E47-BC47-AE51F73805F1downloaded 67 times, used in conservation training Cardiff, University of Catalonia, CCI, UCLA679a459e3fa7a9.27170972trueperformance and sustainability impact of silver conservationImprovements to research infrastructurehttps://www.english-heritage.org.uk/learn/conservation/collections-advice-and-guidance/2022carbon calculator for different methods of interventive and preventive conservation for copper collections https://www.english-heritage.org.uk/learn/conservation/collections-advice-and-guidance/88DC0FA3-BE88-47C4-9892-BB7B9155A370none yet679a45d8b0f6f9.05627673trueperformance and sustainability impact of copper conservationImprovements to research infrastructurehttps://www.english-heritage.org.uk/learn/conservation/collections-advice-and-guidance/2024multi analytical method to determine stability or otherwise of historic glass objects0D6AFABB-FE68-419E-A7A6-C875F53776D5Work using method at Rijksmuseum and Victoria and Albert Museum679a470495b3b7.56920345falseMethods to analyse glass to determine future degradation rateImprovements to research infrastructure2023Calculates carbon footprint and 8 other sustainability parameters for showcases. RiCHeS purchase of the EcoInvent LCA software and database has significantly improved the sustainability indices data.92310BF0-E49F-4725-A31D-663994BB6537downloaded 401 times, using in conservation training University of Catalonia679a4650d27082.39523643truecarbon footprint and LCA tool for showcasesImprovements to research infrastructurehttps://www.english-heritage.org.uk/learn/conservation/collections-advice-and-guidance/2022salt removal by poulticing, removes need to drill a sample from historic worked stone sculpture71501206-9A95-48EB-B977-9068B1D3D6D6none as yet679a4778b01bd5.71545227falseMethods to analyse stone to determine future degradation rate and suitable preservation climateImprovements to research infrastructurehttps://www.english-heritage.org.uk/learn/conservation/collections-advice-and-guidance/2023BE3E6EB7-FC3A-49B4-85BE-180D82B2F176Review of Interpreting Gaseous Pollution Data Regarding Heritage ObjectsHeritage90e385ae1d92b951e8e0650069bd7798Thickett D2023-01-0165e383da0c14c7.4875415932314307-A588-4546-9B71-802D4C7231ACAnalysing Objects to Tailor Environmental Preventive ConservationHeritage90e385ae1d92b951e8e0650069bd7798Thickett D2022-01-0163d05083f27ef1.9758312820E87FD5-7EE2-4A77-B9B0-34F7368E0F5BAnalysing objects to produce more sustainable conservation environments.90e385ae1d92b951e8e0650069bd7798Thickett D2023-01-01657a0767264974.99735048E2FEAE84-6B6C-4161-9F43-6DA483160C84Assessing and predicting sustainability for maintainging silver collections63e204f230453bc3cf81c8a84b87cfbcthickett D2023-01-016530fd82a882e3.326850088FBF4916-1371-4C80-80DC-AAE3DBF4D44FManaging Silver Tranish90e385ae1d92b951e8e0650069bd7798Thickett D2021-01-01653101a988a5c0.51557929E0C657E3-EE8E-457A-A666-F32E1E17FDB7Natural Light Aging of furniture, textile and bone in historic environmentsCultura e Scienza del Colore63e204f230453bc3cf81c8a84b87cfbcthickett D2024-01-01679a3cb3131787.84548857BC37AA0C-839B-4B76-958D-A71228E782DFBeyond Heritage Science: A ReviewHeritage5e86e30f1ab5028aa5e9597ef0d77c3bKennedy C2024-01-0165f431c29d7796.90727246DEB0A9D2-75FD-4109-BFCC-9F12DF8F2D7CLong-term provision of stable environments for metals conservation361d237589e2b1651cd5e7365063da4dLankester P2022-01-0163d05344dffe00.027494967D899FD3-8ADD-417D-B822-6C58FD304342Investigating and Preventing Daguerreotype Glass Deterioration90e385ae1d92b951e8e0650069bd7798Thickett D2022-01-0163d053e4c3b271.45079050DA956B25-205C-474B-BEE6-3D312F45A9D2Oxygen Depletion Testing of MetalsHeritage90e385ae1d92b951e8e0650069bd7798Thickett D2021-01-016230bf594c1396.718449213C0A4C8C-4828-423D-ACB1-C60AF508D55BPractical Use of Damage Functions for Environmental Preventive Conservation and Sustainability-Examples from Naturally Ventilated BuildingsHeritage90e385ae1d92b951e8e0650069bd7798Thickett D2023-01-0163ff44e74ec3f2.60825495B2FC3FB7-A400-48D5-86F2-5A1B5CFCE99BBetter Use of Showcases for Preservation and SustainabilityStudies in Conservation90e385ae1d92b951e8e0650069bd7798Thickett D2022-01-0163d050d851e4a9.756754069AB55B39-D512-492C-911E-562577D12251Using Epidemiology to Validate Scientific Results for Complex Situations90e385ae1d92b951e8e0650069bd7798Thickett D2022-01-0163d052dfeb8b87.985661295E0F8A73-04EA-4D99-A982-35D208B528ECPollution and Heritage Metals-Effectiveness of Oddy Testing and Mitigation.Materials (Basel, Switzerland)90e385ae1d92b951e8e0650069bd7798Thickett D2023-01-011996-1944657a05037e59e9.7895008091F89BC6-95B2-4DC7-8E06-136524F2F45DAnalysis of Salts and Clays for Conservation of Porous Cultural HeritageApplied Sciences90e385ae1d92b951e8e0650069bd7798Thickett D2023-01-01657a0493369088.2974733522C03692-7E2C-456F-BAC8-9EE50DAB5B36Review of analysis for cultural heritage conservationCurrent Topics in Analytical Chemistry436810896aa21c8f2b79f38009b1994ethickett d2020-01-016230c0cef2c9b4.96246046EC978E69-2E34-4BBA-87CC-45065702FFD7Surveying analytical techniques for a comprehensive analysis of airborne particulate samples in museum environmentsTrAC Trends in Analytical Chemistry78e9c1e710df451c16c7cd911964955dBrizzi S2024-01-016664523c6ae4b1.87568437362A9E41-73F1-4044-A87D-C9F5DE881560Measurement of Sorption Isotherms to Guide Mixed Display of Archaeological Iron, Bone, and Glass.Materials (Basel, Switzerland)90e385ae1d92b951e8e0650069bd7798Thickett D2024-01-011996-1944679a3d6f37ccb4.45743055C806B0EF-C0F1-4BA4-BE89-59274B2AD51CComparative assessment of paint systems for use on heritage artillery at coastal forts in England: experimental design and interim reportConservar Património89314afe407ab0f79cf15f9d0f030d85Smith W2023-01-01679a3a9ac62df6.4243764740AC5105-3156-46E0-8A46-83B54846B729Calculating the Carbon Footprint of Interventive and Preventive Conservation at English Heritage, UKStudies in Conservationf209b1c00c8e7fb9be98e3dfc3c2cb59Tate-Harte A2024-01-01679a3d143fde88.97214282AH/V01241X/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified095A3C0E-E4E6-4D44-945E-0036610164BANovel Time-Resolved Thermal Imaging: AlGaN/GaN Heterostructure Field Effect TransistorsClosedEP/D045304/1Research GrantThe increasing complexity of tasks required by communication, radar, aircraft, automotive systems benefits from the use of novel materials in high speed devices. Such devices, for example, radio-frequency (RF) transistors used in mobile communication base stations or phased array radars, have to meet certain performance standards. Electrical characterization is mostly used today to tackle challenges in the device development process to meet these standards. Electrical measurements, however, determine average device properties rather than specific information on spatial characteristics such as temperature and electric field inhomogeneities. If direct imaging of temperature and electric field distribution over a device area was possible with high time resolution this would open a new dimension for the investigation of semiconductor devices. This would be of great benefit to device researchers and developers to study and tackle time-dependent phenomena limiting device performance. Adequate techniques, however, are not existent at present. In the proposed work we will develop the first high-spatial resolution time-resolved thermal prober for semiconductor device imaging ever built to our knowledge. Electric field distribution will be extracted from the temperature information. The technique will be illustrated on the example of the topical AlGaN/GaN HFETs to learn more about how these devices operate in detail and what limiting factors for current devices are. For example, we will obtain information about carrier trapping related to AlGaN/GaN HFET current collapse, but experience shows that other interesting and potentially important discoveries are likely to result as well.2010-03-30798CB33D-C79E-4578-83F2-72606407192CEPSRC2006-06-30INCOME_ACTUAL417913QinetiqUnited KingdomQinetiQ (Malvern)QinetiQ (Malvern)6A2DBCED-9D4F-4C9B-814C-765DD4FD7592b9c18c16b9c18c2a-1Private2006-01-01Selex ESUnited KingdomSELEX Sensors and Airborne SystemsSELEX Sensors and Airborne Systems LtdC94CCF11-ED56-4ADC-BADB-0004FBE5D85Cb9c0ee8cb9c0eeaa-1Private2006-01-01Renishaw PLCUnited KingdomRenishaw Plc61F2C06D-BAC1-41B5-A27A-5DE5120B57D3b9c07fd8b9c07ff6-1Private2006-01-01The technique developed is presently used by us and new groups which subsequently implemented our developments to support defense and space industry product development, as well as on government funded (UK, EC, US) research programs.2010EE08A927-F10E-43DD-8CC5-77897858A69AEconomic54466a091429f1.46471376Aerospace, Defence and Marine,Electronics,TransportA new technique was developed to probe temperature in semiconductor electronic devices with nanosecond time resolution, and submicron spatial resolution.Applicable for reliability testing of electronics in industry. Based on this project Bristol became partner in different programmes, such as NJTT led by TriQuint Semiconductors funded by DARPA. The technique is presently used in commercial setting to support industry. Based on the results software was developed that could be sold to interested customers in the future.8DC352FA-1CD8-4AEC-B97E-AA5FF72C3779r-9033844833.2937857763a8d2ElectronicsD67B8D17-9443-4858-9875-BECE536E99C8Benchmarking of Thermal Boundary Resistance of GaN-SiC Interfaces for AlGaN/GaN HEMTs: US, European and Japanese Suppliers28ca9b64a2a9c24aa9c79896f256b0d2Martin Kuball (Author)2010-01-01m_730785260513efe274A59F8CF6-3D97-4331-8133-603ED98DA2B6Current collapse in AlGaN/GaN transistors studied using time-resolved Raman thermographyApplied Physics Lettersfb1ce42ed1ccadfa7cd5d45137f387a4Simms R2008-01-01doi_53d034034d6d72faDEEEDB9C-8D6B-4F53-A998-296AC069887CReducing Thermal Resistance of AlGaN/GaN Electronic Devices Using Novel Nucleation LayersIEEE Electron Device Letters0ff63e456f4cb53411fed2c6a845dfa7Riedel G2009-01-01doi_53d05a05afada79588ABA1ED-2669-4989-AFB7-FE28B3DCBBC0Time-Resolved Temperature Measurement of AlGaN/GaN Electronic Devices Using Micro-Raman SpectroscopyIEEE Electron Device Letters03a39e2937133e6c4136cf9a465bd7b2Kuball M2007-01-01doi_53d05a05af67395683E061D7-23D5-4D38-9FE1-5996B653C4BBNanosecond Timescale Thermal Dynamics of AlGaN/GaN Electronic DevicesIEEE Electron Device Letters0ff63e456f4cb53411fed2c6a845dfa7Riedel G2008-01-01doi_53d05a05afb913871DA6385C-BF6A-4064-8BDF-AAB2D9DC3A14Nanosecond time-resolved Raman thermography: Probing device and channel temperature in pulsed GaN and GaAs HEMTs28ca9b64a2a9c24aa9c79896f256b0d2Martin Kuball (Author)2008-01-01m_437432809713efe3960A90D0AB-520E-4B82-8C3B-54BDA303F506Channel Temperature Determination in High-Power AlGaN/GaN HFETs Using Electrical Methods and Raman SpectroscopyIEEE Transactions on Electron Devicesfb1ce42ed1ccadfa7cd5d45137f387a4Simms R2008-01-01doi_53d05d05d8e9cc18EP/D045304/11908FDF5-1C61-4F33-B47F-3E91675C88AA55Info. & commun. Technol.50CC55CC-BE0D-4167-BD99-285D6BCC369B20Materials processing945E0A55-10CB-4E91-BCCB-7CB22CFE223225Tools, technologies & methods4D4F63B1-6DA2-42B3-AAF1-0FC07D91E3D325Instrumentation Eng. & Dev.50CC55CC-BE0D-4167-BD99-285D6BCC369B20Materials processing8EC6A705-6D4A-44E8-95FF-27E262DA290C40RF & Microwave Technology811766AE-F6E0-4356-AEBF-17A4DA456AD415VLSI Design09E9D9A8-C863-48AA-B42B-004D4B4A472DOpen Access Block Award 2023 - Armagh Observatory and PlanetariumClosedEP/Y530037/1Research GrantAbstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.2024-03-311B0D1043-BA8E-4AF6-8022-B1BCC1E97FB9Open Access Block Grant2023-03-31INCOME_ACTUAL5693EP/Y530037/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0A9C4768-C996-4303-91F1-020F34284F78Characterising hydrothermal alteration across the Atlantis Massif: IODP Expedition 357ClosedNE/P000061/1Research GrantThe oceans covers approximately two thirds of the Earth's surface yet the oldest ocean floor is less than 200 million years old because it is continuously created and destroyed through the plate tectonic cycle. The ocean floor is made of volcanic rocks that form at mid ocean ridges, a global chain of under-water volcanoes that stretch for ~60,000km around the oceans, where two tectonic plates are moving away from each other. The rate at which the two tectonic plates move away from each other varies across the oceans. Currently 50% of the global mid ocean ridge system is spreading at slow spreading rates (&lt;40 mm/yr, e.g Mid Atlantic Ridge). From dredging and scientific drilling of the ocean crust and studying ophiolites, pieces of ocean crust that have been emplaced onto the continents, the overall structure of the ocean crust has determined. 'Typical' ocean crust has a layered stratigraphy with erupted lavas overlying intrusive feeder channels and frozen magma chambers (gabbros). However along slow spreading ridges this typical stratigraphy is not always present, and ~ 50% is formed by tectonic extension along detachment faults that bring gabbros and mantle rocks to the seafloor. Once new ocean crust is formed cold seawater penetrates downwards into the crust along fractures, becomes heated and reacts with the volcanic rocks until the hot hydrothermal fluids becomes buoyant and exit the crust at the seafloor . These reactions modify the chemistry of both the rocks by the formation of new hydrothermal minerals and the hydrothermal fluids, and are therefore an important process to quantify in order to understand global chemical exchange. The new minerals that form are strongly dependent on the initial rock and the temperature of the reacting hydrothermal fluids. At slow spreading ridges, the exposure of gabbroic and mantle rocks at the seafloor results in different chemical reactions, and mantle rocks in particular undergo extensive alteration to serpentinites. Serpentinisation reactions are accompanied by the formation of calcium carbonate minerals in fractures. The formation of calcium carbonate by fluid/rock reactions is currently being investigated as a potential long-term store of carbon dioxide. Understanding hydrothermal circulation in these environments is critical for understanding this process and ultimately exploiting it for the industrial storage of carbon dioxide. The Atlantis Massif is located on the Mid Atlantic Ridge and is an example of where tectonic extension has exposed gabbroic and mantle rocks at the seafloor. A hydrothermal vent system called the Lost City Hydrothermal Field is present on the southern end of the massif and is driven by serpentinisation reactions. Low temperature (&lt;100degC), high pH hydrothermal fluids vent diffusively at Lost City through carbonate-brucite structures. It is one of only five hydrothermal vents that are known to be hosted on mantle rocks. In this study, new samples recovered by scientific ocean drilling of the Atlantis Massif during IODP Expedition 357 will be used to investigate the role of hydrothermal circulation in the formation of ocean crust along these long-lived detachment faults. For the first time an age transect of samples across the massif has been recovered allowing insight into how the detachment changes and evolves as it progressively ages. By studying the new hydrothermal minerals that have formed during fluid/rock reaction, and documenting their distribution within the different rock types, the pathways for the hydrothermal fluids can be deciphered. This information will be combined with geochemical analyses of the rocks and hydrothermal minerals to quantify the chemical changes that have occurred during hydrothermal circulation across the Atlantis Massif. This combined approach will allow the contribution of hydrothermal circulation along detachment faults to the broader hydrothermal budget of global geochemical cycles to be determined.This project will make significant scientific advances towards our understanding of the role of hydrothermal circulation during the formation and evolution of the ocean crust. It will expand upon our current knowledge of this key Earth process through the variable slow spreading rate crust that represents much of the modern mid ocean ridge network. This project will primarily benefit the extensive ocean crust community, both those working on modern ocean crust and ophiolites, as outlined in the Academic Beneficiaries section. Benefits to: IODP The proposed research will contribute to addressing two of the proposed challenges in the 2013-2023 IODP Science Plan; challenge 9 'how are seafloor spreading and mantle melting linked to ocean crustal architecture' and challenge 10 'what are the mechanisms, magnitude, and history of chemical exchanges between the oceanic crust and seawater?'. This research will contribute to these by characterising and quantifying hydrothermal circulation through the detachment surface of the Atlantis Massif and its contribution to global geochemical cycles. Publication of this research in internationally recognised peer-reviewed journals will highlight the on-going importance of IODP as a world leader in scientific collaboration and high impact science. Benefits to: Public This research will contribute to topical global questions about the response of the Earth system to perturbations (global geochemical cycles) and the limits of life. Through the integration of this study with companion studies addressing the mechanisms of serpentinisation because of the intimate link between the two studies, this research will contribute to the topical debate about the long term storage options for atmospheric carbon dioxide. Involvement with University open days and public engagement activities (e.g. Girls into Geoscience) and the publication of the results in journals accessible to the public will ensure this research is exposed to the public. Benefits to: RA The research assistant will benefit from training and experience in laboratory procedures in addition to being involved with active research. It will provide an opportunity to extend their skill set and develop their future career prospects. Benefits to: Industry The long term storage of carbon in solid mineral form is one of the options available for reducing atmospheric carbon dioxide and is currently an area of research of high interest in both academic (e.g. IODP Expedition 357, ICDP Oman Drilling Project) and industrial (e.g CarbFIX) contexts. A necessary step towards the potential industrialisation of this process is understanding the natural system in a range of environments. This research is intimately linked to serpentinisation across the Atlantis Massif and will therefore help inform our understanding of the formation of calcium carbonate minerals in lower crustal and mantle rocks. This research will add to the growing body of research in this field and in the long term will be of use to carbon capture and storage industries. How does the proposed research generate impact? This research will inform our understanding of the variation in processes that form the ocean crust. The recent recognition of the extent of the detachment mode of seafloor spreading represents a major step in our understanding of how the Earth surface forms. The results of this study will provide crucial evidence for the interaction of hydrothermal fluids and tectonic processes and quantify for the first time the contribution of focused hydrothermal fluids on global hydrothermal budgets. The intimate link between hydrothermal circulation in the gabbroic and mantle rocks will inform our understanding of the natural storage of carbon in ocean crust, a crucial step in knowledge necessary for the potential industrialisation of this process.2017-05-178A03ED41-E67D-4F4A-B5DD-AAFB272B6471NERC2016-04-18INCOME_ACTUAL27616European Consortium for Ocean Research Drilling (ECORD)European Union (EU)Organising committee MagellanPlus workshop &quot;Investigating the oceanic life cycle of tectonic plates by mission specific drilling&quot;9F4043C2-2AB1-40CD-A1A7-1F839457982Ain progress.622b0aba22eda4.47465593-1I co-wrote the MagellanPlus workshop proposal and was nominated to be PI for this award (successfully funded at 15,000 euros). I am hosting and organising the workshop at the University of Plymouth UK, further cementing the leading role that UK scientists play in IODP.I am leading the organisation of this workshop, which builds on science themes but also the nature of IODP Exp 357 in the use of mission specific platforms.Charity/Non Profit2021-01-01Girls into GeoscienceParticipation in an activity, workshop or similarNational19972BE2-E371-4450-BE52-57C2647A05DCThe event includes a mixture of presentations and workshops. This research was featured in a presentation highlighting the variety of opportunities available with an academic career in geoscience, along with highlighting the international projects that UK scientists are involved with.58c696b7e7b9d3.82413922falseSchools2016Virtual Girls in Geoscience 2020Participation in an activity, workshop or similarNational25172F10-9872-462E-A29E-1731CBA66EBEI particppated as a panel member, with particular emphasis on sea-going fieldwork. My experiences from this Expedition (first with more than 50% female participants) featured in my answers603f80df6f2361.95744907falseSchools2020GiG 2019Participation in an activity, workshop or similarNational3893D44F-2369-4777-8DE8-FB935BF12542Results from Atlantis Massif featured as part of the Girls in Geoscience workshop &quot;Exploring the rocks beneath the seafloor&quot;5e54edbc7e92f2.92302306falseSchools2019This research, along with participation in IODP Expedition 357, was featured in an event designed to encourage girls to pursue a career in geosciences (Girls into Geoscience, 3-4th July 2016, Plymouth University). This included a presentation to the registered participants (approx 100 students and teachers) highlighting my role in the expedition, the science being addressed and the opportunities available with international programs such as IODP. Feedback from the event highlighted that this contribution was very well received by the audience. Results and experiences of this research related to IODP Exp 357 was again featured in my participation as panel member at Virtual Girls in Geoscience 202020169DECF660-34FC-4C38-A417-701F3FD67906Societal58c695283fde15.85060497EducationInitial results indicate a greater variability in alteration within a particular lithology across the detachment fault than previously expected. Geochemical analyses indicate a high variability in gabbroic alteration at a cm scale. These data will provide an example of alteration under a detachment fault and will be a useful comparison for gabbros altered around normal faults.Results will be presented at the postcruise meeting and I expect my results to be used by other members of the science party304DE2BD-0F26-4692-9609-8A650B87A53358c6935bb975e1.32723421EducationB398667D-9A0C-4E94-9DFC-EEAFCAD0D753Geochemistry of serpentinized and multiphase altered Atlantis Massif peridotites (IODP Expedition 357): Petrogenesis and discrimination of melt-rock vs. fluid-rock processesChemical Geology6bad4a6264df2d091be74a6716dccc36Whattam S2022-01-01622b095cc2d802.9768255808AE5320-601B-4454-B20C-4AED6489EA23Magmatism, serpentinization and life: Insights through drilling the Atlantis Massif (IODP Expedition 357)Lithosb6a43c0732cdffa546b4fd4ba25dd5caFrüh-Green G2018-01-010024-49375c753067d95871.65577698NE/P000061/1346611FD-47F5-46D6-9813-D4707F62253B100GeosciencesA646062E-6497-4533-8274-47644A7B369C20Earth Resources2334C846-D357-4EF1-B929-0EC4EC1854CB40HydrogeologyF52704F6-1035-4307-9FA9-45BC878F1F1A10Tectonic Processes7F1C4565-EFD3-4BE7-8A4A-B5F39FFD36F330Volcanic Processes0AE039A7-9A84-4943-AA36-001DB5763245Ferroelectrics for Nanoelectronics (FERN)ClosedEP/H023666/1Research GrantThe evolution of silicon technology since the 1960's has focussed on doubling performance and functionality every 18-24 months through miniaturization. Critical dimensions measured in tens of nanometres are now common place and billions of components connected by miles of wiring can be packed onto a wafer no larger than a thumb nail. Today the focus is shifting away from more scaling (called more Moore after the founder of Intel, Gordon Moore) towards increasing functionality through the introduction of mixed technologies on silicon (called more than Moore). This project investigates the incorporation of ultra thin ferroelectric materials into silicon nanoelectronics and two of its many applications.Capacitance is the rate of change of charge with voltage. It is the defining property of capacitors which are necessary in many electronic systems but are relatively large. Ferroelectrics can shrink capacitors by three orders of magnitude, because their electric permittivity is so high. More than that, their capacitance can be made to vary depending on the applied voltage so very small and tunable capacitors can be made, which can find applications in hand held electronics products in order to reduce power consumption. If they could be integrated onto a silicon microchip there would be further space savings. Thin layers are expected to produce even higher capacitance. However there is evidence that capacitance starts to reduce below 50 nm as dead layers are said to form near the interface with electrodes, but this may be an interface effect which can be lessened through engineering. Recently there has been experimental evidence that effective negative capacitance can be seen in ultra-thin ferroelectric films. If such material can be incorporated into a transistor then it would be able to reduce the voltage needed to switch a transistor between its on and off states (the sub-threshold slope). This would transform silicon technology, allowing a new generation of more powerful single core processors. Modern computers have dual or multi-core processors. A single core processor would generate too much heat but is still desirable for many applications. Capacitance places a lower limit on the sub-threshold slope. The consequence is that transistors need a larger applied voltage to be on and/or will leak current and so can never be fully switch off. This leads to increased power loss and heating as more transistors are crammed onto the same area of silicon, which limits component density. Integrating a ferroelectric film with negative capacitance into the gate of a transistor would reduce the overall capacitance and thus the sub-threshold swing. The need to understand and produce high quality ferroelectric ultra-thin films is imperative for each of these applications. Atomic Layer Deposition (ALD) at Newcastle and Pulsed Laser Deposition (PLD) at Imperial College will be used to deposit thin films of the ferroelectric materials barium titanate (BTO) and barium strontium titanate (BST). Both allow deposition thicknesses with atomic level precision. Extensive characterisation is needed to assess quality of these ferroelectric films. First principles computer simulation will be used to gain a better understanding of the films and to direct experiments. The deposition and thermal parameter space will be mapped to identify best ferroelectric properties for given constraints laid down by the silicon fabrication. Transistors will be made incorporating the best ferroelectric films to confirm the reduction in sub-threshold slope. Ferroelectric capacitors integrated onto silicon will be demonstrated, quantifying the capacitance increase per unit area and examining the fabrication constraints needed to maintain high transistor performance. This will also help identify integration issues, which also include equipment contamination and the development of ferroelectric etches.The RAs and PG student trained will have the opportunity to develop excellent analytical, research and communications skills. Such people have previously gone on to work as permanent academic staff, in industry, in finance and in government research labs. The project will offer other RA's and PG students an opportunity to benefit from working on closely related topics in the area of thin film ferroelectrics and it is anticipated that this will boost the activity to benefit all. UK companies spanning the supply chain for high performance integrated circuits will gain competitive advantage. The primary benefits will be proof of concept for new types of semiconductor devices using ferroelectric thin films and the reduction of risk for development and manufacture of products using these devices. Materials companies benefit from expertise within this consortium and IP generated. Knowledge gained will accelerate their progress in producing high quality films for many applications. They can license the recipes for deposition of ferroelectric thin films adding value to their deposition system. They will benefit from the collaboration, especially characterisation and device data which will reassure customers. Mixing silicon with ferroelectrics for high permittivity voltage controlled capacitors will have the benefit of allowing single chip solutions where previously several components may be necessary. Using ferroelectric films to reduce transistor sub-threshold slope is high risk but has the potential for enormous benefits. The exponential increase in microchip leakage power and heating, as critical dimensions reduce and transistor count increases has halted single core processor evolution in favour of multiple core processors in order to have effective thermal management. A reduction in power consumption by integrated circuits must be of global benefit to the environment, since almost every appliance uses some silicon technology. Beneficiaries will include not only the semiconductor manufacturers, circuit designers and product manufacturers, but all of us who use their products. Ferroelectrics are also piezoelectric and pyroelectric and so a range of intelligent sensor/actuator systems might be envisaged. While the UK does not at present have state of the art silicon manufacturing, it is likely that in future UK based companies will partner with overseas semiconductor foundries for the supply of part-processed wafers (the transistors and some interconnect metallisation) which can be completed integrating a variety of mixed technologies (such as thin film ferroelectrics for tunable capacitors) to create IP intensive products of high added value. This may be particularly appropriate for partnering within the EU where it can make economic sense to share expensive semiconductor foundries. Publication of research in high quality journals and at leading international conferences is crucial and will continue. The industrial steering group will be a means of two-way communication and engagement between this academic project and the commercial sector. National electronics networks like Si Futures, UKDF and EU networks like Sinano will be accessed. Press releases to the trade press will also be used to announce the project and to publicise breaking news as it develops. The research will feature on web pages of the two universities. The quarterly management meetings will have a standing item on potential impact of research. Promising strands of research will be pursued and our steering group members will be approached for additional guidance. Patents will be sought where possible prior to publication of the research. Both PIs have previous experience of knowledge transfer to industry. Both universities have excellent media staff to help with communication.2013-11-30798CB33D-C79E-4578-83F2-72606407192CEPSRC2010-05-31INCOME_ACTUAL528498Negative capacitance has been demonstrated experimentally. This has been used by other researchers and has encouraged further research as this is a demonstrated proof of concept. Other findings contribute to the body of knowledge relating to integration of new materials with silicon based technology3E7AD95B-8EB4-4A41-B7FB-0E060AB30EF7Cultural5457674b20dfc4.71339318ElectronicsWe demonstrated experimentally negative capacitance using ferroelectric materialsour papers are commonly cited and there is worldwide interest to achieve steep sub-threshold MOSFETs using ferroelectric negative capacitance3DEC0A56-E18F-4D93-A9DE-43CAB5B69168r-5212102490.67479977641d6cElectronicsEnergy8DDA11EB-3771-4663-B167-340A03618BEFThermopower of LaFe 13-x Si x alloysEPL (Europhysics Letters)f09ad771b7c325be10100cb9f463cc0fHannemann U2012-01-01doi_55f95e95e8743dfdE39C6F2A-BF14-4D88-BB94-1A15A9194131A comprehensive study on the leakage current mechanisms of Pt/SrTiO3/Pt capacitorJournal of Applied Physicsfeac839cf6a4aee7de53db71616eed78Mojarad S2012-01-01doi_53d03803802ab79dDF3D4507-493C-4817-8D8D-AC81A7CE909BAnomalous resistive switching phenomenonJournal of Applied Physicsfeac839cf6a4aee7de53db71616eed78Mojarad S2012-01-01doi_53d038038b0397f1E68E0A59-A87E-4748-83D9-084675E0CCA6Leakage current asymmetry and resistive switching behavior of SrTiO3Applied Physics Lettersfeac839cf6a4aee7de53db71616eed78Mojarad S2012-01-01m_54538498751367c95c4E76721F-0890-4B3A-A431-D10C80339574Oxygen vacancy migration in compressively strained SrTiO3Journal of Applied Physics23288bd9cd6a3d985580de295d68da23Al-Hamadany R2013-01-01doi_53d038038c27f9386A8F770D-3263-4237-9EF7-020A4E1CF77FExperimental Observation of Negative Capacitance in Ferroelectrics at Room TemperatureNano Letters85813e14f3497b39b47b495e9282e3e2Appleby D2014-01-011530-69845457692b29fd98.95195290659F2A65-7139-4CF3-A921-930397B03D6DFerroelectric properties in thin film barium titanate grown using pulsed laser depositionJournal of Applied Physics85813e14f3497b39b47b495e9282e3e2Appleby D2014-01-015457692b0124d8.388047380B97AA62-7974-436A-A25D-49911F90B8E7Effect of deposition conditions and post deposition anneal on reactively sputtered titanium nitride thin filmsThin Solid Filmscaac808b0061fcb1f2d914aacdba4defPonon N2015-01-01doi_55faa0aa040470ccEP/H023666/11908FDF5-1C61-4F33-B47F-3E91675C88AA50Info. & commun. Technol.50CC55CC-BE0D-4167-BD99-285D6BCC369B25Materials processing177C04BB-BFD4-4D65-BA9D-15A50728B8CA25Materials sciences2B23EFD7-00EA-4FCA-8685-A8B4B94BF97650Electronic Devices & Subsys.BEA752D6-11B4-4E5F-937C-2DD41104E22925Materials Characterisation50CC55CC-BE0D-4167-BD99-285D6BCC369B25Materials processing0AF5D063-4580-42D4-B9A9-005CAB06FD35Literary Mapping: Dickens and the Dynamics of PlaceClosedAH/I02352X/1Training GrantAlong with a large collection of nineteenth-century maps of London and topographical materials, The Museum of London (MoL) holds a series of 41 watercolours painted 1860-1870 by J.L. Stewart of 'real places' in Dickens's novels. The Bishopsgate Institute holds a further 60 Victorian watercolours of Dickensian places. Other holdings at MoL include paintings, panoramas, and stereographic images; the covers and illustrations of the serial parts of Dickens's novels; later book-edition illustrations; the archives of Dickensian tourism at MoL (and at the Dickens House Museum), including plans of 'Dickens Walks' and Victorian 'Dickens' souvenirs. MoL also holds significant theatrical collections and large collections of photographs of London. To mark the bicentenary of Dickens's birth in 2012, a major exhibition will run at MoL from December 2011-June 2012, with an international tour to follow. The student would use the exhibition as a significant research resource for thinking about the continuing fascination with the geography of Dickens's London. S/he would be involved in creating a 'Dickens Walk' for the exhibition, also delivered through an phone app, and in running and presenting at events connected to it, as well as in detailed evaluation of its visitor response. \nApplications will be invited which address some or all of the following research questions:\nWas Dickens the only author whose work was mapped so closely to the 'real' during -and after - his lifetime? (comparators could be Scott, Hardy, Wordsworth) \nHow does the map of Dickens's places change over the nineteenth century?\nHow does an ever more pervasive print culture generate new ideas of 'place' and create specific 'places'?\nHow does the representation of place in 'fact-based' articles in Household Words and All the Year Round compare to Dickens's versions in the novels? (Significant places might include: Newgate, bridges, coaching inns, law courts, London churchyards, the City, and what Dickens called 'fairy land': the places of entertainment and theatre). \nHow did Dickens's own travels affect his construction of the provincial and the global? (Locations which might be considered include: the cities of Boston in the US; Paris; Rome and its ruins, Rochester, Preston, Broadstairs). \nHow did Dickens's texts themselves travel? How did his American and/or colonial readers in his lifetime interpret his sense of place? \nWhat was the impact of photography, and -later- film, on the poetics of place and particularly of London? Conversely, what was Dickens's influence on filmic 'placing' - in the early films of Griffith and Eisenstein, for example?\nWhat happens to place when it becomes distanced in time? How do we reconstruct Dickens's places today? \nWhat have been the effects of the heritage industry and mass culture on Dickens's work?\nThere has been much debate about 'place' as historically contingent process in recent years. The thesis will engage with work generated by scholars of geography, history, literature and art, such as David Harvey; Nigel Thrift, Derek Gregory; Henri Lefebvre; Raymond Williams, Lynda Nead and Franco Moretti.\nThe student would have a hot desk space at MoL and access to all the graduate-student facilities at KCL. S/he would spend at least one day every week at MoL, and often more, particularly during the first year, in the run-up to and during the 2012 Dickens exhibition which will stimulate and feedback into the initial research. In years two and three the student will add value to the documentation around MoL's Dickens-related collections, in the light of his/her doctoral research, and will choose and curate a group of objects for an on-line exhibition in year 3 in line with the MoL's ongoing research strategy. Academic supervisions would be supplemented by meetings at least every two months between Werner, Pettitt and the stuDickens is exceptional as a literary figure who continues to excite immense international interest and his bicentenary in 2012 will generate considerable media attention. Both Werner and Pettitt are experienced in giving media interviews and dealing with the press (Pettitt was interviewed on Radio 4's Today Programme, among others, about her last book; and Werner regularly speaks to the press) and are well-placed to capitalise on these opportunities, and maximise the media exposure of both the exhibition and the connected research at MoL.\n\nPettitt is planning a new undergraduate course on 'Dickens and London' inspired by this project. The beneficiaries of the collaboration will include but will also extend well beyond students (UG/PG) and academic staff at KCL and Museum staff at MoL. They will include a wide variety of museum/exhibition visitors, both 'real' and on-line, such as school children, adult learners, academics and journalists, and we expect international impact, both through tourists attending the exhibition and its supporting events, and, in the longer term, through hits on the legacy 'Dickens exhibit' website. \n\nThe student will also be involved in organising and presenting at a series of exhibition-related events, some at the MoL and some at KCL which will be free and open to the public. KCL has a new partnership with Cheltenham Literary Festival so a Dickens event could appear on the 2012 Festival programme too.\n \n'Literary Mapping: Dickens and the Dynamics of Place' will provide new insights into London's past, helping to inform the public histories presented by the Museum in its displays, online and through other outputs. The Museum recently created one of the most successful phone apps interpreting London's historic topography (Streetmuseum), and the student will be well placed to build on this and help the Museum deliver another innovative resource that will reveal the London of Charles Dickens to the general public. Considering the worldwide interest in the works of Dickens, such a resource is likely to have a broad appeal both to national and international visitors as well as those who live and work in the capital, and the intention is to deliver it in a range of languages. It will impact on the Museum's marketing campaign in drawing people to the exhibition (the target has been set at 100,000 visitors between December 2011 and June 2012). It will have a financial impact by increasing revenue for the Museum and other related attractions and sites across London.\n\nThe student's work will demonstrate the potential of the Museum's collections as a research resource and add value to the Museum's existing body of knowledge about its collections. The delivery of an online exhibition around the Museum's Dickens-related collections will create a further publicly accessible output and contribute to the Museum's reputation as a national and international resource on London and, in this case, specifically about literary London in the nineteenth century. It will also form part of the MoL's ongoing commitment to defining itself as a rich research resource both for scholars and for the public.\n\nCrucially, though, the impact of this project will not be only 'one way' - pushing outwards from the MoL towards the public. It will also close the loop and feed back the responses and ideas of the public into MoL's on-line displays. The student will have the opportunity to do this both through devising creative ways of eliciting reactions and responses at the exhibition from different constituencies of visitors, and through the detailed evaluation of this visitor response, and its use in considering the meanings of 'Dickens' to different interest-groups.\n\nThis innovative collaboration between curatorial and academic specialists has the potential to deliver both a highly stimulating doctoral apprenticeship, and2014-09-291291772D-DFCE-493A-AEE7-24F7EEAFE0E9AHRC2011-09-30INCOME_ACTUAL60250AH/I02352X/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0B36FFF3-3789-4DD3-92DF-0184F051FD2FISOL-SRS: ISOL Beam Storage Ring SpectrometerClosedST/M00161X/1Research GrantAbstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.Knowledge transfer: We foresee a number of areas where knowledge transfer could occur. All detectors used with the external solenoid must operate successfully in high magnetic field. In particular, we have highly pixellated silicon detectors. The challenges making these highly-integrated detectors function in this environment are extremely close to the demands of combined PET/MRI or SPECT/MRI, seen as a high priority for medical imaging in the future. Highly integrated electronics and ASICs may also be transferred over to the medical or other relevant sectors. The detectors to be used inside the storage ring must survive baking out to high temperatures and be compatible with very high vacuum. This may have applications to other areas of science. In the exploitation phase, the ISOL-SRS system could be used to gather nuclear data relevant to fission reactors, decommissioning or future fusion reactors. A specific example is the ability to measure beta-delayed neutron branches of ions stored in the ring. All the groups have a strong background in knowledge transfer. The Liverpool and Daresbury groups have experience in transferring nuclear physics detector technology towards the medical sector in areas such as SPECT imaging. York established an industry-facing detector development laboratory working on coupling scintillators to novel photosensors. Manchester has the Dalton Institute in-house who provide a natural linkage to the nuclear energy sector, while Surrey have a diverse group working in applications. Manchester, York and Surrey working on nuclear data relevant to present and future fission reactors, supported by an EPSRC grant. Knowledge transfer may be facilitated between groups and companies concerned with applications in nuclear measurement techniques and instrumentation, including GE Healthcare, BAE Systems, AWE, Canberra, Centronic, Kromek, Canberra Harwell UK, Ametek (Ortec), John Caunt Scientific, National Nuclear Laboratory (NNL) and Rapiscan. Liverpool has a 4 year STFC IPS Fellowship to maximize the impact of the STFC science portfolio. The Fellow will work closely with Liverpool, STFC Daresbury Laboratory and the Cockcroft Institute for Accelerator Science. The role will deliver increased numbers of industrial studentships, enable &quot;pump priming&quot; of collaborative ideas through appropriate routes such as mini-IPS or mini-KTP projects and will facilitate potential staff exchanges with industrial collaborators. The Edinburgh Nuclear Physics Group has been at the forefront of nuclear physics applications of silicon strip detectors since this technology became commercially available. They have a long-standing relationship with the UK company Micron Semiconductor Ltd (MSL). With MSL, they have developed silicon strip detector designs with very thin (~20 micron) and thick wafers (~mm) for our research applications. MSL now has a range and depth of technical capability unmatched by any commercial company worldwide and this technology is now applied to X-ray and space-based applications. Public engagement: There is considerable scope to engage with a variety of general audiences from schoolchildren to the wider public. Big science like nuclear/particle physics and astronomy is acknowledged as one of the key motivators for young people to decide to study Physics at university level and for a career. This project has an inspirational story attached relating to our fundamental understanding of nuclear structure and our understanding of the origin of the chemical elements. We are developing new instrumentation for the world's most famous scientific laboratory. The test bed solenoid magnet has featured in an article in New Scientist. Ongoing educational initiatives include Nuclear Physics Masterclasses for schoolchildren held at Surrey, Liverpool and York, supported by outreach officers co-funded by the Ogden Institute. Public engagement work will be facilitated by the STFC outreach officer, Elizabeth Cunningham.2020-03-30522546B4-4798-4E89-9B88-39938E261897STFC2015-01-01INCOME_ACTUAL913023Binding Blocks Winter Masterclass WebinarA talk or presentationNational3C2E0447-8E1D-4C6D-8606-55B9C13A93BBA webinar about experimental nuclear physics and studying exotic isotopes at the winter masterclass with the Binding Blocks team64072d2fa23c70.50704107falseSchoolshttps://sites.google.com/york.ac.uk/bindingblocks/post-16/webinars-winter-2022232022Binding Blocks Summer Masterclass WebinarA talk or presentationNationalD892B6A6-FC34-42EB-B74B-C17AAA5848FDA webinar about experimental nuclear physics and studying exotic isotopes at the summer masterclass with the Binding Blocks team64072ce65a5d38.54397517falseSchoolshttps://sites.google.com/york.ac.uk/bindingblocks/pre-16/2022I'm a Scientist, Get Me Out Of Here (CERN Zone)Engagement focused website, blog or social media channelNationalD60F27F8-492D-4522-B17F-5F6BA27874F1I am leader of the ISOLDE Team in the CERN Zone of I'm A Scientist Get Me Out Of Here, which directly engages Y10-13 students in online chats, Q&amp;A forums, laboratory updates/tours, etc.64071d74b9bb15.32578062falseSchoolshttps://cern22.imascientist.org.uk/team/isolde2022,2023This award was to design and realise two state of the art detector systems for nuclear structure and nuclear astrophysics studies. These spectrometers will investigate nuclei at the extremes of stability created following stellar events such as super novae. A key unknown for understanding the origin of the elements are the reactions and properties of unstable nuclei. Such nuclei are present in hot, dense explosive stellar environments and strongly influence the path of nucleosynthesis, and energy generation. It is becoming clear that the properties of these unstable nuclei cannot be easily extrapolated from our knowledge of stable nuclei, in particular the development of surprising new shell structures driven by the nature of the underlying nuclear interaction. In order to address such science in the laboratory, measurements of nuclear reactions and properties of unstable nuclei must be studied with a precision sensitive to their underlying quantum structure. Additionally, access to a wide range of radioactive beam species is critical for the scientific reach of the programme. This project involves the use of the established ISOLDE facility at CERN, with the widest range of intense radioactive beams (&gt;700 isotopes). Two spectrometers have been developed, one for use within a heavy ion storage ring and the other an external spectrometer coupled to a superconducting solenoid. During the course of the grant, the storage ring planned for ISOLDE CERN from TSR Heidelberg was cancelled and it was decided to locate the second spectrometer in the CRYRING storage ring at the new radioactive beam facility, FAIR in Germany. The two spectrometer systems, combined with the vast range of isotopes produced at ISOLDE and the cooled beams at CRYRING, will address a wide range of topics in nuclear astrophysics and structure involving unstable isotopes. The in-ring spectrometer will perform high resolution, high luminosity, in-ring direct and indirect reaction measurements with light and medium mass nuclei relevant for understanding explosive nuclear astrophysical processes and perform radiative capture reaction measurements also relevant for these processes. The external spectrometer (ISS) is located in a solenoidal system that will be used for precision studies of inelastic scattering and transfer reactions. This spectrometer has an advanced design that employs the proven HELIOS concept from Argonne National Laboratory. It will exploit beams directly from HIE-ISOLDE and will benefit from special beam manipulations. Both detector systems comprise Si detectors in a compact design, digital electronics, software for data acquisition and control, and mechanical chambers and supports. The project is well embedded in both CERN-ISOLDE and FAIR-CRYRING with strengthened relationships in both places. At FAIR the in-ring spectrometer has full acceptance into facility and its value will contribute to the UK's in-kind contribution to FAIR. At CERN the ISS spectrometer is regarded as a high profile addition to the HIE-ISOLDE facility. Apprentices, students and post-doctoral research assistants as well as the academic staff and experience engineers have benefited from this project in working and developing advanced instrumentation.The spectrometers are part of the research infrastructure at both CERN-ISOLDE and CRYRING FAIR. They are primarily for academic scientific investigation of exotic nuclei key to our understanding of the creation of the elements. As leaders of the two spectrometer projects the UK scientists will perform key experiments to address outstanding questions in this field. However, the instruments will be used and the data from them, by the international community of nuclear physicists, both experimental and theoretical, who will benefit directly from this new knowledge and understanding. The technical developments needed to make these projects a success include advances in radiation detectors, simulations, digital electronics high vacuum systems, cryogenics and data acquisition systems that are of benefit to all areas that require efficient and spectroscopic detector systems. These areas include medical imaging, homeland security, nuclear decommissioning and environmental monitoring. The collaboration has sought to publicise progress during the project. This has resulted in articles for the general public appearing on the web sites of STFC and CERN, as well as in the publications Fascination and CERN Courier. The results of an early implementation experiment were published in Physical Review Letters(https://doi.org/10.1103/PhysRevLett.124.062502). Other coverage: https://stfc.ukri.org/news-events-and-publications/publications/uk-news-from-cern/uknfc78/#two https://stfc.ukri.org/news/uk-apprentices-assist-in-recycling-a-hospital-mri-scanner-to-study-the-stuff-of-stars-at-cern/ https://home.cern/news/news/physics/isolde-steps-unexplored-region-nuclear-chart https://stfc.ukri.org/news-events-and-publications/whats-happening/daresbury-technology-helps-beam-physicists-into-unexplored-territory-at-cern/ https://acceleratingnews.web.cern.ch/article/isoldes-new-solenoid-spectrometer https://www.anl.gov/article/argonne-and-cern-weigh-in-on-the-origin-of-heavy-elements https://phys.org/news/2020-02-isolde-unexplored-region-nuclear-exotic.html https://www.eurekalert.org/pub_releases/2020-03/dnl-aac033020.php https://www.liverpool.ac.uk/physics/research/nuclear-physics/projects/isol/ https://stfc.ukri.org/research/nuclear-physics/isol-srs/ http://npg.dl.ac.uk/isol-srs/index.html https://isolde.cern/experiments/isolde-solenoidal-spectrometer-iss https://stfc.ukri.org/news-events-and-publications/whats-happening/carme-sets-off-from-daresbury-to-germany/7A2DEB33-F1D1-4115-B35C-047D51D35DF656d70e2acfbd21.18771367Digital/Communication/Information Technologies (including Software)EducationElectronicsEnergySecurity and Diplomacyhttp://npg.dl.ac.uk/isol-srs/index.htmlA code to read and process the raw data from the ISOLDE Solenoidal Spectrometer experiment at CERN. It builds physics events and performs correlations, producing a range of histograms for the user.1109CB46-1894-4662-8143-E2BD19BD9D02First experiments of ISOLDE Solenoidal Spectrometer use this code for the online data viewing and offline analysis.622ec2308eb425.69762649trueISOLDE Solenoidal Spectrometer Sort CodeData analysis techniquehttps://github.com/ISOLDESolenoidalSpectrometer/ISSSort2021This release combines a large number of changes over the past year or so, some bug fixes and a couple of long-awaited enhancements. The main enhancements are in the ability to read simulated data from NPTool and PACE4. The histogrammer now makes a complete set of recoil time-random plots that can be used for subtraction, although the user must make the subtraction themselves. Some bug fixes included the n-side mapping, array histogram z bin limits, and some energy-loss and pulse-height-correction fixes. What's Changed Fixed missing dep for &quot;make -j&quot;. by @hanstt in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/18 Silencing some compiler warnings. by @inkdot7 in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/19 Try a CI action file. by @inkdot7 in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/20 Add recoil E and dE eloss spectra. by @dj-clarke in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/21 Extend ex histograms by @ACeulemans in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/22 Print as (int) in error output. by @inkdot7 in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/24 Small bug fix and improvements to energy loss and pulse-height correction calculation by @berjones in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/25 B jones correct nside mapping by @berjones in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/23 Bug in autocal residuals plot by @dj-clarke in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/27 Fix bug #26 reported by Andreas Ceulemans by @lpgaff in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/28 Revert some changes and apply correct fix for issue #26 by @lpgaff in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/29 Update histogram limits for the z axis of the array by @lpgaff in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/30 Make -j fix by @inkdot7 in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/31 Correct the module indexing of detecors from nptool by @berjones in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/32 Histogrammer updates by @lpgaff in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/33 Set the Sumw2 method by default on histograms by @lpgaff in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/34 New Contributors @hanstt made their first contribution in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/18 @inkdot7 made their first contribution in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/19 @berjones made their first contribution in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/25 @lpgaff made their first contribution in https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/pull/28 Full Changelog: https://github.com/ISOLDESolenoidalSpectrometer/ISSSort/compare/v2.4...v3.04E358046-79ED-47E1-937B-BCE54EF56B7EAll data from the ISOLDE Solenoidal Spectrometer is being analysed with this software.true65f0df72ef23e9.88353140ISOLDESolenoidalSpectrometer/ISSSort: v3.0Softwarehttps://zenodo.org/doi/10.5281/zenodo.106947562024F7428A1F-D7B8-427D-A3E9-20DC2C20A70DEnhancing the performance of solenoidal spectrometers for inverse reactionsProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciencesf7a09e176fdb36891561d2e2cec71c9aButler P2023-01-0114712946 1364502165e317b9cdc2f1.8606071193187417-2735-429D-9124-F89C41E7B6AAEvolution of single-particle structure near the N = 20 island of inversionPhysical Review C94d6c926287e6cf3c09d56c1a41f5495MacGregor P2021-01-0124699993 24699985640727d0f1ab72.4576786253D920A6-4ECB-470A-9A47-B8EF0C806DEEDirect Determination of Fission-Barrier Heights Using Light-Ion Transfer in Inverse Kinematics.Physical review letters4743b326a647121835a8b4b8f083caceBennett SA2023-01-010031-900764d3c1683776a0.699741753B42A47A-A5CA-4ACB-BC9A-9A46F9186628Direct Determination of Fission-Barrier Heights Using Light-Ion Transfer in Inverse Kinematicsa2af555eec2c3db3dbc39cd71c4262e1Bennett S2023-01-0165e918d973b159.58049975DCFDDC17-775A-4382-B924-B53052DE9B1CFirst Exploration of Neutron Shell Structure below Lead and beyond N=126.Physical review letters695f56f11b77725f0553d5e1b74b1ed4Tang TL2020-01-010031-90075e5636d6116ea9.62133740F7ED349B-59A2-42AA-A224-2F1EBC405D8ATSR: A storage and cooling ring for HIE-ISOLDENuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atomsf2e00f21587f45a7ee3f3854b9215c8dButler P.A.2016-01-010168583X56debec6a083b2.9371843515622137-090F-484B-9748-8C1E0B3FAE2FFirst Exploration of Neutron Shell Structure Below Lead and Beyond $\boldsymbol{N=126}$9ab368e946473871205b39fa67de072fTang T2020-01-0165e946c863ade9.50608180024D5C2B-9569-4096-9799-5614942B85AEDo nuclei go pear-shaped? Coulomb excitation of 220 Rn and 224 Ra at REX-ISOLDE (CERN)EPJ Web of Conferencesa27cee72c70dfa5e45ff5bb2f038ae1cScheck M2015-01-0158bea96d4649b9.85081992A2A30810-9F7A-47AE-88B6-CD1F4B365789Evolution of single-particle structure near the N = 20 island of inversionPhysical Review C94d6c926287e6cf3c09d56c1a41f5495MacGregor P2021-01-0161faab83489618.15293288FDEC62FF-FD75-471C-8C32-4A280FCF1051TSR: A Storage Ring for HIE-ISOLDEActa Physica Polonica Bf7a09e176fdb36891561d2e2cec71c9aButler P2016-01-0164781a1123475ST/M00161X/18C77C51A-5639-42DA-B4F4-4A184CA2EA00100Nuclear physics5333CE47-4782-4D31-A764-62C2F691410150Nuclear AstrophysicsA4CEBAA4-8692-41A1-89CB-E92E7854929E50Nuclear Structure05D571C9-728D-415A-863C-01778B41FF4EImaging fluorescence from cells in 5-dimensions: x, y, wavelength, lifetime, and anisotropy.ClosedEP/E013422/1Research GrantFluorescent probes are widely used to study the location and function of biomolecules in cells. Using current fluorescence methods, the behavior of molecules within cells can be studied. Examples include: clustering, rotational motion, and intermolecular distance. These three examples are studied by measuring fluorescence lifetime and anisotropy. Simultaneous monitoring of the behavior of many types of molecules in cells over an extended area is an important unsolved physical problem. This proposal seeks to develop, study, and use a new approach to fluorescence imaging combining spectroscopy, fluorescence lifetime, and anisotropy with a goal of studying the behavior of many types of molecules in cells simultaneously. This will produce images with x and y spatial dimensions and fluorescence emission wavelength, fluorescence lifetime, and fluorescence anisotropy. The research has three parts: construction of new instrumentation, tests on defined mixtures of fluorescent compounds in a solution, and study of an important cell surface receptor. Successful completion of the study will provide biologists with new ways to study clustering, motion, and intermolecular distances of multiple molecular species in the field of a microscope.2008-08-20798CB33D-C79E-4578-83F2-72606407192CEPSRC2007-02-22INCOME_ACTUAL118280This has had by facilitating knowledge and skills transfer between countries. Specifically, Dr Yanzhou Zhou returned to China and continued to publish in the area.2010650F7C92-F7C4-429E-A4CE-E8DD19C5E7D1Cultural5461227f482fa7.43609021Other074E82EE-17A6-4DB7-9445-850C0C50EAE6Global analysis of dynamic fluorescence anisotropy by a polarized phasor approach.Journal of fluorescence07c2a4af9f42a88efefb696767d62dd9Zhou Y2011-01-011053-0509doi_53cfdcfdcd67ab031CACFD43-5CF6-438F-ADF1-1928B51A675BFrequency Domain Imaging of Lifetime and Anisotropy Spectra766085aca81bbb99c78e6e9428e02d34n/a Zhou2008-01-01m_607868183513f3d938A409CE76-9320-4A28-B540-63CF79E1AA06Imaging lifetime and anisotropy spectra in the frequency domain.Journal of microscopy07c2a4af9f42a88efefb696767d62dd9Zhou Y2009-01-010022-2720doi_53d064064d1538db42B53FE1-6014-406F-B8B9-73B9A55E153DSpectrally resolved fluorescent lifetime imagingJournal of The Royal Society Interface68d6abe74d8f161d8d0d74e1876a6c84Hanley Q2008-01-01doi_53d048048f64416aD7876EC7-A083-4BCF-98AE-E2979623591DImaging The Anisotropy Spectrum Of Mixtures Of Anti-human IgG-FITC, R6G, and Fluorescent Beads766085aca81bbb99c78e6e9428e02d34n/a Zhou2008-01-01m_543948033813f3d9f63D18308F-B73F-480F-951C-177E081A779DProcessing of Fluorescence Lifetime Image Using Modified Phasor Approach: Homo-FRET from the AcceptorJournal of Fluorescence07c2a4af9f42a88efefb696767d62dd9Zhou Y2013-01-011053-0509doi_53cfdcfdcd73f2209A918D94-2703-4651-B15A-346323092CE4Confocal detection of planar homogeneous and heterogeneous immunosorbent assays.Journal of biomedical optics82ebc73b25c44aae0fe3b138abab49d2Ghafari H2009-01-011083-3668doi_55f950950f01dff1EP/E013422/12D9083F0-05FA-4726-9EB2-3FCC293CAAF950Biomolecules & biochemistryCD31C09B-E4ED-4429-8639-2B258858CDE150Optics, photonics & lasersC3F75436-9E3C-49EA-937B-37595DB168EC50Chemical Biology26CDCF2A-8EF5-45B3-88A4-09064D3F279A50Lasers & Optics05EDCC8E-392F-4032-B566-0148F8E61927Assessing hurricane damage and species vulnerability across six Jamaican forest ecosystems following catastrophic and compounding hurricanesActiveUKRI4071Research GrantOn 28 November 2025, Hurricane Melissa, a Category 5 hurricane with maximum sustained winds &gt;295 km/h, made landfall on Jamaica's south-western coast as the most powerful hurricane on record (since 1851) and the third most intense Atlantic hurricane, damaging six tropical forest ecosystems. These include the Blue Mountains (BM) cloud forest, John Crow Mountains (JCM) wet montane forest, Cockpit Country (CC) moist forest, Portland Ridge (PR) and Hellshire Hills (HH) (the last remaining habitat for the critically endangered Jamaican iguana) dry forests, and the Black River Lower Morass (BRLM) herbaceous wetland. Two sites (CC and BRLM) experienced significant damage. Melissa's impact was compounded by Hurricane Beryl, (Category 4, 3 July 2024) that damaged the BRLM and PR. All sites are internationally recognized biodiversity hotspots and protected areas including a National Park (BM and JCM), World Heritage site (BM and JCM), tentative World Heritage Site (CC), and RAMSAR wetland (BRLM). The frequency of high-intensity hurricane impacts has increased due to climate change. The JCM is the most frequently impacted – five hurricanes in 21 years (2004-2025) versus nine in 153 years (1851-2003) – while the CC is the least frequently impacted – two hurricanes in 37 years (1988-2025) versus three in 136 years (1851-1987). Past hurricane damage at three sites (PR, HH and CC) was never assessed and species/ecosystem vulnerability remains unknown. Hurricanes alter plant species composition through differential mortality and recruitment over years or decades. Compounding impacts reduce populations of vulnerable species. Jamaica has a high diversity of endemic frogs (23 species), many threatened with extinction. Many use bromeliads - funnel/vase-shaped rosette plants growing in trees and on the ground that holds water - as habitats. Most have fallen or are buried, and recovery may take decades. Accurate pre-recovery damage mapping is essential for tracking these changes and identifying vulnerable plant and frog species. Current mapping methods have limitations. Pre- and post-hurricane satellite image differencing is limited by image availability and cloud cover and validated using qualitative, subjective categories. Maps from our hurricane damage model can track forest structural changes and predict frog population responses but were validated using a subjective, site-specific parameter. To generalize our model across forest types and scales, we need data from objective, three-dimensional (3D) measurement methods. We have pre-hurricane data from 217 permanent plots (13.8 ha) monitoring 20,000+ stems of 200+ plant species across five impacted ecosystems, with recent surveys (2011-2025) including 3D data, plus 32 additional BM plots (1.426 ha), some monitored since 1974. Consequently, we have an unprecedented opportunity to quantify damage from a single Category 5 hurricane – the first in 174 years – and compounding hurricanes and identify accurate damage metrics and vulnerable species. With existing and newly established plots, we will (1) characterize hurricane damage across six tropical forest types using 3D data, (2) validate our damage model and satellite image differencing maps for broader applications, (3) assess frog populations at damaged and undamaged sites, and (4) identify plant and frog species vulnerable to damage from single catastrophic and compounding hurricanes. Follow-up surveys over 1-2, 2-5, and &gt;5 years will track species responses to identify vulnerable/resilient species for conservation prioritization. Findings from our rapid and medium to longer term assessments will guide conservation and management initiatives aimed at reducing ecosystem vulnerability and supporting recovery in an era of intensifying hurricanes.2026-12-318A03ED41-E67D-4F4A-B5DD-AAFB272B6471NERC2025-12-31INCOME_ACTUAL81924UKRI40716CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified062C376C-EA2E-4D2B-8173-0064A2960852Using blockchain technology to improve UK telephone number managementClosed104673Collaborative R&DAwaiting Public Project Summary2020-03-3012E03F45-B517-4D83-A182-3D142D1A471AInnovate UK2018-09-30INCOME_ACTUAL9356001046736CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified063F2C3E-7D22-4388-B177-002D56313CFDAI-driven design of enzyme replacement therapiesClosed2260824StudentshipEnzymes are molecules catalysing all the reaction in a cell and, when defective, they can cause life threatening diseases, such as Gaucher's disease. Patients with enzymatic deficiencies can be treated by injecting a recombinant version of the defective enzyme; however, injection of wild-type human enzymes is usually ineffective, as they are less active and often cause immune response. Thus, human enzymes must be engineered to optimise their therapeutic properties. Designing enzymes is challenging as standard biochemical or biophysical methods do not work well on large proteins as they are not sufficiently accurate to identify new functional enzymes in large protein sequence space. Generative Machine Learning (ML), instead, represents an attractive approach to learn design principles to build new enzymes directly from the sequences of molecules found in nature. Recently, conditional recurrent neural networks (cRNN), a particular type of neural networks (NN) suitable for working with sequences, were successfully used to generate novel antimicrobial peptides and protein structures, but scaling these methods to design complex molecules, including enzymes, remains a largely unexplored field. We will develop deep generative models to learn the functional design space of human enzymes and implement optimisation methods to find the most likely amino acid sequence encoding a specific catalytic function. To do that, we will integrate proteomic, evolutionary and structural data publicly available across biological databases and develop variational methods to fit enzyme sequence models. The availability of these methods will enable design of new designer enzymes.2023-08-30B71128B2-1767-4204-9D19-EEB1383C2D1EOther NPIF2019-08-31INCOME_ACTUAL022608246CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0C15BC4F-A128-4F7E-ADAB-013E262DD5CFMicrobial Interactions Within Denture BiofilmsClosed2119089StudentshipMost microorganisms naturally grow within biofilms in both environmental and industrial systems. Biofilms on denture surfaces are widely acknowledged and arise in cases of poor oral/denture hygiene and where dentures are not removed whilst sleeping. Key microorganisms in denture biofilms include fungi of the genus Candida as well as bacteria that can originate from other oral sites or from exogenous sources. The majority of denture biofilm studies have targeted Candida as these fungi are highly adept at adhering to denture acrylic and can induce the infection, denture associated stomatitis. Denture biofilms are, however, ideal for investigating microbial interactions since they are readily accessible, polymicrobial and variable in their microbial composition and can be modelled in vitro. Furthermore, difference in conditioning of the denture surface may also lead to differential species colonisation and biofilm behaviour. Preliminary studies in our School of Dentistry have highlighted the effect that bacterial species may have on denture biofilm composition and behaviour of Candida albicans. We have found that Candida growth can be inhibited in biofilms by Pseudomonas aeruginosa, whilst other bacteria, such as certain streptococcal species can influence the morphologyof C. albicans. The reasons for these effects remain unclear, but could be due to specific associations between species, or a feature of a wider community effect on the biofilm. Project aims The aims of this PhD are therefore to explore the types and mechanism(s) of microbial interactions that occur in biofilms, using denture biofilms as model systems.2022-12-31198E4A3D-B2DC-45D4-8351-7CCEC4061876BBSRC2018-09-30INCOME_ACTUAL021190896CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0C552636-8921-4940-9DAB-01530F14011ASafe and Sound - secure and sustainable Cloud3D servicesClosed750553VouchersSafe and Sound will enable Hao2.eu to research and develop good practise standards and approaches to deliver secure and sustainable Cloud3D services which proactively anticipate and support the needs of vulnerable groups such as people with autism and learning disabilities.2014-01-3112E03F45-B517-4D83-A182-3D142D1A471AInnovate UK2013-07-31INCOME_ACTUAL50007505536CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0C60F5D3-E107-48CC-B301-001DF513DA5EDoctoral Training Grant (DTG) to provide funding for 3 PhD studentships.ClosedNE/H526886/1Training GrantDoctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at https://www.ukri.org/apply-for-funding/how-we-fund-studentships/. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.2011-03-308A03ED41-E67D-4F4A-B5DD-AAFB272B6471NERC2009-09-30INCOME_ACTUAL71627NE/H526886/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0C7B57E9-2B50-4E12-863B-01EFA021D066Undestanding microbial communities through in situ environmental 'omic data synthesisClosedNE/L011956/1FellowshipThe purpose of this research is to integrate different sources of 'omics data in environmental science for microbial community analysis. The computational based comparative analysis of DNA sequences may provide information about genome structure, gene function, metabolic and regulatory pathways and how microbial genomes evolve. However, to fully delineate microbial activity and its response to environmental factors, it is necessary to include all levels of gene products, mRNA, protein, metabolites, as well as their interactions. I propose to use large-scale whole genome metagenomic sequencing for assessment of taxonomic and functional diversity of microbial communities. The data generated by metagenomic experiments are both enormous and inherently noisy, containing fragmented DNA sequences representing as many as thousands of microbial species. After using pre-filtering steps, including removal of redundant, low quality sequences, the short DNA sequences are assembled together into longer contigs of overlapping reads, and these contigs may then be scaffolded into full genomes in a bottom-up approach. Having obtained the assembled contigs, the obvious next step is to use publically available databases to annotate the coding regions in these contigs. This will tell us WHAT functionality is available and provide information on WHO is there, the metagenomic sequences are binned, i.e., by associating a particular sequence with an organism. This can be done by either searching for phylogenetic markers or by looking for similar sequences in existing public databases. The end result is the community profile of different samples in terms of organismal abundances within each sample. Whilst metagenomic analysis gives a profile of the microbial community at a specific place or time, and their potential functional, it does not reveal which genes are actually being transcribed. I thus propose to integrate sequencing-based metatranscriptomics in which total RNA (a proxy for gene activity) is extracted from microbial community, converted to cDNA and sequenced without the need for cloning. This will provide information on the regulation and expression profiles of complex communities by enabling quantitative measurements of dynamic expression of RNA molecules and their variation between different states reflecting the genes that are being actively expressed at any given time. However, the story is still far from complete, as we do not have direct evidence of the metabolism within a cell. To give a more complete picture of living organisms, I will integrate metabolomics which will provide unique chemical fingerprints that are a function of specific cellular activity. In particular, the focus will be on identifying habitat-specific endogenous and exogenous metabolites along distinct geochemical conditions. These metabolites will be detected using two-dimensional gas chromatography coupled with mass spectrometry. They will be related to the expression levels from transcriptomes using information on metabolic pathways readily available from annotating metagenomic sequences. In this way we will integrate all three sources of information, mapping the metatranscriptome onto the assembled annotated metagenomes and reconciling the reconstructed metabolic pathways with observations on metabolite concentrations and fluxes. From this we will be able to predict the metabolic function of the entire community not simply who is there.The removal of complex organic contaminants from soils will be one of the major environmental challenges facing the United Kingdom over the coming decades and recommendations based on this proposal will be of use to stakeholders especially, the remediation consultants, industry regulators i.e. SEPA and local councils. Brownfield development is an important part of the societal shift towards sustainability. Many contaminated brownfield sites sit unused for decades because the cost of cleaning them is more than the land would be worth after redevelopment. This research will impact on our ability to achieve sustainable reclaim of environmental capital and will allow adaptive re-usability. The Earth Microbiome Project has generated an enormous collection of data with the intention of producing a global Gene Atlas describing protein space, environmental metabolic models, and characterizing a global environmental parameter space for microbial communities. This global environmental sample database is an ambitious initiative that is community-driven. The tools developed in this fellowship will exploit this vast amount of information to provide useful insights on the Earth's microbiome and to catalogue all the microbes that live on earth. This will be of great benefit to mankind as whole, these microbes are performing vital functions, and to environmental researchers. Methanogenesis is a key process in the carbon cycle, methane is a more potent greenhouse gas than carbon dioxide, therefore understanding its metabolism at a community level is of fundamental importance if we are to incorporate microbial processes into models of climate change. Methane is an important greenhouse gas yet its production could play a part in the transition to a low carbon economy. Water treatment is the fourth most energy intensive sector in the UK and consumes approximately 1% of the UK's electricity. Reducing the energy required to treat wastewater would therefore have major benefits both by reducing costs and carbon dioxide emissions. Anaerobic digestion (AD) reactors have the potential to provide these benefits. They do not require the same energetically costly aeration as aerobic methods and through the action of methanogens produce biogas. Better understanding of methanogenesis could lead to more efficient AD reactors.2019-10-318A03ED41-E67D-4F4A-B5DD-AAFB272B6471NERC2014-11-01INCOME_ACTUAL425506The analytical tools led to the exploration and in turn development of a CD-TREAT diet for treatment of Crohn's Disease https://www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/76931and was published in Gastroenterology 20190D9510CA-6BEE-4A11-8C15-17D4CDE5D323SocietalEconomic56db53d617c9b4.68617352Agriculture, Food and Drink,Education,Environment,Healthcare,Pharmaceuticals and Medical BiotechnologyI established my Environmental'Omics lab in School of Engineering, University of Glasgow in November 2014 which specialises in developing novel pipelines for analysing genomic data in an environmental context. My lab is centered around my fellowship and focuses on microbial ecology at both mesoscopic and macroscopic scales by integrating 'omics data (metagenomics, metatranscriptomics, metabolomics, and metaproteomics) for microbial community analysis. Software (http://userweb.eng.gla.ac.uk/umer.ijaz/#bioinformatics): Under this grant I am developing software tools and methodologies to integrate different sources of omics data, namely, metagenomics, metatranscriptomics, metabolomics, and metaproteomics. Here are the list of major software I have contributed to during my fellowship: RvLab (R virtual Laboratory for ecological community analysis) Software:https://portal.lifewatchgreece.eu/ Reference: A. Oulas et al. Biodiversity Data Journal, 4, e8357, 2016.(doi:10.3897/BDJ.4.e8357) CONCOCT (A software for binning metagenomic contigs with coverage and composition) Software: https://github.com/BinPro/CONCOCT Reference:J. Alneberg et al. Nature Methods, 11(11):144-1146, 2014. (doi:10.1038/NMETH.3103) (PMID:25218180) TAXAassign (A bash based pipeline for generating taxonomic profiles using NCBI's Taxonomy) Software: http://www.github.com/umerijaz/taxaassign Reference: J. Alneberg et al. Nature Methods, 11(11):144-1146, 2014. (doi:10.1038/NMETH.3103) (PMID:25218180) NMGS (A software for fitting the Unified Neutral Theory of Biodiversity with Hierarchical Dirichlet Proces) Software: https://github.com/microbiome/NMGS Reference: K. Harris et al. Proceedings of the IEEE, 105(3):516-529, 2017 (doi:10.1109/JPROC.2015.2428213) seqenv (A pipeline capable of annotating genetic sequences with Environmental Ontology) Software: https://bitbucket.org/seqenv/seqenv/src Reference: L. Sinclair &amp; U. Z. Ijaz et al. PeerJ, e2690, 2016. (doi: 10.7717/peerj.2690) microbiomeSeq (An R package for microbial community analysis in an environmental context) Software: https://github.com/umerijaz/microbiomeSeq Tutorial/Demo: http://userweb.eng.gla.ac.uk/umer.ijaz/projects/microbiomeSeq_Tutorial.html SeqEnv-Ext (A taxa-centric extension to seqenv pipeline, which consisted of two parts, each providing environmental annotations under different context, with first part providing taxon abundance on a per term basis while the second part lists environmental term abundance under a per taxon context. A separately developed program that required the use of the original seqenv pipeline, this enabled two different methods of viewing environmental annotations, which significantly augments the analysis capability of the pipeline. Software: http://hie-pub.westernsydney.edu.au/0610b020-39fb-11e7-b55d-525400daae48/ Reference: A. Z. Ijaz, T. Jeffries, U. Z. Ijaz et al. PeerJ, 5:e3827, 2017. (doi:10.7717/peerj.3827) pyTag (A tool for identification and analyses of ontological terms in application area specific literature surveys) Software: https://github.com/KociOrges/pytag NanoAmpli-Seq (A workflow for amplicon sequencing from mixed microbial communities on the nanopore sequencing platform) Code: https://github.com/umerijaz/nanopore Reference: S. T. Calus, U. Z. Ijaz, and A. Pinto. bioRxiv 244517, 2018 (doi: 10.1101/244517) Orion Cluster: Without any institutional or dedicated technical support, I have single-handedly built and managed an HPC facility in Engineering called Orion Cluster (http://userweb.eng.gla.ac.uk/umer.ijaz/#orion). I bought first server in 2012 through the Unilever grant and since then I have religiously pursued my collaborators for in-kind contributions, as well as allocating small equipment budget on every grant I am applying. Five years later, I have spent ~&pound;114K on 13 servers with more equipment to be purchased in two months time through recently allocated &pound;22K (on SAIC) grant. Orion Cluster stands at an operational capacity of 368 cores, ~450TB disk space, and will serve &gt;70 PGR/T and staff (60 existing and regular users and hence the reason why I have an increasing supervision workload). This facility now sits at the heart of all major research groups I am involved with and is envy of many others. One of the reason why I have managed to attract funding and collaborators is through development of bespoke workflows (originating from my research) that I regularly updates and share on my website (http://userweb.eng.gla.ac.uk/umer.ijaz/#bioinformatics; http://www.tinyurl.com/JCBioinformatics; and http://www.tinyurl.com/JCBioinformatics2) as well as providing a single place for &gt;400 bioinformatics tools. My cluster and bioinformatics tutorials are of strategic importance Expansion to other technologies/hardware and award generation (http://userweb.eng.gla.ac.uk/umer.ijaz/#research_Grants): The developed tools/software methodologies and the research being conducted under my NERC fellowship was instrumental in getting further funding from numerous research councils. This includes recent expansion to population genomics and epidemiology (Scottish Infection Research Network/Chief Scientist Office Project entitled &quot;Molecular epidemiology of Clostridium difficile in Scotland: developing novel, clinically applicable research methods to combine genomic analysis with health informatics&quot;). For the past one year, I am trying to put my engineering experience to good use, by expanding my research to include: Raman spectroscopy enabled microfluidics (NERC NE/P003826/1 grant entitled &quot;Stable Isotope Probing with Resonance Raman Cell Sorting to profile influence of ocean acidification on microbial carbon fixation&quot;); hardware system integrating liquid handling, incubation and sensing with an embodied genetic algorithm, which directs evolutionary optimisation of microbial growth (with Professor William T Sloan, University of Glasgow; EPSRC Global Challenges Research Fund EP/P029329/1); and development of artificial intestinal Salmon gut system through bioreactors (BBSRC BB/P001203/1 grant entitled &quot;A microbial basis for Atlantic Salmon energetics&quot;). Supervision (http://userweb.eng.gla.ac.uk/umer.ijaz/#supervisions): I have been directly involved with the supervision of 13 PhD students and 2 PDRAs (with more to be recruited). Two PGR students (Caitlin Jukes, and Asha Rani) have recently defended their viva successfully. All of my supervisions involve utilisation of tools developed under my NERC grant. Repute: I have gained considerable repute at both national and international levels. I am collaborating widely with academics located in Manchester, Warwick, Dundee, Aberdeen, Liverpool, Norwich, Reading, London, Belgium, Finland, Greece, Norway, Ireland, Austria, Thailand, Czech republic, Australia, Germany, France, and Netherlands. As a consequence I have been invited to visit/speak at numerous institutes including: Faculty of Science, Cesk&eacute; Budejovice; Helenic Centre for Marine Research, Greece; Centre for Microbial Ecology and Technology, Ghent, Belgium; Edinburgh Amplicon Sequencing Group; Earhlam Institute (formerly TGAC); Unilever R&amp;D laboratories (Colworth/Port Sunlight); London School of Hygiene and Tropical Medicine; and Health Informatics Centre Dundee. My research leadership potential was recognized by NERC who funded me to attend a &pound;23,100 advanced leadership course in Cambridge.Please see the section on &quot;What have you discovered or developed through the research funded on this grant&quot;82EEF600-34B3-4677-A72F-564B37CF3C0A56db4f3db020b5.66717896Agriculture Food and DrinkDigital/Communication/Information Technologies (including Software)EducationHealthcarehttp://userweb.eng.gla.ac.uk/umer.ijazAmplicon sequencing on Illumina sequencing platforms leverages their deep sequencing and multiplexing capacity, but is limited in genetic resolution due to short read lengths. While Oxford Nanopore or Pacific Biosciences platforms overcome this limitation, their application has been limited due to higher error rates or smaller data output. In this study, we introduce an amplicon sequencing workflow, i.e., NanoAmpli-Seq, that builds on Intramolecular-ligated Nanopore Consensus Sequencing (INC-Seq) approach and demonstrate its application for full-length 16S rRNA gene sequencing. NanoAmpli-Seq includes vital improvements to the aforementioned protocol that reduces sample-processing time while significantly improving sequence accuracy. The developed protocol includes chopSeq software for fragmentation and read orientation correction of INC-Seq consensus reads while nanoClust algorithm was designed for read partitioning-based de novo clustering and within cluster consensus calling to obtain full-length 16S rRNA gene sequences. The datafiles and protocols provided here represent the intermediate files during data processing and associated detailed workflow.7A32DB19-A404-4195-9218-220EF5A7713FB0282B32CAAtrueSupporting data for "NanoAmpli-Seq: A workflow for amplicon sequencing for mixed microbial communities on the nanopore sequencing platform."Database/Collection of data2018This article presents metagenomic-assembled genomes (MAGs) of prokaryotic organisms originating from chicken caeca. The samples originate from broiler chickens, one group was infected with Newcastle Disease Virus (NDV) and one uninfected control group. There were four birds per group. Both groups were raised on commercially available antibiotic free feed under a semi-controlled setup. The binning step of the samples identified 130 MAGs with50% completion, and10% contamination. The data presented includes sequences in FASTA format, tables of functional annotation of genes, and data from two different approaches for phylogenetic tree construction using these MAGs. Major geochemical cycles at community level including carbon, sulfur, and nitrogen cycles are also presented.90B9AC9B-2955-4EF9-BC4A-6667E669C9F265a5a993843e80.18637899true<b>Dataset of 130 metagenome-assembled genomes of healthy and diseased broiler chicken caeca from Pakistan</b>Database/Collection of datahttps://figshare.com/articles/dataset/_b_Dataset_of_130_metagenome-assembled_genomes_of_healthy_and_diseased_broiler_chicken_ceca_from_Pakistan_b_/249018782024AD5DE8C6-3D34-46D7-85A9-CB2EE2736F87Microbial Influencers and Cotton Leaf Curl Disease (CLCuD) susceptibility: A network perspectivebc32f3a8cc40351683169581b006a88dAqueel R2024-01-0167528aff424239.91837029D503DAAB-9903-4285-ABF4-00EFB3D131EFBacterial diversity along a 2600 km river continuum12c967eac14a8bb6c3d9f72489cc9e57Savio D2014-01-0156db4d982a3dc1.873105713AA7B117-915B-49C9-B48E-C42FE6C65280Analysis of 61 exclusive enteral nutrition formulas used in the&nbsp;management of active Crohn's disease-new insights into dietary disease triggers.Alimentary pharmacology & therapeutics4146c13ab42c36eb8f95381540ba3073Logan M2020-01-010269-28136023de9f43a1e5.738528822F3F9092-4268-4CB7-A30D-81D90546C9B4Additional file 4 of Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-0165e8e7b6e474e6.821156221389C83C-6291-44FA-BA0C-03B48EDA93BDA prospective study on linking diarrheagenic E. coli with stunted childhood growth in relation to gut microbiome.Scientific reports7f2f30a3b1d435bc063bb9a7cfd90b75Aziz I2023-01-012045-232264490f2ecaad40337647B-96DE-4C30-951F-42BEF47C4C1BSeqenv: linking sequences to environments through text mininge506342dcf52c1c6e1b4a7839ce2ca75Sinclair L2016-01-0167526c3a23fc37.2950897117C7E2C4-B8F5-4486-B059-B9FD39B41EC0P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn's disease patients who adhered to the CD-TREAT diet and responded by calprotectin.Journal of Crohn's and Colitisd7345234614416bb9bd579b4d96b81e4Svolos V2023-01-0163dc07a5a370fDAA79C97-D3F8-46EA-8586-9A5DC23307EFMetagenomic Sequencing Unravels Gene Fragments with Phylogenetic Signatures of O2-Tolerant NiFe Membrane-Bound Hydrogenases in Lacustrine Sediment.Current microbiologybe94d5eb9393a826452c381fc2cb9789Couto JM2015-01-010343-86515675e5e906740669A417D-7040-46D8-89F8-5C99ABE97618Assessment of the influence of intrinsic environmental and geographical factors on the bacterial ecology of pit latrines.Microbial biotechnology8703ad164021168fbb518a8586736317Torondel B2016-01-011751-791556db4d97b6de43.187119185E684998-A49D-4B35-BEAC-6057022D9A01Bioreactor Scalability: Laboratory-Scale Bioreactor Design Influences Performance, Ecology, and Community Physiology in Expanded Granular Sludge Bed Bioreactors.Frontiers in microbiologyd3511033c1f7a8f7a6513110b6910a5fConnelly S2017-01-011664-302X5a661483380892.544809443FE26FB1-104A-43D9-B649-B9A8CF2C8B47Molecular 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of Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-0165e8e7e002ff86.65341696681938B5-006D-46E0-83DA-4475DB1B283EMdaB and NfrA, Two Novel Reductases Important in the Survival and Persistence of the Major Enteropathogen Campylobacter jejuni.Journal of bacteriologydd4798bd654736ef3a72d32bd9c6c502Nasher F2022-01-010021-9193616596600a7320CFC2F47-D447-4174-BB8A-26EDDBDB78CCIndividual methanogenic granules are whole-ecosystem replicates with reproducible responses to environmental cues.Environmental microbiomec49c8e05d15160edb97d85e408c9fd1bTrego A2024-01-012524-637266fc21be995590.60255943FCB9FBDD-361F-4F86-8BA2-903AF713049DComprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for Campylobacter.Frontiers in microbiology3c5d0b2967e8b09d545e2deb131e89f6Ijaz UZ2018-01-011664-302X5e3c33e923f158.72314874B7CFB80C-841C-427F-BF29-17969A53887FTerminal restriction fragment length polymorphism is an &quot;old school&quot; reliable technique for swift microbial community screening in anaerobic digestion.Scientific reports39207eeeb3e0ec22ec112980ea9a6788De Vrieze J2018-01-012045-23225c5aba21094629.971870375053252A-B101-4211-B9DE-B9020E76F0AAOptimized R functions for analysis of ecological community data using the R virtual laboratory (RvLab).Biodiversity data journalbe2a94fc825354e834eb05a8745e7180Varsos C2016-01-011314-2828589482abecdb27.78714439136826B9-D43C-4C0F-8E6E-6559F45B61BAIllumina error profiles: resolving fine-scale variation in metagenomic sequencing data.BMC bioinformatics596d9dfa2eaaf473b1e4dc87210b939dSchirmer M2016-01-011471-2105589482aca6c1d9.537113140A0B84FC-3D28-4E84-B65E-7E615CB235FEA prospective study on linking diarrheagenic E. coli with stunted childhood growth in relation to gut microbiomefb59bfc4867c742b2174168e75d99ebeI. Ab Aziz2023-01-0166a895d347d409ADB4654-E8D5-478E-B879-4CBDCEB786B3Linking Statistical and Ecological Theory: Hubbell's Unified Neutral Theory of Biodiversity as a Hierarchical Dirichlet ProcessProceedings of the IEEE1fa8ef0e8045ee05324b9c8e75169e76Harris K2017-01-015536d3637b4077.82054936C8737949-DDC5-404A-826A-CD10F1768734Dietary Triggers of Gut Inflammation Following Exclusive Enteral Nutrition in Children with Crohn's Disease: A Pilot Study7d782475214c1e77b1f4c44845973befGkikas K2021-01-0160fecb64cbf181B7B6F23-EF9A-4907-B9C5-776BE452CF72Response and oil degradation activities of a northeast Atlantic bacterial community to biogenic and synthetic surfactantsMicrobiome61ac1dc6db0e8a5735887de507ea5c31Nikolova C2021-01-012049-2618614c29f75296b823BFA72-8D98-4CCC-9652-DEEDD4692FB8Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori -induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor useee380db2dd0572ff1f27c88b0e07f243Parsons B2017-01-01602718da27d4723D5CEB7-4F79-475F-A249-29A46040B1B3Additional file 8 of Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-0165e8e7a5cb7374.78103932D278E1E1-9295-4496-ADF2-1AC4BAE159BEGrowth and Break-Up of Methanogenic Granules Suggests Mechanisms for Biofilm and Community Development.Frontiers in microbiologya97ab20d06486826771a13be390cc515Trego AC2020-01-011664-302X6023df4d82b835.316907204E1C75A0-6A41-4A1A-A504-BC18928DEF25Emerging investigators series: microbial communities in full-scale drinking water distribution systems - a meta-analysisEnvironmental Science: Water Research & Technology3bf3bace9d94ea130939e341c0f5b065Bautista-de los Santos Q2016-01-01589482acd19003.3320716724EC4F9D-28A2-4393-8C05-E7BEA5978045Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-01602717e100d2f83073A64-3EDF-485B-A47A-D3C09F113E02Additional file 7 of Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-0165e8e7b003eb91.70146720CA09FA4E-2945-411D-BB58-3B8F2EC21718Temporal changes in the gut microbiota in farmed Atlantic cod ( Gadus morhua ) outweigh the response to diet supplementation with macroalgae17af8dd4a59a944e9d8515761540a353Keating C2020-01-01602717b48c843B7C865C8-C97C-4FD7-B69B-53DED71D5A76Host-microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intakeBritish Journal of Nutrition687a9ee4731147702ef3139511110ff0Pedersen C2016-01-010007-1145589482ad1b3518.81218164BF781276-BA8E-4CE3-BCD8-B7451DC7CF99Bioreactor scalability: laboratory-scale bioreactor design influences performance, ecology, and community physiology in expanded granular sludge bed bioreactorsd3511033c1f7a8f7a6513110b6910a5fConnelly S2017-01-0167526b0fcff079.5628025489EED3B9-51FA-4D97-B16C-DC789F166482Temporal stability and community assembly mechanisms in healthy broiler cecum.Frontiers in microbiology925dce5bd100310f214d8772867fae3fAmeer A2023-01-011664-302X65c36129929520.699992747642FC10-A231-4235-873C-529674027BE2Linking microbial community structure and function during the acidified anaerobic digestion of grassf0daad434060fd5eb8027acc38087e5dJoyce A2018-01-0167526bf8671ab8.122391439A08ED77-AE79-4C98-9A35-BDCBD87E3971Analysis of pit latrine microbiota reveals depth-related variation in composition, and key parameters and taxa associated with latrine fill-up rate4b41deb51497fa0019816de7ecbb0828Umer Zeeshan Ijaz2022-01-016752824651a7a3.564764544363AABB-7972-4319-AB7C-448BCFF27577Additional file 2 of A comprehensive benchmarking study of protocols and sequencing platforms for 16S rRNA community profiling8e1eeaf0112eb212b235f054c78094ffDâ??Amore R2016-01-0167526b0aa52a76.77767089712908AE-6148-44B7-B9FB-2B39B88AAFE8Reverse transcriptase enzyme and priming strategy affect quantification and diversity of environmental transcripts.Environmental microbiology88c82403c77579dd7f204f2c5d7c2d77Cholet F2020-01-011462-29126023df3fdc16f6.16964328FB47F53F-0A64-48EF-A800-D3A7507ACE88Temporal changes in the gut microbiota in farmed Atlantic cod (Gadus morhua) outweigh the response to diet supplementation with macroalgae.Animal microbiome17af8dd4a59a944e9d8515761540a353Keating C2021-01-012524-4671602717af47e7111E53A0E-EBB9-4772-8363-09BDB09B1D93Terminal restriction fragment length polymorphism is an &quot;old school&quot; reliable technique for swift microbial community screening in anaerobic digestion39207eeeb3e0ec22ec112980ea9a6788De Vrieze J2018-01-0165e8eb2524d5e6.39333812AB3BFEDF-3385-4C18-B828-103AE97CB42EDisinfection exhibits systematic impacts on the drinking water microbiome257749f715b398b71deec930dc78d7a3Dai Z2019-01-01602717fd3b4feF06DEF9A-D3D9-4A32-A7CB-AB081783C200Response and oil degradation activities of a northeast Atlantic bacterial community to biogenic and synthetic surfactants61ac1dc6db0e8a5735887de507ea5c31Nikolova C2020-01-0160271928aa8fcE8F2862E-1E89-43D3-8AD2-C07168483AF8Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter.Microbiome33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-012049-26185f852f9dd975d3.656171095EC46325-C122-4396-967C-D969D2383478SalmoSim: The Development of a Three-Compartment In Vitro Simulator of the Atlantic Salmon GI tract and Associated Microbial Communitiesbd8899b572ba2cff70a3204d25097102Kazlauskaite R2021-01-0167527d5dd0bcd2.90019562EB322CE1-7F01-4434-88ED-9C862EB5E071An automated identification and analysis of ontological terms in gastrointestinal diseases and nutrition-related literature provides useful insightsPeerJ592e1ddfe7dfc345bf8f35baa0882163Koci O2018-01-012167-83595c5aba0b5ca0e2.2715929907B7857D-9D1D-4919-8685-87E43FD31A1EGut metabolome and microbiota signatures predict response to treatment with exclusive enteral nutrition in a prospective study in children with active Crohn's disease.The American journal of clinical nutrition5ca7b1bb586940a4e6b03c3eb9275dbaNichols B2024-01-010002-9165662262e4ea55a0.7712777772B9F837-98A3-4618-B0A1-63D5484B8D05First evidence for temperature's influence on the enrichment, assembly, and activity of polyhydroxyalkanoate-synthesizing mixed microbial communitiesFrontiers in Systems Biologyc49c8e05d15160edb97d85e408c9fd1bTrego A2024-01-01675288f39dd0a2.78388107EC69DE85-A6A9-45C1-85C6-BDFD0EC8C816An automated identification and analysis of ontological terms in gastrointestinal diseases and nutrition-related literature provides useful insights592e1ddfe7dfc345bf8f35baa0882163Koci O2018-01-01602718c58a16691043722-0403-4898-8036-93378586934FDietary triggers of gut inflammation following exclusive enteral nutrition in children with Crohn's disease: a pilot study.BMC gastroenterology7d782475214c1e77b1f4c44845973befGkikas K2021-01-011471-230X61ac3c19c8aacB9BADE53-533A-4AFE-AA75-2C1F8919A06EAdditional file 1 of Community recovery dynamics in yellow perch microbiome after gradual and constant metallic perturbationsebf4406f047e3e8937b4f5853015c88dCheaib B2020-01-0165e8e89361f5d4.462614720BF6B207-9486-45EF-8999-7FAE9B4634B1A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated Clostridium difficile PCR Ribotype 078.mBio384f794748bc85c2fc08a066092b27a1Dingle KE2019-01-015e3c332ac7e903.813980159573986B-1B87-405A-B6A6-2D0B0C91BE97Assessment of the influence of intrinsic environmental and geographical factors on the bacterial ecology of pit latrines29f43963559065d949816972cfbe29e9Belén Torondel2016-01-016694c6ea77cd23A7197DB-354C-414A-BEA5-DACCDA3D1AE4Additional file 10 of Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter33ac40eabdbbe3c78670b76114ce3d1aMcKenna A2020-01-0165e8e7dc04b709.63263041FFEF24C8-D2E4-45F4-AC1B-066CB55CCC2CComprehensive longitudinal microbiome analysis of the chicken cecum reveals a shift from competitive to environmental drivers and a window of opportunity for Campylobacter45bd288f291517f9c4ab0972a477cb2fIjaz U2018-01-01602718baea831NE/L011956/1F673FD2B-013B-47E5-9E62-03BAB1E7348E10Environmental engineering4CCA4C04-0C28-41BE-8869-FA6391A7F00520Microbial sciences29F3DF16-3094-4F79-BC69-8D05FB55182670Omic sciences & technologies513702B4-7C48-41F2-A1A0-8B4E8BEDCABC10Assess/Remediate ContaminationC6A85141-ED79-4266-86E5-F6D25217C97F40Environmental GenomicsAF3F5E7C-7FB6-4588-9174-6018BA2A231B20Environmental Microbiology7E61B40B-93E5-4D69-8C89-426ED7E0D2B420Metabolomics / Metabonomics937A9F23-021A-4604-8979-A28E0E04F82510Transcriptomics0C8BB41D-B4B5-4A91-B6AA-00D48582C5AEReal-time prediction of cellular states in 3D lattice light sheet microscopyClosed2430216StudentshipProgramme overview: This MRC-funded doctoral training partnership (DTP) brings together cutting-edge molecular and analytical sciences with innovative computational approaches in data analysis to enable students to address hypothesis-led biomedical research questions. This is a 4-year programme whose first year involves a series of taught modules and two laboratory-based research projects that lead to an MSc in Interdisciplinary Biomedical Research. The first two terms consist of a selection of taught modules that allow students to gain a solid grounding in multidisciplinary science. Students also attend a series of masterclasses led by academic and industry experts in areas of molecular, cellular and tissue dynamics, microbiology and infection, applied biomedical technologies and artificial intelligence and data science. During the third and summer terms students conduct two eleven-week research projects in labs of their choice. Project overview: Lattice light sheet microscopy (LLSM) is a new technology to visualise fast cellular processes at the time scale of 1 second, in 3D. LLSM is very low through-put however, limiting its use for studying rare events, such as cell divisions. In close collaboration with industrial partner Intelligent Imaging Innovations Ltd. (3i), suppliers of LLSM, we will develop an integrated imaging pipeline to classify and anticipate physiologically meaningful events during the cell cycle using state of the art machine learning. The main goal is to 1) enable automated control of the image acquisition and increase its throughput, and 2) make it possible to analyse statistically significant numbers of well-defined cellular events and their progression from an early stage, which often go unnoticed by even the most expert human experimenter. Enabling detailed spatio-temporal analysis of the 3D imaging data will help to better understand the timing and control of different stages of cell division and recognise more subtle defects in cell division which can affect development or diseases such as cancer where divisions occur uncontrolled. This is an interdisciplinary project at the interface of cell biology, computer science and engineering, enabling fundamental science to improve human health through world-class biomedical research. Health focus is enabling biological research into genetic risk and disease mechanisms, aiming at new strategies for early diagnosis and treatment. The specific training the student will receive is geared towards quantitative and interdisciplinary skills and understanding of whole organism physiology in addition to that of single cells in the main project. The training in advanced machine learning and computing addresses the demand for team scientists and technology specialists and will help to build new software technologies and imaging instruments that will become available to the biomedical community in the future.2024-12-30C008C651-F5B0-4859-A334-5F574AB6B57CMRC2020-10-04INCOME_ACTUAL024302166CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0C8EFA4E-C025-4E68-9E67-009F0D44E7B4Molecular recognition in post-transcriptional regulation 2ClosedMC_PC_13051IntramuralThe functioning of the human body and of complex organisms in general requires different proteins to be produced in different types of cells. This cell-type-specific protein production is achieved by precisely regulating the translation of the genetic code into proteins. The two steps in this process of translation are, first, the translation of the DNA-encoded information into RNA and, then, the translation of the RNA code into a protein molecule. Both processes are regulated by biological machines, which are composed of proteins and, in some cases, RNA molecules. We focus on the regulation of the RNA-to-protein step (or post-transcriptional regulation) and investigate how the protein RNA machines assemble in a solution environment and regulate gene expression. Our structural studies complement other techniques such as X-ray crystallography, which can be used to study molecules in a static crystalline state. Analysing the structures of the molecules that govern regulation of protein synthesis has a direct medical relevance, as this process lies at the basis of common genetic diseases, cancer and viral infections. We work on an important regulatory mechanism, called ARE mediated mRNA decay (AMD), that increase the synthesis of specific proteins in inflammation and healing processes. This mechanism, if permanently switched on, can lead to inflammatory arthritis and cancer. We want to understand how the switch works at the molecular level and design specific therapies to switch in off when required.||Using a similar technical approach we are also investigating a key regulatory protein from herpes virus. This project wants to facilitate the design of anti-herpes drugs to treat people infected with this virus, which forms a major threat to immunodepressed patients, increases the risk of organ transplantation and chemotherapy and reduces the life expectancy of AIDS sufferers. Molecular insight into the interaction of ICP27 with its functional binding partners needs to be obtained if we are, for example, to design or optimise compounds to lock protein and RNA in a non-functional conformation or to (de)stabilise protein RNA complexes.Multifunctional eukaryotic regulatory proteins and their viral functional equivalents control gene expression by interacting with mRNAs in large macromolecular aggregates. Dissection of the molecular basis of post-transcriptional regulatory mechanisms has a direct medical relevance, as changes in the regulation of mRNA metabolism lie at the basis of common genetic diseases, cancer and viral infection. Current therapies for these diseases do not focus on the post-transcriptional steps of regulation but rather on the transcriptional ones, that are better understood. Our aim is to clarify the structure-function relation that is at the basis of mRNA recognition by post-transcriptional regulatory proteins and to suggest strategies to control this recognition. Adenine-uracil-rich element (ARE)-mediated mRNA decay (AMD) regulates the concentration of mRNAs that contain AREs within their 3 untranslated regions (3 UTRs) by promoting their degradation. Transient AMD shut-off up-regulates the stability of these mRNAs and is important for processes that require a fast response of the organism such as cellular growth, immune response, cardiovascular toning and external stress-mediated pathways. However, impaired AMD and the consequent pathological long-term increase in the stability of a subset of mRNAs have been related to several types of cancer (skin tumours, colorectal cancer, Hodgkins lymphoma, lung carcinoma and leukaemia) and auto-inflammatory diseases (Crohn-like inflammatory bowel disease and inflammatory arthritis). K-homology splicing regulator protein (KSRP) is an important player in AMD that interacts with several different AREs mediating the degradation of the corresponding mRNAs. Our work centers on the analysis of the structural and functional elements that contribute to KSRP-RNA interactions and to mRNA degradation. We are studying the structure and dynamics of the different domains of the protein and investigated their relationship to mRNA degradation. Using structural and functional information, we plan to dissect the details of the interaction with the RNA and help the design of a strategy for the tuning of KSRP activity. Herpes viridae induced infections are a major threat to immunodepressed patients, increasing the risk of transplants and chemotherapy and reducing the life expectancy of AIDS sufferers. Current herpes virus therapies (e.g. Acyclovir) aim to block the synthesis of new DNA, but resistance to these treatments is increasing. Successful viral replication is achieved through the tightly regulated expression of viral genes. A key component of the regulatory mechanism is ICP27, an essential HSV-1 RNA binding protein that regulates protein expression, both at the transcriptional and post-transcriptional level. We will study both ICP27 and the mechanism of post-transcriptional regulation acted upon by this protein, in particular 3 mRNA editing. Using the same strategy described above for the protein KSRP, we will obtain a better understanding of the regulatory cycle of the virus and define specific structural features amenable to structure-aided drug design.2017-03-30C008C651-F5B0-4859-A334-5F574AB6B57CMRC2013-09-30EXPENDITURE_ACTUAL894993Francis Crick InstituteUnited KingdomIMP1 structure and function87A7B8D1-CC50-4EAE-9636-700E96708178PMID: 28147274 This is a a multi-disciplinary collaboration.56c5e1a073e070.46559036-3University of Freiburg - genomic analysis UCL - functional analysis Crick - biophysical modelling and use of facilitiesstructural and functional analysis of IMP1 interactions with the protein and RNA partnersAcademic/University2015-01-01Sapienza University of RomeItalyDepartment of ClassicsMolecular basis of syncrip-RNA recognition533A78FF-FED9-4C0F-9D7A-E52FD3799271This is a multi-disciplinary collaboration. A paper has been published this year.56c4aeb30f1bb7.96532939-2provided information on the interaction between the Syncrip protein and cellular mRNA, provided some original clonesAll the molecular and structural biology workAcademic/University2014-01-01University College LondonUnited KingdomInstitute of Structural and Molecular BiologyDevelopment and application of NMR methods for the study of macromolecular complexesF9945898-594F-40A7-9913-5C66F7D846A3PMID: 25586222; PMID: 23142982; PMID: 20711187; PMID: 20385598; PMID: 19198587; PMID: 17437720; PMID: 16407062; PMID: 15929005; PMID: 15665873; PMID: 2710977656c5d533987dc3.48976039-2intellectual input, recording and processing of experiments, data analysis. Recent we started a collaboration on a related problem with the group of John Christodoulou in UCL, SMB where we provided data and intellectual input and the Chrristodoulou group provided the framework of analysis.Framework, samples, intellectual input, recording and processing of experiments, data analysisAcademic/UniversityUniversity of TorontoCanadaRBM10 RNA recognition and mRNA metabolism1C4E0AE1-6BC4-407D-B7A0-4AB01FC22ACFThis is a multi-disciplinary collaboration. the paper is under review56c4b056b37422.01334175-3Bioinformatic work, functional splicing assays - Kings College Support with X-ray crystallography work - Crick Institute University of Toronto - RNAcompete assaysMolecular and structural work on RBM10 structure and RBM10-RNA recognitionAcademic/University2015-01-01Francis Crick InstituteUnited KingdomRBM10 RNA recognition and mRNA metabolism12521AF1-90F5-456D-802C-0F69EB21BBB3This is a multi-disciplinary collaboration. the paper is under review56c4b056b37422.01334175-2Bioinformatic work, functional splicing assays - Kings College Support with X-ray crystallography work - Crick Institute University of Toronto - RNAcompete assaysMolecular and structural work on RBM10 structure and RBM10-RNA recognitionAcademic/University2015-01-01Medical Research Council (MRC)United KingdomMRC Biomedical NMR CentreDevelopment and application of NMR methods for the study of macromolecular complexes32F037DB-2059-4AD8-9D15-3C0883F6A6B1PMID: 25586222; PMID: 23142982; PMID: 20711187; PMID: 20385598; PMID: 19198587; PMID: 17437720; PMID: 16407062; PMID: 15929005; PMID: 15665873; PMID: 2710977656c5d533987dc3.48976039-1intellectual input, recording and processing of experiments, data analysis. Recent we started a collaboration on a related problem with the group of John Christodoulou in UCL, SMB where we provided data and intellectual input and the Chrristodoulou group provided the framework of analysis.Framework, samples, intellectual input, recording and processing of experiments, data analysisPublicUniversity College LondonUnited KingdomiCLIP studies of multi-domain protein-RNA recognition0739CB47-61FA-49B5-AD70-331460D56605This is a multi-disciplinary collaboration, the outputs are to come56c4ad5e22b845.36509193-1provide expertise for designing iCLIP experiments, sequencing, co-analysing iCLIP the datadesign of protein mutants, all cell biology studies, performing iCLIP, co-analysing iCLIP dataAcademic/University2013-01-01Albert Ludwig University of FreiburgGermanyIMP1 structure and functionA3EB2A82-BCEF-4E9B-9150-CCCE26750818PMID: 28147274 This is a a multi-disciplinary collaboration.56c5e1a073e070.46559036-1University of Freiburg - genomic analysis UCL - functional analysis Crick - biophysical modelling and use of facilitiesstructural and functional analysis of IMP1 interactions with the protein and RNA partnersAcademic/University2015-01-01University of OxfordUnited KingdomMolecular basis of syncrip-RNA recognitionC18F7FEA-FE4E-4059-9D83-07B263FF544AThis is a multi-disciplinary collaboration. A paper has been published this year.56c4aeb30f1bb7.96532939-1provided information on the interaction between the Syncrip protein and cellular mRNA, provided some original clonesAll the molecular and structural biology workAcademic/University2014-01-01University College LondonUnited KingdomIMP1 structure and function95EE642B-4C1B-4025-BCBD-D5C6278F044BPMID: 28147274 This is a a multi-disciplinary collaboration.56c5e1a073e070.46559036-2University of Freiburg - genomic analysis UCL - functional analysis Crick - biophysical modelling and use of facilitiesstructural and functional analysis of IMP1 interactions with the protein and RNA partnersAcademic/University2015-01-01University College LondonUnited KingdomInstitute of NeurologyIMP1 structure and function678CB8C6-2C27-4F4C-AEB1-28E47206145CPMID: 28147274 This is a a multi-disciplinary collaboration.56c5e1a073e070.46559036-4University of Freiburg - genomic analysis UCL - functional analysis Crick - biophysical modelling and use of facilitiesstructural and functional analysis of IMP1 interactions with the protein and RNA partnersAcademic/University2015-01-01King's College LondonUnited KingdomRBM10 RNA recognition and mRNA metabolismC76B3BD7-755B-4831-942D-3F836C17EE6DThis is a multi-disciplinary collaboration. the paper is under review56c4b056b37422.01334175-1Bioinformatic work, functional splicing assays - Kings College Support with X-ray crystallography work - Crick Institute University of Toronto - RNAcompete assaysMolecular and structural work on RBM10 structure and RBM10-RNA recognitionAcademic/University2015-01-01Established and continuously run the London RNA clubA formal working group, expert panel or dialogueRegional273D958F-294D-498D-9291-034ED92F0761We have set up a London RNA Club as a forum for the London RNA community. No such forum existed previously. We have designed a webpage for the forum: http://londonrnaclub.uk/. We have run the forum since. This has brought together the London RNA community545b6eabdb5169.42150100falsePostgraduate studentshttps://londonrnaclub.uk/2014,2016,2018,2020,2022,2024221606BelgiumEURAustriade_ATResearch Executive Agency (REA)Marie Curie FP72016-09-01European Commission6269202BAFE155-05D8-44D8-B5B6-114573A059E1545b6af4058da1.34889161Public2014-08-311500000United KingdomGBPUnited Kingdomen_GBWellcome Trust Institutional Strategic Support FundWellcome Trust Institutional Strategic Support Fund UCL2015-06-01Wellcome Trust097815/Z/11/B7E315A82-B319-4920-8931-170479ED424B58bd85ba8c9cd1.04509675Charity/Non Profit2014-03-318D3F2239-1772-4594-AF1A-3A34E8C23BE065dfa25de61653.72163795trueNMR solution structure of Hml-2 C-terminal dimer domainDatabase/Collection of datahttps://bmrb.io/data_library/summary/?bmrbId=344192020High-throughput analysis of protein-RNA interactions using Scaffold Independent Analysis and Principal Component AnalysisE8BE422A-2637-4543-A813-E63E636A08FDThis is a new tool. In the group has allowed to analyze a large number of protein-RNA binding domains56c5dafc78c804.77202397falseHigh-throughput analysis of protein-RNA interactionsTechnology assay or reagentA tool to extract kinetics and affinity information from 2D NMR lineshape analysis during a titration. This work is a collaboration with John Christodoulou's group.05963283-90B7-4041-AEB4-6EDD9CE7704AMore than 100 users have visited the site.58ab5cf99b85d1.26842435true2D NMR lineshape analysisTechnology assay or reagent2016This is a macro within the NMRPipe program to process NMR spectra and implement a PCA analysis. as described in the DOI below.5F934F07-D0E6-4D31-AE9A-6EEA21B5473DThe macro has been requested from groups in the US and Canada58bd82cabf8129.26293908Macro for the PCA analysis of NMR spectraSoftware2015C38C688D-D914-49EC-BB51-475E82E11184The structure of the RbBP5 ß-propeller domain reveals a surface with potential nucleic acid binding sites.Nucleic acids research9042c8bdaebefcbe423a3bc8f9fc4cfaMittal A2018-01-010305-10485c5a255495a8b4.1461524716E0AD5C-5629-4FEA-8A75-791B8B36A43FA method for the unbiased and efficient segmental labelling of RNA-binding proteins for structure and biophysicsScientific Reports6914c87992e85b96609ba8f459dd498bGallagher C2017-01-012045-23225a95c65a6a0c98.8153463562770E81-B411-41EB-9C31-E799B87A1A9EThe distinct RNA-interaction modes of a small ZnF domain underlay TUT4(7) diverse action in miRNA regulationf6080d8482a5ff56c1d1c982c0fca036Chaves-Arquero B2021-01-0165e8b580df4d67.411591850AB28424-E240-4D5C-A3C4-E7967A53A668IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling propertiesf58f8f41e9784651d8c4566c1aae0f18Dagil R2019-01-0165e8c4e5be4bf1.33976350A3777FE6-ABC5-4AC2-94AA-17FE0D9AA88BMechanism of ß-actin mRNA Recognition by ZBP1.Cell reports90c323ba11b74c906d70b5f1a25642cbNicastro G2017-01-0158ab4c96dddda7.953448759B260151-00F2-4EC1-9AF1-67243F10E59CThe distinct RNA-interaction modes of a small ZnF domain underlay TUT4(7) diverse action in miRNA regulation.RNA biologyf6080d8482a5ff56c1d1c982c0fca036Chaves-Arquero B2021-01-011547-62866189b164a6c7d935B7785-74D4-4E4B-8C72-DA3AF593A8B5Two-Dimensional NMR Lineshape Analysis.Scientific reportsd04f57d1cb87f1ede0d6e8a3bec0257aWaudby CA2016-01-012045-232258ab4c978ee724.06035541B12AEB99-3F31-4DBE-ACDA-5407602B5B9AStructure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid.PLoS pathogens5d530841f4562583ab7c134d1c6836a6Ball NJ2016-01-011553-736658ab4c9741b4b4.383931363010F903-0A79-44F7-93AE-D0A08B6E412EKSRP controls pleiotropic cellular functions.Seminars in cell & developmental biology1ddb3a12d81c9a64e05315087eb95337Gherzi R2014-01-011084-9521545b451b43cb30.9137380114B43B2B-4262-45D2-8FAA-DFB8E96DAF4FJoining the dots - protein-RNA interactions mediating local mRNA translation in neurons.FEBS letters6914c87992e85b96609ba8f459dd498bGallagher C2018-01-010014-57935b658b85aaf7b2.35361743F58533AA-C58D-4AF6-A7A2-D1A98245F012Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.RNA (New York, N.Y.)14f5685f49d9cb8c69a7ea1537471102Nowak JS2017-01-011355-838258ab4c971529d3.61490418F35DEE53-0790-4F4F-B683-8B88B86EE1CEProtein-RNA specificity by high-throughput principal component analysis of NMR spectra.Nucleic acids research802d43177e3f8cfcaa9b06c0bebc6ca6Collins KM2015-01-010305-104856c4a99f72b7e2.883821037575FB2A-5815-4400-9008-BDEE6D21B805The devil is in the domain: understanding protein recognition of multiple RNA targetsBiochemical Society Transactionse934d4babaae7c0f8a2cc96ae349fd5bGronland G2017-01-010300-5127644a472533c979.7550574316CCF2B8-DDFC-46BD-81EE-A2E1692B39C6Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.PLoS biologyd87383292ff314baabba8e48b3e9fc3aPatel A2019-01-011544-91735e2f1b15891f41.5501969550B02DAA-9E3C-4107-A52C-1CC56F99786EThe TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.Nucleic acids researche2a70b861c9ef430a92720e545afc638Hertweck A2022-01-010305-1048625fc0361c322F90FA61F-2F7F-4CD0-9869-97A365376568A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.Nature communications25168da7db32dfec8c632fe7f337dca4Hobor F2018-01-012041-17235c5a25543d3031.86571435CBFE794A-D944-41C7-823E-CD5EE305FBF5KH-RNA interactions: back in the groove.Current opinion in structural biology90c323ba11b74c906d70b5f1a25642cbNicastro G2015-01-010959-440X5675df0d6382e0701CADB-7645-46BA-B9F9-0A66F625F94EH19 long noncoding RNA controls the mRNA decay promoting function of KSRP.Proceedings of the National Academy of Sciences of the United States of Americacb95bcf8c032cc0a981864a0e122d4b9Giovarelli M2014-01-010027-84245675dcb7224d12D19FFC1-8588-4D04-9CED-2DA6CAACA533Structural basis for Fullerene geometry in a human endogenous retrovirus capsid.Nature communications82d31d59f2d2733e8423b06a7e546ca8Acton O2019-01-012041-17235e2f1db69d9f64.6504247955E6D9DA-FB7B-4413-A9D6-5307E0EFA4F1The distinct RNA-interaction modes of a small ZnF domain underlay TUT4(7) diverse action in miRNA regulationf6080d8482a5ff56c1d1c982c0fca036Chaves-Arquero B2021-01-0167524cc96660c1.744869798C65A7F4-F5BB-47AB-8579-902ED1CE2865PolyQ-mediated regulation of mRNA granules assemblyBiochemical Society Transactions893057bb08f80b1ebadce701e7d6a946Castilla-Llorente V2014-01-010300-5127545b451b69c569.93013053F0E8C784-8C59-49A0-B5F2-FB6EB1371762Structural basis for Fullerene geometry in a human endogenous retrovirus capsid82d31d59f2d2733e8423b06a7e546ca8Acton O2020-01-0167524780c2b7c9.895913167813D987-615D-442E-BE7A-F0E03DE56AC1Affinity-enhanced RNA-binding domains as tools to understand RNA recognition.Cell reports methodsf6080d8482a5ff56c1d1c982c0fca036Chaves-Arquero B2023-01-012667-2375649a12098c9bc9741ED51-81C6-458F-910A-A12C90738D5BIMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling propertiesNucleic Acids Researchf58f8f41e9784651d8c4566c1aae0f18Dagil R2019-01-010305-10485e2f19fed12c61.660651635C4A172C-450D-4A60-B155-9A4C21C25F0FTerminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms.Biochemical Society transactions893057bb08f80b1ebadce701e7d6a946Castilla-Llorente V2013-01-010300-5127pm_15035_25_2386314534DBEB55-93DE-4F57-A053-0D2C2CC0C753An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.Nucleic acids research802d43177e3f8cfcaa9b06c0bebc6ca6Collins KM2017-01-010305-10485a95c65aa9c537.5469271801D8EE13-18E6-40FB-9A83-3E2F58617DD3Functional and molecular insights into KSRP function in mRNA decay.Biochimica et biophysica actab665919c79892167c1bc569384bc2219Briata P2013-01-010006-3002pm_15035_25_231784640F55507E-271B-4198-9403-F6255B870CC5Structural basis for Fullerene geometry in a human endogenous retrovirus capsid82d31d59f2d2733e8423b06a7e546ca8Acton O2020-01-0165e8c49053ab33.02167469589D946B-B27E-4D7A-87AE-4CF8421FC597Antimalarial activity of cupredoxins: the interaction of Plasmodium merozoite surface protein 119 (MSP119) and rusticyanin.The Journal of biological chemistrya5d85495962fb493f9fb6427937d4d2bCruz-Gallardo I2013-01-010021-9258pm_15035_25_23749994MC_PC_130516CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0CABBA18-5FC8-4B1F-BE98-00848D0342B4ERDERA - EUROPEAN RARE DISEASES RESEARCH ALLIANCEActive10159543EU-FundedAbstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.2031-08-30240CEBFD-1052-4EAC-88DF-D88A163D61C8Horizon Europe Guarantee2024-08-31INCOME_ACTUAL265671101595436CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0CB9A4A7-4DC8-45F0-9A0C-01AC782A2E0EUsing Artificial Intelligence to Understand Zeolite CatalystsClosed2594586StudentshipElectron microscopy provides a unique tool for studying the local structure of materials at the atomic scale. However, a major challenge lies in correlating bulk measurements of properties with highly selective structural data. One approach is to take advantage of fast electron detectors to acquire large data sets of millions of images and to develop automated analysis tools based on deep learning to analyse these. The overall aim of this project is to study defect structures in zeolites involved in heterogeneous catalysis. This project will use recent developments in fast direct electron detectors for transmission electron microscopy for low dose imaging and neural networks trained for pattern recognition of specific defect structures. The potential impact of these studies is a better understanding of catalytic processes of interest to the industrial sponsor and an improved understanding of the relationships between catalytic performance and local structure. Initially the project will use new detectors operating at kHz frame rates to record large datasets containing many TEM images of defect structures. In parallel the project will develop the use of machine learning based on convolution neural networks to build image analysis tools suitable for analysing large data sets containing millions of images. A convolutional neural network will be trained using simulated data of known defect structures for various electron dose budgets and other imaging conditions. This will then be used to analyse the experimental data to gain meaningful statistics on defect types. The research proposed relies heavily on unique instrumentation available at the electron Physical Sciences Imaging Centre. Specifically, a new high speed direct electron detector operating at a frame rate in excess of 2KHz in 12 bit counting mode will be used to acquire low dose data. Within all of the above aims and objectives it will be necessary to ensure that the methods developed are robust to low dose data acquisition as zeolites are known to be radiation sensitive and to ensure that electron beam induced effects are minimised. Initially pure zeolites will be studied but the project will also be extended to study metal loaded zeolites and comparisons between defects in these systems and the pure materials will provide insights into the mechanisms and structural consequences of metal loading. Finally catalytic data will be measured at the industrial sponsors laboratories to attempt to correlate catalytic performance with the nature and densities of defects present across a range of loaded and unloaded samples The project falls within the EPSRC energy, Artificial Intelligence and Robotics and physical sciences research areas The project is funded by Johnson Matthey plc through the iCase initiative.2025-09-29798CB33D-C79E-4578-83F2-72606407192CEPSRC2021-09-30INCOME_ACTUAL025945866CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0CF15F24-E99E-4496-83E0-0191A65E11DBPredicting Biological Carbon in the Ocean Globally (PRECOG)ActiveMR/Y016629/1FellowshipEmissions of carbon dioxide (CO2) from our society are rapidly warming our climate to currently 1.1 degrees C warmer than in preindustrial times. Global governments have pledged to reduce emissions to stabilise our warming climate at 1.5 degrees requiring us to reduce emissions of CO2 to a point where they no longer accumulate in the atmosphere: Net Zero. A crucial consideration in this effort are natural reservoirs of carbon on the Earth's surface such as permafrost and soils that store large amounts of carbon away from the atmosphere, but which are vulnerable to environmental change. The destabilisation of these reservoirs over time, releasing more CO2 into the atmosphere, presents a challenge to stabilising climate upon reaching Net Zero. Therefore, predicting how these natural carbon reservoirs will change in the future is a crucially important task. The Biological Carbon Pump is one of these natural reservoirs of carbon in our Earth System. It stores carbon in the ocean by plankton (microscopic plants) taking up CO2 as they grow in the surface ocean. The sinking remains of these plankton carry the carbon into the deep ocean locking it away for hundreds to thousands of years. This carbon pool is equivalent in size to the anthropogenically-driven increase in atmospheric CO2 over the 20th century. The Biological Carbon Pump is widely expected to be sensitive to environmental change and could therefore release CO2 in the future. However, we have limited knowledge of what those changes might be and why because we don't have the necessary outputs from the state-of-the-art future projections by Earth System Models that underpin the Intergovernmental Panel on Climate Change (IPCC) reports that inform social, economic and political decisions about Climate Change. PREdicting biological Carbon in the Ocean Globally (PRECOG) will build a team of experts at the University of Liverpool to comprehensively explore the future of the Biological Carbon Pump using state-of-the-art Earth System Model projections. PRECOG will strategically align with an international network of researchers and industry partners to build a new knowledge framework that will inform future IPCC reports and mitigation strategies. PRECOG will: 1) Derive new standard quantitative measures of the Biological Carbon Pump in a future changing ocean. 2) Quantify how and why the Biological Carbon Pump changes in state-of-the-art future projections that underpin the IPCC reports. 3) Determine the long-term impact of the Biological Carbon Pump beyond the year 2100 using new Earth System Model simulations. 4) Predict which future projections of the Biological Carbon Pump are most likely and how this might impact schemes to artificially enhance carbon storage by combining future projections with new compilations of observations. PRECOG has a strong focus on connecting scientific outcomes to societally relevant outcomes. The research team will maintain a strong and active link with IPCC activities through its international network with the aim of raising the profile of Biological Carbon Pump research. PRECOG will also work with industry partners interested in techniques that will enhance the carbon storage of the Biological Carbon Pump to help mitigate rising CO2 such as kelp farming and seeding the ocean with iron. PRECOG will provide the state-of-the-art estimates for the best locations to undertake these activities and disseminate these findings through its industrial partners. In summary, the Biological Carbon Pump is a vulnerable natural carbon pool in the ocean that can influence atmospheric CO2 in response to environmental change. The future of this carbon pool is however poorly known. This Future Leaders Fellowship, PRECOG, will establish a team of experts to explore the Biological Carbon Pump in state-of-the-art IPCC projections to find out what the likely future changes are and translate this is into a societally relevant agenda.2028-10-3150B4BB1A-2D10-4C8C-A35D-1ED2DB0ABB51UKRI FLF2024-11-01INCOME_ACTUAL1346258MR/Y016629/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0D04DE14-61BF-4341-8A74-000659372E3EDigital Empowerment in Language Teaching (DELTEA)ClosedES/X002500/1Research GrantThe aim of this innovative project is to enable a step-change in foreign language (FL) teaching and learning in the primary school (PFL), an important goal because of the many benefits that language learning can bring for learners from a young age and for society more broadly. Educational policy across the UK recognises these benefits, through, for example, officially requiring an FL to be taught at primary school (England and Scotland), or encouraging PFL while not making it a statutory requirement (Wales and Northern Ireland). Yet across all four nations, problems with FL teacher language knowledge and classroom skills, supply and retention mean that young learners often do not reap the benefits that FL learning can and should bring. This is especially the case in areas of greater social deprivation. The project will achieve its aim by investigating whether and how digital technology can: 1) improve teachers' language knowledge and classroom skills; 2) improve teachers' ability to enhance pupil language and literacy skills, including their empathy and creativity; and 3) whether such improvements also have a positive impact on teacher confidence, motivation, job satisfaction and commitment to FL teaching. It brings together researchers with international reputations for studying the classroom factors that influence the language development of young learners, whose research has shown the importance of teacher language proficiency and pedagogical skills (Graham et al., 2017) and of developing learners' literacy in the foreign language (Porter, 2014; 2020a; 2020b). It also draws on the applicants' recent and successful experience of improving language teacher and learner knowledge, skills and confidence through digital platforms. Through three inter-related work packages the project will: 1. Develop a Digital Professional Development (DPD) programme for primary foreign language (PFL) teachers in England and Scotland, and track any resulting changes in teacher language knowledge and classroom skills, teacher motivation, professional confidence, job satisfaction and intentions regarding staying in the profession 2. Develop and evaluate a digital FL (DFL) literacy teaching intervention, for improving learners' FL language and literacy outcomes, as well as their creativity and empathy for the FL culture 3. Establish the mechanisms through which any changes for teachers and learners occur 4. Work with DPD teachers to create and evaluate a scaled-up, peer-supported version of the Digital Professional Development programme, and roll it out to all four UK nations. In achieving its aim, the study will provide policymakers and practitioners with concrete and sustainable solutions for improving not only teacher supply and retention, but also learning outcomes. While it will do so within the context of the UK, it will have implications for the many other countries facing similar challenges in delivering PFL education. Furthermore, it will offer crucial understanding of how teacher motivation is developed and sustained, that will be of relevance across all curriculum subject areas.2026-03-31924BE15C-91F2-4AAD-941A-3F338324B6AEESRC2022-12-01INCOME_ACTUAL687742DELTEA researchers have developed, based on existing digital stories that were freely available, abridged simplified stories in both French and Spanish. These stories explore themes of interculturality, solidarity, tolerance and understanding. The team have added native speaker sound files to each story.987A7142-0993-4BE0-B142-943BE1A368FATeachers are using sample stories in the teaching intervention phase of the DELTEA project. Data are being collected with respect to children's responses to tasks which are embedded in a version of the story which is hosted on Nearpod. Tasks relate to the development of intercultural understanding, empathy and creativity as well as reading comprehension and the use of reading strategies.65e78b6eec5686.43716848DELTEA multimodal storiesArtefact (including digital)2024We have documented evidence (through questionnaire data and teacher comments on our learning platform) of changes in their understanding and knowledge about teaching foreign languages. This relates directly to DELTEA since we can demonstrate changes relating to the teaching of creativity, culture and empathy which were key facets of the DELTEA digital professional development. We have exemplars of teachers using our resources and creating their own resources based on DELTEA professional learning activities and we have children's responses to some of those tasks for example, how/whether they affected their sense of confidence in reading.2023C0C9FF5E-6729-490C-9C03-83D2446BCAA0SocietalPolicy & public services67bdbd05e3b618.69382966EducationDELTEA's aims were: 1) improve teachers' language knowledge and classroom skills; 2) improve teachers' ability to enhance pupil language and literacy skills, including their empathy and creativity; and 3) whether such improvements also have a positive impact on teacher confidence, motivation, job satisfaction and commitment to FL teaching. Our main findings so far relating to these aims are: Teachers' language knowledge and classroom skills - during the digital professional development programme which lasted nine months, teachers' sense of competence improved in teaching reading in a foreign language and culture, creativity and empathy through languages pedagogy. They also reported an increased sense of autonomy, feeling particularly empowered to adapt and experiment with resources. Learners' linguistic and non-linguistic outcomes - during the second year of DELTEA, schools conducted a classroom experiment using resources they had been involved in creating through the professional development activities. These resources were also linked to the pedagogies and research evidence they had been exploring in the professional development programme. Learners, when compared to a control group, significantly improved their knowledge of vocabulary linked to the teaching, their reading comprehension, and ways of thinking creatively. There is a small amount of data that shows that the phonics app developed by the project team, significantly improved children's ability to sound out (and therefore read aloud) non-words. This is particularly interesting because non-word reading is the optimal measure of the ability to apply learned sound/spelling links. We found that higher levels of FL attitude/motivation, vocabulary, reading comprehension and empathy are linked to greater levels of self-efficacy. Interestingly, self-efficacy improved for the intervention group (almost reaching statistical significance). Empathy increased for the intervention group whilst the control group remained static but this improvement was not statistically significant.We are aiming for multiple areas of change based on our outcomes. First, influencing policy and practice on a national scale across primary languages provision in schools and also teacher professional development and initial teacher education in primary languages. Next we are aiming to support teachers in their classrooms through the provision of the DELTEA stories and associated tasks. This work has already taken place within the project and through our outreach (e.g. working with NCLE) but we are developing a MOOC for release in June 2025 which will reach audiences on a global scale. There is the possibility too to develop the phonics app we've trialled in a pilot version subject to follow on or commercialisation funding.D1779A37-3F2A-48EF-871F-1087B9CDFEC667b886ffcbc315.71978021Digital/Communication/Information Technologies (including Software)Educationhttps://ripl.ukDELTEA research findings - Curriculum and Assessment ReviewNational839E8C22-86BB-487E-8A91-EA9DF888B53D67b87d85cb1573.67071781Contribution to a national consultation/reviewDigital Empowerment in Language Teaching: The importance of supported challenge - National Consortium for Languages EducationNational1DB12FDF-58CA-4ACB-B26A-22D0E961978C67b87b6324c9d0.46033456Contribution to new or improved professional practiceDELTEA submission to Oracy Commission call for evidenceNational07EB2C9B-22C5-489B-8564-496D451C93A967b87ce6630a56.87401253Contribution to a national consultation/reviewSupporting Students from KS2 to KS3 - National Consortium for Languages EducationNational4FC0D6B9-011E-4FE5-BF6A-491A234F589167b87be289e6f2.34288347Contribution to new or improved professional practiceDigital Empowerment in Language Teaching: Association for Language LearningNational70262130-5CED-42DB-B4F2-6F800564FB5F67b87dfb623d62.21765467Contribution to new or improved professional practiceThis app has been developed which trains and gives feedback on French and Spanish pronunciation. It is available under license to DELTEA until December 2027. The IP is owned by Niter Ltd and the DELTEA research team have provided the rationale for which sounds to teach as well as exemplar and test words.D353ED38-3E0C-42D8-AE61-C97C16F42B5CThe DELTEA study will collect data from all the children who use the app in primary schools. Researchers will evaluate the effectiveness of the app on sound/spelling link learning as well as the process of learning each sound because every participant's attempt at producing those sounds will be recorded and analysed.65e78a1f3d9a84.61259630SpeacherWebtool/Application2024F6576000-1648-4F02-8509-9B1A709734EEAssessing young learner phonology and decoding: Insights from an AI-based app484596d0d869ec25f4638d547dbeece9Porter, A.2024-01-0167b8769116f8b4.601758799E3159CE-59FC-4780-96B1-73211E0DEBA0Levelling up the language learning experience for pupils and teachers in primary schools79117a8ac484652ef8a20eec32b48093Porter, A M2024-01-0165e788f41f1f55.7664746475B789CA-68FA-4630-8A47-1AF975F9880EUsing AI in the languages classroom5a58091476dbbe5cdd6cd10eba551e1dGraham, S.2024-01-0167b87a397b0253.24063943441A063C-735F-4428-A326-0AF356B4E29EDigital Professional Development: Can it improve language teacher sense of competence, autonomy and relatedness?0ff6c693cb3467c1433cbcc9e40121afGraham, S J2023-01-0165eb4e29131f75.03408472F1092E96-B7E1-4097-94AA-9E8C0ACDC695The impact of digital stories on young learners' linguistic and non-linguistic outcomes484596d0d869ec25f4638d547dbeece9Porter, A.2024-01-0167b8772eab9969.718609456AFE1FBF-50A4-4BEB-87BE-178EBEFB1D76Digital professional development: Can it improve language teacher sense of competence, autonomy and relatedness?cf4084ed69f4a1d2d46b513f030d1bc9Graham, S2024-01-0167b879933c1df5.5006827099EA30FA-0F1C-4670-AA0B-2CCC3E5262FECreativity and Empathy in Language Teaching (under contract for delivery Feb 2026)0ff6c693cb3467c1433cbcc9e40121afGraham, S J65e7880289ef81.98051563899C54AC-B54E-4999-96C0-B2A81AD819FBDigital stories in the primary languages classroom: Can they improve linguistic knowledge and non-linguistic outcomes?9a431052afe97ea76ccda31be79d0eb2Porter, A2024-01-0167b8779ceb79c7.36564789ES/X002500/1E12B3AB7-FE71-49CB-9EA4-848D8647056520Education1908FDF5-1C61-4F33-B47F-3E91675C88AA40Info. & commun. Technol.BE93F554-53E6-4746-9504-420B206B4DCE40Linguistics78550E0D-4094-4267-B0F0-97A935443AD620Applied Linguistics990813BA-F64D-4C20-BF55-5D96210DAA9E20Artificial IntelligenceA0BA2FAD-83B8-4C8D-9951-79B5C1E1D66620ICT and education9267BEB7-2181-4DDD-A4A2-A172F57921D220MultimediaF55FDC85-C0D4-4507-9834-0F35FBEC2FA020Phonetics0D4FB24F-91B7-400B-BAD1-01BB249985A1De Montfort University And 4G Design LimitedClosed508785Knowledge Transfer PartnershipTo develop and embed new approaches to sustainable design in retail fixturing, presenting validated quantifiable benefits of the commercial impact of new designs and materials.2015-02-2812E03F45-B517-4D83-A182-3D142D1A471AInnovate UK2013-02-01INCOME_ACTUAL817805087856CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0D6E6D94-136D-4B17-8B74-00F4E6632CFAFLICC (Front of pack food Labelling: Impact on Consumer Choice)ClosedMR/J000256/1Research GrantSince 2006, retailers and manufacturers in the UK have begun using front of pack (FOP) nutrition labelling on foods. Presently, around four fifths of foods in UK supermarkets carry FOP labelling. There have been many studies of consumer understanding of FOP labelling, and of use of FOP labelling in experimental settings. However, little is known about how consumers use FOP labelling in real-life shopping situations. This project will investigate the use of FOP labelling during real-life shopping situations, and explore the feasibility of a trial of two interventions aimed at amplifying the impact of FOP labelling - tailored feedback to consumers on food purchases, and interactive education about FOP labelling. Two recent studies involved participants being tailed by researchers during real-life shopping situations, in order to investigate facilitators and barriers to buying healthy foods. Transcripts of the interviews from these studies will be re-analysed with a focus on the role of FOP labelling in food purchasing decisions. A new qualitative study will then be conducted with innovative data collection techniques. Participants will be asked to wear SenseCam - a wearable camera that takes time-stamped first-person photos at regular intervals. After the shop, the participants will be interviewed, and images collected by SenseCam will be used to aid recall of the food purchase decisions at each stage in the shop. These interviews will be used to gauge the influence of FOP labelling in food purchase decisions, in relation to other competing influences. Participants will also be asked to consider how the influence of FOP labelling might be amplified in future shopping experiences, and their responses will feed into the development of two interventions. The tailored feedback intervention will consist of automatic delivery of information about the FOP labels of recently purchased products with alternatives from within the same product range with a more healthy FOP label profile. The interactive education intervention will consist of a web-based programme that educates individuals about how FOP labelling systems are designed and work, what consumers should look for in different food product ranges, and the range of FOP labels that are likely to appear in different food product ranges. A pilot RCT will then be conducted, which will assess the feasibility of conducting a full RCT of these two interventions. Stores from the Co-operative supermarket chain will be the setting. Approximately 400 participants will be recruited from all Co-operative store card holders. They will be randomised into four arms: control; tailored feedback only; interactive education only; tailored feedback and interactive education. Data collection will take place over 12 weeks. During this time, all food purchases made by participants using their Co-operative store cards will automatically be relayed to the researchers. For the first four weeks of data collection, no intervention will take place. Both tailored feedback and the interactive education intervention will take place during weeks 5-8. No intervention will take place during weeks 9-12. The primary outcome variables for the full RCT will be average healthiness of ready meals, pizzas, sandwiches and breakfast cereals purchased in weeks 5-8 minus average healthiness of similar foods purchased in weeks 1-4, and similar comparison between weeks 9-12 and weeks 1-4. Telephone interviews with participants and Co-operative staff will be conducted after data collection. The results of the pilot RCT and the telephone interviews will be used to assess feasibility of recruitment method, recruitment rates by demographic subgroups, effective delivery of intervention, feasibility of data collection, and estimates of drop-out rates. Because of the automated nature of the interventions, both could be rolled out to a wider population of supermarket shoppers if a full RCT demonstrates effectiveness.Front of pack (FOP) nutrition labels are displayed on most foods available in UK supermarkets but little is known about how they are used in real-life shopping situations, or whether their influence can be amplified to encourage healthier food purchases. This project involves three phases. Phase 1 is secondary analyses of two studies where researchers accompanied shoppers and observed behaviour. The analyses will focus on the influence of FOP labels. Phase 2 is a qualitative study of use of FOP labels in shopping situations using innovative data collection techniques. 30 participants will conduct a routine shop wearing SenseCam (a wearable camera which automatically takes photos from a first-person viewpoint at a standard interval), and 30 participants will conduct both a routine shop and a 'healthy shopping' task whilst wearing SenseCam. The images will be used to prompt recall in a semi-structured interview conducted immediately after the shop. Participants will be asked about two interventions to amplify the impact of FOP labels (I1) tailored feedback promoting foods with healthier FOP labels than previous purchases, (I2) a web-based education programme about FOP labels. Phase 3 is a pilot RCT of the effectiveness of I1 and I2. The pilot RCT will be conducted in Co-op supermarkets nationwide. 400 participants will be randomised to four arms: control; I1; I2; I1 and I2. Data collection will take place over 12 weeks, during which time electronic sales data from the participants will be automatically delivered to researchers. I1 and I2 will be delivered during weeks 5-8. Final outcome measure will be average healthiness of foods purchased during weeks 5-8 compared to weeks 1-4, and between weeks 9-12 compared to weeks 1-4. Data on these final outcome measures will be used to inform power calculations for a full RCT. A process evaluation involving telephone interviews with Co-op staff and study participants will be conducted to assess the feasibility of a full RCT.Recent trends in adult obesity continue to rise, and the contribution of unhealthy diets to excess mortality is estimated to be 33,000 death per year. Food labelling is assumed to be a broad population approach to improving food purchases but the impact of labelling remains unknown. Our study will assess the impact of front of pack (FOP) labelling schemes commonly used in the UK on consumer purchasing decisions. FOP labelling is defined here as schemes that highlight the level of nutrients within a food in an 'at a glance' format on the front of the pack (e.g. traffic light labelling, % GDAs, 'healthy choices' logos). This research will not only assess the evidence of this impact but also develop new methods, provide a unique and rich dataset of food purchasing, and pilot test a key current UK government public health initiative. This dataset will be generated, for the first time, by an academic and food retail partnership using new method of automated delivery and analysis of electronic sales data. There is a real opportunity to capitalise on the 82% of packaged products available in UK supermarkets currently carry FOP labelling and this research will aid the development of interventions aimed at facilitating choice of healthy foods. NPRI funding presents a unique opportunity to create a research, industry and third sector collaboration, optimising a diverse range of methodologies and skills to add value to a policy led public health area, where nothing was previously available. We feel that NPRI's focus on building an evidence base for population approaches to prevention will be a real contribution to British and international research which would be unlikely to emerge from other funding bodies. Beneficiaries from this research are: WHO? - Other Academic Researchers HOW? - The development and utilisation of new and innovative methodologies, equipment, techniques, technologies, and cross-disciplinary approaches. Use of digital images within qualitative methods to explore use of FOP labels. Construction of automated delivery, analysis and feedback of electronic sales data. Dataset of food purchasing. Use of technology to feedback on food purchasing behaviour. WHO? - The Public HOW? - Enhancing health and well-being Improve opportunity for healthier choices by better understanding of how FOP labels are used and deliver systems to public to nudge behaviour. Optimise use of FOP labels within existing retail shopper feedback systems and delivery of messages via choice of digital or written media. WHO? - NHS HOW? - Transforming evidence based policy in practice and influencing and informing practitioners and professional practice. Use of FOP labels to raise the impact on chronic disease management and dietary management via National Obesity Observatory and NICE. WHO? - Industry HOW? - Changing organisational culture and practices. Improve consumer choices by systematic feedback about food choices via store cards and delivered via choice of digital or written media. WHO? - Government Departments HOW? - Contributing towards evidence based policy-making and influencing public policies and legislation at a local, regional, national and international level. FOP labels matches four main approaches supported by the new responsibility deal - the Food Network and DH. Improve information to consumers on the content of food, improving awareness on the availability of healthy food, and direct promotion of healthier food choices. WHO? - Third sector (Health NGOs) HOW? - Contributing towards evidence based policy-making and influencing public policies. British Heart Foundation, National Heart Forum, WHICH, Sustain all advocate for improvement to promotion of FOP labels.2016-05-30C008C651-F5B0-4859-A334-5F574AB6B57CMRC2012-03-01INCOME_ACTUAL584922186261United KingdomGBPUnited Kingdomen_GBPublic Health Intervention Development Scheme (PHIND)2020-02-02Medical Research Council (MRC)MR/R015465/125105233-F504-4F90-A443-956EE9DE908B5a84423d0e6b01.18809159Public2018-01-0157494United KingdomGBPUnited Kingdomen_GBNuffield Department of Population HealthDepartmental pump priming award2017-06-01University of Oxford39E8BA9D-789C-4C7C-A635-1B2404CD89E35a84412ec34c27.36232247Academic/University2016-05-314156781United KingdomGBPUnited Kingdomen_GBBiomedical Research Centre at Oxford2022-03-02National Institute for Health and Care Research935ACE5B-70B5-4494-BA50-61264164F98B5a8441ce4114a7.29636981Public2017-03-3100D69B2C-04EE-490D-9ACC-0E59AE15D6DAAnalgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.Lancet (London, England)82bcfd7fa55d85b02f9f8b60d3f39cbcHartley C2018-01-010140-673665b8140ced6a54.4985151933AF4C56-A3FF-4351-AF3F-DF927F041A44A Pilot Randomized Controlled Trial of a Digital Intervention Aimed at Improving Food Purchasing Behavior: The Front-of-Pack Food Labels Impact on Consumer Choice Study (Preprint)930cce292367934748c8abcd8a9c52b3Harrington R2018-01-015e306e39a33b00.73967097736CBF03-D73C-4780-A6B8-32AF6630C83AThe front of pack nutrition information panel: using novel methods to explore consumer decision making at point of choice during routine supermarket shopping349f42a3ed1a2f7badcd69b4b19df65cCowburn G2016-01-01675f5901128d24.233488064EFB0BF9-B65A-4453-9C7D-61465477D9EBA Pilot Randomized Controlled Trial of a Digital Intervention Aimed at Improving Food Purchasing Behavior: The Front-of-Pack Food Labels Impact on Consumer Choice StudyJMIR Formative Research930cce292367934748c8abcd8a9c52b3Harrington R2019-01-012561-326X5e306e586cf980.61143483D1D5F921-F790-4D56-B06B-5D555D0C020EReds are more important than greens: how UK supermarket shoppers use the different information on a traffic light nutrition label in a choice experimentInternational Journal of Behavioral Nutrition and Physical Activity2603196648d8fb25d244ed87814581e2Scarborough P2015-01-011479-586856b9f04578f9c0.2992652078402C55-8E3E-4488-9658-DD3DF42C7E40Protocol for a pilot randomised controlled trial of an intervention to increase the use of traffic light food labelling in UK shoppers (the FLICC trial).Pilot and feasibility studies2603196648d8fb25d244ed87814581e2Scarborough P2015-01-012055-5784545cd123e85931.01899400MR/J000256/16CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0DD41F14-E16D-4CD0-803A-0189A148F0D3Identity Attributes Matrix Inititative (IAMI)Active10139724EU-FundedAMI aims to revolutionize entity identification and resolution in security, intelligence, and investigation contexts. It addresses the challenges and limitations faced by current identification techniques and offers a visionary solution through advanced AI-powered software. The project's long-term vision is to propel EU LEAs and security/intelligence organizations into a new era of intelligence, investigation, and forensic capabilities. IAMI's core innovation is the development of an AI-powered software system that can seamlessly integrate with existing case management systems and analytic tools. At the heart of IAMI is the concept of the 'Identity-Attributes Matrix (IAM)', a 3D construct that encompasses a broad spectrum of multi-modal identity-related attributes, including biometric data, non-biometric identity-related data, and analytic results. These attributes are used to facilitate large-scale entity identification/resolution, including a broader range of entity types, simultaneous and rapid multi-entity identification/resolution, systematic and continuous analysis of flux of probe attributes, confidence in noisy/corrupted probe data, reduced false positive rates, access to contact attributes, and the ability to classify fake identities and bots/avatars. Furthermore, IAMI sets the groundwork for effective collaboration and data sharing across European agencies, including international organizationslike EUROPOL and INTERPOL through the establishment of a new EU Wide IAMI enrolled data collection repository for terrorist threat assessment and awareness which enriches their capabilities and assets. The realization of IAMI's vision will be achieved through the demonstration of the developed IAMI solution. It will be communicated and disseminated among EU LEAs and security/intelligence agencies through project activities, including deliverables, training curricula, workshops, and pilots. IAMI represents a significant step forward in EU fight against terrorism.2028-01-31240CEBFD-1052-4EAC-88DF-D88A163D61C8Horizon Europe Guarantee2025-02-01INCOME_ACTUAL220124101397246CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified0E159D6D-FBAC-4204-B854-016C43D201F8UKBIC – Core Operational FundingClosed900254CentresAbstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.2025-03-30082B386F-6FF5-40C0-B99E-1B7F867318BEISCF2023-03-01INCOME_ACTUAL293320009002546CFA1E1F-F25C-4C23-8FE1-C47AE53E333EUnclassified