US Partnering Award: An integrative approach to understanding the GnRH pulse generator: combining in-vitro, in-vivo and in-silico methodologies.
Lead Research Organisation:
King's College London
Department Name: Women's Health
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Lass G
(2022)
GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice.
in Journal of neuroendocrinology
Plain Z
(2022)
Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation.
in Current opinion in endocrine and metabolic research
| Description | We have been able to incorporate significant in-vitro data from our American colleagues into the mathematical model to enhance it's efficiency and calibration and published out finding in eLife 2024 |
| Exploitation Route | The mathematical modelling can from a foundation for other biological systems. Similarly, the in-vitro electrophysiological data on the hypothalamic arcuate kisspeptin neural network will have relevance to other neural networks |
| Sectors | Education Healthcare Pharmaceuticals and Medical Biotechnology |
| Description | A novel mechanism underlying GnRH pulse generation by KNDy neurones |
| Amount | £571,812 (GBP) |
| Funding ID | BB/s000550/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2018 |
| End | 11/2022 |