Responsive Probes for Molecular Imaging Applications: COST D38 Support
Lead Research Organisation:
Durham University
Department Name: Chemistry
Abstract
The project seeks partial support over a 4 year period, for an international collaborative project spanning 7 European research laboratories, operating under the ESF COST Action D38: 'Metal Based Systems for Molecular Imaging Applications'. The key objectives are to improve our basic understanding of quenching mechanisms that shorten the lifetime of emissive probes (lanthanide luminescence probes) and to devise 'concentration independent' magnetic resonance (MR) probes taht are responsive to selected analytes of biochemical interest. We shall apply the combined expertise of the cooperating groups to improve metal complex probe design. In particular, we shall evaluate the utility of new lanthanide complexes in bioanalysis and for the microscopic imaging of living cells, focusing on applications in cellulo (luminescence) and in vivo (MR). The Durham group were co-proposers of the Action and lead a working group entitled 'Responsive Probes', that embraces laboratories in Geneva, Tubingen, Dublin, Turin, Bagnols-sur-Ceze and Leicester. The funding requested will be used to facilitate particpation in the defined research progamme between these laboratories, with the Durham group taking the lead in the first phase of the collaboration.
Organisations
Publications
New E
(2010)
Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes
in Chemical Science
New EJ
(2010)
Development of responsive lanthanide probes for cellular applications.
in Current opinion in chemical biology
Palmer A
(2014)
Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots
in RSC Advances
Smith DG
(2011)
Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells.
in Chemical communications (Cambridge, England)
Description | Methods to develop emissive probes that respond to their environment |
Exploitation Route | In creating brighter and functionally reversible optical probes |
Sectors | Chemicals Education Pharmaceuticals and Medical Biotechnology |
Description | In increasing our basic knowledge of how to design responsive probes, including those for key oxyanions such as bicarbonate, citrate and lactate, measured in biological fluids and inside cells. |
First Year Of Impact | 2010 |
Sector | Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Description | CISbio Bioassays |
Amount | £150,000 (GBP) |
Funding ID | Durham 2011 |
Organisation | Cisbio Bioassays |
Sector | Private |
Country | France |
Start | 01/2012 |
End | 03/2015 |
Description | European Research Council |
Amount | £2,000,000 (GBP) |
Funding ID | FCC266804 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 05/2011 |
End | 05/2016 |