Revealing DNA's Secret Structures
Lead Research Organisation:
University of East Anglia
Department Name: Pharmacy
Abstract
Think you know the structure of DNA? Think again. It is often assumed that DNA exists only as the iconic Watson-Crick "twisted ladder" double helix; but it can actually adopt many different types of structures. These "alternative" structures may play a role in gene expression (whether genes are switched on or off) and also in the development and progression of genetic diseases. Compared to the double helix, much less is known about these structures, how and when they may form in the genome. Potentially, targeting these alternative DNA structures could allow for specific interventions and therapeutics for genetic diseases.
This PhD project will involve developing fluorescent probes so we can learn more about these alternative DNA structures.
This PhD project will involve developing fluorescent probes so we can learn more about these alternative DNA structures.
Organisations
People |
ORCID iD |
| Zoë Ann Ella Waller (Primary Supervisor) | |
| Philip Spence (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011216/1 | 01/10/2015 | 31/03/2024 | |||
| 1800176 | Studentship | BB/M011216/1 | 01/10/2016 | 30/09/2020 | Philip Spence |
| Description | Have submitted a paper that shows the development of a new class of DNA probes. |
| Exploitation Route | The class of compounds that act as DNA probes can be taken on and derivatised to find new ones. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Description | BIONIC 2018 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a poster of my work at this international conference. Gained insight into my work and managed to share it with others. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.bionic2018.org/ |
| Description | G4thering 2017 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented a poster at an international conference. Gained lots of ideas and insight into my research and was able to share my research with others. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.rsc.org/events/detail/25441/g4thering-2017 |
| Description | Norwich Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Engaged with the general public at the Norwich Science Festival 2017, demonstrating the research that our group undertakes. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://norwichsciencefestival.co.uk/ |