SSA Regulation of microglial activity to promote central nervous system homeostasis and limit harmful neuroinflammation
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Adequate microglial activity is necessary to support a healthy central nervous system (CNS) environment. As the immune competent cells of the CNS it is also important to ensure microglial responses to potential stressors are controlled to avoid potentially harmful neuroinflammation. This project will explore mechanisms that regulate microglial homeostatic and neuroinflammatory activity with a focus on TREM2.
Organisations
People |
ORCID iD |
| Rona Barron (Primary Supervisor) | |
| Barry McColl (Primary Supervisor) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M010996/1 | 01/10/2015 | 31/03/2024 | |||
| 1807879 | Studentship | BB/M010996/1 | 01/09/2016 | 31/08/2020 |
| Description | This work has identified alterations to the brain's immune system during inflammation. This work has shown that when a specific cell surface receptor is missing from the resident immune cells of the brain, microglia, alternation to the normal inflammation response occur. The exact mechanisms by which these changes happen and whether they are beneficial or detrimental to the inflammatory response is still being explored in this project. |
| Exploitation Route | The outcomes of this work identify mechanisms by which the immunorecptor TREM2 is involved in the acute inflammatory response of the brain. Others may use this work to understand how TREM2 is involved in specific cases of neuroinflammatory conditions and how TREM2 may be targeted therapeuticially to benefit both chronic and acute neuroinflammatory conditions. |
| Sectors | Other |