Nuclear Spins far from Equilibrium
Lead Research Organisation:
University of Southampton
Department Name: Sch of Chemistry
Abstract
The project involves the generation, manipulation and application of nuclear spin systems which are far from equilibrium. Modalities of generating non-equilibrium spin systems include the enrichment and chemical reaction of spin isomers such as parahydrogen, and the strong polarization of nuclear spins using dynamic nuclear polarization. Manipulations of these systems to generate highly enhanced NMR signals will be developed. The enhanced NMR signals will be applied to the characterization and imaging of biological processes.
Organisations
Publications
Elliott SJ
(2018)
NMR Lineshapes and Scalar Relaxation of the Water-Endofullerene H217 O@C60.
in Chemphyschem : a European journal of chemical physics and physical chemistry
Stevanato G
(2017)
A pulse sequence for singlet to heteronuclear magnetization transfer: S2hM.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Bengs C
(2020)
A master equation for spin systems far from equilibrium.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Bengs C
(2018)
SpinDynamica: Symbolic and numerical magnetic resonance in a Mathematica environment.
in Magnetic resonance in chemistry : MRC
Meier B
(2018)
Spin-Isomer Conversion of Water at Room Temperature and Quantum-Rotor-Induced Nuclear Polarization in the Water-Endofullerene H_{2}O@C_{60}.
in Physical review letters
Elliott SJ
(2019)
Nuclear singlet relaxation by scalar relaxation of the second kind in the slow-fluctuation regime.
in The Journal of chemical physics
Bengs C
(2020)
Rotational-permutational dual-pairing and long-lived spin order.
in The Journal of chemical physics
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509747/1 | 01/10/2016 | 30/09/2021 | |||
| 1842822 | Studentship | EP/N509747/1 | 01/01/2017 | 31/12/2019 | Christian Bengs |
| Description | Nuclear magnetic spins can be visualised as tiny magnets attached to atoms and molecules. These give rise to observable magnetisation. The most prominent example being Magnetic Resonance Imaging (MRI). The response of the magnetic spins is in general fairly weak. This means that one has to acquire data for a long time to get a good image for example. In recent years much effort has been put into increasing the sensitivity of magnetic resonance experiments by temporarily increasing the sensitivity. These are called "hyperpolarized" systems. Hyperpolarized systems generate signals with high intensity, which only persist for a short amount. They eventually eventually return to their original value. The process of the enhanced intensity returning to its original value is called relaxation. The mathematical description of this process is fairly involved. Within this project it was found that the current methods to model these phenomena are wrong and a corrected version was suggested. |
| Exploitation Route | People in the field that want to model the relaxation behaviour would need to take the new formalism into account to generate reliable simulations. |
| Sectors | Other |
| Title | SpinDynamica |
| Description | The developed software package is a Mathematica addon that allows simulation of a wide range of magnetic resonance experiments. |
| Type Of Technology | Software |
| Year Produced | 2018 |
| Open Source License? | Yes |
| Impact | The software package is used by the majority of the group and a big part of the magnetic resonance community. |