Stereoretentive enantioconvergent synthesis
Lead Research Organisation:
University of Edinburgh
Department Name: Sch of Chemistry
Abstract
This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive enantioconvergent catalysis. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no deracemisation required. Several approaches will be pursued to demonstrate proof-of principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.
Organisations
People |
ORCID iD |
| Andrew Lawrence (Primary Supervisor) | |
| Helen Jones (Student) |
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/N509644/1 | 01/10/2016 | 30/09/2021 | |||
| 1940582 | Studentship | EP/N509644/1 | 01/09/2017 | 31/08/2021 | Helen Jones |
| Description | I have focused a Diels-Alder dimersation as part of my project. Specifically I have been working towards the synthesis of the monomer, and trying to make to monomer in a large quantity so I can later scope different chiral reagents and catalysts to render the original Diels-Alder dimerisation enantioconvergent. |
| Exploitation Route | The synthesis of the monomer |
| Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |