The effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics
Lead Research Organisation:
University of Cambridge
Department Name: Chemical Engineering and Biotechnology
Abstract
The project will explore the effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics relevant to catalyst preparation routes. The work will include an analysis of drying kinetics, wetting (e.g. impregnation/washcoating) and wicking. Furthermore, the project aims to investigate the use of terahertz spectroscopy and imaging as a method for determining catalyst porosity, non-destructively and quickly
Organisations
- University of Cambridge (Lead Research Organisation)
- EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation (CMAC) (Collaboration)
- University of Copenhagen (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- OMYA UK Ltd (Collaboration)
- Aalto University (Collaboration)
- University of Eastern Finland (Collaboration)
- Johnson Matthey (United Kingdom) (Student Project Partner)
Publications
Al-Sharabi M
(2024)
Investigating the effect of sintering rate and solvent type on the liquid transport kinetics of a-alumina powder compacts
in Chemical Engineering Science
Al-Sharabi M
(2021)
Terahertz pulsed imaging as a new method for investigating the liquid transport kinetics of a-alumina powder compacts
in Chemical Engineering Research and Design
Al-Sharabi M
(2020)
Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration.
in International journal of pharmaceutics
Alqahtani F
(2020)
An investigation into the formations of the internal microstructures of solid dispersions prepared by hot melt extrusion.
in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Edinger M
(2019)
Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and Near-Infrared Spectroscopy.
in AAPS PharmSciTech
Moysidou C
(2021)
3D Bioelectronic Model of the Human Intestine
in Advanced Biology
Skelbæk-Pedersen AL
(2020)
Effect of particle size and deformation behaviour on water ingress into tablets.
in International journal of pharmaceutics
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/P510440/1 | 01/10/2016 | 30/09/2022 | |||
| 1943009 | Studentship | EP/P510440/1 | 01/10/2017 | 30/12/2021 | Mohammed Al-Sharabi |
| Description | - For the first time, terahertz pulsed imaging (TPI) was used for simultaneously investigating the liquid transport and swelling performance during the tablet disintegration of complex pharmaceutical formations. These formulations are used for patients with swallowing difficulties. - TPI was also used for the first time to study the liquid transport kinetics of ceramic catalytic materials, i.e. a-alumina powder compacts, which revealed that, beside porosity, the surface properties of the solid catalytic material impact the water transport kinetics. - X-ray computed microtomography (XµCT) can be used for the analysis of the microstructure properties of the inkjet-printed pharmaceuticals on porous substrates. The XµCT results revealed the high porosity of the substrate is optimal for inkjet printing. - TPI was also used as a novel method to investigate the liquid transport of non-polar solvents, such as 1-octanol, into ceramic catalytic materials, i.e. a-alumina powder compacts. The results show the great potential of the TPI method for investigating the liquid transport kinetics of ceramic catalysts and catalyst supports. |
| Exploitation Route | - Help the formulation scientists in the pharmaceutical industry design better solid dosage forms. - Help the scientists in the catalysis field enhance the design and performance of heterogenous (solid) catalysts. |
| Sectors | Chemicals,Pharmaceuticals and Medical Biotechnology |
| Description | The effect of chemical composition, pretreatment and microstructure of the catalyst pellet on the mass transport characteristics |
| Amount | £89,640 (GBP) |
| Funding ID | 1943009 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2021 |
| Description | Aalto University, School of Chemical Engineering, Department of Bioproducts and Biosystems, Aalto, Finland |
| Organisation | Aalto University |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark |
| Organisation | University of Copenhagen |
| Country | Denmark |
| Sector | Academic/University |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, University of Strathclyde, Glasgow, UK |
| Organisation | EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation (CMAC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Helping with the analysis of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | Institute of Photonics, University of Eastern Finland, Joensuu, Finland |
| Organisation | University of Eastern Finland |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Feedback on the results of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | Omya International AG, Forschackerstrasse 6, CH 4622 Egerkingen, Switzerland |
| Organisation | OMYA UK Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Making the functionalised calcium carbonate material and conducting the the mercury porosimetry analysis of the tablets. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | School of Pharmacy, Promis Centre, University of Eastern Finland, Kuopio, Finland |
| Organisation | University of Eastern Finland |
| Department | Pharmacy Department |
| Country | Finland |
| Sector | Academic/University |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Making the tablets used for investigating the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |
| Description | Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, UK |
| Organisation | University of Strathclyde |
| Department | Strathclyde Institute of Pharmacy & Biomedical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Measuring the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Collaborator Contribution | Helping with the analysis of the liquid transport and swelling kinetics of complex pharmaceutical formulations using terahertz technology. |
| Impact | A manuscript entitled "Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet Disintegration", which is still under review. |
| Start Year | 2017 |