Role of CIZ1 in X chromosome inactivation
Lead Research Organisation:
University of York
Department Name: Biology
Abstract
X chromosome inactivation (XCI) serves as a model for establishment and maintenance of selective transcriptional silencing throughout the genome,through the action of polycomb repressive complexes (PRC) 1 and 2. The nuclear matrix (NM) protein Cip1-interacting zinc finger protein 1 (CIZ1) plays a role in DNA replication in association with cyclins, and is linked with adult and paediatric cancers. We recently showed that CIZ1 is located at the Xi in mouse and human female cells, and that absence of CIZ1 leads to highly penetrant female-specific lympho-proliferative disorder. The data argue for a role in maintenance of X chromosome inactivation through association with the nuclear matrix. This project will investigate the mechanism by which CIZ1 functions in the maintenance of epigenetic marks as cells pass through the cell cycle, and will use a range of molecular and cellular biology techniques including high resolution and live imaging.
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/M011151/1 | 01/10/2015 | 30/09/2023 | |||
| 1949445 | Studentship | BB/M011151/1 | 01/10/2017 | 30/06/2022 |
| Description | BSCB BSDB Joint Annual Spring Meeting |
| Amount | £490 (GBP) |
| Organisation | British Society for Cell Biology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 04/2018 |
| Description | Rotary group visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | The York Rotary Club attended for a visit to the cancer research labs at the University of York. I presented the work I was doing to small groups and did a tour of the lab, this sparked questions and discussion. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Second year talk to University of York students/staff |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 15 minute presentation regarding my work so far in my PhD to both students and staff of the University of York, Biology Department. This was a chance for me to show my data and to also discuss future ideas with my peers. |
| Year(s) Of Engagement Activity | 2019 |