Submitted thesis 17/08/2021
Lead Research Organisation:
University College London
Department Name: Institute of Health Informatics
Abstract
Organisations
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/T502583/1 | 01/01/2019 | 30/09/2020 | |||
| 2227735 | Studentship | MR/T502583/1 | 22/09/2016 | 30/09/2019 | Myrto Kremyda-Vlachou |
| Title | Next generation De Novo Whole Genome sequencing |
| Description | The utility of Whole genome sequencing was explored to support clinical and public health responses to HCV. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | No |
| Impact | The use of WGS in genotyping and identifying transmission of HCV was assessed. Approaches for clinical and research study of HCV were mainly based on different sections of the HCV genome, but not on the entirety of the genetic material of a HCV infection. Using WGS, might provide an opportunity to enrich our understanding of HCV and achieve improved care for patients. |
| Title | Computational methods to analyse whole genomes of HCV |
| Description | Different pieces of software were used to analyse HCV samples and obtain whole genomes. Downstream analyses involved the development of scripts using Bash and R languages. |
| Type Of Material | Computer model/algorithm |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | Computational approaches were developed to study the quality of whole genomes and indicate how reliable this method is to study HCV both at a clinical and research level. Phylogenetics using whole genomes of HCV. |
| Description | International Conference for Computational Biology (RECOMB) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation based on whole genome assembly of viral samples. This triggered conversations about the impact of different sequencing techniques to clinical decision making. |
| Year(s) Of Engagement Activity | 2019 |