Understanding the role of inflammation in the pathogenesis of amyotrophic lateral sclerosis
Lead Research Organisation:
University of Oxford
Department Name: Clinical Neurosciences
Abstract
DPhil will focus on understanding the role that neuroinflammation plays in the pathogenesis of ALS using a combined neuropathological approach and in vitro models
Organisations
Publications
Vahsen BF
(2021)
Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers.
in Nature reviews. Neurology
Vahsen BF
(2022)
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons.
in Scientific reports
Giacomelli E
(2022)
Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.
in Cell stem cell
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| MR/N013468/1 | 01/10/2016 | 30/09/2025 | |||
| 2283992 | Studentship | MR/N013468/1 | 01/10/2019 | 30/09/2022 | Bjorn Vahsen |
| Description | The role of microglia in the pathophysiology of C9orf72-related amyotrophic lateral sclerosis |
| Amount | £285,000 (GBP) |
| Funding ID | Talbot/Apr22/889-791 |
| Organisation | Motor Neurone Disease Association (MND) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2022 |
| End | 09/2025 |
| Description | MND Encourage 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | 2-day workshop for ECRs and PhD students working on MND to exchange and give lay talks to people living with and affected by MND |
| Year(s) Of Engagement Activity | 2022 |
| Description | Patient group talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Our lab gave a talk to MND patients and carers (local Oxford branch). I gave a lay talk on my DPhil project |
| Year(s) Of Engagement Activity | 2022 |