The role of NKT cells and lipid stimuli in the development of allergic sensitisation
Lead Research Organisation:
University of Nottingham
Department Name: School of Life Sciences
Abstract
This project aims to investigate the influence of lipids from an allergen source to shift towards a Th2 response of allergic sensitisation.
Techniques will be developed to isolate and characterise natural killer T (NKT) cells from human blood samples and then co-culture iNKT cells with lipid and/or protein-loaded dendritic cells. The subsequent cytokine response will be measured using assays to determine whether a Th2 response has been produced. These techniques will be applied to allergic and non-allergic blood samples to characterise the lipid-activation profiles of NKT cells in each group.
Techniques will be developed to isolate and characterise natural killer T (NKT) cells from human blood samples and then co-culture iNKT cells with lipid and/or protein-loaded dendritic cells. The subsequent cytokine response will be measured using assays to determine whether a Th2 response has been produced. These techniques will be applied to allergic and non-allergic blood samples to characterise the lipid-activation profiles of NKT cells in each group.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| BB/S506928/1 | 01/10/2018 | 31/03/2023 | |||
| 2397745 | Studentship | BB/S506928/1 | 01/10/2018 | 31/03/2023 | Georgina Hopkins |