Hyperpolarised xenon MRI as a new platform for epithelial function assessment
Lead Research Organisation:
University College London
Department Name: Medical Physics and Biomedical Eng
Abstract
1 Brief description of the context of the research including potential impact
The development of new acquisition methods and analysis methods for hyperpolarised 129-xenon MRI, focusing on the development of methods to quantify epithelial gas transfer rates.
2 Aims and Objectives
-The specific objectives are to:
Design and implement novel 129-Xe MRI acquisition methods for preclinical and clinical measurement of epithelial gas transfer rates in the lung and the bowel
Design and implement novel analysis methods to model 129-Xe signals to determine gas transfer rates in the lung and the bowel
To define a general framework/platform for epithelial function measurements using 129-Xe MRI
3 Novelty of Research Methodology
New methods of image acquisition for 129-Xe in the lungs will be developed
129-Xe MRI in the bowel has not to date been reported in either preclinical or clinical settings.
A general platform for epithelial function measurement using 129-Xe MRI has not previously been described.
4 Alignment to EPSRC's strategies and research areas
Healthcare Technologies theme
Artificial Intelligence Technologies research area
Image & Vision Computing research area
Medical Imaging research area
5 Any companies or collaborators involved
This is an ICASE studentship with GlaxoSmithKline.
The development of new acquisition methods and analysis methods for hyperpolarised 129-xenon MRI, focusing on the development of methods to quantify epithelial gas transfer rates.
2 Aims and Objectives
-The specific objectives are to:
Design and implement novel 129-Xe MRI acquisition methods for preclinical and clinical measurement of epithelial gas transfer rates in the lung and the bowel
Design and implement novel analysis methods to model 129-Xe signals to determine gas transfer rates in the lung and the bowel
To define a general framework/platform for epithelial function measurements using 129-Xe MRI
3 Novelty of Research Methodology
New methods of image acquisition for 129-Xe in the lungs will be developed
129-Xe MRI in the bowel has not to date been reported in either preclinical or clinical settings.
A general platform for epithelial function measurement using 129-Xe MRI has not previously been described.
4 Alignment to EPSRC's strategies and research areas
Healthcare Technologies theme
Artificial Intelligence Technologies research area
Image & Vision Computing research area
Medical Imaging research area
5 Any companies or collaborators involved
This is an ICASE studentship with GlaxoSmithKline.
Studentship Projects
| Project Reference | Relationship | Related To | Start | End | Student Name |
|---|---|---|---|---|---|
| EP/V519625/1 | 01/10/2020 | 30/09/2026 | |||
| 2431878 | Studentship | EP/V519625/1 | 01/10/2020 | 30/09/2024 | Yohn Taylor |